obyvatel
The Living Force
I recently listened to an audio lecture of Dr Candace Pert (neuroscientist and pharmacologist who discovered the opiate receptor and author of Molecules of Emotion) with the title "Your Body is Your Subconscious Mind". It was interesting and in order to get some clarification on some terms she had used in that audio lecture, I got her more recent book "Everything You Need to Know to Feel Go(o)d". In this book, she carries on from the Molecules Of Emotion and outlines findings in mainstream scientific research which throw light on a new view of the body mind. The book is written as an experiential journey with scientific data and I found it an interesting read despite some New Agey slant that crept up in places. I am sharing portions of the audio lecture and the book here.
Starting off with a primer on the cell biology and the molecules of emotion.
[quote author=Dr Pert]
Virtually every cell in the body is is studded with thousands of tiny structures called receptors. Like the sense organs - the eyes, nose and ears - the job of the receptors is to pick up signals coming at them from the surrounding space. They are so important that a full 40% of our DNA is devoted to making sure they are perfectly reproduced from generation to generation.
Once the receptors receive a signal, the information is transferred to deep within the cell's interior where tiny engines roar into action and initiate key processes. Data coming in this way directs cell division and growth, cell migration for attacking enemies and making repairs, and cell metabolism to conserve or spend energy - to name just a few of the receptor activated activities.
The signal comes from other cells and is carried by a juice that we call an informational substance. These juices from the brain, sexual organs, gut and heart - literally everywhere - communicate cell to cell, providing an infrastructure for the conversation going on in the body mind. You know these juices as hormones, neurotransmitters and peptides, and we scientists refer to all three with one word: ligand. This term is from ligare, a Latin word meaning "to bind", and is used because of the way that the substances latch on so tightly to the cell's surface receptors.
Information carrying ligands are responsible for 98% of all data transfer in the body and brain. The remaining 2% of communication takes place at the synapse, between brain cells firing and releasing neurotransmitters across a gap to hit the receptors on the other side.
.............
My personal favorites among the ligands are the peptides, which consists of a string of amino acids, joined together like beads in a necklace; larger strings of amino acids are called proteins. There are over 200 peptides mapped in the brain and body, each one sounding a complex emotional chord - such as bliss, hunger, anger, relaxation or satiety - when their signal is received by the cell. I've devoted my 30+ year career to studying peptides such as endorphins and other substances.
In addition everyone should know that most ligands have chemical equivalents found outside the body, such as Valium, marijuana, cocaine, alcohol and caffeine, to name a few. [BTW, valium and alcohol bind to the GABA receptor]
You've now learned about two components that make up this bodymind communication system - the receptor and the ligand. These are what I have called molecules of emotion. But how do the two find each other across the vast reaches of intercellular space, hook up - or bind- and then transfer information to affect cellular bodywide activity?
We used to explain the attraction by a quality called receptor specificity, which is that each receptor is specifically shaped to fit one and only one ligand. A lock and key model helped with visualizing this method of connecting or binding, The key (a peptide) floats by until it finds its perfect keyhole (the receptor). The key inserts into the keyhole, opening the lock of the cell, and cellular activities begin.
While this is partially accurate, w now understand a more dynamic relationship between ligand and receptor, involving something called 'vibratory attraction'. Sitting on the surface of the cell, the receptor wiggles and shimmies, changing from one configuration to another in a constant state of flux. This dance creates a vibration that resonates with a ligand vibrating at the same frequency, and they begin to resonate together. Cellular resonance - it's like when you pluck one string in on two different guitars in the same room - one will resonate with the other, both striking the same note. This creates a force of attraction, and that way the peptides resonate with their receptors and come together to strike the emotional chord as they bind.
I've said that the emotions are the link between the physical body and the non-physical states of consciousness, and the receptors on every cell are where this happens. The attracting vibration is the emotion, and the actual connection - peptide to receptor - is the manifestation of the the feeling in the physical world.
.........
What we experience as a 'feeling' is the actual vibrational dance that goes on as the peptides bind to the receptors, whether it happens in your conscious awareness or not. Below what we notice happening,a huge amount of emotionally mediated information is being exchanged throughout the body and the brain, much of which never rises into our consciousness. This is why I say : "Your body is your subconscious mind."
...............
What is the result of all this activity? On a bodywide scale, the receptors are dynamic molecular targets , modulating our physiology in response to our emotion. One example is that receptors wax and wane in number and and sensitivity, depending on how often they are occupied by peptides or other informational substances. In other words, our physical body can be changed by the emotions we experience.
We used to think that peptides latched on to a single receptor, but we know now that receptors are often clumped together in tight, multiple complexes. Together they form the walls of deep channels leading into the interior of the cell; and they open and close with a rhythmic, pumping action. As they move, these channels let substances in and out of the cell, setting up an ionic flux, or electrical current, which can course throughout the bodymind. One of the things that this current does is influence the firing set point of neurons in the brain, determining the path of brain cell activation. So you can see that the molecules of emotion are directly affecting how you think.
[/quote]
In 1985, Dr Pert and her husband Michael, an immunologist proposed the existence of a psychosomatic network that is mediated by emotions in a paper published in the Journal of Immunology. This paper eventually launched a new field known as psychoneuroimmunology (PNI).
Stem cells and migration
Dr Pert cites the research of Dr Eva Mezey at the NIH laboratory where it was found that stem cells migrate from the bone marrow into the brain and become neurons as an irrefutable case of body and mind being one and the same. The initial reaction to Dr Mezey's data almost got her lab closed down.
Emotions and Memory
This chimes well with the core ideas of trauma healing as espoused by Peter Levine and others. Also brings to mind the central tenet of homeopathy that for a body to heal itself of a disease, a substance which produces symptoms similar to the state created from the disease, is required - or "like cures like" .
Multiple Personalities
Dr Pert has some interesting findings which relate the "many I" model of 4th Way Work. She cites Dr Richard Schwartz who described a theory of non-pathological multiple personalities in a single person and created the Internal Family System (IFS) of therapy. She studies findings from pathological MPD cases and correlates them to non-pathological cases using the underlying substratum of molecules of emotion.
To be contd.
Starting off with a primer on the cell biology and the molecules of emotion.
[quote author=Dr Pert]
Virtually every cell in the body is is studded with thousands of tiny structures called receptors. Like the sense organs - the eyes, nose and ears - the job of the receptors is to pick up signals coming at them from the surrounding space. They are so important that a full 40% of our DNA is devoted to making sure they are perfectly reproduced from generation to generation.
Once the receptors receive a signal, the information is transferred to deep within the cell's interior where tiny engines roar into action and initiate key processes. Data coming in this way directs cell division and growth, cell migration for attacking enemies and making repairs, and cell metabolism to conserve or spend energy - to name just a few of the receptor activated activities.
The signal comes from other cells and is carried by a juice that we call an informational substance. These juices from the brain, sexual organs, gut and heart - literally everywhere - communicate cell to cell, providing an infrastructure for the conversation going on in the body mind. You know these juices as hormones, neurotransmitters and peptides, and we scientists refer to all three with one word: ligand. This term is from ligare, a Latin word meaning "to bind", and is used because of the way that the substances latch on so tightly to the cell's surface receptors.
Information carrying ligands are responsible for 98% of all data transfer in the body and brain. The remaining 2% of communication takes place at the synapse, between brain cells firing and releasing neurotransmitters across a gap to hit the receptors on the other side.
.............
My personal favorites among the ligands are the peptides, which consists of a string of amino acids, joined together like beads in a necklace; larger strings of amino acids are called proteins. There are over 200 peptides mapped in the brain and body, each one sounding a complex emotional chord - such as bliss, hunger, anger, relaxation or satiety - when their signal is received by the cell. I've devoted my 30+ year career to studying peptides such as endorphins and other substances.
In addition everyone should know that most ligands have chemical equivalents found outside the body, such as Valium, marijuana, cocaine, alcohol and caffeine, to name a few. [BTW, valium and alcohol bind to the GABA receptor]
You've now learned about two components that make up this bodymind communication system - the receptor and the ligand. These are what I have called molecules of emotion. But how do the two find each other across the vast reaches of intercellular space, hook up - or bind- and then transfer information to affect cellular bodywide activity?
We used to explain the attraction by a quality called receptor specificity, which is that each receptor is specifically shaped to fit one and only one ligand. A lock and key model helped with visualizing this method of connecting or binding, The key (a peptide) floats by until it finds its perfect keyhole (the receptor). The key inserts into the keyhole, opening the lock of the cell, and cellular activities begin.
While this is partially accurate, w now understand a more dynamic relationship between ligand and receptor, involving something called 'vibratory attraction'. Sitting on the surface of the cell, the receptor wiggles and shimmies, changing from one configuration to another in a constant state of flux. This dance creates a vibration that resonates with a ligand vibrating at the same frequency, and they begin to resonate together. Cellular resonance - it's like when you pluck one string in on two different guitars in the same room - one will resonate with the other, both striking the same note. This creates a force of attraction, and that way the peptides resonate with their receptors and come together to strike the emotional chord as they bind.
I've said that the emotions are the link between the physical body and the non-physical states of consciousness, and the receptors on every cell are where this happens. The attracting vibration is the emotion, and the actual connection - peptide to receptor - is the manifestation of the the feeling in the physical world.
.........
What we experience as a 'feeling' is the actual vibrational dance that goes on as the peptides bind to the receptors, whether it happens in your conscious awareness or not. Below what we notice happening,a huge amount of emotionally mediated information is being exchanged throughout the body and the brain, much of which never rises into our consciousness. This is why I say : "Your body is your subconscious mind."
...............
What is the result of all this activity? On a bodywide scale, the receptors are dynamic molecular targets , modulating our physiology in response to our emotion. One example is that receptors wax and wane in number and and sensitivity, depending on how often they are occupied by peptides or other informational substances. In other words, our physical body can be changed by the emotions we experience.
We used to think that peptides latched on to a single receptor, but we know now that receptors are often clumped together in tight, multiple complexes. Together they form the walls of deep channels leading into the interior of the cell; and they open and close with a rhythmic, pumping action. As they move, these channels let substances in and out of the cell, setting up an ionic flux, or electrical current, which can course throughout the bodymind. One of the things that this current does is influence the firing set point of neurons in the brain, determining the path of brain cell activation. So you can see that the molecules of emotion are directly affecting how you think.
[/quote]
In 1985, Dr Pert and her husband Michael, an immunologist proposed the existence of a psychosomatic network that is mediated by emotions in a paper published in the Journal of Immunology. This paper eventually launched a new field known as psychoneuroimmunology (PNI).
The body is not an appendage dangling from the almighty brain that rules over all systems. Instead, the brain itself is one of the many nodal or entry points into a dynamic network of communication that unites all systems - nervous, endocrine, immune, respiratory, and more. This is called the psychosomatic network, and the linking elements to keep it all together are the informational substances - peptides, hormones and neurotransmitters - known as the molecules of emotion.
Stem cells and migration
Dr Pert cites the research of Dr Eva Mezey at the NIH laboratory where it was found that stem cells migrate from the bone marrow into the brain and become neurons as an irrefutable case of body and mind being one and the same. The initial reaction to Dr Mezey's data almost got her lab closed down.
Stem cells - cells that are undifferentiated and have yet to become organ cells - are made in the bone marrow, which we already knew. We also knew that stem cells move through the blood to other systems and organs. But the news that they move out of the bone marrow, eventually becoming neurons in the nervous system was shocking.
Dr Mezey found that this migration happens not only in response to illness, as when stem cells grow into immune cells, but as a matter of course, And even more shocking was that these stem cells were not just showing up in the spinal cord but also in the highest part of the brain, a structure known as the frontal cortex.
............
The bones are giving rise to the brain. Ancient Chinese medicine says that chi, loosely translated as the life force, originates in the bone. Now we are showing in the Western model that cells start as baby stem cells born in the bone marrow, become immune like cells as they pass through the body, and then arrive in the brain as brain cells. This migration, our lab had shown in the 80's, was directed by the molecules of emotion in a process known as chemotaxis.
Emotions and Memory
Classically, the hippocampus is the structure of the brain associated with memory, because when you remove it surgically, a person will have deficits in memory. But contrary to what many neuroscientists believe, this does not necessarily prove that the hippocampus is the seat of memory. In fact recent findings support the theory that recall is stored throughout the body, not in the brain alone. Dr Eric R. Kandel, a neurobiologist at Columbia University , received a NObel Prize for medicine in 2000 for showing that memory resides at the level of the receptor.
The activity of cellular binding throughout the body can impact neuronal circuitry, influencing memory and thinking. When a receptor is flooded with a peptide or other ligand, the cell membrane is changed in such a way that the probability of an electrical impulse traveling across the membrane is affected.
Recent discoveries are important for appreciating how memories are stored not only in the brain but in the body as well, where a psychosomatic network extends throughout all systems of the organism. A major storage area is in the receptors distributed near the spinal cord, between nerve and ganglia and all the way out to the internal organs and the surface of the skin.
Whether your memories are conscious or not is mediated by the molecules of emotion. They decide what becomes a thought rising to the surface, and what remains buried deeply in your body. What this means is that much of memory is emotion driven, not conscious, although it can be made conscious by intention.
....
Buried painful emotions from the past make up what some psychologists and healers call a person's "core emotional trauma". The point of therapy - including bodywork, some kinds of chiropractic, and energy medicine is to gently bring that wound to gradual awareness, so it can be re-experienced and understood. Only then is choice possible, a faculty of your frontal cortex, allowing you to reintegrate any disowned parts of yourself; let go of old traumatic patterns; and become healed or whole.
.....................
Studies by Dr Donald Overton on dissociated states demonstrates that what you learn in one drug induced state, you can't retrieve from your memory at a later time unless you are in the same condition.
This chimes well with the core ideas of trauma healing as espoused by Peter Levine and others. Also brings to mind the central tenet of homeopathy that for a body to heal itself of a disease, a substance which produces symptoms similar to the state created from the disease, is required - or "like cures like" .
Multiple Personalities
Dr Pert has some interesting findings which relate the "many I" model of 4th Way Work. She cites Dr Richard Schwartz who described a theory of non-pathological multiple personalities in a single person and created the Internal Family System (IFS) of therapy. She studies findings from pathological MPD cases and correlates them to non-pathological cases using the underlying substratum of molecules of emotion.
[In pathological MPD cases] The fact that subpersonalities such as these have been shown to have different brain scans is less interesting than the fact that they truly look physically distinct. This is not just because they have different hairstyles and clothes, but because the muscles of their faces are held and shaped differently from one personality to the next. Films of patients taken by psychologists show that these whole body "state changes" occur instantaneously during transition - truly qunatal shifts.
[Alternate personalities are also known to show completely different physiological responses - like one would have a severe allergic reaction to cats while the other personality would be completely unaffected.]
................
In normal people, emotions are the quantal trigger for changes from one personality to the next.The link, the bridge between them that transforms one to the other, is the emotions. Like light, which is both a particle and a wave, feelings become matter (receptors, ligands, and sudden expressions of gene programs like that for inflammation) as they vibrate in the quantum field.
............
Emotions are the flow of information perceived to be essential for the survival of any particular state of consciousness being observed. This definition recognizes that our own observations, perceptions, beliefs and notions of reality can switch around. because emotions have their hardwired roots in millions of years of our survival and evolution, any given subpersonality observing the world will be pretty darn sure that he or she is the "right" one. This explains why being right sometimes feel like a matter of life and death.
To be contd.