Re: Re: Endothelial dysfunction
LQB said:
I don't think the keto diet (as we refer to it) is high protein - protein should be restricted.
You're right -- corrected above.
LQB said:
Looks like there is a bazillion methylation support protocols out there - this blog post might help a bit: http://cfsmethylation.blogspot.com/2012/04/bumbling-around-methylation.html
Yes it does -- it also has some good links, so thank you.
LQB said:
In a recent WAPF article (http://www.westonaprice.org/cancer/cancer-to-the-rescue), Stephanie Seneff suggests the importance of sulfate in the body (and its transport) in relation to cancer. She suggests that an unacknowledged benefit of epsom salts is the sulfate (as opposed to the Mg), and that curcumin/turmeric are good sulfate transporters (besides anti-inflammatory/anti-oxidant). She doesn't mention methylation but there may be a connection considering how many pathways are involved.
It's a fascinating article, and would also be a good addition to the Cancer thread. Thanks again!
Redfox said:
Some things I've picked up along the way [...] Well that's the overview of some of the research I've done, I'll see if I can post more relevant stuff later.
This is all good information, and I appreciate you posting it. This video was good, and I sent it out to my extended family today:
RedFox said:
I also posted it to FB along with this video:
These are the recommendations I pulled from it as I was taking notes:
- Methylfolate (Deplin)
- Methyl B-12 (absorbed under tongue: Jarrow)
- Tetrahydrobiopterin BH4 (Nutrimedical.com – search for BH4 or mood balance)
- NAC
- Full spectrum minerals
- Epsom salts
- Vitamin B6 (P5P)
- Vitamin C
- DMG-Dimethylglycine or TMG
- Zinc
- Omega 3 fish oil
- Vitamin E
- Silymarin
- Glutathione SR
- Filtered water (reverse osmosis)
- Vegetables and fruits
- Heavy metal test
He also mentions how PCBs from plastic can contribute to the slowing of the methylation pathways -- I learned last weak that dental sealants can leach PCBs into the body, just like amalgams do with mercury
RedFox said:
Finally (for a wider scope on the MTHFR problem) Doctor Amy seems to have done some excellent research.
_http://www.dramyyasko.com/our-unique-approach/methylation-cycle/
I agree -- it looks like she also has a new book available here:
http://www.holisticheal.com/feel-good-nutrigenomics-your-roadmap-to-health-book.html
And here are a couple of MTHFR support and research sites:
http://mthfr.net/
http://mthfrsupport.weebly.com/index.html
There are also a number of books relevant to this topic -- some of them are pretty pricey, but here are the titles if anyone wants to look them up on Amazon:
Nutrigenetics: Applying the Science of Personal Nutrition
Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition
Recent Advances in Nutrigenetics and Nutrigenomics, Volume 108
Nutrigenetics And Nutrigenomics (World Review of Nutrition and Dietetics)
Nutrigenetics
Impact of Nutritional Epigenomics on Disease Risk and Prevention: Special Topic Issue: 'Journal of Nutrigenetics and Nutrigenomics'
Nutritional Genomics: Discovering the Path to Personalized Nutrition
Genetic Bypass: Using Nutrition To Bypass Genetic Mutations (by Amy Yasko)
Methyl Magic: Maximum Health Through Methylation
The Methylation Miracle: Unleashing Your Body's Natural Source of SAM-e
The Homocysteine Revolution
The H* Factor Solution: *(Homocysteine, the Best Single Indicator of Whether You are Likely to Live Long or Die Young)
Could It Be B12?: An Epidemic of Misdiagnoses
The Dynamic Genome and Mental Health: The Role of Genes and Environments in Youth Development
Nutritional Genomics: Impact on Health and Disease
Two books which I already have that have some information about this are
Nutrient Power and
Feed Your Genes Right. The former doesn't have an index for some reason, so I'm having to hunt through it linearly, but here are some sections from the latter on MTHFR:
p. 15 said:
How Jerry Saved His Heart
Jerry, now age fifty-six, is alive and well and in exceptionally good health – thanks to the fact that he has used nutrition to offset a potentially fatal defect.
Nearly all of the men in Jerry’s family have died at relatively young ages. His paternal grandfather died of a heart attack at forty-six. Jerry’s father died after suffering his second heart attack at age thirty-eight. And Jerry’s older brother died after a stroke at age forty-two.
Several years ago genetic testing found that Jerry carried a subtle defect in the gene programming the construction of methylenetetrahydrofolate reductase (MTHFR), an enzyme needed for normal utilization of the b vitamin folic acid. Because of this defect, Jerry did not efficiently use the modest levels of folic acid found in his diet. As a result his blood levels of homocysteine, a major risk factor for heart disease, were extremely high – 34 micromoles per liter of blood. It is very likely that other men in Jerry’s family carried the same MTHFR polymorphism.
To offset the sluggish MTHFR enzyme created by the gene, a nutritionally oriented physician recommended that Jerry take a daily high-potency B-complex vitamin supplement containing 800 mcg of folic acid. She also suggested that Jerry eat more vegetables and fewer high-carb and high-fat fast foods. Literally fearing for his life, Jerry also began exercising regularly and adopted stress-reduction habits, such as meditation, to deal with work-related pressures.
Today Jerry is a paragon of cardiovascular fitness. His homocysteine and blood-fat levels are normal, about 7 micromoles per liter of blood. In addition, his blood pressure is normal, and a treadmill test recently found him to be exceptionally fit.
p. 60 said:
Vitamins Help Crystal Have a Healthy Baby
Crystal, age thirty-three, had experienced more than her share of difficulties on the road to motherhood. During her twenties she miscarried once, gave birth to a stillborn baby, and delivered a son with spina bifida, a serious birth defect that led to his death several months later.
A new physician, looking at Crystal’s medical history, recommended that she undergo genetic testing for a subtle defect in the gene coding for methylenetetrahydrofolate reductase (MTHFR). MTHFR is an enzyme needed for the normal utilization of folic acid, and both the genetic defect and low folic acid intake have been associated with a higher risk of birth defects.
It turned out that Crystal did have that genetic defect, and a simple blood test also revealed that she had elevated levels of homocysteine, a sign of inadequate folic acid intake. Following her physician’s recommendation, Crystal began eating more spinach and dark green lettuces, good sources of folic acid, and taking a B-complex supplement plus 1,000 mcg of extra folic acid. Her doctor also recommended that she eat fewer sweets, because diets high in sugar have also been linked to a greater risk of birth defects.
Last year Crystal gave birth to a healthy eight-pound girl, and she and her husband are planning to have another baby in the next couple of years. Crystal’s improved eating habits and the B-vitamin supplements she now takes successfully counteracted an inborn genetic weakness.
p. 63 said:
Methylation Reactions and Molecule-Building Processes
[…] When methylation becomes sluggish, all of the subsequent molecule- and cell-building reactions begin to stall. One sign of sluggish or defective methylation is an elevation in the blood levels of homocysteine. Homocysteine is highly toxic and damages blood vessel walls, leading to the subsequent deposition of cholesterol, the body’s attempt to deal with the damage.
Elevated homocysteine levels were first proposed as a risk factor for coronary heart disease by Dr. Kilmer McCully in 1969, at a time when medicine was committed to the idea that excess cholesterol was a leading cause of heart disease. Since the early 1990s, hundreds of studies have confirmed homocysteine as a leading risk factor for heart disease, stroke, Alzheimer’s disease, and many other diseases.
Today many physicians routinely measure their patients’ levels of homocysteine to assess their risk of heart disease. (Ideal homocysteine levels are less than 6 micromoles per liter of blood, and levels above 13 micromoles per liter are a serious risk factor.) No drug will lower homocysteine levels; only folic acid, vitamins B6 and B12, choline, and betaine can. But despite considerable attention to homocysteine in the medical journals, most physicians see it only as a risk factor for heart disease, not as a sign of seriously impaired methylation and chemical reactions throughout the body. Furthermore, excess homocysteine is also toxic to the methylation process and to many different types of cells in the body, likely damaging brain cells and creating mutations that give rise to some cancer cells.
Some population groups, ranging from about 7 percent of Irish to perhaps as much as 42 percent of French Canadians, carry a subtle genetic defect (technically known as a polymorphism) that reduces their bodies’ ability to use folic acid efficiently. This genetic polymorphism produces an inefficient form of methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in using folic acid. Either a diet high in folic acid (found in dark leafy green vegetables) or folic acid supplements can offset this polymorphism, improve methylation, and lower homocysteine levels. The effect is comparable to “loading,” or saturating, MTHFR’s cellular environment with folic acid to improve its activity […]
There are also MTHFR-related sections on depression (p. 142-3), birth defects (p. 163-4), heart attack and stroke (p. 174), and neurotransmitters (p. 183-4).
Finally, the combination of genetic mutation and repeated reference to vegetables in regard to folic acid has me thinking about some topics in the transcripts (caveat: the following are condensed notes from my health file, not meant to replace the original transcripts -- if you want to look up the context, do a keyword search and it should get you there).
First, there is this part that was asked in relation to D'Adamo's books either directly or indirectly:
The Atkins diet for waistline okay, heart smart?! Naah! Atkins plan is good with two exceptions: suggest inclusion of bran fiber and liquid dairy, due to blood type, and need for elimination. This is greatly inhibited by “Atkins” plan, which is a fundamental flaw therein.
Regarding the diet you’re eating now: mostly fruits and vegetables and a little bit of meat. More protein needed for amino acids of a natural and balanced type. Stop amino acid supplements and eat meat. Your type needs the highest level and quality of protein.
The author of this blood type diet didn’t really just invent stuff out of his head, but the RH factor hones it in better. The RH factor will refine what this guy says exactly. It matters what type you are, and find out. The genotype diet is a very good start. It and the blood type diet have different goals. The genotype diet is more complete in a sense because it covers more genes and the blood type does just one.
What happened last time you had kogel mogel? This means that as a general rule, in terms of establishing brain chemistry generally speaking, it's good for everyone to stick to the blood type diet (closer), but don't obsess...
You should investigate blood type diet differentials, there is validity there.
The solution to hyperinsulism is more complicated than what you have read so far, but your RH factor is the key. There is more, but remember it is a mosaic. {I don't think this was in relation to D'Adamo, but I include it because it mentions RH factor}
Then possibly this (not sure):
You have this question from {XXXXX}: "It's about my difficulty with mammalian meat. Is there some reason besides leaky gut?" Incorrect formulation of the question. She does have a problem with mammalian meat, but that is not a feature of leaky gut. It is a feature of multiple system breakdown. Epigenetics mainly, but also specific genetic line problems. First, the gene expression has been altered after many years of abuse of the system design. This is something like what Gedgaudas writes about that once you’ve been eating carbs and grains and things for so many years, your body gets conditioned to it and it's very very difficult to switch over, and more. It is mostly reversible for {XXXXX}, but more difficult for her child who is third generation. Her mother has also put her system through improper use of the natural genetic profile.
Full siblings of schizophrenics are nine times more likely than the general population to have schizophrenia, and four times more likely to have bipolar disorder. XXXXX is affected by this genetic tendency -- oh indeed! However this requires explanation. First of all, the genetics that are associated with schizophrenia can be either a doorway or a barrier. Second, the manifestation of schizophrenia can take non-ordinary pathways. That is to say that diet can activate the pathway without the concomitant benefits. Primitive societies that eat according to the normal diet for human beings do not have "schizophrenics", but they do have shamans who can "see". When these genetic pathways are activated through wrong diet, it screws up the shamanic capacity. So, schizophrenia as you understand it or have witnessed it is a screw-up of something that could or might manifest in a completely different way on a different diet.
This seems directly relevant:
The cause of alzheimer’s disease is genetic. Biogenetic engineering can prevent it or lessen its effects, but will resolve anyway in the near future. And much other as well.
And there's always this to keep in the back of our minds:
The bloodlines that converge in the Percys and the Mortimers are incredible! You should know that these bloodlines become parasitically infected, harassed and tinkered with whenever a quantum leap of awareness is imminent. Such as “now.” We are talking about bloodlines becoming parasitically infested and harassed at times of quantum leaps such as now, when you were reading back over this, it seems that this is a repeating cycle, this parasitic infestation; and then reading the history of Gregory of Tours, and all of these truly amazing things - lights in the sky, plagues, repeated incidents of aerial phenomena... a ‘light like a serpent’ in the sky... a bright light and ‘snakes fell from the clouds...’ in 590, fiery globes traversed the heavens and then an eclipse of the sun. These astronomical phenomena were usually followed by inclement weather which, in its turn, brought plague... this may be the kind of parasitical infestation, harassment and so forth that we are talking about, look for more clues. Undulating matrix/mosaic. Wait for more... and good night.
In doing research earlier last and this year on pleomorphism and cancer (specifically the connection to molds and yeasts), there seemed to be a possible connection to 'parasitic infestation', possibly designed to respond to electrophonic effects. Now, this thing about MTHFR polymorphisms seems like it could fit the description of 'tinkering'. They seem common enough in the population, and are connected to
so many autoimmune and psychological disorders and "diseases of modern civilization" which are connected to MTHFR when you watch the above videos, that it seems a little suspicious.
