AUTOIMMUNE DISEASES CAUSED BY AN INFECTION?

Thanks to all who have contributed in this thread, I'm pretty interested in this protocol mycoplasma infections, especially respiratory diseases, during my childhood, hath suffered asthma, allergies, bronchitis, had treatment with ampicillin for several years, flu each change of station, in fact now I have a bad cold, I'll try to get everything you need, here in Mexico is difficult to get some antibiotics without prescription, I hope to achieve.


Laura said:
I don't know about you, but for me, having to remember to take medicine for six months, and even enduring a herxheimer reaction is worth feeling better.

I agree with you Laura, thank you for being an example of fortitude and strength to us all.
 
A simply amazing thread. After reading, notwithstanding the links, pdf's and video's (made some notes for those to revisit), can't believe the roller coaster effects during the protocols of unhinging these parasitic critters who change, camouflage and hide deep within - good grief - although you knew what was needed, thanks for the courage of doing, Laura, hoping this will flush them out for good.

The Iron reference was very interesting halfway back in the thread, right to the Toxoplasma gondii infection and schizophrenia. TG came up a longtime ago in other threads, so this ties in, and wow, what a likely connection.

I was wondering, similarly to the discussions on turpentine treatments, or if even that should be utilized, if ultimately there is not another similar plant/tree resin that would have affective properties in regard to the outcomes in treatments...

Much appreciation to everyone who contributed in such a dynamic way - great!
 
RedFox said:
Not only does the breakdown of the system lead to chronic disease, but so does chronic disease lead to the breakdown of the system. Catch 22.

That's exactly what I've been thinking. Hulda Clark had 2/3 of the picture, I think -- toxicity and infection. Amy Yasko's tripartite model adds the crucial third element, which is genetics. It comes down to knowledge of the machine, which in the current context means knowledge of your genetic profile and weaknesses, knowledge of environmental toxicity and how it affects your body, and knowledge of infectious agents and how they interact with the first two. Gaps in knowledge along any of these three lines will weaken the effects of what you are trying to accomplish along the others.

I came across an interview with Chris Kresser and Paul Jaminet yesterday that is relevant to the diet/infection question, particularly if you're looking at protozoa like toxomoplasma gondii. The whole article is probably worth reading, but here's the relevant part:

http://chriskresser.com/episode-15-dr-paul-jaminet-on-chronic-infections-depression-more/

Chris: Right, so how can somebody, the second part of that question is how can someone distinguish between, what are the symptoms of infection first and then how can someone distinguish between the different types of infection fungal, bacterial, parasitic?

Paul: Yeah well this is one place I think diet can really help, is in diagnosis. Medicine is still in a primitive state it’s not very good for diagnosing these infections much less treating them. But a lot of these pathogens respond very differently to different diets. So one of the key differences is in how they respond to a ketogenic diet for instance. So pathogens that have mitochondria like fungi and protozoa can metabolize ketones for energy. Bacteria and viruses can’t, and so if you go on a ketogenic diet you’ll starve bacteria and viruses but you’ll feed fungi and protozoa. And so a simple thing to do is go on a ketogenic diet for a while, do your symptoms get worse or better. And that can tell you which class of pathogen you have, one with mitochondria or one that doesn’t have mitochondria. And those kinds of tests can be a big help, and I think part of the reason medicine doesn’t succeed against all these diseases is that nobody varies their diet, they’re always eating the same diet. It’s always 50% carbs with lots of wheat and sugar, plenty of vegetable oils, if you tell people to change their diet and eat healthy they look around and find other sources of the same nutrients, certainly never sample a ketogenic diet. So our basic diet, the perfect health diet, aims to be pretty much balanced, it aims to supply in food the amounts of nutrients that your body needs. And we tweak it in various ways so we tend to be very slightly low carb, but for therapeutic purposes and certain diseases we might go to more extreme diets like a ketogenic diet that’s more low carb or there’s a few diseases that may benefit from going higher carb. But also even apart from treatment the diet is a good diagnostic tool. And it’s also helpful for gut infections to vary the types of food you eat, different foods get digested in different places in the digestive tract. Different things are accessible to different kinds of pathogens, the time scales in which things happen have diagnostic value. So fungi tend to do everything slower than bacteria, they multiply a lot slower, so fungal infections tend to be relatively stable whereas bacterial infections can be much more variable. There’s a lot of ways you can manipulate diet and help understand your own disease and that can guide you to good treatments.

Chris: What’s interesting is, as you’re probably aware in the alternative health world there’s a lot of different perceptions about how to deal with fungal infections and the word candida is thrown around a lot, which I think obviously that candida infection is real but I also, in my experience see it kind of slapped on as a diagnosis of exclusion, meaning we can’t figure out what else it is so we’ll just call it candida. But I’m really interested in what you were saying, I read your article when you talked about how fungi can utilize ketones and tend to progress on ketogenic diets because one of the interesting things about how the candida diet is typically administered is people remove fruit, they remove carbohydrates, starchy tubers and grains and I think they end up being on a very low carbohydrate diet in a lot of cases and perhaps not completely ketogenic or not strongly ketogenic but maybe mildly ketogenic and I see a lot of patients who just get worse and worse on those diets so I wonder if it has something to do with this mechanism that you’re talking about.

Paul: Yeah I think it’s very likely. It’s not bad to go low carb by standard American diet standards, I think probably optimal for candida might be 600-800 carb calories a day, the average American gets maybe 1700 so cutting carbs in half for the average American is a good move. But going too low carb definitely risks systemic invasion so the very low carb approach, it’s not bad for a fungal gut infection but it’s not that good either. It doesn’t do that much to promote good bacteria taking over the gut. A lot of plant foods can really help suppress fungi in the gut and promote bacteria. So they can help give you a better gut flora and I think a lot of people who go extremely low carb can end up with a gut dysbiosis of some kind after years on these extreme low carb diets.

Chris: Yeah I agree with that and I’ve definitely seen that to be true in my practice. And what about brain infections Paul, this is something you’ve talked a lot about are the nerves in the brain susceptible to the same pathogens?

Paul: Yeah they are. The brain seems to be more vulnerable to bacteria especially and a little less vulnerable to fungi. There are some protozoa that can live well in the brain, some viruses flourish there. The thing about the brain is it’s pretty rich in glucose which bacteria like. Or glucose products like pyruvate or lactate which they can metabolize. So it’s kind of a paradise for bacteria and so it’s very important to maintain the integrity of the blood-brain barrier and try to help keep them out. But just like people get leaky guts they get a leaky blood-brain barrier. Also it’s not uncommon if people get some kind of trauma to the head, they get some kind of brain injury involving bleeding, that breaches the blood-brain barrier and very commonly people get brain infections that develop after some kind of head trauma. They’re not uncommon and bacteria do well in the brain, and fortunately ketogenic diets can be very helpful. Bacteria can’t metabolize ketones, when you’re on a ketogenic diet glucose levels decrease, so you’re starving the bacteria. And ketogenic diets also promote autophagy which is part of the immune response. And you can also promote that even more with a low protein diet and so in that process the cell basically has its own self digestion machinery, little digestive vesicles called lysosomes that go around and look for junk that the cell doesn’t need and they destroy it, digest it, and among the things they’ll find when they’re looking for junk are bacteria and viruses. So keeping autophagy going very frequently by occasional fasting or occasional ketogenic dieting or low protein dieting either intermittently or regularly, all of those things will help promote brain health and help keep your brain free of infections. And I think brain infections are responsible for a lot of late life degenerative diseases like Alzheimer’s, Parkinson’s, and probably others too. The brain is kind of a special place, it’s a little sheltered in terms of its nutritional status, it doesn’t vary as much with diet as the rest of the body. It has its own kind of immune functions, it’s own kind of needs, so the symptoms are a little different. So I would say in general the three places to look for different kinds of, classes of symptoms would be the gut, brain, and the body. And each one has it’s own characteristic symptoms and pathologies.

So that's a bit of a revelation about candida. At first, one might think that it would be a good idea to starve fungi and protozoa of ketones, but the issue may be a bit more complex. If you have infections, you're essentially eating for two, kind of like being pregnant (I know that's a weird thought) -- so the situation might be something like this Q/A interchange on Stephen Buhner's site about arginine:

http://buhnerhealinglyme.com/uncategorized/okay-to-supplement-l-arginine-with-mycoplasma/

Dear Stephen,
I read an article on the Rain-Tree website about supplementing l-arginine with mycoplasma, saying: “supplementing back the depleted amino acids has been reported to be helpful in some recovering from these infections. These include L-cysteine, L-tyrosine, L-glutamine, L-carnitine, and malic acid. Remember, however, that mycoplasmas thrive on arginine! Avoid L-arginine supplements and multi-amino acid formulas containing L-arginine, as well as foods rich in arginine to avoid feeding the mycoplasmas. The richest food sources of arginine (to avoid) are nuts and seeds, including the oils derived from seeds and nuts which should be eliminated or drastically reduced in the diet.” Under these circumstances, is the use of L-arginine when treating mycoplasma still okay? Also, would it be okay to take milk thistle, which is a seed?

Stephen’s response:
Here is the skinny on mycoplasmas and arginine: many mycoplasmas take arginine from the body to grow. THINK ABOUT IT: many mycoplasmas take arginine from the body to grow. WE, their human hosts, NEED arginine to be healthy. The mycoplasmas are going to get arginine no matter what. In fact what they do is scavenge if from your body’s tissues. That depletes your body of that substance and believe me, it is a crucial substance that you really do need. Some websites share horror stories About FEEDING the mycoplasmas if you take L-arginine. No matter what they will get it one way or another, so it matters not, for them, if you take a supplement or not. However FOR YOU, it is rather crucial to keep your arginine levels high since it is essential to your healthy functioning. Further, a number of mycoplasmas are actually sensitive to arginine, it can reduce their numbers in the body. So no matter what, you should be taking an L-arginine supplement or else eating foods high in arginine. Several score peer reviewed journal papers have noted that the only way to resolve cellular problems in infected mycoplasma cells is TO REPLACE THE ARGININE. So, yes, take the arginine. And the milk thistle is good to take as well.

While doing some other research yesterday, I ran across this guy named Gary Tunsky:

http://www.phcelltox.com/

He seems to be one of a group of doctors that I think of loosely as Christian Libertarian (also including Dr. Tent, Douglass Kaufmann, Joel Wallach, Leonard Horowitz, etc). This is a video of his where he talks about his basic model of health:


I'm not quite sure what to think of him yet -- he claims in another video that he gained his most significant insights after receiving a "download from the Holy Spirit", and when he emphasizes certain points, his pronunciation changes and it reminds me of how Barbara Marciniak speaks when she's channeling the Pleiadians. Anyway, from one article that's been carried on Rense's site (again, the whole article is worth taking a look at, maybe especially the part about cholesterol):

_http://www.rense.com/general62/molecularterrorism.htm

Protocols To Treat Mycoplasma

Since Mycoplasma cannot be successfully treated with the usual short course duration of antibiotics due to their intracellular location, slow proliferation rate and inherent resistance to most antibiotics, the few Mycoplasma experts that specialize in this field are recommending six-months to one year of non-stop treatments using strong antibiotics such as Cipro and Doxycycline. However, if a patient does not want to destroy their body and immune system with Cipro and Doxycycline, a total overhaul of every cell from head to toe using a multi-faceted, non-toxic, holistic treatment approach is absolutely necessary to overcome Mycoplasma infections naturally. This is why vitamins and nutritional supplementation are so important in the therapy. Chronic illness patients must also be weaned off antidepressants and other potential immune suppressing drugs before they can fully recover from their illnesses.

I'm not sure what to think of this, although I know it's the direction Stephen Buhner is going in (Herbal Antibiotics, Herbal Antivirals). Whether or not one uses an antibiotic protocol to treat a chronic infection may ultimately depend on several factors, including access to resources, cost variables, and a number of other things. I'm considering the antibiotic protocol myself, and will talk to my doctor about it in a few days, but I wanted to bring this up as something that may deserve some additional research.

Speaking of disinfo sites, there's one thing I'd like to ask for some help on from anyone with the interest and time. It turns out that mycoplasmas have been discussed on several alt/disinfo forums, and there's a particularly good collection of links here:

_http://forum.prisonplanet.com/index.php?topic=190065.0

In several cases, there are links to other forums, and sometimes those have links to other forums (etc, etc). Some of it is blatant disinfo about things like chemtrails, but I noticed that there are also some links to threads on Grant and Nancy Nicolson, who are the developers of the protocol that Gaby is currently refining and has recently attached a few papers on. That may be worth following up on.

Finally, here's a paper on mitochondria and osteoarthritis that has some interesting information that ties in to other things we're looking at:

http://www.wellnessresources.com/health/articles/mitochondria_and_osteoarthritis_an_exciting_new_frontier/

Laura said:
Now, another thing has been on my mind over the last few weeks. Keep in mind that today I'm finishing up my 8th cycle of metronidazole and on this one, have had virtually no reaction that I can detect. What is on my mind, what I have noticed for a few weeks now, is a subtle change in thinking. I don't want to say too much because I need to continue to observe this, but what I will say is that it is like chains are falling off my mind.

In addition to that, there is a different feeling in my legs. I've commented often enough about the fact that my legs have always felt leaden especially when I go up and down stairs. Well, it's too soon for a significant change, but there is enough difference to notice.

That's excellent news, Laura -- it would certainly be unsettling to find out one has been living for decades with psychedelic compounds in their system. Best wishes on your continued improvement, and looking forward to updates!
 
Laura said:
So, I would say that one doesn't necessarily have to have an autoimmune condition that is obvious to benefit from this protocol: obviously, some mental conditions like OCD, anxiety, and so much more, might be related to a long-term infection. Go back and re-read the list of things that can be related to long-term, slow burning infections. I don't know about you, but for me, having to remember to take medicine for six months, and even enduring a herxheimer reaction is worth feeling better.

Really interesting info that makes a lot of sense, thanks a lot Laura. Actually thinking about it, i think its highly possible that mental conditions and autoimmune diseases are related to long term infections.

A related personal experience - about 4 years ago sometime 2011, i suddenly had the onset of eczema all over my body, and especially the palm of my hands - at the same time, i felt that some of the mild OCD habits i had was slowly getting worse (especially the urge to wash hands often)....the eczema was held back through special soaps, and steroidal creams, but the OCD was slowly getting worse. Then in 2012, i started going low-carb and eventually to the full keto diet - and this basically cleared up all the eczema, and "push backed" the OCD back to mild levels :)...

Also, when I'm on full keto , i think my anxiety levels drop drastically for the body is more relaxed (also helped by exercise) - hence i'm quite keen to try the low-dose doxy for 6 months, just as an experiment to see if i can completely flush out any remaining critters.

Apologies if this has been asked before to Forum Mods/Admins, as i tried the search function, but could really find a thread on "low-dose doxycycline " - is there a unique thread for this, or is it part of other health section threads ? Many thanks for the help.
 
Mr.Cyan said:
Also, when I'm on full keto , i think my anxiety levels drop drastically for the body is more relaxed (also helped by exercise) - hence i'm quite keen to try the low-dose doxy for 6 months, just as an experiment to see if i can completely flush out any remaining critters.

Apologies if this has been asked before to Forum Mods/Admins, as i tried the search function, but could really find a thread on "low-dose doxycycline " - is there a unique thread for this, or is it part of other health section threads ? Many thanks for the help.

I think that what is being discussed here is not so much a low dose doxy protocol, but 300 mg a day for 6 months. The low-dose protocol, which I did for a year a few years ago, is about 50 mg per day.

Gaby also noted that one can try a couple of antibiotics to see if there is a Herx reaction so as to determine what type of critter may be present. Obviously, whatever I had REALLY didn't like the metronidazole. And I guess my low-dose doxy run didn't really kill off the baddies. So now, I'm going to do the 300 mg per day for the next four months - having done the metro for two months already - with one cycle of metro for two days a month.

For those who just want to try the doxy, you can get it at fludan.com. It's a bit pricey, but when you consider that a 25 gram bottle is 25000 mg, or 250 doses, which is enough for 83 days (100 mg 3 X day), it's not too bad. A 100 gram bottle is enough for the full 6 months with some left over. You can read up about doxycycline on wikipedia. It's a useful thing to have on hand anyway.

On amazon, there is a set of measuring spoons:
http://www.amazon.com/Libertyware-Smidgen-Pinch-Measuring-Spoon/dp/B002X9I4RC/ref=sr_1_3

The "drop" measure is 50 mg. The "smidgen" measure is 100 mg. I checked with a gem scale. That's a flat measure, not rounded.

When you take cycline medications, you need to limit your sun exposure and no dairy, I think. Read up on it at wikipedia.
 
Thanks a lot Laura for the clarifications and information, much appreciated.

My mistake for assuming it was low dose doxy. Im going to do more reading and research as suggested, and then attempt the 300mg a day for 6 months. Thanks again :)
 
Mr.Cyan said:
Thanks a lot Laura for the clarifications and information, much appreciated.

My mistake for assuming it was low dose doxy. Im going to do more reading and research as suggested, and then attempt the 300mg a day for 6 months. Thanks again :)

As far as I understand it, it is also recommended that, after completing the 6 months of doxy, one might also wish to do the 6 cycles (2 days per week for 6 weeks) of metronidazole and one week of allopurinol, just to get at the encysted critters that may still be trying to hide. And then, theoretically one is done, unless there is reinfection. However, if one also works on restoring gut flora and doing some supplementation, again, theoretically, the immune system ought to be back in full battle readiness to ward off future infection.
 
Shijing said:
I came across an interview with Chris Kresser and Paul Jaminet yesterday that is relevant to the diet/infection question, particularly if you're looking at protozoa like toxomoplasma gondii. The whole article is probably worth reading, but here's the relevant part:

http://chriskresser.com/episode-15-dr-paul-jaminet-on-chronic-infections-depression-more/

Chris: Right, so how can somebody, the second part of that question is how can someone distinguish between, what are the symptoms of infection first and then how can someone distinguish between the different types of infection fungal, bacterial, parasitic?

Paul: Yeah well this is one place I think diet can really help, is in diagnosis. Medicine is still in a primitive state it’s not very good for diagnosing these infections much less treating them. But a lot of these pathogens respond very differently to different diets. So one of the key differences is in how they respond to a ketogenic diet for instance. So pathogens that have mitochondria like fungi and protozoa can metabolize ketones for energy. Bacteria and viruses can’t, and so if you go on a ketogenic diet you’ll starve bacteria and viruses but you’ll feed fungi and protozoa. And so a simple thing to do is go on a ketogenic diet for a while, do your symptoms get worse or better. And that can tell you which class of pathogen you have, one with mitochondria or one that doesn’t have mitochondria. And those kinds of tests can be a big help, and I think part of the reason medicine doesn’t succeed against all these diseases is that nobody varies their diet, they’re always eating the same diet. It’s always 50% carbs with lots of wheat and sugar, plenty of vegetable oils, if you tell people to change their diet and eat healthy they look around and find other sources of the same nutrients, certainly never sample a ketogenic diet. So our basic diet, the perfect health diet, aims to be pretty much balanced, it aims to supply in food the amounts of nutrients that your body needs. And we tweak it in various ways so we tend to be very slightly low carb, but for therapeutic purposes and certain diseases we might go to more extreme diets like a ketogenic diet that’s more low carb or there’s a few diseases that may benefit from going higher carb. But also even apart from treatment the diet is a good diagnostic tool. And it’s also helpful for gut infections to vary the types of food you eat, different foods get digested in different places in the digestive tract. Different things are accessible to different kinds of pathogens, the time scales in which things happen have diagnostic value. So fungi tend to do everything slower than bacteria, they multiply a lot slower, so fungal infections tend to be relatively stable whereas bacterial infections can be much more variable. There’s a lot of ways you can manipulate diet and help understand your own disease and that can guide you to good treatments.

Chris: What’s interesting is, as you’re probably aware in the alternative health world there’s a lot of different perceptions about how to deal with fungal infections and the word candida is thrown around a lot, which I think obviously that candida infection is real but I also, in my experience see it kind of slapped on as a diagnosis of exclusion, meaning we can’t figure out what else it is so we’ll just call it candida. But I’m really interested in what you were saying, I read your article when you talked about how fungi can utilize ketones and tend to progress on ketogenic diets because one of the interesting things about how the candida diet is typically administered is people remove fruit, they remove carbohydrates, starchy tubers and grains and I think they end up being on a very low carbohydrate diet in a lot of cases and perhaps not completely ketogenic or not strongly ketogenic but maybe mildly ketogenic and I see a lot of patients who just get worse and worse on those diets so I wonder if it has something to do with this mechanism that you’re talking about.

Paul: Yeah I think it’s very likely. It’s not bad to go low carb by standard American diet standards, I think probably optimal for candida might be 600-800 carb calories a day, the average American gets maybe 1700 so cutting carbs in half for the average American is a good move. But going too low carb definitely risks systemic invasion so the very low carb approach, it’s not bad for a fungal gut infection but it’s not that good either. It doesn’t do that much to promote good bacteria taking over the gut. A lot of plant foods can really help suppress fungi in the gut and promote bacteria. So they can help give you a better gut flora and I think a lot of people who go extremely low carb can end up with a gut dysbiosis of some kind after years on these extreme low carb diets.

Chris: Yeah I agree with that and I’ve definitely seen that to be true in my practice. And what about brain infections Paul, this is something you’ve talked a lot about are the nerves in the brain susceptible to the same pathogens?

Paul: Yeah they are. The brain seems to be more vulnerable to bacteria especially and a little less vulnerable to fungi. There are some protozoa that can live well in the brain, some viruses flourish there. The thing about the brain is it’s pretty rich in glucose which bacteria like. Or glucose products like pyruvate or lactate which they can metabolize. So it’s kind of a paradise for bacteria and so it’s very important to maintain the integrity of the blood-brain barrier and try to help keep them out. But just like people get leaky guts they get a leaky blood-brain barrier. Also it’s not uncommon if people get some kind of trauma to the head, they get some kind of brain injury involving bleeding, that breaches the blood-brain barrier and very commonly people get brain infections that develop after some kind of head trauma. They’re not uncommon and bacteria do well in the brain, and fortunately ketogenic diets can be very helpful. Bacteria can’t metabolize ketones, when you’re on a ketogenic diet glucose levels decrease, so you’re starving the bacteria. And ketogenic diets also promote autophagy which is part of the immune response. And you can also promote that even more with a low protein diet and so in that process the cell basically has its own self digestion machinery, little digestive vesicles called lysosomes that go around and look for junk that the cell doesn’t need and they destroy it, digest it, and among the things they’ll find when they’re looking for junk are bacteria and viruses. So keeping autophagy going very frequently by occasional fasting or occasional ketogenic dieting or low protein dieting either intermittently or regularly, all of those things will help promote brain health and help keep your brain free of infections. And I think brain infections are responsible for a lot of late life degenerative diseases like Alzheimer’s, Parkinson’s, and probably others too. The brain is kind of a special place, it’s a little sheltered in terms of its nutritional status, it doesn’t vary as much with diet as the rest of the body. It has its own kind of immune functions, it’s own kind of needs, so the symptoms are a little different. So I would say in general the three places to look for different kinds of, classes of symptoms would be the gut, brain, and the body. And each one has it’s own characteristic symptoms and pathologies.

So that's a bit of a revelation about candida. At first, one might think that it would be a good idea to starve fungi and protozoa of ketones, but the issue may be a bit more complex.

The above may be the explanation for why some do so well on keto and others get sick in one way or another. I guess it depends on what kind of critters are using you for their food supply. Because, in the end, that IS what it is about: we are food and colonies for critters whose main aim is to make more colonies.

I'm still astounded as to how deep the rabbit hole goes regarding these things.
 
Laura said:
The above may be the explanation for why some do so well on keto and others get sick in one way or another. I guess it depends on what kind of critters are using you for their food supply. Because, in the end, that IS what it is about: we are food and colonies for critters whose main aim is to make more colonies.

I'm still astounded as to how deep the rabbit hole goes regarding these things.

Yes, I'm still astounded too.

Like two or three years ago I thought we had it pretty much figured out. There were always the ones that didn't fit the paradigm, but I have tended to "blame the victim", as in not doing it well enough or some sort of other vague "blame". My sister was such a case, and while I could see that she was really trying, she said that for her the KD sucked, she felt weak and listless. And I didn't understand why, so I just filed that under "anomaly" - a bit like our science is unwilling to look at facts that don't fit.

Well, turns out, it's way more complicated. But I think that Paul's approach is really interesting. Just downloaded his book, will read it in due course.

While I have had the infectious angle in my view for quite some time, I've never really thought about treating the critters with long-term antibiotics. Mainly because I don't like the idea to do so for an extended period of time. Well, it's probably time to review that. I still wish there was another way ...
 
Just caught up on this thread. Very interesting developments in the last few days of finding many more clues and a bunch of new details (though the gist of all this was known to me for a very long time without some of the new details and wrinkles). A while back I also read somewhere on the forum about recommendations of having an "overeating" day about once a week and kicking yourself out of ketosis. That may be helpful for some for the reasons given by Paul Jaminet (who I remember running into early on in the keto experiment talking about people that have problems with keto diets, the "keto flu", and safe starches, etc., I think around 2011 and 2012, but didn't pay much attention because in my family everyone was doing real well on the keto diet and adapted quite quickly).

One other thought that keeps coming up for me over a couple decades is that the environment getting more and more toxic over the last couple of centuries must have played a big part in how widespread these issues eventually became - like the missing link for these things to go "viral" (pun intended).
 
nicklebleu said:
Laura said:
I'm still astounded as to how deep the rabbit hole goes regarding these things.

Yes, I'm still astounded too.

Me too!

I started reading "Plague Time" and is changing my whole view on antibiotic therapy.

Aternative remedies go a long way, but quite possibly not all the way through.

Doxycycline penetrates the blood brain barrier very well. That is very important when you want to address atypical bacteria in the brain. Metronidazol also has a good blood brain barrier penetration:

_http://jac.oxfordjournals.org/content/3/3/239

Researchers have found mycoplasmas and related bacteria in Multiple Sclerosis, Parkinson's disease, Alzheimer's disease, autism spectrum disorders, ALS and so forth.

Children of people who had Chronic Fatigue and Gulf War Illness, were diagnosed with autism spectrum disorders when their parents returned of the Gulf war, suggesting it was an infection.

Researchers highlight the importance of treating parasites and atypical bacteria in time, before permanent damage is done.

Shijing said:
Finally, here's a paper on mitochondria and osteoarthritis that has some interesting information that ties in to other things we're looking at:

http://www.wellnessresources.com/health/articles/mitochondria_and_osteoarthritis_an_exciting_new_frontier/

Oh yes, I quoted this article earlier on this thread. I think that the big missing puzzle missing from this article is atypical bacteria and parasites. It is quite fascinating how everything ties in!

I'm also reminded me of last Friday's H&W show with Dr. Rostenberg where he said that some people do worse on probiotics, or something among the lines (?) Some people's gut flora overproduce folic acid and even vitamin B6 which cannot be used by the body and then they feel worse.

It seems that the role of atypical bacteria in neurological diseases is discussed in the book "Plague Time", but I'm attaching a relevant article written by the Nicolson's on the subject, FWIW.
 

Attachments

nicklebleu said:
Like two or three years ago I thought we had it pretty much figured out. There were always the ones that didn't fit the paradigm, but I have tended to "blame the victim", as in not doing it well enough or some sort of other vague "blame". My sister was such a case, and while I could see that she was really trying, she said that for her the KD sucked, she felt weak and listless. And I didn't understand why, so I just filed that under "anomaly" - a bit like our science is unwilling to look at facts that don't fit.

I've been guilty of that too, and I think that's always a potential pitfall whenever we think that we've found all the answers and there's nothing more to learn. I've also blamed myself as well -- I've had some persistent candida symptoms for quite awhile, and I didn't know why because I tried very hard to be strict about the ketogenic diet and couldn't figure out what I was doing wrong. Now it makes a little more sense if candida is able to thrive in a ketogenic environment, and I'm considering what other things I might look into to treat it instead of relying on the ketogenic diet to starve it (several authors recommend plant products such as carrot juice, olive and oregano oil, because many plants have developed natural defenses against fungi that we can exploit; several of these were discussed on the H&W show about medicinal herbs a couple weeks ago).

But knowing the distinction between microorganisms discussed in the Kresser/Jaminet article is still really useful -- if you're going after bacteria or virii, then the ketogenic diet should still be very beneficial. The same goes for cancer, which was discussed on the same H&W show.

nicklebleu said:
While I have had the infectious angle in my view for quite some time, I've never really thought about treating the critters with long-term antibiotics. Mainly because I don't like the idea to do so for an extended period of time. Well, it's probably time to review that. I still wish there was another way ...

I'm still a bit skittish about that too. In my present understanding, replacing the sheer number of beneficial bacteria in the gut with probiotics shouldn't be a problem -- the biggest issue is diversity. The total species diversity you replenish is only as good as the number of strains you feed back into your gut. For people who are starting out with a limited amount of diversity, it may not be an issue since there's not really much to lose -- Western urban populations tend to have a reduced amount of diversity compared to other world populations anyway, due to antibiotic use, C-sections, and so forth.

At the end of the day, it's going to be about weighing all the factors. I'm pretty sure that I would benefit from some form of antibiotic therapy (using the term broadly), and I have family members who most likely need it too. If it turns out that there's no optimal solution, I'll probably still choose treating chronic infection over preserving gut diversity, and hope that the effects on the liver are minimal. That being said, looking into all possible options is probably wise. From what Gaby says above, it also sounds like some of these questions might be addressed in Plague Time.

SeekinTruth said:
One other thought that keeps coming up for me over a couple decades is that the environment getting more and more toxic over the last couple of centuries must have played a big part in how widespread these issues eventually became - like the missing link for these things to go "viral" (pun intended).

I think that's spot-on, and it's pretty much what Dr. Rostenberg said at the end of the last H&W show. His opinion was that methylation defects may not have played a very significant role in the health of earlier populations because the environment they were living in and food they ate was enough to compensate for them, and undermethylation wouldn't have been such a big problem. In the modern world, the multiple forms of toxicity we're exposed to are enough to challenge the methylation pathways of even people without polymorphisms (as Redfox said above), and for those with polymorphisms it can tip them over completely, with symptoms manifesting wherever they have weak points in their system; it also increases vulnerability to infection. This makes developing a general one-size-fits-all protocol much more complicated, because everyone's individual genetic weaknesses become expressed in different ways.

Gaby said:
Oh yes, I quoted this article earlier on this thread.

Oops -- I think that's where I got it from originally. I keep a couple of windows loaded with tabs of articles I want to read as I search, and don't always keep track of where they came from -- sorry about that, Gaby :-[

Gaby said:
I'm also reminded me of last Friday's H&W show with Dr. Rostenberg where he said that some people do worse on probiotics, or something along the lines (?) Some people's gut flora overproduce folic acid and even vitamin B6 which cannot be used by the body and then they feel worse.

Yes, you're remembering that correctly -- I need to go back and listen again, but I'm pretty sure the gist was that even beneficial gut bacteria can do this if they're too overgrown. For people without polymorphisms (and who are otherwise healthy), it isn't usually an issue because they can process and cycle the extra folic acid and B6, but for those with polymorphisms it can become a problem because the excess nutrients back up the methylation pathways. That was my understanding at the time, anyway.

Gaby said:
It seems that the role of atypical bacteria in neurological diseases is discussed in the book "Plague Time", but I'm attaching a relevant article written by the Nicolson's on the subject, FWIW.

I ordered a copy of Plague Time a couple of days ago, and it should arrive soon -- I'm looking forward to reading it. Thanks also for attaching the series of papers by the Nicolsons -- I'm going to read them as soon as I can, and am also printing copies for my doctor for when I see her tomorrow.
 
Shijing said:
Gaby said:
I'm also reminded me of last Friday's H&W show with Dr. Rostenberg where he said that some people do worse on probiotics, or something along the lines (?) Some people's gut flora overproduce folic acid and even vitamin B6 which cannot be used by the body and then they feel worse.

Yes, you're remembering that correctly -- I need to go back and listen again, but I'm pretty sure the gist was that even beneficial gut bacteria can do this if they're too overgrown. For people without polymorphisms (and who are otherwise healthy), it isn't usually an issue because they can process and cycle the extra folic acid and B6, but for those with polymorphisms it can become a problem because the excess nutrients back up the methylation pathways. That was my understanding at the time, anyway.

I asked him to clarify that a bit and he confirmed that he was talking about a condition called SIBO (small intestinal bacterial overgrowth). It's when proper colon bacteria get up into the small intestine and colonize there. It's not that they're bad bacteria, it's that they're in the wrong spot. There were a number of paleo bloggers talking about it a year or two ago, including Chris Kresser. Kresser had said that adding a typical probiotic in this situation can be like adding gasoline to a fire. He recommended using non-lactic acid producing strains, like soil-based probiotics, to combat the problem. One called "prescript assist" was a popular recommendation (both Kresser and Mark Sisson recommend it), but there are others like AOR Probiotic 3. Taking one of these should help with species diversity, too.
 
Amazing thread!

I'm a bit confused on the implications of the ketosis feeding fungus.

Does that mean we should aim to eliminate the fungus first before going into ketosis?

Or is it better as he states, to cut carbs to half or a third of the SAD to balance out the fungus with the bacteria, etc?
 
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