zak
The Living Force
I put this pun from this thread_http://cassiopaea.org/forum/index.php/topic,40440.0.html#lastPost_ to thisBluelamp said:Well above all i wanted to check on microtubule, it was the first thing that come to "my" mindzak said:https://cassiopaea.org/forum/index.php/topic,42506.0.html#lastPost
25 May 1996 said:Q: (L) Well, okay. We have several issues just now...
Q: (L) Does 'fluted' have anything to do with 'grooving?'
A: Columns.
Q: (L) What columns are we talking about?
A: Ionic.
Q: (L) Why are we talking about Ionic fluted columns?
A: Because they are a link to previous direct contact between
humans and density 4 STO!
when i read the last quote in the answer of Laura to MK Scarlett, so let's go !
...there was a theory that anesthesia worked by causing brain microtubules to fall apart. It turns out, fortunately, that that’s not true. You need about five times the amount of anesthesia for microtubule depolymerization than you need to cause somebody to lose consciousness. But it showed that anesthetics do affect microtubules, which further suggested that microtubules might have something to do with consciousness...
The tubulin proteins self-assemble into hollow cylinders whose walls are elegant lattices which are both hexagonal and helical, the helical winding patterns having beautiful Fibonacci geometry. I became somewhat obsessed, enchanted really, with the structure of microtubules...
The structure of microtubules consisted of a cylindrical lattice of tubulin proteins. Each of these could switch between different conformational states, and be programmed by genetics and other factors, and be influenced by lattice neighbors, like gates and switches in computers. This was more support for the notion that microtubules might be acting not only as bone-like support, but also as molecular-scale computers, the intelligence system inside cells...
...I had a hunch that microtubules were “Nature’s computers.” So I started working with engineer and physicist colleagues to model and simulate tubulin states in microtubule lattices. We assumed each tubulin could be in two alternative states correlating with its dipole, and that neighboring dipoles interacted, or computed according to rules set by the microtubule geometry—very much like cellular automata, self-organizing computers...
Hameroff proposed that microtubules were suitable candidates for quantum processing.[32] Microtubules are made up of tubulin protein subunits. The tubulin protein dimers of the microtubules have hydrophobic pockets that may contain delocalized π electrons. Tubulin has other, smaller non-polar regions, for example 8 tryptophans per tubulin, which contain π electron-rich indole rings distributed throughout tubulin with separations of roughly 2 nm. Hameroff claims that this is close enough for the tubulin π electrons to become quantum entangled.[33] During entanglement, particle states become inseparably correlated...
That would be an interesting pun between ionic fluted columns and the Hameroff fluted channels with ionic dipole polarization states spiraling around the microtubule cylindrical columns.
new one, and let's go to see if we can learn something, or it will stay only an interesting pun (Bluelamp ,)
with words of the same sound, but different sense.
Here a video with the transcription of Dr. Roderick MacKinnon
on the "Ion Channel Chemistry":
http://scarc.library.oregonstate.edu/events/2008mackinnon/video-mackinnon.html
Some excerpts:
For the case of arrhythmia, its an abnormal electrical activity in the heart. And so, how does it relate? Well it’s the ion channels that are underlying the electrical activity. And so some drugs that treat arrhythmia work by binding to the ion channels and affecting their activity. And the hope in the future is that by understanding more about these ion channel molecules, they can someday develop drugs that will help with arrhythmias that don’t exist today. That’s sort of a short answer. There’s one kind of arrhythmia, called long QT syndrome, that is actually caused by drugs, and it causes sudden death. And the understanding of that happens to do with a particular potassium channel in the heart, and how certain drugs interact with it. So it’s related to arrhythmia because the ion channel is the little hardware unit that is making the electrical activity. And drugs work on proteins, such as ion channels, to regulate their function. So that’s the connection.
[Audience question #8]
Epilepsy is abnormal electrical activity in the brain and it, in many ways, is connected to ion channels. It doesn’t mean that every form of epilepsy has an abnormal ion channel - that’s not the case at all. In many forms of epilepsy there are abnormal ion channels. And even in forms where there are no abnormal ion channels, by modifying the function of certain ion channels, you can change the electrical activity to reduce the probability that there will be a seizure. [66:55]
Schematic diagram of an ion channel:
https://en.wikipedia.org/wiki/Ion_channel#/media/File:Ion_channel.png
On Channelopathy:https://en.wikipedia.org/wiki/Channelopathy
A video (without transcripts) of Dr. Stafstrom speak on:http://videos.med.wisc.edu/videos/303
1) Structure, function and genetics of ion channels
2) Disorders of ion channel function - "channelopathies"
3) Ion channels as therapeutic targets
Maybe we can find some puns with those threads
http://cassiopaea.org/forum/index.php/topic,23062.msg329158.html#msg329158
http://cassiopaea.org/forum/index.php/topic,7462.0.html