Ion Channel Chemistry

zak

The Living Force
Bluelamp said:
zak said:
https://cassiopaea.org/forum/index.php/topic,42506.0.html#lastPost

25 May 1996 said:
Q: (L) Well, okay. We have several issues just now...
Q: (L) Does 'fluted' have anything to do with 'grooving?'
A: Columns.
Q: (L) What columns are we talking about?
A: Ionic.
Q: (L) Why are we talking about Ionic fluted columns?
A: Because they are a link to previous direct contact between
humans and density 4 STO!
Well above all i wanted to check on microtubule, it was the first thing that come to "my" mind
when i read the last quote in the answer of Laura to MK Scarlett, so let's go !
...there was a theory that anesthesia worked by causing brain microtubules to fall apart. It turns out, fortunately, that that’s not true. You need about five times the amount of anesthesia for microtubule depolymerization than you need to cause somebody to lose consciousness. But it showed that anesthetics do affect microtubules, which further suggested that microtubules might have something to do with consciousness...

The tubulin proteins self-assemble into hollow cylinders whose walls are elegant lattices which are both hexagonal and helical, the helical winding patterns having beautiful Fibonacci geometry. I became somewhat obsessed, enchanted really, with the structure of microtubules...

The structure of microtubules consisted of a cylindrical lattice of tubulin proteins. Each of these could switch between different conformational states, and be programmed by genetics and other factors, and be influenced by lattice neighbors, like gates and switches in computers. This was more support for the notion that microtubules might be acting not only as bone-like support, but also as molecular-scale computers, the intelligence system inside cells...

...I had a hunch that microtubules were “Nature’s computers.” So I started working with engineer and physicist colleagues to model and simulate tubulin states in microtubule lattices. We assumed each tubulin could be in two alternative states correlating with its dipole, and that neighboring dipoles interacted, or computed according to rules set by the microtubule geometry—very much like cellular automata, self-organizing computers...

Hameroff proposed that microtubules were suitable candidates for quantum processing.[32] Microtubules are made up of tubulin protein subunits. The tubulin protein dimers of the microtubules have hydrophobic pockets that may contain delocalized π electrons. Tubulin has other, smaller non-polar regions, for example 8 tryptophans per tubulin, which contain π electron-rich indole rings distributed throughout tubulin with separations of roughly 2 nm. Hameroff claims that this is close enough for the tubulin π electrons to become quantum entangled.[33] During entanglement, particle states become inseparably correlated...

That would be an interesting pun between ionic fluted columns and the Hameroff fluted channels with ionic dipole polarization states spiraling around the microtubule cylindrical columns.
I put this pun from this thread_http://cassiopaea.org/forum/index.php/topic,40440.0.html#lastPost_ to this
new one, and let's go to see if we can learn something, or it will stay only an interesting pun (Bluelamp :thup:,)
with words of the same sound, but different sense.

Here a video with the transcription of Dr. Roderick MacKinnon
on the "Ion Channel Chemistry":
http://scarc.library.oregonstate.edu/events/2008mackinnon/video-mackinnon.html
Some excerpts:
For the case of arrhythmia, its an abnormal electrical activity in the heart. And so, how does it relate? Well it’s the ion channels that are underlying the electrical activity. And so some drugs that treat arrhythmia work by binding to the ion channels and affecting their activity. And the hope in the future is that by understanding more about these ion channel molecules, they can someday develop drugs that will help with arrhythmias that don’t exist today. That’s sort of a short answer. There’s one kind of arrhythmia, called long QT syndrome, that is actually caused by drugs, and it causes sudden death. And the understanding of that happens to do with a particular potassium channel in the heart, and how certain drugs interact with it. So it’s related to arrhythmia because the ion channel is the little hardware unit that is making the electrical activity. And drugs work on proteins, such as ion channels, to regulate their function. So that’s the connection.

[Audience question #8]

Epilepsy is abnormal electrical activity in the brain and it, in many ways, is connected to ion channels. It doesn’t mean that every form of epilepsy has an abnormal ion channel - that’s not the case at all. In many forms of epilepsy there are abnormal ion channels. And even in forms where there are no abnormal ion channels, by modifying the function of certain ion channels, you can change the electrical activity to reduce the probability that there will be a seizure. [66:55]

Schematic diagram of an ion channel:
https://en.wikipedia.org/wiki/Ion_channel#/media/File:Ion_channel.png

On Channelopathy:https://en.wikipedia.org/wiki/Channelopathy

A video (without transcripts) of Dr. Stafstrom speak on:http://videos.med.wisc.edu/videos/303
1) Structure, function and genetics of ion channels
2) Disorders of ion channel function - "channelopathies"
3) Ion channels as therapeutic targets

Maybe we can find some puns with those threads :lol:
:
http://cassiopaea.org/forum/index.php/topic,23062.msg329158.html#msg329158
http://cassiopaea.org/forum/index.php/topic,7462.0.html
 
Q: (L) We would like to ask some more questions about the architectural project mentioned the other night. [Swimming pool, session 25 May 1996] We were given the height and distance apart of the three column structure, would it be okay to build this on the perimeter of the existing pool?

A: No. You must wait until you have the financial resources to construct an inground pool. The spiral must be below ground level by at least 1 meter, must be constructed of blue, gold ceramic tile perfectly cut and even. Columns cannot be purchased as prefabricated. Must be constructed onsite. Cap should be 18 centimeters in height, 2 meters in length, same dimensions for cap and base.

Q: (L) Can or should we do this with our own hands?

A: Hire a contractor... you are not adequately skilled.

Q: (L) How many grooves in each column?

A: Diameter of columns should be 10 to 14 centimeters, width of fluting should be 2 centimeters. Use illustrations of authentic ionic columns as a guide.

Q: (L) The counter-clockwise spiral of tile, how many turns?

A: Turns not important. Width should be 1.6 meters.

Q: (L) Blue tile with gold border?

A: Mixed blue and gold.

Q: (L) Blue with specks of gold?

A: Close. Translucent.

Q: (L) Is azure an appropriate blue?

A: Close.

Q: (L) Should anything be incorporated into the cement mix to pour the columns?

A: No.

Q: (L) Should the columns be hollow and used for flowing water?

A: No. Place fountain or hydrable pond in front of columns.

Q: (L) Pool shape: square on one end then rounded at one end. Rectangular with a curved end. [planchette is drawing shape of pool] (Curved end to follow guide of columns at end).

A: The fountain should be in between and the spiral in the middle of the pool.

Q: (L) Are you having fun designing a 3rd density pool?

A: 6th density is always "fun!"

Q: (L) What about the turns on the spirals at the top of the columns?

A: Up to you.

Q: (L) Is this pool meant to be built here, on this property?

A: Up to you.
http://cassiopaea.org/forum/index.php/topic,34922.msg496574.html#msg496574
And:
A: Before we discuss that, we would like you to ponder further the previously given responses. We suspect there is much to be gained from insights lurking there. Now: Portals... ionic column... hmmm...

Q: (V) Are portals archetypal?

A: Are they? Hmmm....

Q: (MM) So, my column is an ionic column? (L) I don't think that is exactly what they mean. I think that they are saying that an ionic column represents a portal into the next density. It is an archetype.

A: Third density facsimile.

Q: (V) So, this is how we choose to see it with our eyes? (L) I think they mean that it is a representation, that it follows in its form the 4th density form, only it is material here.

A: And 5th density, etc...

Q: (L) Okay, MM's portal. She has been experimenting with it, with this trans-density transceiver...

A: No, she does not have a trans-density transceiver, she has a portal presence.

Q: (L) What is the function of a portal presence?

A: Function is not the correct concept.

Q: What is it?

A: The presence of a portal.

Q: (L) Is this portal that is present related to any person in her house, or related to the area.

A: It is.

Q: (L) Which.

A: It just is.

Q: (L) Was it there before she moved there?

A: That is not important.

Q: (L) What is important?

A: Ask yourself that. Awareness.

Q: (L) On the one hand you could think it is a good thing and be wrong, and on the other hand you could think it is a bad thing, and miss a good thing?

A: Learning is fun.

Q: (MM) I'm getting ready to work with it in meditation. But, I have been working with it and finding out more about it, and I was just wondering....

A: Hey lady, don't you get it yet?

Q: (V) Who is 'hey lady?' It must be me...

A: No.

Q: (V) That is very odd? (MM) I was wondering if it goes to other densities?

A: Yes, but so what? This does too.

Q: (L) Why was this portal represented by a completely different figure?

A: None.

Q: (L) Is she supposed to channel through this portal?

A: The portal is not "importaltent!"

Q: (L) I guess that implies intent... The portal is not important, what is important is what is going on inside you. And only you can know that.

A: On that note, Good Night.
http://cassiopaea.org/forum/index.php/topic,34928.msg496616.html#msg496616
 
zak said:
Bluelamp said:
That would be an interesting pun between ionic fluted columns and the Hameroff fluted channels with ionic dipole polarization states spiraling around the microtubule cylindrical columns.
I put this pun from this thread_http://cassiopaea.org/forum/index.php/topic,40440.0.html#lastPost_ to this
new one, and let's go to see if we can learn something, or it will stay only an interesting pun (Bluelamp :thup:,)
with words of the same sound, but different sense.

Here a video with the transcription of Dr. Roderick MacKinnon
on the "Ion Channel Chemistry":
http://scarc.library.oregonstate.edu/events/2008mackinnon/video-mackinnon.html
I have seen ion channels mentioned as something that could be effected via quantum mechanics by the "ionic" microtubules of Hameroff's quantum consciousness model. More directly, the "ionic" for the microtubules is described here:

https://en.wikipedia.org/wiki/London_dispersion_force

The LDF is named after the German-American physicist Fritz London. The LDF is a weak intermolecular force arising from quantum-induced instantaneous polarization multipoles in molecules. They can therefore act between molecules without permanent multipole moments... Additionally, an approximation, named after Albrecht Unsöld, must be introduced in order to obtain a description of London dispersion in terms of dipole polarizabilities and ionization potentials.
 
A video of london dispersion force:

https://youtu.be/1iYKajMsYPY

And:
McKemmish et al (2010) challenged the Orch OR contention that tubulin switching is mediated by London forces, pointing out that mobile π electrons in a benzene ring (e.g. a phenyl ring without attachments) are completely delocalized, and hence cannot switch between states, nor exist in superposition of both states. Agreed. A single benzene cannot engage in switching. London forces occur between two or more electron cloud ring structures, or other non-polar groups. A single benzene ring cannot support London forces. It takes two (or more) to tango. Orch OR has always maintained two or more non-polar groups are necessary (Figure 8). McKemmish et al are clearly mistaken on this point.

McKemmish et al further assert that tubulin switching in Orch OR requires significant conformational structural change (as indicated in Figure 2), and that the only mechanism for such conformational switching is due to GTP hydrolysis, i.e. conversion of guanosine triphophate (GTP) to guanosine diphosphate (GDP) with release of phosphate group energy, and tubulin conformational flexing. McKemmish et al correctly point out that driving synchronized microtubule oscillations by hydrolysis of GTP to GDP and conformational changes would be prohibitive in terms of energy requirements and heat produced. This is agreed. However, we clarify that tubulin switching in Orch OR need not actually involve significant conformational change (e. g. as is illustrated in Figure 2), that electron cloud dipole states (London forces) are sufficient for bit-like switching, superposition and qubit function. We acknowledge tubulin conformational switching as discussed in early Orch OR publications and illustrations do indicate significant conformational changes. They are admittedly, though unintentionally, misleading.

The only tubulin conformational factor in Orch OR is superposition separation involved in EG, the gravitational self-energy of the tubulin qubit. As previously described, we calculated EG for tubulin separated from itself at three possible levels: 1) the entire protein (e.g. partial separation, as suggested in Figure 2), 2) its atomic nuclei, and 3) its nucleons (protons and neutrons). The dominant effect is 2) separation at the level of atomic nuclei, e.g. 2.5 Fermi length for carbon nuclei (2.5 femtometers; 2.5 x 10-15 meters). This shift may be accounted for by London force dipoles with Mossbauer nuclear recoil and charge effects (Hameroff, 1998). Tubulin switching in Orch OR requires neither GTP hydrolysis nor significant conformational changes.
http://journalofcosmology.com/Consciousness160.html
 
An other track to consider: http://cassiopaea.org/forum/index.php/topic,13524.0.html
Brought by RyanX:
Citation de: Coats

The Double-Spiral-Flow Pipe

Both in cross-section and longitudinal section the double-spiral-flow pipe
satisfies all the criteria necessary for a water-supply pipe, if it is to convey
healthy water to the place of use. By means of a system of vanes made of
precious metal arranged on the inner surface of the pipe walls (see figs. 8, 9,
10 & Patents Nos. 134543 & 138296 in Appendix), the water-masses are conducted
along a double-spiral-flow pipe in such a way that the movement of the individual
filaments of water at the periphery takes the form of a secondary
helical motion along a primary helical path (see fig. 11).32 Through
this arrangement both centrifugal and centripetal forces evolve simultaneously
in the cross-section of the pipe, which convey bodies heavier than
water down the centre. Bodies lighter than water are impelled towards the
periphery.

http://lh5.ggpht.com/_QOOlshAiGuo/SqgQ1I8EQVI/AAAAAAAAAGg/cE3Y0WDR_-c/s720/coats1.jpg

Water-masses conducted in this fashion are slightly warmed through the
interplay of mechanical forces of friction on the vane-surfaces, leading to the
separation of oxygen in the inner region of the pipe and its subsequent concentration
at the periphery.

At the same time as the oxygen is ejected, all the bacteria migrate towards
the periphery as well, since their living conditions in the more central part
of the cross-section have now become unsuitable. In company with the bacteria,
all the water-polluting particles are also dispatched towards the
periphery of the pipe. Thus the water is easily and simultaneously purged
of suspended matter.



http://lh4.ggpht.com/_QOOlshAiGuo/SqgQ1Z0yDtI/AAAAAAAAAGo/ntfz2xbyzw0/s720/Coats3.jpg

Once bacteria have transferred to the peripheral zone in search of the
required oxygen, and after a certain period of time in water completely cut
off from outside influences, they are overwhelmed by a localised concentration
of oxygen. In this way precisely those pathogenic bacteria susceptible
to an excess of oxygen are advantageously eliminated, whereas non-pathogenic
bacteria which are not harmful to human health, but in many cases
are actually beneficial, are to a certain extent retained. At the same time as
the content of absorbed oxygen is separated from the carbones contained in
all water, the inner core of the water surges ahead in a simple spiral movement
(vortical movement along the longitudinal axis), because the surface
tension of the water becomes physically reduced as a result of the abovementioned
separation of oxygen from the particles of carbone.

The physical reduction in surface tension results in a mechanical acceleration,
leading to the self-purification and energetic charging of the centrallyaccelerating
water-masses. On the other hand this charging of energy gives
rise to further processes related to the overall equilibrium between the
heavy, centrally-accelerating bodies and the energy-rich water. With the
ensuing simultaneous cooling solid particles are separated and are again
directed towards the periphery. There they combine with oxygen and are
reunited with the centrally-accelerating water in the form of additional
energies. Those particles of matter not drawn into the centre will be pressed
onto the surface of the pipe walls by the prevailing mechanical pressure,
there to combine with the raw materials from which the timber was originally
formed. Thus they seal the pores of the wood, which in this way
becomes more durable than iron. Once again we are here concerned with a natural
process whose active principle is operative in the formation of all capillaries.
The capillaries not only construct themselves, but also protect
mselves against harmful influences.

As a result of acceleration of the entire body of water peculiar to the double-
spiral-flow pipe, greater quantities of water can be conveyed than in an
ordinary smooth-walled pipe and, due to the efficacy of the oxygen, extensive
self-purification and self-sterilisation of the water occurs which constantly
increases in quality through the uninterrupted build-up of energy as it
moves along its path. The reason for this is as follows: as they accelerate,
centrally-conducted water-masses are simultaneously cooled, with the
result that gases evolving from the carbones become concentrated in the
flow-axis, where the lowest temperatures reside. This concentration decreases
towards the periphery. The oxygen on the other hand is concentrated
around the periphery of the pipe, reaching its most aggressive state at the
interface with the warmer pipe-wall, giving rise to mutual interactions
between the two basic substances from the periphery inwards. This subsequently
leads to the aforementioned interactions which qualitatively
enhance both water and wood.

In the course of time the relative spacial distribution of the more central
flow of water and the interactions at the surface of the pipe walls arrive at a
certain state of equilibrium. These processes then cease - the water is now
mature and both wood and water have become almost immune to harmful
outside influences. Whereas oxygen is located in the peripheral zones of the
pipe, the free particles of carbonic acid congregate in the boundary zone of the
inner core of water as a result of the water temperatures prevailing there. The
carbones contained in the water, in bound form, necessarily accumulate in
the central axis, which is predominantly saturated with carbones. By
arranging the in-built, specially-shaped vanes in a particular way, aggressive
particles of oxygen on the boundary layer of the outer edge of the inner
core of water, are brought into continuous and direct contact with the most
aggressive carbon dioxide, resulting in a continuous generation of energies.
These are drawn further towards the centrally-accelerating water-masses,
due to the decrease in temperature towards the central axis of the pipe.

Accordingly two types of circulation are created in the cross-section of the
pipe: the mechanical circulation of the water and the counter-circulation of
those energies that evolve when aggressive particles of oxygen encounter
free carbon dioxide. This circulation of energy manifests itself in the form of
a continuous electro-dynamic process. In this instance it does not take place
at the walls of the pipe, but at the boundary zone of the water's inner core,
resulting in the qualitative uplifting of its physical, material, energetic and immaterial
attributes - but not in the destruction of the pipe walls.

These double-spiral-flow pipes also convey matter heavier than water
down the middle of the pipe and at the same time ennoble and refine it, so
that oils of inferior quality, for example, will be improved during flow. After
smelting, iron ores transported in this fashion yield a higher-grade iron,
because in the process of being transported, the oxygen in the ore is consumed
in the formation of new carbone compounds (reduction processes),
which then contribute towards the materially higher composition of the carbone
- iron.

Iconoclast:
in the thread about the recent session transcript of dec. 29th, Windmill knight quoted an excerpt from an older session i had forgotten:
Citer

Q: (L) Why are we talking about Ionic fluted columns?
A: Because they are a link to previous direct contact between humans and density 4 STO!
Q: (L) Okay, Ionic columns fluted and grooved...
A: Plastic hoses, fluted and grooved.
Q: (L) Well, you are getting more and more obscure. How do we establish this direct link between us and 4th density STO through the concept of fluting, and grooving, and columns?
A: Magnetic telemetry profile.
Q: (L) Are you suggesting that the hose with the water rushing through it can transmit something from 4th density STO to us?
A: Tranceive.
Q: (L) The original Ionic column structure was a hollow tube?
A: Not the point.
Q: (L) It is the fluting, grooving and spiraling that are important?
A: Yes.
Q: (L) Okay, once you mentioned that I ought to move the pool and install a maze, or spiral. Well, I am hoping to get some money from the insurance company soon, and I was thinking about putting in an in-ground pool as part of my improvements. Couldn't I have the spiral inlaid in the bottom of the pool in tile?
A: Good. Suggest that you install a triple Ionic column with top beam and base, as the Romans and Greeks did, near the deep end. [The next part of the discussion involves drawing the plan of said structure and the design of the spiral]
A: Two sided triangle when seen from above, flat top of beam, no gables. 1.3 meters between bases of the three columns. Columns: 1.6 meters tall. Base set at 30 degree angle. Center column placed to the East of the pool. Use pure spiral, counterclockwise, corresponding to Northern hemisphere of the planet.
Q: (L) Okay, once we have set this up, what is it going to do for us?
A: Empower 4th through 6th density STO channel transceiver.


it immediately made me think about schauberger's double spiral pipes (seen on pg. 1 of this thread)

maybe there is a connection?
 
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