dredger
The Living Force
Hi,
There was a good & recent french article on the ivermectin and i searched here on the forum which post/threads were posted about, with ivermectin in the title, I found the 4 following ones. The number in parenthesis is the number of posts of the thread at this date + the name of the section of the forum the thread is :
I propose to open this new thread in order to centralize the information on the ivermectin, and, if one admin agrees and have time to, to merge these 4 threads (or not all, it's to decide), in this thread, which would be located in the "Diet & Health" section which is more logical. In this case, do not hesitate to modify the title of this thread, or to remove the link to the threads just above (if they are merged in this one, they won't be valid anymore)
To come back to the french article, here's the original post, which is date of 20/10/2024 :
Here's the link to the google auto-translation of it
And here's the auto-translated article in quote mode :
I finally created 2 PDF from it, one for the french and one for the auto-translated version to english that i attached to this post.
Another nice resources is from the comments of the article, a 3 pages well -fited posology of taking ivermectin, just that it's in the context of "long covid", but it's worth it. It's also in french, if some want to translate it, use google translate :
About posology, the one which is recommended here on the forum is to take 12mg of IV during 6 to 8 days for the treatment. And it's worth it to take 12mg per week for prevention.
That's all for today
There was a good & recent french article on the ivermectin and i searched here on the forum which post/threads were posted about, with ivermectin in the title, I found the 4 following ones. The number in parenthesis is the number of posts of the thread at this date + the name of the section of the forum the thread is :
IVERMECTIN good or bad? (25 - What's on your mind )
Can ivermectin disrupt our gut flora? (19 - Diet and Health)
Will Hydroxychloroquine and/or Ivermectin be effective against the "black death" mutation that the mRNA vaccine will possibly cause? (12 - Questions For the Cs)
Ivermectin (12 - What's on your mind )
I propose to open this new thread in order to centralize the information on the ivermectin, and, if one admin agrees and have time to, to merge these 4 threads (or not all, it's to decide), in this thread, which would be located in the "Diet & Health" section which is more logical. In this case, do not hesitate to modify the title of this thread, or to remove the link to the threads just above (if they are merged in this one, they won't be valid anymore)
To come back to the french article, here's the original post, which is date of 20/10/2024 :
Here's the link to the google auto-translation of it
And here's the auto-translated article in quote mode :
SATOSHI OMURA AND IVERMECTIN
Posted onOctober 20, 2024by Gérard Maudrux
Charles de Gaulle said: " We find researchers who search, but we only look for researchers who find ". There is one researcher who finds in Japan, little known in our country. However, his work has already saved hundreds of millions of people in the world, probably billions of domestic and livestock animals. And I think that it is not over if politicians, Bill Gates' WHO, the pharmaceutical industry and the medical orders return to real medicine.
This man is Satoshi Omura, the discoverer of avermectin and the inventor of ivermectin, a product that is also little known, and yet unmatched. No drug has such a range of actions, no drug is so non-toxic. I used to say that the more effective a product is, the more side effects it can have, until ivermectin contradicted me. Many promising avenues are still unexplored, such as multi-resistant bacteria, cancers, and even certain neurological diseases. Satoshi Omura is neither known nor recognized in our country, but he is recognized elsewhere, including a Nobel Prize in 2015 to recognize his work and his service to humanity.
A pharmacist specializing in antibiotic research, who then became a researcher in the USA, he was recalled by Kitasato University in Tokyo for a professorship. To provide himself with the means for his research, he created the first industry-university collaboration: the industrialist financed the research and in return recovered ownership of the patents. What interested Omura was not the money that could be collected by a patent, but having the means for effective research. He signed with the Merck laboratory, headed the university's pharmacology laboratory in addition to his professorship, finding a number of usable compounds. The biggest catch was avermectin. A professor, he also trained 120 specialist doctors and 32 university professors during his career.
A researcher and field worker, he discovered a new actinomyces (a type of bacteria) in the soil on the edge of the Kawana golf course in Shizuoka Prefecture. After giving a culture solution of this bacteria mixed with food to mice infected with nematodes ( worms), he observed a deworming effect. He developed 522 compounds with Merck, 26 of which were marketed as pharmaceutical products, veterinary drugs, pesticides and biological research reagents. For his part, his collaborator at Merck, Dr. William Campbell, studied the thousands of microbes in the Merck bank, without finding a single one capable of producing such components. The actinomyces discovered was called Streptomyces avermectinius .
Streptomyces avermectinius produces avermectin , an organic compound with 8 components with fairly similar properties, which was difficult to separate industrially, which could be done thanks to the catalyst of Geoffrey Wilkinson, who received a Nobel Prize for this discovery in 1973. It is only with this catalyst that the double bond can be selectively reduced to produce ivermectin . For this discovery, with the immense benefits it will generate, the WHO will declare ivermectin an "essential product". Satoshi Omura and William Campbell will receive the Nobel Prize in Medicine in 2015.
IVERMECTIN, VETERINARY PRODUCT
Omura then conducted several experiments, to note that ivermectin was active not only on nematodes, but also on arthropods ( invertebrates, with the largest number of species and individuals in the animal world), effective both in ingestion and injection, and on internal and external parasites. After an experiment (on 24 pasture cows, 12 of which were injected subcutaneously) presented at a conference in Philadelphia in 1979 and having excited the audience (practically 100% of the parasites having disappeared after a single injection at 0.2 mg/kg), ivermectin was marketed as a veterinary product in 1981 and after 3 years it became the best-selling veterinary drug in the world for 20 years.
Thanks to this, Merck having agreed to donate part of the profits, the financially troubled Kitasato Institute will be saved. Better still, since the prefectures of Saitama or Chiba have the lowest number of beds per capita, a large plot of land was purchased in the city of Kitamoto and a hospital with more than 400 beds was built. Omura and his institute were also able to open the Kitasato Medical Center, as well as a nursing school with internship. Different times, different morals of the pharmaceutical industry and efficient researchers, working for the population.
IVERMECTIN AND ONCHOCERCHOSIS
In 1973, Robert McNamara , then president of the World Bank (an international financial institution financing operations in developing countries), declared: "Onchocerciasis is the most serious disease from a health and economic point of view for the populations of West African countries ." He would lead the eradication of this onchocerciasis, which would go badly, with several deaths.
Onchocerciasis, also known as "river blindness", is transmitted to humans by midges, the causative agent is a nematode called onchocerca volvulus . This worm, almost invisible to the naked eye (microfilaria), lives in the body for 14 to 15 years, during which time it gives birth to millions of larvae, up to 1,000 per day, moving throughout the body, and becoming adults after 6-12 months. They can spread to the skin and eyes, causing severe itching and skin lesions, the most serious being blindness.
Omura tested ivermectin on onchocerciasis, and found that it did not kill the adult worms but only the larvae, which is not a disadvantage, because the adult worms only live a few days, it is the eradication of the larvae that quickly treats the disease. This point is beneficial because the campaign set up in 1973 by McNamara with other treatments, led to deaths by shock due to a reaction called Mazotti: when an adult onchocerca dies, it bursts causing the intervention of a bacterium with which it lives in symbiosis, Wolbachia, causing a rapid inflammation that can be fatal, as can be the cytokine shock with Sars-Cov-2. Ivermectin, which only kills the larvae, eliminates this risk of an adverse effect that can be fatal, with just as much efficiency, killing all the larvae and letting the adults live their lives and die a natural death after a few days.
Originally from Africa, onchocerciasis passed to America in the 18th century , accompanying slaves. In 1987, nearly 40 countries in Africa and South America and more than 21 million individuals were affected. France will be the first country to authorize ivermectin for onchocerciasis, thanks to a Marketing Authorization (MA) from the ancestor of the ANSM (National Agency for the Safety of Medicines). The 1987 Medicines Agency authorized it for the onchocerciasis indication based on a single publication covering 1,206 patients, the 2021 ANSM refuses the marketing authorization of ivermectin for the covid indication that could save tens of millions of lives worldwide despite, at the time of our request, 50 publications covering 40,000 patients (including 2 French experiments showing 100% success in prophylaxis and curative). Different times, different customs: the health authorities of the time aimed at the interest of the populations before that of the industry, the current authorities aimed at the interest of the industry before that of the populations.
Ivermectin would then be used successfully to eradicate onchocerciasis, with one dose per year generally being sufficient to prevent the disease without transferring it. Omura would then focus on other parasitic diseases, such as lymphatic filariasis , another disease caused by a nematode transmitted by mosquitoes, causing considerable edema by destruction of lymphatic tissue (elephantiasis). The endemic area affected 1.3 billion people in 2000, with approximately 120 million infected. Areas where lymphatic filariasis is endemic often overlap with areas where onchocerciasis is endemic, so ivermectin is used in both areas where both are endemic. More than 300 million people are currently treated with ivermectin in both areas .
In fact, ivermectin is effective in humans against all intestinal worms and other parasites such as scabies in 2006, replacing with only 2 doses previously difficult and long treatments. Further research is still underway against all tropical diseases, but also against several viral diseases. As of 2020, 4.5 billion doses had been produced and distributed to humans since its inception .
IVERMECTIN AND CORONAVIRUS
Studies of the activity of ivermectin on viruses, and on the deleterious effects of Sars-Cov-2 such as the fatal cytokine shock, do not date from covid but from the beginning of the century, despite what Ms. Costagliola of Inserm says, who used all her weight to ensure that ivermectin was not used, both in France and with Dr. Andrew Hill, who was responsible for writing a report used by the European Agency and the WHO. She created a controversy by basing her study on only one study, that of Doctors Kylie and Wagstaff of Monash University in Australia. She simply ignored all the other work on ivermectin through ignorance and incompetence on the subject.
Indeed, Satoshi Omura reminded me, when he sent me his book that I wanted to translate (his publisher was not interested), that in his Nobel Prize conference, he pointed out that "it has been found that ivermectin has anticancer effects, but also antiviral effects, inhibiting in particular the growth of flaviviruses" . Flaviviruses are RNA viruses (like corona) transmitted by mosquitoes and mites and comprising about 70 species, such as the Japanese encephalitis virus, the dengue virus, or the West Nile virus. This is what Mrs. Costagliola should have known before denigrating ivermectin to the authorities, what Mrs. Christelle Ratignier-Carbonneil, director of the ANSM (director of the ARS Grand Est since June 15, 2024) should have known by inquiring at the source when she was asked for a marketing authorization for ivermectin. When millions of lives are at stake, we leave nothing to chance, we do not rush.
Kitasato University, where ivermectin was born, has been researching since February 2020 to find out if ivermectin could be effective, and there are researchers who search and find, whereas here no one has found anything because we have not sought anything, except to hide our actions.
In an experiment by Professor Kazuhiko Katayama, Vero cells were infected with the novel coronavirus, and ivermectin was administered to study the evolution of this virus. Vero cells are cell lines cultured from African green monkey kidney epithelial cells, and are widely used in vaccine research and production due to their good proliferation of various viruses and their high sensitivity to bacterial toxins. This experiment showed that it was clear that ivermectin inhibited the growth of the virus in a concentration-dependent manner, without reaching a cytotoxic concentration contrary to what Ms. Costagliola claimed without relying on any study from her organization, Inserm, which is the National Institute of Health and Medical Research.
Experiments using hamsters were also conducted by Professors Hideaki Hanaki and Takayuki Uematsu, infecting them with the new coronavirus, finding that the viral load in the lungs of the hamster group treated with ivermectin on the third day was reduced to about 90% compared to the group not treated with ivermectin. The Pasteur Institute will confirm in 2022 a beneficial effect of ivermectin in a similar study.
The university researchers also found a powerful anti-inflammatory effect in animal experiments. Omura then tried to induce artificial pneumonia in mice to see what ivermectin could do, finding that it was 10 times more active than clarithromycin (an antibiotic from the macrolide family), known for its anti-inflammatory properties, with a reduction in inflammatory cytokines. Without going that far and questioning Japan on this point, the ANSM and Costagliola could have opened the Vidal or the Soolantra file, which is ivermectin in ointment form. In the Vidal we can read : "Ivermectin belongs to the class of avermectins which have anti-inflammatory effects by inhibiting the production of inflammatory cytokines induced by lipopolysaccharide". Let us recall that at the time patients were dying of covid due to cytokine shock.
Furthermore, since studies on flaviruses, we know that ivermectin blocks the transport of the virus into the cell by acting on importins α and β. Prof. Hideaki Hanaki of Kitasato University has also shown that ivermectin binds to the spike protein, blocking its binding to the ACE2 receptor, the gateway for the virus to enter the cell, and Dr. Hiroshi Maruta, in Australia, that ivermectin inhibits a substance called PAK1 kinase. This kinase increases when infected by bacteria and inhibits immune function, preventing the production of antibodies, a function restored by ivermectin, hence its known immunomodulatory action. All this was developed at the 96th Congress of the Japanese Society of Infectious Diseases and the 69th Annual Congress of the Japanese Society of Chemotherapy on May 8, 2021. Only "conspiracy theorists" follow this information and make it public, the others hide it.
All these actions are confirmed by a number of publications, regularly mentioned here. To make a long story short, I will recall the first two French experiments by Pierre Loué and Charlotte Bernigaud showing an efficacy exceeding 90% in nursing homes, where there were the most deaths, both in prophylaxis and in curative treatment. These experiments were known to the ANSM, Costagliola and Inserm, as are currently the 7 French publications , all favorable, the 18 global studies in prophylaxis, all exceeding 80% efficacy and the 105 global studies in more than 30 countries, involving more than 220,000 patients, signed by 1206 different doctors.
Let us also not forget the report by Dr. Andrew Hill requested by Unitaid (which had as its president our former Minister of Health Marisol Touraine), and the WHO publication ( page 17 ) on possible treatments for covid. Both show a 75% drop in mortality in patients on ivermectin versus patients without treatment, in randomized studies selected for their quality. To refuse to prescribe them, both recommend that even more studies would be needed to confirm them, studies that all countries have refused to do, like the refusal of Inserm by Ms. Costagliola and Dr. Yazdan Yazdanpanah to Dr. Loué who proposed to reproduce his results in 5 nursing homes, during his meeting on May 4, 2020.
This refusal of authorization in the face of so many studies compared to the conditions of validation in onchocerciasis or filariasis clearly shows that current decisions are political and not medical, the interest of the pharmaceutical industry coming before that of patients. Different times, different morals.
The studies carried out on ivermectin since its creation indisputably made it possible, from the first days of the epidemic, to put forward a possible efficacy against Sars-Cov-2, and to guide towards a rapid treatment trial given that ivermectin was also known as one of the safest drugs in the world.
Those who did it, found a remarkable effectiveness, unexpected in the context, relegating the disease to the level of seasonal flu in terms of danger. The authorities, the professionals who prevented treatment, who prevented this information from being disclosed, could not not know, or they were totally incompetent and should have kept quiet if they did not know. Once the facts were put under their noses, they continued to hide and prevent any prescription, with full knowledge of the facts, endangering the lives of others.
IVERMECTIN AND CANCERS
In February 2023 , I mentioned the action of ivermectin on several cancers, following a spectacular testimony that I reported. In fact, these properties are known and have been under evaluation by a few researchers, too few in number, for years. In the manuscript of his book that he sent me, I note that Satoshi Omura already mentioned it when he was awarded the Nobel Prize.
A book could be written on all the studies done on the subject by isolated researchers around the world. To make a long story short, the action of ivermectin has been observed and studied in all cancers. The most spectacular is in gynecological cancers, breast and ovarian, and in many other indications (colon, rectum, kidneys, lungs, melanoma, leukemia, etc.), actions that can be found in several hundred studies and publications. I invite you to reread my February 2023 post, which cites among others a 2020 article from Pharmacologic Research . This article studies, based on 114 studies, the different mechanisms of action of ivermectin in different cancers. It states that "Ivermectin has potent anti-tumor effects, including on metastasis, in a variety of cancer cells,…Ivermectin promotes programmed cancer cell death or apoptosis (a process by which cells initiate self-destruction in response to a signal), autophagy and pyroptosis , …Ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts an optimal effect when used in combination with other chemotherapeutic agents."
In addition to these potential effects on cancers, let's not forget this other discovery (which is 5 years old anyway!): remyelination, opening up avenues in the treatment of multiple sclerosis ( here and there ). We have also found an action against multi-resistant bacteria , such as tuberculosis, an infectious disease that is regaining strength in the world, after having exhausted conventional drugs. Indeed, ivermectin destroys the biofilm , a protective membrane developed by bacteria to protect themselves from a hostile environment, thus making the bacteria resistant, once again sensitive to antibiotics.
CONCLUSION
Ivermectin has not finished surprising us, as its molecule is complex and its range of indications is wide, unmatched, and by far, in the pharmacopoeia. A real miracle molecule. Its possible new indications are not recent discoveries following its promotion in covid, but I am afraid that the attitude of the authorities and doctors on sets and in living rooms has put a brake on research that is nevertheless promising in this field. Indeed, today we cannot pronounce the word ivermectin in front of 90% of doctors, without being considered an incompetent, evil and conspiratorial doctor to be avoided and especially not listened to. The same goes for any doctor who would have the idea of talking about his discovery in a new disease, in a patient who was by chance on ivermectin for another indication. Yet this is how medicine has progressed for centuries: through experience, observation, dissemination, and not through money and statistics.
The other problem with ivermectin is that its production costs nothing (a few euros per kilo while it is prescribed in milligrams), and that it has fallen into the public domain. No laboratory will finance any research without any return on investment, the drug can then be produced and marketed by any other laboratory, which would then benefit from the results of the research and the discovery. Thus, Merck, which financed research on ivermectin 40 years ago, was able to reap the profits for around thirty years, but denigrated its baby in 2020, in the hope of releasing Molnupiravir, which was known to be bad, but could be marketed at 1,500 euros per dose. Ivermectin marketed for covid represents tens of billions of losses for the pharmaceutical industry (and the WHO, the EMA, certain politicians, financiers, funds, etc.), such as Pfizer, Moderna, AstraZeneca, for the main ones.
I finally created 2 PDF from it, one for the french and one for the auto-translated version to english that i attached to this post.
Another nice resources is from the comments of the article, a 3 pages well -fited posology of taking ivermectin, just that it's in the context of "long covid", but it's worth it. It's also in french, if some want to translate it, use google translate :
About posology, the one which is recommended here on the forum is to take 12mg of IV during 6 to 8 days for the treatment. And it's worth it to take 12mg per week for prevention.
That's all for today
