I recently wrote to Nicklebleu and Gaby for some advice. Amongst the things they recommended was Lactobacillus rhamnosus GG. It has been mentioned a couple of times on the forum, but I thought it may be good to start a thread about it and collect some research. We've just ordered some, so we can't attest to its benefits yet, but it does look promising.
So, posting a bit in a hurry here, but this is what Gaby sent me, and an article she wrote:
So, posting a bit in a hurry here, but this is what Gaby sent me, and an article she wrote:
http://www.health-matrix.net/2013/04/16/lactobacillus-gg-and-its-potential-role-in-tolerance-development/It would be good to experiment with the following one:
Culturelle is a patent of lactobacillus rhamnosus gg. There are very good reports with those and the lactobacilli have "pilli" which helps it to attach to the colon lining, promoting a good neighborhood in general. Here is some research about it:
I found a few more articles about it that were interesting (obviously, scratch the idea of taking it via diary products - evil!):I had the opportunity to listen to a talk given recently by Jon Vanderhoof, a pediatrician from the University of Nebraska. He was talking about the wonders and peculiarities of Lactobacillus GG and its role in digestive health.
Lactobacillus rhamnosus GG is a probiotic unlike any other because it has little “hairs”(pili) that helps it stick to the inner lining of the digestive system. It also acts as the good guy which promotes the proliferation of other good bacteria in the neighborhood and it survives stomach acidity, making it likely to reach the intestinal walls where it’s needed the most. Vanderhoof was presenting his clinical experience with the use of Lactobacillus GG in children’s gut problems and he seemed to be very pleased with the results.
It was interesting to see how researchers are approaching the role of food allergens and their role in modern diseases, a damage which doesn’t involve the classically allergic mediated reactions and its diagnostic tools with such things as a prick test. In fact, from a strictly mainstream medicine point of view, Vanderhoof explained that a host of inflammatory conditions along the digestive tube were increasingly associated with food intolerances. He gave the example of proctitis (inflammation of the rectum) as a reaction to gluten intolerance and other “idiopathic” diseases as well. He explained that gut motility issues (i.e. constipation) in small children were a result of gut inflammation due to food sensitivities. This is arguably the case for everybody else I should add! He emphasized that he was seeing children constipated as the only reaction to a milk allergy. Other less fortunate little ones were having blood on their stools and vomiting (among other things) in response to their mother’s awful diet. So of course, mothers are instructed to do an elimination diet when they are breastfeeding their babies.
Gluten also shows up in mother’s milk contributing thus to colics, failure to thrive, acid reflux, diarrhea, eczema, chronic diaper rash, vomiting, seizures and so forth. For more information see glutenfreesociety.org
The classical allergic reaction is IgE mediated (a component of your defense system) and it could send you to the emergency room for a life saving adrenaline shot. It can be that dramatic. But as classical as it may be, it is actually very rare. Most food allergens create great havoc through a non-dramatic but very harmful long-term effect.
The most common food allergens are from agricultural-based foods, either GMO or non-GMO. This is one of the reasons why a paleo or ketogenic diet can be very beneficial for a lot of folks with several different conditions or health problems.
Anyhow, the take home message is that Lactobacillus GG seems to be unique in its capacity to promote gut health and wellness in general, and that foods from the Agricultural revolution are at the root of mankind’s deteriorating health.
Vanderhoof seemed to imply that Lactobacillus GG would increase the chance that a baby would tolerate a certain food allergen better. But if the body reacts to certain foods as it does, it is probably because the food per se is very harmful and was never part of mankind’s natural diet to begin with. Arguably the case for GMOs and the so called Agricultural revolution! For more information see Origins of Agriculture – Did Civilization Arise to Deliver a Fix?
Below are some assorted studies and quotes that are relevant to the topic at hand.
IgE-mediated allergic responses to foods are the most dramatic and perhaps the most easily diagnosed type of food allergy. Non-IgE-mediated food hypersensitivity is more chronic, less acute, less obvious in its clinical presentation, and often more difficult to diagnose. It usually presents in infants between one week and three months of age with vomiting and diarrhea, although irritability, poor feeding, and failure to thrive are not uncommon. A thorough history and physical examination are often key in establishing a diagnosis of food protein hypersensitivity. In non-IgE-mediated disease, skin tests and immunological studies are not helpful. Eliminating the food allergen is the only means of dealing with a food allergy in most patients.[Vanderhoof JA.. Food hypersensitivity in children. Curr Opin Clin Nutr Metab Care. 1998 Sep;1(5):419-22.]
The gut contains a diverse bacterial flora that is acquired at birth and has a number of physiological functions. Administration of prebiotics or probiotics may favourably alter this gut microflora. Prebiotics are poorly digested oligosaccharides that promote the growth of desirable bacteria and may have other beneficial gastrointestinal and systemic effects. Probiotics are “helpful” human bacteria that provide a variety of health benefits when administered exogenously. Probiotics produce beneficial effects in the prevention and treatment of traveller’s diarrhoea, viral diarrhoea, and diarrhoea in day care centres. Moreover, probiotics have been shown to reduce relapses associated with Clostridium difficile, and Lactobacilli are effective in the prevention of antibiotic-associated diarrhoea. Probiotics may also be efficacious in the treatment of gastroenteritis. Clinical studies of probiotics in inflammatory bowel disease have proved disappointing, but beneficial effects in adults with irritable bowel syndrome have been reported with Bifidobacterium infantis 35624. Lactobacilli GG reduces the incidence of gastrointestinal symptoms and gut permeability in patients with atopic dermatitis, and administration of probiotics reduces the frequency and severity of atopic eczema when administered to pregnant women and then to newborn infants. In conclusion, probiotics are effective in the treatment and/or prevention of a number of conditions, including diarrhoea, irritable bowel syndrome and atopic dermatitis, and the product used should be selected based on the particular indication. [Vanderhoof JA.. Probiotics in allergy management. J Pediatr Gastroenterol Nutr.2008 Nov;47 Suppl 2:S38-40.]
“The most extensive studies of the modification of allergic reactions have been reported for atopic eczema with Lactobacillus GG as the probiotic”[…] “Randomized double-blind studies have provided evidence of probiotic effectiveness for the treatment and prevention of acute diarrhea and antibiotic-induced diarrhea, as well as for the prevention of cow milk–induced food allergy in infants and young children. Research studies have also provided evidence of effectiveness for the prevention of traveler’s diarrhea, relapsing Clostridium difficile–induced colitis, and urinary tract infections. There are also studies indicating that probiotics may be useful for prevention of respiratory infections in children, dental caries, irritable bowel syndrome, and inflammatory bowel disease. Areas of future interest for the application of probiotics include colon and bladder cancers, diabetes, and rheumatoid arthritis. The probiotics with the greatest number of proven benefits are Lactobacillus rhamnosus strain GG and Saccharomyces boulardii.” [B.R. Goldin, S.L. Gorbach. Clinical Indications for Probiotics: An Overview. Clin Infect Dis. (2008) 46 (Supplement 2): S96-S100.]
It is estimated that ventilator-associated pneumonia (VAP) complicates the care of up to 30% of patients receiving mechanical ventilation. Patients with VAP have increased morbidity, mortality, and hospital costs as well as prolonged intensive care unit (ICU) and hospital lengths of stay and increased costs […] Probiotic prophylaxis of VAP using Lactobacillus rhamnosus GG appears safe and efficacious in a select population of patients who are at very high risk for contracting VAP. This therapy may also offer an opportunity to prevent related ICU complications, such as C. difficile and ICU-associated diarrhea. Ultimately, probiotics may fulfill a role in antimicrobial stewardship programs given the reductions in antibiotic consumption[Morrow LE, Kollef MH, Casale TB. Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med. 2010 Oct 15;182(8):1058-64.]
http://www.livestrong.com/article/398927-what-is-lactobacillus-rhamnosus-gg/Lactobacillus rhamnosus GG - Many Names, Many Health Benefits
Lactobacillus rhamnosus GG, also known as "L. rhamnosus GG" or "LGG" is a probiotic bacteria with many health benefits. As you learned on the Lactobacillus rhamnosus general page, this species of bacteria has some unique characteristics depending on the strain. LGG stands alone as being one of the most different strains currently known in this probiotic species.
What is LGG ?
Lactobacillus rhamnosus GG was isolated from the intestinal tract of a healthy human. Dr. Sherwood Gorbach and Dr. Barry Goldin from Boston, MA filed for a patent in April of 1985, and called it “GG” because of their last names. Therefore, unless a product specifically says that it contains this strain, it does not contain L. rhamnosus GG, and you're not getting what you may hope to be paying for.
LGG® is a registered trademark of Valio Ltd., Finland. In the patent application, it was claimed that Lactobacillus rhamnosus GG can survive in normal human stomach acid at pH of 2.5 for 30 minutes and is bile stable. This means that it can survive passage through the stomach and small intestine. They also claimed that LGG was able to vigorously adhere to human intestinal cells, a claim that is disputed because some studies show that it can adhere only moderately to mucus cells.
The patent for L. rhamnosus GG also stated that it is used for 7 conditions:
Treatment of antibiotic-associated diarrhea
Prevention of antibiotic-associated diarrhea when taken prior to or during antibiotic therapy
Treatment or prevention of ulcerative colitis
Colonization resistance to pathogenic microbes
Reduction of the amount of cholesterol eliminated in feces, thereby reducing colon cancer risk
Reduction of the amount of estrogen excreted in menstruating women
What Does Other Research On LGG Show ?
Over 400 studies have been conducted on LGG. In addition to the results stated in the patent application for Lactobacillus rhamnosus GG, other research has shown that LGG:
Does not adhere to the vaginal interior, but has some vaginal benefit (for more information, see Lactobacillus rhamnosus GR-1 page )
Has been shown to decrease the incidence of eczema in children
Modulates the immune system in allergic-type conditions
Was effective against diarrhea from E. coli, Salmonella and Shigella
Was able to protect the small intestine in mice when exposed to radiation therapy if given before, but not after, the radiation therapy. (Once again, the theme so often echoed in this website is to preserve health by preventing disease, and you'll save money in the process.)
Significantly reduced C-reactive protein, a marker of inflammation, when given 1.6 x 1010 CFU/d to healthy adults
Where to Find Lactobacillus rhamnosus GG
At the time of this writing, Lactobacillus rhamnosus LGG is found in many products all over the world. For example, Aktifit® by Emmi Switzerland is a yogurt drink containing LGG with Streptocucus thermophilus, although the amounts of each in a serving are unknown. Since there are so many products, the best advice is to always, always, read product labels.
http://weightlossleaders.com/lactobacillus-rhamnosus-weight-loss-reviewWhat Is Lactobacillus Rhamnosus GG?
Last Updated: Jan 28, 2015 | By Charis Grey
What Is Lactobacillus Rhamnosus GG? Fermented foods like yogurt contain probiotics. Photo Credit Yogurt image by Infs from Fotolia.com
Lactobacillus rhamnosus GG is the most extensively studied probiotic microorganism available for sale in retail markets, according to USProbiotics.org. Probiotic microbes are good for you. They confer positive health benefits when consumed live, either in fermented foods like yogurt, or as supplements sold in capsules at health food stores. Lactobacillus rhamnosus GG has been shown to have numerous positive effects on health.
Your body naturally contains vast numbers of beneficial bacteria that actually protect your gastrointestinal health. These bacteria, called normal flora, live in your intestinal tract, occupying space that could otherwise be overrun by harmful pathogens. Live beneficial bacteria that are found in foods and supplements are called probiotics. By consuming probiotic foods, such as those containing Lactobacillus rhamnosus GG, you transfer beneficial bacteria to your intestinal tract and put them to work for your health.
Not all probiotics offer the same effects. The health benefits of probiotics are strain specific, meaning that different types of probiotic microbes affect your body differently. Lactobacillus rhamnosus GG is a specific bacterial strain. Lactobacillus is the name of the genus to which it belongs. Rhamnosus is the name of the species. GG denotes the strain. Even something so slight as a different letter or two in the spelling of its name can mean that your probiotic is a different strain and may not have the same effects. Lactobacillus rhamnosus GR-1, for example, is different from Lactobacillus rhamnosus GG, and confers different health benefits.
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Effects of Lactobacillus Rhamnosus GG
Numerous studies have confirmed the effects of Lactobacillus rhamnosus GG on human health. According to a study published in May 2008 in the “World Journal of Gastroenterology,” it can alter the blood lipid profiles and may be helpful in treating diseases associated with inflammation. It has demonstrated effectiveness in treating a condition called pouchitis, which can occur after colon surgery, as noted in a study published in March 2003 in “Alimentary Pharmacology and Therapeutics.” Additionally, a study published in April 2008 in “Annals of Allergy, Asthma and Immunology" suggests it may be helpful in preventing and treating atopic eczema.
http://www.probioticscenter.org/best-probiotics-for-weight-loss-women/Lactobacillus Rhamnosus Probiotic
Is Lactobacillus Rhamnosus one of the perfect probiotics to help people lose weight faster and easier?
This is a question Dr. Oz asked in his article, The Good Life of March/April 2014 issue. This was a text especially designated to help people choose a probiotic that will address their digestive issues.
More than this, studies on Lactobacillus Rhamnosus were meant to show overweight people how to lose their belly fat.
It seems this probiotic showed great weight loss results in animals. While things went great for mince, results were not so sure about humans. Another new British Journal of Nutrition study showed this probiotic leads to significant weight loss just in women.
Lactobacillus Rhamnosus Probiotic Overview
Have a look over the next few paragraphs. You will discover how this Lactobacillus Rhamnosus improved many women’s weight, causing them to drop many pounds.
The studies went further, at the Laval University in Québec. Here, scientists searched to determine how consuming a certain strain of bacteria or probiotics could improve the intestinal flora. This thing was used to favor weight loss management.
The previous studies performed at this University proved bacteria in those who are obese is different from the one that develops in thin individuals.
What is Lactobacillus Rhamnosus?
Lactobacillus Rhamnosus is one of the most broadly studied bacterial strain. This is all due to the fact that this probiotic doesn’t present any pathogenicity. It exists in the human body by natural means.
It is primarily existent in the digestive tract, but the urinary and genital tracks also contain it. Its most important use is to keep up a balanced quantity of bacteria in the digestive system. It looks like it prevents harmful bacteria to develop.
It seems there are no other bacteria to have more health benefits. Lactobacillus Rhamnosus features only healthiness and digestive improvement. Besides the amazing weight loss effects, Lactobacillus Rhamnosus has also anti-inflammatory characteristics.
Lactobacillus Rhamnosus Weight Loss
Since this form of bacteria preserves a healthy digestive system, the weight loss process gets to be activated and inevitable. The human body needs a healthy and constant flow. As soon as the stomach and intestines get to digest and process foods at much higher speeds, the weight loss begins to accelerate and take place without too many efforts.
It is very important to feature a decent amount of Lactobacillus Rhamnosus in the digestive tract. The balance of bacteria will sustain a healthy system that doesn’t add any more fat.
Where To Find Lactobacillus Rhamnosus?
What foods contain the most Lactobacillus Rhamnosus?
This for of bacteria is naturally present in whole foods and dairy products. Try consuming yogurts, cheese and fermented milk. Some strains of Lactobacillus Rhamnosus can be found in fermented meats and dry sausages.
If you are allergic or you happen to not be a fan of such products, try health supplements developed with this bacterium.
Make sure your body contains enough bacteria to balance and sustain proper digestion. You will lose weight without any efforts or diets that limit your neurons from enjoying a good meal.
Anyway, just FWIW, in case anyone is interested. Their ideas about diet are not always right, as we know, but perhaps it can be an extra support for the keto diet, and to those who struggle a bit with it or who have auto-immune conditions, chronic damage of the gut, etc.? What I found to be the most interesting stuff about it is the link with inflammation.Best probiotics for Weight Loss in Women • Study Reveals
February 28, 2014 By Ken Silvers Leave a Comment
Talking about the best probiotics for weight loss in women might sound as an obvious scam. However, it might be the real thing. We know that probiotic bacteria in your gut are essential to enjoy good health. But is are some bacteria in control of our weight? And could there even be specific bacteria strains that promote weight loss in women and not in men?
Several recent studies reveal that, among the hundreds of bacteria species colonizing your digestive tract, a few specific bacteria are involved in weight control. Some bacteria as Akkermansia muciniphila even have the unique ability to determine the rate of weight loss of both women and men. In addition to Akkermansia muciniphila, researchers has now found another probiotic bacteria that seems best for weight loss in women only.
Best probiotics for Weight Loss in Women, no scam
best probiotics for weight loss
Consuming probiotics promotes weight loss. However, cerains bacteria are better for women than for men. (Image courtesy of luigi diamanti at FreeDigitalPhotos.net)
But a recent study published in the British Journal of Nutrition showed some surprising results, that there might actually exist probiotics for weight loss in women.
Previous studies have already demonstrated that the intestinal flora of obese individuals differs from that of thin people. This difference is likely due to a person’s diet. An unhealthy diet high in sugar, processed foods, low quality fat and low in fiber will promote growth of bacteria species promoting weight gain at the expense of other beneficial bacteria supporting weight loss. Therefore researchers tried to determine if the consumption of certain probiotics could help reset the balance of the gut in favor of bacteria that promote a healthy weight.
Researchers tested this on 125 obese men and women that during 12 weeks were put on a weight-loss diet. After this followed 12 weeks trying to maintain body weight. During this time half of the subjects took 2 pills daily containing the probiotics Lactobacillus rhamnosus. The other half of the group received a placebo—a pill without any effect.
Remarkable weight loss results after 12 weeks
On the average, there was a weight loss of 4.4 kg (almost 10 pounds) in women in the group taking probiotics and 2.6 kg (just under 6 pounds) in the placebo group not taking a probiotic supplement. However, there was no different in weight loss among males in the two groups.
“We don’t know why the probiotics didn’t have any effect on men. It may be a question of dosage, or the study period may have been too short,” says Professor Tremblay, who is also the Canada Research Chair in Environment and Energy Balance.
After an additional 12-weeks period trying to maintain their weight, the women in the placebo group had remained stable but the probiotic group had continued to lose weight; in total these women lost 5.2 kg (11.5 pounds) per person. This is twice as much as the control group.
Overweight women consuming Lactobacillus rhamnosus lost 5.2 kg (11.5 pounds) over a 24-week period
Researchers also noted a drop in the appetite-regulating hormone leptin in this group, as well as a lower overall concentration of the intestinal bacteria related to weight gain and obesity. This indicates that certain probiotic gut bacteria influence a person’s weight. How is this possible?
It is likely that probiotic bacteria affect the permeability of the intestinal wall. By keeping certain pro-inflammatory substances from entering the bloodstream, beneficial bacteria help preventing the chain reaction that leads to glucose intolerance, type 2 diabetes, and weight gain.
Probiotic bacteria also communicates with the brain and can thereby increase or decrease appetite which is a powerful factor in weight control.
Lactobacillus rhamnosus, were can you find it?
The Lactobacillus rhamnosus strain used in this study is found in some yogurts. But researchers believe other probiotics bacteria found in dairy products in North America could have a similar effect on weight. However, the benefits of these probiotic bacteria increase with an adequate fiber intake. Most people eat too little fiber.
L. rhamnosus has been shown to affect certain brain regions and lowers the stress hormone corticosterone. Thus this bacteria has the ability to reduce anxiety and depression.
L. rhamnosus also promote destruction of harmful bacteria and absorption of minerals by aiding in the digestion of lactose. It causes the body to manufacture natural antibiotic substances to fight disease, increasing your resistance to viral infections.
Lactobacillus rhamnosus can be found in probiotic supplements as…
Dr. Mercola Complete Probiotics
This weight loss promoting bacteria species are included in some fermented foods. For example, Lactobacillus rhamnosus GG is included in some yogurt brands.
One of the best sources is preparing fermented food at home using a starter culture containing L. rhamnosus. Dr. Mercola Complete Probiotic contains L. rhamnosus and nine other highly beneficial bacteria. This works fine as a starter culture for preparing yogurt, kefir or fermented vegetables. You can also get the excellent starter culture Kinetic Culture from Dr. Mercola.
Gut bacteria communicate with your brain
Research on probiotic bacteria indicates that beneficial bacteria in your gut communicate with your brain through the vagus nerve. This is why some gut bacteria can control your appetite. For example, there’s a feedback loop between the foods you crave and the microorganisms in your gut. These microorganisms depend on certain nutrients to survive.
For example, microbes that feed on sugar can signal your brain to consume more sweets. People who suffer from Candida overgrowth often have severe sugar cravings because Candida feed on sugar for their survival.
Changing diet can alter your gut bacteria composition very fast, even during a few days!
This illustrates how you are ultimately the one who controls the composition of your intestinal microflora. How is that? The foods you eat will affect the composition of bacteria in your digestive tract. Therefore your diet directly impacts the community of microorganisms colonizing your gut—for better or worse.
Akkermansia muciniphila promotes weight loss in both overweight men and women
Akkermansia muciniphila has been shown to promote weight loss in all obese people. Akkermansia muciniphila has unique properties and promotes the repair of a disturbed metabolism that is often associated with obesity, inflammation and type-2 diabetes. This beneficial bacteria is naturally present in a healthy gut. However, the concentration of Akkermansia muciniphila is lower in humans with intestinal disorders like Crohn’s disease and also in obese people.
Can you consume Akkermansia muciniphila and loose weight?
At the time of writing this post, I’m not aware of any probiotic supplement containing Akkermansia muciniphila. But since this bacteria is found naturally in all humans, a good option is to promote the growth and well-being of these and other beneficial bacteria already colonizing your gut. What you consume will to a great extent effect the growth of Akkermansia muciniphila in your gut.
How to stimulate the growth Akkermansia muciniphila and other gut bacteria promoting weight loss
Add more fiber to your diet; chances are that you are not eating enough. Psyllium husk is one of the best sources of soluble and insoluble dietary fiber. They are commonly used to relieve constipation, irritable bowel syndrome, and diarrhea. Research show that psyllium husk promote growth of probiotic bacteria in your gut. Good bacteria feed on fiber, keep your gut colony well fed.
Lower you intake of sugar. Excess sugar from processed foods, soda and candy disturbs the delicate gut balance causing growth of unwanted bacteria responsible for weight gain.
Eat fermented foods like yogurt, kefir, fermented vegetables and natto.
Stress has a bad effect on your digestive tract and can cause severe imbalances. Find ways to calm down. A soothing walk in a park, by the sea or a lake, listen to soothing music, sing or play an instrument. Doing something for others is great way to feel joy and relax.
Take antibiotics only when you absolutely have to.
The above recommendations work well for both men, women and children but especially those who are overweight or suffer from inflammatory bowel diseases and type-2 diabetes.
Best strategies for weight loss
The latest research all point in one direction: The best way to enjoy a natural and permanent weight loss is to support your gut bacteria responsible for controlling your weight.
Consume fermented foods. Yogurt, kefir, and fermented vegetables on a daily basis can have a tremendous effect on your gut and help balance your gut and control appetite. Homemade cultured foods are packed with probiotic bacteria and you can even control which beneficial bacteria are included.
L. rhamnosus. As a woman you will maximize weight loss benefits if you consume Lactobacillus rhamnosus daily; you do not need very high doses. Men will benefit also but in other ways than weight loss.
High quality probiotic supplement. A simple, fast way to get going in the right direction. However, choose a probiotic supplement carefully as the market is full of scams.
Add extra fiber. Simple but highly effective way to stimulate growth of beneficial bacteria already colonizing your gut. Fiber promotes bowel movement. Psyllium husk is a natural and excellent source of fiber that probiotic bacteria love and consume. This promotes weight loss.
Lower sugar intake. A high sugar intake can cause bacteria responsible for weight gain and obesity to dominate your digestive tract. People with such imbalances have very difficult loosing weight as they have battle on several fronts—a strong appetite and gut bacteria promoting weight gain. However, simple changes to your diet can have a big, fast, positive impact.
Learn to control stress. Stress can disrupt the delicate balance in your digestive tract.
Avoid Antibiotics. Very rarely a person will be in real need of antibiotics. But if you are, be sure to add a probiotic supplement daily and continue taking a supplement long after you completed your antibiotics course. The onslaught of antibiotics on you gut is severe and can cause imbalances that can take a long time to repair.
Exercise. A great way to maximize your weight loss efforts. High intensity training has proven very beneficial. If you run, jump, or use a bicycle—go 30 seconds in full speed the 1.5 minutes very slow, again 30 full speed and 1.5 minutes slow. Do 6-8 such intervals. This training stimulates your body to release human growth hormones (HGH) and promotes insulin sensitivity. This is all highly beneficial for weight loss.
Intermittent fasting. There are many variations but it means to have periods of fasting for 12-24 hours. Some do this two days per week, others (like me) fast daily. This basically means eating you last meal at 6 PM, skipping breakfast the next morning and then have your first meal at noon. This way your body has been in a fasting state for 10-12 hours. Intermittent fasting requires that you eat healthy first otherwise it will not work. Do some reading on the subject to learn the benefits for optimal health and losing weight.