MRNA anti-aging technology:good or bad?

gottathink

The Living Force
FOTCM Member
COVID vaccinations/prophylactics are just the start of population wide mRNA interventions. It sounds wonderful to treat our aging bodies, but really is it?
Is this part of our bright future or something else?
“The studies show that aged muscle stem cells treated with this combination therapy fully regenerate age-related muscle dysfunctions.”
Jay Sarkar, PhD, Co-founder and CTO, Turn Biotechnologies
Turn Biotechnologies announced today that it has acquired global rights for new artificial niche (AN) technology that can be used to restore muscle stem cells damaged by aging. The company licensed its AN technology from Stanford University where it was developed by a researcher who serves as an advisor to Turn. AN technology is used to create a microenvironment that maintains stem cells in a quiescent state to repair or replace specific types of damaged tissue.

Turn is developing medicines that induce the body to heal itself by instructing specific cells to fight disease or repair damaged tissue. Turn's technology uses messenger RNA to produce instructions that induce cells to treat or prevent disease. Messenger RNA, used to develop two COVID-19 vaccines, is expected to make the development of therapies safer, faster, and more efficient. The company is focused on reprogramming the epigenome to address multiple aging-related diseases using a powerful reprogramming therapy that turns old cells into young cells to rejuvenate the human body. Turn is currently completing pre-clinical research on tailored therapies targeting indications in dermatology, ophthalmology, osteo-arthritis and cartilage damage and musculature.”
 
COVID vaccinations/prophylactics are just the start of population wide mRNA interventions. It sounds wonderful to treat our aging bodies, but really is it?
Is this part of our bright future or something else?
“The studies show that aged muscle stem cells treated with this combination therapy fully regenerate age-related muscle dysfunctions.”

Turn Biotechnologies announced today that it has acquired global rights for new artificial niche (AN) technology that can be used to restore muscle stem cells damaged by aging. The company licensed its AN technology from Stanford University where it was developed by a researcher who serves as an advisor to Turn. AN technology is used to create a microenvironment that maintains stem cells in a quiescent state to repair or replace specific types of damaged tissue.

Turn is developing medicines that induce the body to heal itself by instructing specific cells to fight disease or repair damaged tissue. Turn's technology uses messenger RNA to produce instructions that induce cells to treat or prevent disease. Messenger RNA, used to develop two COVID-19 vaccines, is expected to make the development of therapies safer, faster, and more efficient. The company is focused on reprogramming the epigenome to address multiple aging-related diseases using a powerful reprogramming therapy that turns old cells into young cells to rejuvenate the human body. Turn is currently completing pre-clinical research on tailored therapies targeting indications in dermatology, ophthalmology, osteo-arthritis and cartilage damage and musculature.”
What can go wrong??
 
I think we get to see part of what’s following international application of mRNA COVID-19 prophylactics. The huge push for people to accept this type of medical intervention and greedy corporations ready to sell it as an elixir of youth, alongside eugenics on a global scale.
 
Thanks, but no thanks. Over my dead body seems appropriate, when the discussion is about something that will assuredly kill you. Even if it gave eternal life, it'd still kill the individual receiving it - because the moment one opens an external pathway to insert new code into what transcribes the Self, that individual has been overwritten, no longer exists. Therefore, for any type of mRNA experimental gene therapy, over my dead body is my basic stance.
 
I tend to keep an open mind whenever I read about new developments on technology that have medical implications for a better treatment and what not, Stem cell treatment, for instance, might've sounded like a crazy idea years ago, but with the right focus it can be beneficial I think.

The trouble I have with this is that there's just so much we do not know about how our bodies are written that tempering with it, specially with the intent to keep people young, seems like a recipe for disaster. Not that we ought not to seek ways to live better and heal better and whatnot, but I also think that there's a purpose for aging that goes beyond beauty or strength, there's a purpose for your body to need certain time to heal from injuries or wounds that goes beyond efficiency.

And I think all those purposes are written in our genes with far more wisdom than the one that is at the core of this effort. Does that make sense? It feels like they're trying to develop a way to make the body "better", but that seems a bit arrogant, that feels as though whoever is working on it is convinced that it understands the body well enough and has found a way to make it better, and with that attitude, the most likely outcome is disruption.
 
I am a bit like Alejo - not against new technologies that can be used for all sorts of beneficial treatments, including genetic treatments. The problem is that at this point in time we don’t know exactly what happens with all these new technologies, when applied to human beings. A major obstacle is that the firm developing these new technologies are doing the safety and efficacy studies themselves - and most are so profit oriented, that they will fudge the data just to get certifications, consequences be damned.

So at the moment I would be very reluctant to get any of these therapies, unless it is a life-threatening condition, for which there is no real alternative treatment. In this case you might not have a lot to loose. But anti-ageing? There are a lot of other treatments that have a good track record of slowing biological ageing - like metformin, keto diet, just to name two that pop into my head.

Another issue is not only danger to yourself, but danger to those around you. There is the possibility that genetic therapies might trigger the expression of human endogenous retroviruses (HERVs) that lie dormant in your genetic code. And this would put those around you at risk. I have no idea how likely this scenario is, but my hunch is, neither do the scientists.

It’s a bit the old ‘no pain, no gain’ - everyone is looking for a ‘magic bullet’. One injection, and you’re 20 years younger. Who knows, maybe that might happen in the future, although I don’t think I’ll see that in my lifetime.
 
Recently, this community of Biohackers have been growing fast; focusing mainly on how to live much longer, and obviously healthier, but I agree with Alejo and nicklebleu that this could be a bit counterproductive when It is taken as an obsession, not as an alternative that may be used in extreme cases like nicklebleu mentioned earlier.

I rather think we all could gain knowledge from these people and those studies that the Biohackers have done, mainly those who use therapies with vitamins and herbs (Berberine, Nicotinamide Ribioside (NR), etc), but with the objective of living healthier and prevent upcoming health issues. Above all (at least in my case), a good mental health that allow me to focus on my learning journey.

My two cents.
 
All good points that make sense. Perhaps there is potential for benefit from this science but we just don’t know enough about how our bodies physiology, energy, environment, genetics, etc etc would interact with any mRNA interventions. We are just not sophisticated enough to know what we are doing.
But I do wonder if we are seeing the beginnings of life by design. Yes it is particularly interesting to read the process is emulated by safer bio hacks (ie Keto diet, fasting etc). All interventions that recreate the environments for stem cell proliferation.
I guess it’s super interesting because of the developing knowledge of how life is maintained and degeneration of biology is not necessarily the only outcome for human life forms.
 
Recently, this community of Biohackers have been growing fast; focusing mainly on how to live much longer, and obviously healthier, but I agree with Alejo and nicklebleu that this could be a bit counterproductive when It is taken as an obsession, not as an alternative that may be used in extreme cases like nicklebleu mentioned earlier.

I rather think we all could gain knowledge from these people and those studies that the Biohackers have done, mainly those who use therapies with vitamins and herbs (Berberine, Nicotinamide Ribioside (NR), etc), but with the objective of living healthier and prevent upcoming health issues. Above all (at least in my case), a good mental health that allow me to focus on my learning journey.

My two cents.

It is the corruption of mind

over time that worries me. In the beginning it is always super cool and interesting and rather innocent, e.g. wether biohacking or any other enthusiastic areas of discoveries and experimentations.

Then… along the road sneaks in that sense of obsession and competition, even extreme deviations. And corruption.

In a world of 3D STS it seems that many nobel ideas and progresses tend to end up being “harvested” at the end of the road. Not honesty being used for humanity, just mainly against her.

I would never understood that as a young man… not fully. Not seriously. Not on a deeper level.

what is done - is trying to change physics but always leave out the greater dimension of it: spirit.

So, we change DNA / RNA to do what exactly ? Yet spirit is the source of all matter. Not the other way around.

I am not saying it shouldn’t be experimented in this world - even in there are deep lessons dwelling, waiting to be learned. The constant exclusion of spirit in most things we people do, is i believe the wheel around the neck that burdens humanity.
 
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It is the corruption of mind

over time that worries me. In the beginning it is always super cool and interesting and rather innocent, e.g. wether biohacking or any other enthusiastic areas of discoveries and experimentations.
Yes illustrated here by Margaret Colagnos latest Linked In post:

During the COVID-19 pandemic regulatory authorities accelerated processes to release COVID-19 vaccines to the world, Colangelo hopes that regulators will also fast track longevity treatments. "We want to fast track longevity treatments so that we don't have to wait 10 years. Obviously we want regulators to take all the necessary steps to make sure that longevity treatments are safe and effective, but if they reduce the red tape and streamline processes, they might be able to make longevity treatments available sooner."

“In this way,” the specialist emphasizes, “a lot of unnecessary suffering could be avoided for millions and millions of people, which is the ultimate goal behind the longevity industry beyond just seeking to extend life. People usually say: 'Oh, these treatments will help people to live longer; maybe we can live 120 years.' That may be true, but I always think how millions people will avoid suffering with age related diseases. I think it is important to see it that way."

"In the future we won't have to see our parents decline with Alzheimer's and dementia or strokes because they will remain healthy as they age. This will be the first time in all of human history that children do not have to see their parents and grandparents suffer with age related diseases." she emphasizes. "Longevity research is the most positive thing that is happening on the planet."

Margaretta Colangelo speculates that some new drugs and treatments may be available, in as soon as five years. Until then, people should follow basic care measures: healthy diet, regular exercise, minimizing stress, and getting enough sleep. "Many people work under stress, and that causes a whole cycle of diseases. Stress contributes to inflammation" she says.

A factor that could affect life expectancy is COVID-19 since some people have long term effects after recovering. COVID-19 can affect the heart or brain causing neurological problems," reiterates Colangelo. "There can also be kidney failure; many people hospitalized with COVID-19 have needed dialysis. Some people may develop heart or kidney problems that will disable them for life." But even something as simple as persistent insomnia in those who have beaten the coronavirus can have a damaging impact, as sleep is essential for healthy longevity. "We are supposed to have 8 hours of sleep every night, and those who have their regular periods of sleep live longer. That is a very important part for healthy longevity," insists the specialist.

Colangelo feels a special fascination for the influence of the social environment in Mexico on longevity, especially since Mexico has the highest proportion of people over 100 years old living with their families. 800 centenarians live in Mexico City and 95% of them live with their families. Most other countries worldwide report that 60% of centenarians live in nursing homes. "That's amazing! Living with relatives can help older people stay healthy, especially during the COVID-19 pandemic. The people who lived in nursing homes during the pandemic were very vulnerable. First, because of the disease itself, but also because they couldn't have visitors for a whole year; they couldn't see their family so they were alone. Mexican society stands out for taking the greatest care of its elderly " she acknowledges.

Finally, Colangelo, who recently participated in the 2021 Innovation Week, organized by the Mexican Association of Pharmaceutical Research Industries (AMIIF), also highlights that Mexico has the highest average retirement age for men (72 years) and the second-highest for women (69 years) in all OECD countries. In Mexico one in four men over 80 years of age continues to work. Giving these people access to longevity treatments could allow them greater functionality; "They would be 80 years old, but biologically they would be younger of healthier" Colangelo highlighted at Innovation Week. "If the (Mexican) government recognizes early that in 10 or 20 years Mexico will have more people living longer, it could develop public policies to help the population, and it could save a lot of money on healthcare" she said.

From her experience as a member of the advisory board of multiple companies and speaking closely with scientists and disseminating the results of their research, Margaretta Colangelo has absolute confidence in something: the future is going to be better than anyone anticipates. "The future will be better because we will have incredible technology. These technologies will be so good that companies will be able to develop treatments to slow down, delay, and maybe even reverse aging. Companies that develop these treatments will become the most valuable companies in human history and they will also help the largest number of people in history" says the specialist. "Drugs are usually developed to target a specific disease such as cancer or cardiovascular disease. But everyone ages. All 7 billion people on earth are aging. So everyone will benefit from longevity treatments at some point. This is very positive. "

In her opinion, most people don't understand the incredible potential of technology to help us solve the world's biggest problems. "Many people who work with technology want to use it to help solve problems to improve life for everyone. So it is important to understand that this is not just for people in Silicon Valley and not just for billionaires. No. Many scientists I know want to make these advanced technology accessible to every human on all continents, " she says. "The most important thing in the world is access to knowledge. If people spent time learning about science and technology they could update their mental model and understand that we are already in the middle of a scientific revolution."

99% of the people in the world don't realize that we are in the middle of a scientific transformation that will change everything. The most important thing for people to do is to read about science and technology. They should read about AI, quantum computing, and messenger RNA. And, she explains, when they read about technological advancements they will feel more comfortable with technology and discard some old beliefs. "I think there are many people who fear that AI is going to hurt us. No, cancer is going to hurt us; AI is going to help us beat cancer. "The world is going to be very surprised when they see how good the future is going to be," she concludes.

To read the original article by Israel Sánchez please click here Prevén revolución antienvejecimiento
 
And I think all those purposes are written in our genes with far more wisdom than the one that is at the core of this effort. Does that make sense? It feels like they're trying to develop a way to make the body "better", but that seems a bit arrogant, that feels as though whoever is working on it is convinced that it understands the body well enough and has found a way to make it better, and with that attitude, the most likely outcome is disruption.

Yes that makes sense, it is a strange excitement with trying to make changes to a system of evolution that they don’t understand but won’t admit they don’t know what they are doing. A case of “a little knowledge is a dangerous thing”.
 
what is done - is trying to change physics but always leave out the greater dimension of it: spirit.

So, we change DNA / RNA to do what exactly ? Yet spirit is the source of all matter. Not the other way around.
That’s a great question, so it’s going to do what exactly? I’m going to use that a lot I think.
 
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