Gene editing, a new type of GMO?

Glenn

The Living Force
FOTCM Member
This article showed up on my Firefox start page. It is from the industry perspective, and is for the most part a glowing proponent of this new technology.

(You might also want to check out this recent SOTT article on other ramifications of this same technology
https://www.sott.net/article/372147-Biohackers-playing-God-We-are-in-the-midst-of-a-genetic-revolution )


Rewriting Life

These Are Not Your Father’s GMOs



A new wave of gene-edited crops are dodging regulators, and they’re about to reach stores.

by Antonio Regalado December 19, 2017

_https://www.technologyreview.com/s/609230/these-are-not-your-fathers-gmos/

When I visited Jason McHenry’s farm in South Dakota, the young farmer, dressed in worn jeans and sunglasses, led me up a slippery steel ladder on the side of a grain bin. We tumbled through the manhole into a shifting mountain of soybeans. You could sift them through your fingers and taste their sweet, cloudy flavor.

The U.S. soybean crop is four billion bushels a year, about 240 billion pounds. It generates the most cash receipts for American farms after cattle and corn. Of those beans, more than 90 percent are genetically modified organisms, or GMOs—that is, they’ve been genetically enhanced, most often through the addition of a gene from a soil bacterium that renders them immune to the weed killer glyphosate, commonly known as Roundup.

The 4,000 bushels McHenry and I were sitting in, however, represent a new type of plant that’s been modified using gene editing. A startup had employed the technology to introduce changes in two genes involved in fatty-acid synthesis, so that oil pressed from the beans is more like olive oil than typical soy oil.

McHenry first heard the pitch for the beans last December, at a hotel near the cooperative of South Dakota soybean processors. “We have something new and exciting,” a salesman told the farmers. “You’ve heard about the ban on trans fats?” Soybean oil has been losing market share since the U.S. government banned unhealthy fats created when soy oil is partially hydrogenated and turns to a solid (think Crisco). Those fats have been killing people. They’re bad food.

Oil from the gene-edited beans could solve that problem, because it doesn’t need to be processed in the same way. Any farmer who agreed to plant the beans, McHenry heard, would be part of the wave of innovation filling store shelves with Greek yogurts, green packaging, and healthy ingredients. What’s more, it would mean a few quarters more per bushel. “You make a little more money, you have a great experience, and you are part of a revolution,” said the pitchman, Thomas Stoddard, a lanky biologist turned seed seller who visited McHenry’s farm with me.

To McHenry, a farmer just starting out with his own acres, his own debts, and his own decisions, the pitch made sense. The Roundup-resisting beans his father still plants are expensive. What’s more, the tumbleweeds have evolved to survive spraying and grow as high as your waist. “Looking at the market as a whole, Europe and China are questioning GMOs,” McHenry says. “You have to keep your finger on what the consumer wants, and as a farmer, you have to differentiate yourself. If you are looking at a market that could be gone, you have to think about alternatives.”

The new beans are the creation of a startup called Calyxt, located 300 miles away, near Minneapolis, where Stoddard works, and nearly a straight shot east on Highway 90 from McHenry’s farm. At the company’s greenhouses, thousands of plants are being altered with gene editing every week. The virtue of the technology is that it lets scientists create designer plants that don’t have foreign DNA in them. The technique, which adds or deletes snippets of genetic information, is similar to what could be achieved through conventional breeding, only much faster. In essence, if there’s some quality about a soybean that you like, and if you know the genetic instructions responsible, gene editing can move them to another bean in a single molecular step.

To many scientists, the potential of gene editing seems nearly limitless, offering a new way to rapidly create plants that are drought-resistant, immune to disease, or improved in flavor. A supermarket tomato that tastes good? That could happen if scientists restore the flavor-making genes that make heirloom varieties delicious. What about a corn plant with twice as many kernels? If nature allows it, scientists believe, gene editing could let them build it.


'Until now, every successful GMO on the market has had as its objective increasing the yield from each acre of farmland. Marketing “healthier” food made from GMOs has been a taller order. But if gene-edited plants can avoid the stigma of GMOs, that could change'.


There is another reason gene editing is causing excitement in industry. The U.S. Department of Agriculture has concluded that the new plants are not “regulated articles.” The reason is a legal loophole: its regulations apply only to GMOs constructed using plant pathogens like bacteria, or their DNA. That means Calyxt can commercialize its beans without going through the process of permits, inspections, and safety tests required for other genetically modified crops. It’s counting on that to cut at least half the 13 years and $130 million that companies have, on average, invested in order to create a new GMO and get it into farmers’ hands.

To GMO opponents, the new, unregulated plants are a source of alarm. For years, they have argued that GMOs should be opposed because they might be unsafe. What if they cause allergies or poison butterflies? Now the battle lines are shifting because companies like Calyxt can create plants without DNA from a different species in them. They can argue that gene editing is merely “accelerated breeding technology.”

To the critics, any attempt to reclassify engineered plants as natural is a dangerous fiction. “If they don’t have to go through the regulatory requirements, then it is game on again for genetic modification in agriculture,” says Jim Thomas, head of a nonprofit called the ETC Group that lobbies on environmental issues. “That is the prize. They are constructing a definition of a GMO so that gene editing falls outside it.”

Already, the effort to persuade governments and food groups is reaching a planetary scale. New Zealand decided that the new plants are GMOs after all, and so did the USDA’s own organic council. The Netherlands and Sweden don’t think they are. China hasn’t said. The European Union still has to make up its mind. Billions in global grain exports could ultimately hang in the balance.

Opponents say they’re ready to fight for rules, regulations, and labels. “Our position has never changed. This is just a form of genetic engineering, so the same things should happen—there should be required safety assessments,” says Michael Hansen, a staff scientist at the Consumers Union, a lobby group attached to Consumer Reports magazine. “I can’t see this being resolved anytime soon.”

But McHenry has already accepted the argument. Pointing to his rows of grain bins, he ticked off whether the beans inside were GMOs or not. The one full of Calyxt beans he called “non-GMO.” “To me a GMO is [adding] an outside organism into a plant. The way I understand it there’s no foreign DNA put into the seed,” said McHenry. “It’s like we found a switch to make people’s lives easier. If it’s that easy, it makes sense to me.”

Drug companies see gene-editing technology as a versatile molecular scissors that could offer a radical new means to cure genetic diseases such as muscular dystrophy (see “Can CRISPR Save Ben Dupree?”). What’s not so widely appreciated is how close the technology is to large-scale implementation in agriculture and in our food. By the end of 2018, Calyxt says, it will be crushing beans and selling oil, potentially becoming the first company to enter the market with a gene-edited crop. At least one other crop is nearing commercialization from DuPont, which used gene editing to create a starchier corn plant.

To be sure, neither product is expected to take over farmland the way herbicide-resisting GMOs did. Instead, these initial examples are niche products with prosaic objectives. DuPont’s “waxy” corn is going to end up in glue sticks and as an emulsifier in salad dressing. Calyxt’s oil will fry doughnuts and chips. Even so, the mountain of beans at McHenry’s farm shows how quickly these crops could arrive. McHenry, making some fast calculations, estimated that we were sitting on 600 million of them. By then Stoddard, the salesman, had climbed into the story-tall grain bin too. “Gene editing is the future, and the first place it’s growing at scale is here in South Dakota,” he said reverently, letting beans drift through his hands.

Flipping a switch

The beans at McHenry’s farm are all descendants of a single soybean cell modified in 2012 by Dan Voytas, the cofounder of Calyxt and a professor of genetics at the University of Minnesota. Voytas told me he inherited a scientific interest in plants from his father, a government forest manager. “It was ‘Okay, son, what tree is that? Latin name, please,” he recalls.

I met Voytas at the startup’s greenhouse outside of Minneapolis, where he showed me fluid-mixing robots and a tall gene gun that fires the DNA into a plant cell. Green blobs growing on clear jelly in petri dishes were canola plants “regenerating” from a single cell after receiving new genetic instructions. The company has a staff of 35, two-thirds of whom are scientists. “We have a long list of ideas,” says Voytas. “But you can get a great oil and a sick plant. A lot of it is experimental.”

The startup uses a gene-editing technology called TALEN that Voytas helped develop—and patented. By the late 1990s, he had been part of a small group of biologists trying to move past the first round of GM plants not by adding entire genes, but instead by using cutting enzymes, called nucleases, to precisely sever the DNA chain—the life instructions found inside every living cell. To make Calyxt’s beans, Voytas used his technology to disable two genes.

Today, a different gene-editing technology, CRISPR, dominates the headlines, because it is easy to employ and inexpensive. However, because TALEN was developed two years earlier than CRISPR, the technique has advanced further toward commercial crops. Moreover, other plant biotech companies have been slowed by an ongoing patent fight over CRISPR, which left it unclear which of them would be able to use that technique.

In the meantime, Calyxt says, it has already used TALEN to design 19 plants and is banking on gene editing to make it one of the first small companies to introduce a successful genetically engineered crop. It says the USDA has already confirmed that six of its plants won’t be regulated, including, in September, an alfalfa plant modified to have less lignin, making it easier for cows and horses to digest. The company, which went public in July, has spent only $47 million so far.

Until now, every successful GMO on the market has had as its objective increasing the yield from each acre of farmland. Marketing “healthier” food made from GMOs has been a taller order. But if gene-edited plants can avoid the stigma of GMOs, that could change. In Calyxt’s view, that would open up valuable new uses of genetic engineering. In addition to its soybean oil, Calyxt claims it has changed wheat plants so they can be ground into white flour with three times as much fiber as usual. A bread company might even be able to claim that hamburger rolls help prevent cancer.

In 2017, the USDA acknowledged that plants with even profound genetic alterations “may entirely escape regulation.”

Some of the more radical changes gene editing may bring were apparent the day I visited Voytas at his university laboratory. He was meeting with his students, who diagrammed their plans on a whiteboard. (By now, all the students are using CRISPR.) A woman from Ethiopia wanted to change a local grain plant, teff, so that it stands up straight instead of drooping and losing seeds. Another student was investigating how to inject DNA into the stem cells found in the roots and shoots of growing plants. “We’re almost getting to the point where if you ask ‘What’s the best oil crop?’ we could create the genome to make that plant,” Voytas says.

Some significant obstacles remain. Drug companies working on gene therapy have learned it is easier to design and make DNA strands than to get them inside a person’s cells. That is also true of many plants, where delivery of the gene-editing ingredients is still difficult. Understanding which genes should be edited is yet another roadblock. Scientists know a lot about how oils are synthesized and why fruit turns brown. But the list of valuable plant traits whose genetic causes are both well understood and easy to alter drops off quickly after that. “Right now it’s a grab bag of traits,” says Rebecca Bart, a plant scientist at the Danforth Center, in St. Louis. “We still need to have pretty significant investment in discovery before you can manipulate them with gene editing. It has to go in that order.”

What’s more, for traits that are well understood, gene editing isn’t the only way to create such plants—just the newest. For instance, Calyxt’s soybeans will face competition from beans with similar oil content that are already on the market, including one, called Vistive Gold and sold by Monsanto, that was created via old-fashioned GMO technology. Voytas acknowledges that his beans aren’t entirely novel but says they will be a useful test of Calyxt’s fast-to-market business model and a way to prove to investors that the company can make money. “Calyxt is the first plant gene-editing company out there and needs to show it can commercialize products,” he says. “The advantage is getting to revenue in the short term.”

Some entrepreneurs think gene editing will have a big impact only when it can change the amount of food an acre can produce. “In real estate, the saying is ‘Location, location, location.’ Well, in agriculture, it’s ‘Yield, yield, yield,’” says Oliver Peoples, CEO of Yield10, a plant-engineering company in Cambridge, Massachusetts.

So Calyxt is also working on plants that could increase the amount of food farmers can reap, like a wheat plant resistant to powdery mildew. To date, no GMO wheat has ever been commercialized, partly because, as happens with many plants, wheat’s genome accumulates extra DNA like a closet that never gets cleared out. In fact, wheat is hexaploid—its cells harbor six mostly identical copies of every chromosome. That has made it massively complicated to genetically engineer, but Voytas says that with gene editing it is fairly easy. In a single reaction, the TALEN tools can search out and cut all six copies of any wheat gene they want to remove.

GMO or not?

Outside of Penn Station, in Manhattan, a 10-story-tall advertisement for Ketel One, a brand of vodka, declares that it is “made with 100% NON GMO grain.” At any supermarket, it is easy to find a profusion of similar claims, even for products like salt, which don’t contain plant material. About 40 percent of U.S. adults think foods made from GMOs are less healthy to eat.

Such beliefs are the result of warring messages from scientists, agriculture lobbies, and nonprofits like Greenpeace that stir doubts about the safety of GM organisms. The result for the first generation of GMOs has been a global split decision. While GMOs cover millions of acres of cropland in the U.S., Brazil, Argentina, and India, governments have banned the cultivation of such plants through much of the rest of the world, including France, Germany, China, and Russia.

Now the question is whether gene-edited crops can dodge the GMO label. Broadly speaking, companies argue that these plants should be unregulated because they could have been created by conventional breeding. The proof? In many cases, there would be no way to tell a gene-edited plant from a natural one.

GMO critics now fear a tidal wave of “frankenfood” if such plants slip through regulations, something that is already occurring in the U.S. The reason gene-edited plants can be exempt from USDA rules is that the agency employs an outdated 30-year-old definition of a GMO that is triggered only if a plant was modified using plant bacteria, as early products were. The agency, in January 2017, acknowledged that plants with even profound genetic alterations “may entirely escape regulation” depending on how they are made. Since then, four more gene-edited plants have been waved forward, including a salt- and drought-tolerant soybean developed by the USDA itself, Calyxt’s alfalfa plant, a type of camelina grass created by Yield10, and a species of millet with a delayed flowering time. “They’re trying to fit a square peg in a round hole of old laws not meant to address these new technologies,” says Gregory Jaffe, who follows biotechnology at the Center for Science in the Public Interest, in Washington, D.C.

What’s missing, then, is enough scrutiny of whether the plants could harm insects, spread their genetic enhancements to wild cousins, or create superweeds like the ones resistant to Roundup. Companies do typically consult with the U.S. Food and Drug Administration to confirm that their plants are safe to eat. But that process is voluntary. Jaydee Hanson, senior policy analyst at the Center for Food Safety, which promotes organic farming, thinks companies have been astute in starting with simple, even obscure, products. “The public has not had a chance to say ‘Wait a second,’” he says. “As we move into more complicated gene editing, there are going to be more questions. And we could see the same kind of kickback we saw before.”

The “GMO or not” question is going to be a global one. Food regulators will have to decide if store packaging needs to disclose the presence of gene-edited plants. Some organic associations have already said such plants cannot carry that label, reasoning that they really are GMOs. The European Court of Justice, meanwhile, is set to weigh in on the issue in Europe, where scientists have argued that gene editing is simply an advanced form of breeding. Opponents are counting on Europe to classify the plants as GMOs, a decision that would frustrate the technology’s spread.

“It would be sad if opponents won,” Voytas told me. We were in his office and students were passing outside his window, waiting to for a chance to review their gene-editing plans with him. Even undergraduates, he noted, are now able to edit plants. “In some sense,” he said, “I think the genie is out of the bottle.”
 
I found this story from GreenMedinfo "Biotech's Dark Promise: Involuntary Cannibalism for All"

Biotech's Dark Promise: Involuntary Cannibalism for All
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" Technological progress is like an axe in the hands of a pathological criminal." ~ Albert Einstein
Whereas the quote above could easily be dismissed as the 'progress-denying' sentiment of a disgruntled anti-GMO activist, the fact is that it came from a scientist representing the very epitome of Western rationality and accomplishment.
Perhaps Einstein was reflecting on the inevitable existential consequences of the so-called "technological imperative"--whatever can be done, will be done. Fundamentally amoral and irrational economic and political forces drive technology's feverish pace, infusing a certain arbitrary cruelty and disequilibrium into everything it touches.
In our continual drive to 'improve upon Nature' in the name of much-hyped, 'life-saving' biotechnological innovations, the line between humane and inhumane eventually is crossed, and there seems no going back. Biopollution from defective or dangerous GMO genes, for example, is virtually impossible to undo once unreleased into the biosphere; you can't "recall" a defective gene like you can an automobile. Nor can we remove from our bodies the surreptitious viruses (e.g. simian virus #40 (SV40)) that contaminated millions of first-generation polio vaccines. In many ways our moral fiber suffers from the same susceptibilities. Once we have crossed a certain line – be it theft, lying, or worse, etc., – it is difficult, if not impossible to 'go back' and regain our innocence. Such is the human condition. And this is why we must carefully consider the medico-ethical implications of new technologies, whose developments we must first be aware of in order to guide, regulate and sometimes terminate.
The Scientific Community Moves To Embrace Embryo Cloning for Medical Purposes
For example, few are aware that the cloning of human embryos for 'therapeutic purposes' was made legal in the UK in January, 2001 through an amendment to the Human Embryology Act.http://www.greenmedinfo.com/blog/biotechs-dark-promise-involuntary-cannabilism-all-1#_edn1 Not long after, in August 2004, the Human Fertilisation and Embryology Authority (HFEA) approved the first license for cloning human embryos in the UK. Media reports at the time alleged the legal changes would result in the use of cloned human embryos to create "spare body parts."
In an article published in 2000 titled, "Biotech Cannabalism,"[ii] C. Ben Mitchell, PhD reflects on the pro-cloning movement by quoting a proponent's justification: "If you could use tissue from human embryos to save hundreds of lives, there must be a moral imperative to do it." Mitchell disagrees, countering: "[C]reating a human being for the purposes of killing that person for another human being's health, sounds an awfully lot like cannibalism, only worse."
Calling Vaccines From Aborted Fetuses What They Are: Cannibalistic
Whereas cannibalism is considered by most modern societies to be the ultimate expression of uncivilized or barbaric behavior, it is intrinsic to many of the Western world's most prized biotechnological and medical innovations. Probably the most 'taken for granted' example of this is the use of live, aborted fetus cell lines from induced abortions to produce vaccines. Known as diploid cell vaccines (diploid cells have two (di-) sets of chromosomes inherited from human mother and father), they are non-continuous (unlike cancer cells), and therefore must be continually replaced, i.e. new aborted, live fetal tissue must be harvested periodically. A good portion of the CDC's immunization schedule requires the use of these human fetus-originated vaccines, and these include: rubella, measles, mumps, rabies, polio, smallpox, hepatitis A, chickenpox, and herpes zoster. Additionally, so-called "abortion tainted vaccines" cultivated on transformed fetal cells (293, PER.C6) are in the developmental pipeline, including: "flu, Respiratory Syncytial and parainfluenza viruses, HIV, West Nile virus, Ebola, Marburg and Lassa, hepatitis B and C, foot and mouth disease, Japanese encephalitis, dengue, tuberculosis, anthrax, plague, tetanus and malaria." [iii]
Unfortunately, to millions who find injecting the biological derivatives of living aborted fetal cells into their bodies, or their children's, morally objectionable, an increasingly Draconian biomedical establishment is either pressuring, coercing or mandating this to occur, using the faulty concept of "herd immunity" and concomitant biosafety concerns to override an individual's right to refuse them. And most are completely unaware that aborted cells are used and being injected into their bodies, because the medical ethical principle of informed consent remains just that: a principle, not practiced regularly. Furthermore, beyond the obvious moral/religious/philosophical reasons to reject aborted fetal cell derived vaccines, there are real health concerns associated with the introduction of this type of biological material into the human body that are largely considered taboo to discuss. I addressed this intractable moral contradiction in greater depth in my article: Pro-Life AND Pro-Vaccine?
Biopharming: The End of Choice for Those Who Do Not Want to Ingest Human Proteins

Another way in which the dark specter of cannibalism is resurfacing in our lives is through biotech's intense investment in biopharming technologies. Also known as molecular farming, biopharming involves creating "drug-producing" GMOs by inserting a gene that code for useful pharmaceuticals or biological products (e.g. antibodies, lactoferrin) into host plants, insects or animals that do not naturally express those genes.
Concerns over the unintended, adverse effects of this technology are growing, primarily because once the genes are inserted into laboratory- or field-trialed organisms, their escape into the biosphere is not just possible, but a statistical inevitability. As we have seen with GMO crops, contamination is a default business strategy for biotech stakeholders, whose GM plants pollinate (some say "biorape") organic or wild plants rendering them also GMOs. This means that -- short of using 'terminator technology' which renders the plants incapable of reproduction – foolproof GM containment is impossible. Eventually we will all be exposed to these GMO plants, insects and animals in some form or other.
There is intense work being done today to create biopharmed "edible vaccines," which contain deadly viral or bacterial vectors. Obviously, the biopollution created by inserting these genes into plants traditionally used for human consumption and which could find their way into the human food supply could cause life-threatening health problems. But edible vaccines are only a subset of biopharmed products in the developmental pipeline. There are a broad range of human proteins being 'pharmed' using genetically modified animals expressing human genes as 'bioreactors.'
Below is a small sample of biopharmed organisms in development that could at some point in the future result in the inadvertent ingestion of human proteins (technically, cannibalism):
  • GMO Bulls expressing human lactoferrin in their tissues, intended for human consumption.[iv]
  • GMO Mice expressing a human granulocyte-macrophage colony stimulating factor under control of a goat gene (goat alpha-S1-casein gene).[v]
  • GMO Cattle milk expressing the human breastmilk proteins human α-lactalbumin (TC-LA), lactoferrin (TC-LF) or lysozyme (TC-LZ).[vi]
  • GMO Pigs designed to express human α-galactosidase.[vii]
  • GMO Chickens designed to express human urokinase-type plasminogen activator.[viii]
  • GMO Chickens designed to express human parathormone.[ix]
  • GMO Flies expressing human taste receptor genes.[x]
  • GMO Silkworm cells expressing human glycoproteins.[xi]
  • GMO Tomatoes expressing a human brain protein (humanβ-secretase).[xii]
  • GMO Tobacco expressing human erythropoietin intended to be used to treat tissue injury.[xiii]
  • GMO Tobacco expressing human interferon alpha intended for medical use.[xiv]
  • GMO Yeast expressing human Apolipoprotein A-II intended for study.[xv]
  • GMO Lettuce and chicory expressing human interferon alpha intended for medical use.[xvi]
  • GMO Rapeseed expressing human interferon alpha intended for medical use.[xvii]
  • GMO Rice expressing human serum albumin (blood protein) intended for medical purposes.[xviii]
  • GMO Rice expressing human lactoferrin intended for medical use.[xix]
  • GMO Rice expressing human CYP1A1 enzyme (found in placenta and liver) intended to help remediate pesticides in soil.[xx]
  • GMO Rice expressing human amyloidβ-peptide 'Alzheimer's brain protein' intended as an oral vaccine producing plant.[xxi]
With biotech weaving into the web of life arbitrarily placed human genes and their biological products, cannibalism (human consumption of human proteins) will become an inevitably in the future. The question is, will we stand for this reworking of the very molecular and genetic infrastructure of life, or pretend like it won't also result in the genetic modification of our own bodies.



http://www.greenmedinfo.com/blog/biotechs-dark-promise-involuntary-cannabilism-all-1#_ednref1 BBCNews.com, Scientists given cloning go-ahead, 11 August, 2004
[ii] The Center for Bioethics and Human Dignity, Biotech Cannabalism, 4 April, 2000
[iii] José Luís Redondo Calderón. [Vaccines, biotechnology and their connection with induced abortion]. Cuad Bioet. 2008 May-Aug;19(66):321-53. PMID: 18611078
[iv] Jie Zhao, Jianxiang Xu, Jianwu Wang, Ning Li. Nutritional composition analysis of meat from human lactoferrin transgenic bulls.
[v] GMI-Cite:
I A Burkov, I A Serova, N R Battulin, A V Smirnov, I V Babkin, L E Andreeva, G A Dvoryanchikov, O L Serov. Expression of the human granulocyte-macrophage colony stimulating factor (hGM-CSF) gene under control of the 5'-regulatory sequence of the goat alpha-S1-casein gene with and without a MAR element in transgenic mice.
[vi] Ran Zhang, Chengdong Guo, Shunchao Sui, Tian Yu, Jianwu Wang, Ning Li. Comprehensive assessment of milk composition in transgenic cloned cattle.
[vii] J Zeyland, B Gawrońska, W Juzwa, J Jura, A Nowak, R Słomski, Z Smorąg, M Szalata, A Woźniak, D Lipiński. Transgenic pigs designed to express humanα-galactosidase to avoid humoral xenograft rejection.
[viii] Sung Ho Lee, Mukesh Kumar Gupta, Young Tae Ho, Teoan Kim, Hoon Taek Lee. Transgenic chickens expressing human urokinase-type plasminogen activator.
[ix] S H Lee, M K Gupta, D W Han, S Y Han, S J Uhm, T Kim, H T Lee. Development of transgenic chickens expressing human parathormone under the control of a ubiquitous promoter by using a retrovirus vector system.
[x] Ryota Adachi, Yuko Sasaki, Hiromi Morita, Michio Komai, Hitoshi Shirakawa, Tomoko Goto, Akira Furuyama, Kunio Isono. Behavioral analysis of Drosophila transformants expressing human taste receptor genes in the gustatory receptor neurons.
[xi] Jia-Biao Hu, Peng Zhang, Mei-Xian Wang, Fang Zhou, Yan-Shan Niu, Yun-Gen Miao. A transgenic Bm cell line of piggyBac transposon-derived targeting expression of humanized glycoproteins through N-glycosylation.
[xii] H-S Kim, J-W Youm, K-B Moon, J-H Ha, Y-H Kim, H Joung, J-H Jeon. Expression analysis of humanβ-secretase in transgenic tomato fruits.
[xiii] Farooqahmed S Kittur, Mamudou Bah, Stephanie Archer-Hartmann, Chiu-Yueh Hung, Parastoo Azadi, Mayumi Ishihara, David C Sane, Jiahua Xie. Cytoprotective Effect of Recombinant Human Erythropoietin Produced in Transgenic Tobacco Plants.
[xiv] I M Gerasymenko, L O Sakhno, M G Mazur, Y V Sheludko. Multiplex pcr assay for detection of human interferon alpha2b gene in transgenic plants.
[xv] Manman Su, Yitian Qi, Mingxing Wang, Weiqin Chang, Shuang Peng, Tianmin Xu, Dingding Wang. Expression and Purification of Recombinant Human Apolipoprotein A-II in Pichia pastoris.
[xvi] N A Matveeva, Iu I Kudriavets, A A Likhova, A M Shakhovskiĭ, N A Bezdenezhnykh, E Iu Kvasko. [Antiviral activity of extracts of transgenic cichory and lettuce plants with the human interferon alpha-2b gene].
[xvii] L O Sakhno, O Y Kvasko, Z M Olevinska, M Y Spivak, M V Kuchuk. Creation of transgenic Brassica napus L. plants expressing human alpha 2b interferon gene.
[xviii] Qing Zhang, Hui Yu, Feng-Zhen Zhang, Zhi-Cheng Shen. Expression and purification of recombinant human serum albumin from selectively terminable transgenic rice.
[xix] Chaoyang Lin, Peng Nie, Wei Lu, Qing Zhang, Jing Li, Zhicheng Shen. A selectively terminable transgenic rice line expressing human lactoferrin.
[xx] Hiroyuki Kawahigashi, Sakiko Hirose, Hideo Ohkawa, Yasunobu Ohkawa. Transgenic rice plants expressing human CYP1A1 remediate the triazine herbicides atrazine and simazine. J Agric Food Chem. 2005 Nov 2;53(22):8557-64. PMID: 16248553
[xxi] Taiji Yoshida, Eiichi Kimura, Setsuo Koike, Jun Nojima, Eugene Futai, Noboru Sasagawa, Yuichiro Watanabe, Shoichi Ishiura. Transgenic rice expressing amyloidβ-peptide for oral immunization. Int J Biol Sci. 2011;7(3):301-7. Epub 2011 Mar 25. PMID: 21448341



Sayer Ji is founder of Greenmedinfo.com, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

 
Ok, so I suppose this is all part of the "Dionysian Syndrome". From C's Scripts 14April2018...

L) No. It was about death and destruction and even cannibalism. They would find a victim and cut him in pieces and eat him! Ok, so I suppose that you are specifically referring to the political behavior of the US, the UK, and France and their attack on Syria?

A: Yes and so much more.

Q: (Pierre) Their first reply goes beyond the Syrian conflict. Like the whole human population is starting to embrace this syndrome.

(L) So, we need to explore the Dionysian thing a little more to have more understanding of what that could possibly mean. Of course, what's going on right now might put a different understanding on the ancient reports.
 
There are other threads on GMO and I was not sure where to post this but this is a more recent thread so I hops it fits well enough here.

I was wondering where you can even find non-GMO corn products and checked the state of affairs in Mexico (I love Mexican food and miss being able to find restaurants that have non-GMO corn). As it turns out even Mexico has problems with the GMO too.

GM corn found in over 90% of tortillas in MX

corn-1.jpg

UNAM research team also found the herbicide glyphosate

Published on Wednesday, September 20, 2017

A team of researchers has been surprised by the discovery that slightly over 90% of tortillas sold in Mexico contain traces of genetically modified corn.

Overall, the study by the National Autonomous University of México found that 82% of all corn products, such as tostadas, flour, cereals and snacks, contained some level of genetically modified sequences.

The researchers also found the herbicide glyphosate in approximately 27.7% of the samples that tested positive for transgenic corn.


In a paper published in August by the journal Agroecology and Sustainable Food Systems, the researchers said the traces of genetically modified genes found in corn products sold in Mexican stores and markets have their origin in plants that have been manipulated mainly in laboratories located in the United States.

Most commercially available corn in the U.S. has been genetically modified to tolerate glyphosate, the world’s most common herbicide, and the active ingredient in Roundup, made by Monsanto.

Although a review by the World Health Organization (WHO) suggested glyphosate may have some carcinogenic potential, the current consensus amongst the world’s regulatory agencies is that it is safe for consumption.

The WHO’s review concluded last year that: “glyphosate is unlikely to pose a carcinogenic risk to humans from exposure through the diet.”

The UNAM team also tested handmade tortillas made using more artisanal processes and homegrown corn varieties. GM content in those tortillas had a “significantly lower frequency” when compared to commercial products.


Handmade tortillas also had zero glyphosate content, the researchers found. All of their samples were tested for transgene presence in UNAM laboratories and the results certified by a German laboratory. This last facility also tested the samples for glyphosate content.

The head researcher said the team was surprised to find genetically modified corn “in our tortillas and other corn products.”

Elena Álvarez-Buylla Roces called the results “striking” because “cultivation of genetically modified corn in open fields is not allowed in Mexico,” due to long and ongoing legal action and a temporary ban.

She did not mention what risks, if any, the public might be facing given the research results.

She did say that Mexico should recover its food sovereignty, and warned that Mexicans have fewer GM-free corn options.

Mexicans eat an estimated half a kilogram per day of tortillas and other corn-based products. Álvarez-Buylla told the UNAM news service DGCS that in 2016 “the country produced 25.7 million tonnes of corn, 12.3 million of which were sold for human consumption, 4.2 million were grown by subsistence farmers, 4.4 million were to feed animals and 1.5 million tonnes were exported.”

She also believes that Mexico produces enough corn for human consumption, “native and hybrid and transgene-free.”


The 10 million tonnes of corn Mexico imports from the United States every year “should be used only to feed livestock or as highly processed industrial consumables, and no longer for human consumption, much less if it is contaminated with glyphosate,” said the researcher.

Álvarez-Buylla recommended more support for subsistence and agro-ecological farming of “highly nutritional” native and hybrid varieties of corn to cover the country’s needs.

Mexico News Daily

It is certainly depressing remembering how much better it was before we were attacked by the mad scientists. Not one shred of guilt is felt by these experimenters using us as the guinea pigs.
 
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