Idiopathic Vestibular Disease or “old dog vestibular disease”

Eva

Jedi
Yesterday morning and without any previous warning my dog, 12 years old now, completely lost orientation and tilting his head to the left he was bumping into walls and moaning as if in terrible pain .
The vet said the most likely diagnosis is idopathic vestibular disease, if this is the case he should show considerable improvement over the next 48 hours

Here's a few things I found about it here _http://www.pettalkwithdrb.com/did-dog-have-stroke.php

"The vestibular system is the neurological equipment responsible for perceiving the body’s orientation relative to earth. It is responsible for maintaining posture, balance of the head and trunk, and the position of the eyes in relation to head movement. The vestibular system can be divided into central and peripheral components. Central vestibular structures are located within the brainstem and cerebellum. Peripheral vestibular structures involve the nerves related to receptors in the inner ear. Idiopathic vestibular disease involves the peripheral vestibular system.

Idiopathic means that the cause of the condition is unknown. Dogs with acute idiopathic vestibular disease are often older than 7 years of age; hence, the disease is sometimes referred to as “old dog vestibular disease.” Feline idiopathic vestibular disease most often occurs in late July and August in the northeastern part of North America, and for unknown reasons tends to affect male outdoor cats more often.

Clinical signs of vestibular disease often occur quickly. Animals will often have a head tilt due to the loss of antigravity muscle tone on one side of the neck. The head will tilt toward the side of the problem. Animals can also have a nystagmus, which is an abnormal eye movement from side to side. The eye movement will include a rapid phase,which will often be away from the side of the problem. Other clinical signs that may occur include falling (often toward the side of the lesion), gait disturbance, circling and motion sickness.

Other causes of vestibular problems include inner ear infections and brain lesions. Inner ear infections also involve the peripheral vestibular system and can cause clinical signs similar to idiopathic vestibular disease. Animals with vestibular disease typically have a history of chronic ear infections and must have their ear drums examined for any evidence of possible infection. Brain lesions involve the central vestibular system. Central vestibular problems can be differentiated from peripheral problems based on cranial nerve abnormalities of the opposite side, or a nystagmus that is vertical or only present when the head is placed in certain positions.

The prognosis for idiopathic vestibular disease is excellent and the improvement of clinical signs usually occurs within 72 hours. Animals usually return to normal within 10-14 days, but some may continue to have a head tilt long term. Treatment usually involves supportive care, including preventing motion sickness, and an idiopathic vestibular disorder will rarely reoccur. "


He also has a history of inner ear infections - he had his left ear removed along with the auditory tube 4 years ago, so he is taking a blood brain barrier penetrating antibiotic treatment just in case.
Other causes for vestibular dysfunction, which present under the same symptomatology are better listed here _http://www.canine-epilepsy.com/vestibular.html

"[...]
Clinical signs:
Signs of vestibular disease include ataxia, head tilt, and abnormal nystagmus. A wide-based stance and swaying of the head and trunk characterize ataxia. The patient may tend to lean and fall to one side. In severe cases, the animal may continuously roll to one side. Head tilt is an abnormal position of the head such that one ear is held lower than the other. Nystagmus is a rhythmic movement of the eyes, where the eyes move back and forth or up and down. In some cases of vestibular disease, there is a sudden onset of severe signs. This may initially be confused with a seizure
[...]

Vestibular diseases:


Ear infection:
Infection of the middle/inner ear is a common cause of vestibular disease in the dog. Most cases can be diagnosed by a thorough examination of the ear with an otoscope. Ear culture, X-rays, computed tomography or magnetic resonance imaging is sometimes necessary. If bacteria cause the infection, treatment consists of appropriate antibiotics.

Canine idiopathic vestibular syndrome:
This is also a common cause of vestibular disease in the dog. Another name is geriatric vestibular syndrome. Older dogs (mean age 12.5 years) are primarily affected. There is a sudden onset of ataxia (which can be severe), head tilt, nystagmus and occasionally vomiting. The cause of this syndrome is unknown. Diagnosis is based on the signs and excluding other causes of vestibular dysfunction. Affected dogs improve spontaneously within 2 weeks, although there may be a mild, persistent head tilt. Nursing care is important during recovery. Unfortunately, affected dogs are sometimes euthanized because of the severe signs and concerns that the patient has a brain tumor or stroke.

Hypothyroidism:
Hypothyroidism can cause vestibular dysfunction in dogs. Signs may develop suddenly or over time. Diagnosis is based on laboratory evaluation of thyroid function and response to thyroid supplementation. Vestibular dysfunction typically resolves within 2 months of treatment.

Toxicity:
Medications placed in the ear are the most common cause of vestibular toxicity; although some orally administered drugs can also be a problem, especially at high doses. Ear drops or other substances should never be placed in a dog's ear except on the specific recommendation of a veterinarian.

Cancer:
Tumors in the inner ear or brain can cause vestibular problems. Older animals are more commonly affected and there may be pain on opening the mouth. Diagnosis is based on x-rays, CT, MRI, and/or biopsy.

Encephalitis:

Inflammation of the brain (encephalitis) can cause vestibular dysfunction. Causes include infections, such as distemper virus, and non-infectious causes. Diagnosis often requires analysis of spinal fluid. Some types of infection can be specifically treated with medications."



My old boy is in the hospital and will stay there for the next two days. He can hardly stand on his feet, turning on his side takes considerable effort and he's obviously in pain, yet he still finds the strength to push his face against mine and lick me.
 
I'm sorry to hear this, Eva. I hope your dog recovers quickly, fully, and permanently. It certainly looks like his earlier ear problems, surgery, and the vestibular disease are linked.
 
I am sorry, Eva, about your dog, and wish for him to recover quickly. :hug2: You also did a good research, but just in case you'll find it useful, here are some snapshots from one of the vet books.
 

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Eva, in dogs vestibular syndrome can be caused by trauma to the neck resulting from either a blow to the head or sharp jerk on leash when the dog is wearing a halti or gentle leader type training tool. An old dog who is losing sight may crash into something head first causing trauma to the neck - specifically atlanto axial subluxation where the skull in relation to the first two cervical vertebrae are pushed out of alignment. This causes both pressure from both the bony structures being out of place and inflammation from the soft tissue damage and impacts on the brain stem. The vestibulocochlear nerve (eighth cranial nerve) originates in this area and dogs (also horses from what I’ve read) vestibular syndrome can be a symptom of atlanto axial subluxation.

In dogs it is speculated that the effects of atlanto axial subluxation on the vestibulocochlear nerve are frequently misdiagnosed as epilepsy or brain tumour without further investigation when funds are low. Or if there is no relief of symptoms with veterinary interventions and the dogs are put down.

Trauma can account for the sudden onset of symptoms, and atlanto axial subluxation can also account for the head tilt.

So you may want to consider a visit to an animal chiropractor and a prescription of anti-inflammatory because this could get fast relief for the dog if this is indeed the problem.

I hope he recovers soon, this is horrible for a dog – his world is spinning and he can’t balance himself in it. Hugs to you both.
 
Thank you all for your replies and wishes. :flowers:

Keit, looking at the symptoms in the vet book it seems vestibular disease is confirmed as he still has a head tilt, drunken gait and he falls after taking 4-5 steps.

Jonas, he's wearing a harness and he hasn't had eyesight problems yet so I doubt his condition is due to trauma. Thank you for looking into it, and for explaining it so thoroughly.

Now, he only eats when I visit him and even then only a few bites, hopefully due to stress, tonight should be the last night he spends in hospital though.
On Monday I'll take him for an MRI just to be sure we know what we're dealing with.
 
Eva said:
Thank you all for your replies and wishes. :flowers:

Keit, looking at the symptoms in the vet book it seems vestibular disease is confirmed as he still has a head tilt, drunken gait and he falls after taking 4-5 steps.

Jonas, he's wearing a harness and he hasn't had eyesight problems yet so I doubt his condition is due to trauma. Thank you for looking into it, and for explaining it so thoroughly.

Now, he only eats when I visit him and even then only a few bites, hopefully due to stress, tonight should be the last night he spends in hospital though.
On Monday I'll take him for an MRI just to be sure we know what we're dealing with.

Thank god he has got you, Eva. Please keep us updated.
 
Eva said:
Keit, looking at the symptoms in the vet book it seems vestibular disease is confirmed as he still has a head tilt, drunken gait and he falls after taking 4-5 steps.

Well, if so, I am attaching some more info.

I am sure your vet knows what he/she is doing, and sometimes too much information can cause too much worry, but it may be important in order to make a correct diagnosis and then devise a proper treatment. I know that your vet said it's idiopathic, especially since the dog isn't young, but there are also other reasons for the vestibular disease. Look at the risk factors on page two. I think that considering them and your dog's history, maybe it was indeed a good idea to give him a blood brain barrier penetrating antibiotic just in case.
 

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I hope your dog, Eva, is coming along and you can get to the root of what is going on. :hug:
 
My dog, Zen, is at home now. He is calm and sleeps a lot.
Nystagmus is gone but the head tilt and drunken gait persist. He loses balance when he raises his leg to pee and can't find a treat dropped on the ground in front of him. His usual beastly appetite is back, but it seems as if he has no control of his left lip, he chews at it along with the food if I don't push it out of his mouth. When he drinks water he drools heavily - something he never did before.

Going from Jones' post and to exclude trauma with certainty, I asked the vet to check his eyesight yesterday in case it has deteriorated with age and we hadn't realized, but it was fine.
Yet she also said his hearing is fine.. but it doesn't seem to be! He doesn't hear me calling him even from 50cm away. I have to walk around in front of his eyes to which he pops his head in pleasant surprise.
He's now taking Medrol and Dalacin (methylprednisolone and clindamycin) along with Zantac for 15 days.

Keit, on page 2 under causes other than otitis - which is very likely with his histroy - hypothyroidism is also listed. Zen has had hypothyroidism from birth and has always been taking T4. He hasn't taken it since the onset of symptoms and I am not supposed to give him any for the next 15 days, the vet said that he's having enough stress with all the antibiotics so if I could spare him some pills I should. But after reading this I think he should continue on his usual T4 dosage, I'll call her tomorrow and discuss it. In fact, maybe tests are due to see if he should be on a higher dose!

As for the MRI, it will take general anaesthesia for 2 hours and from 180 euros it was the last time he needed one, now it is 350! I will probably have to postpone it until all other means of indirect diagnosis are exhausted :(
 
Eva said:
He's now taking Medrol and Dalacin (methylprednisolone and clindamycin) along with Zantac for 15 days.

I am only a student, so it's quite possible for me not to know or understand why this or that drug is used. Perhaps Z can give better advice.

In any case, from what I was able to understand, methylprednisolone is a corticosteroid and is used to rapidly stop an infection or an allergy. At least in human medicine it isn't recommended to take it for more than 3-5 days. Here what it says about usage in vet medicine: _http://www.1800petmeds.com/Methylprednisolone-prod10181.html

Do not stop giving methylprednisolone suddenly if you have been giving the medication to your pet for a few weeks. A gradual reduction in dosage may be needed. Give methylprednisolone with food to prevent stomach upset. [...]

Do not give methylprednisolone if your pet has a serious viral, bacterial, or fungal infection. Tell your veterinarian if your pet has kidney disease, liver disease, high blood pressure or heart disease, colitis or stomach ulcers, hypothyroidism, diabetes, or any other medical condition.

And clindamycin is a strong antibiotic that is used to treat infections that aren't treatable with other drugs. One of the side effects is developing Clostridium difficile-associated diarrhea, so beside (or instead?) Zantac it may be best to take probiotics. Here is a link with more info: _http://www.uptodate.com/contents/clostridium-difficile-and-probiotics

Eva said:
Keit, on page 2 under causes other than otitis - which is very likely with his histroy - hypothyroidism is also listed. Zen has had hypothyroidism from birth and has always been taking T4. He hasn't taken it since the onset of symptoms and I am not supposed to give him any for the next 15 days, the vet said that he's having enough stress with all the antibiotics so if I could spare him some pills I should. But after reading this I think he should continue on his usual T4 dosage, I'll call her tomorrow and discuss it. In fact, maybe tests are due to see if he should be on a higher dose!

Here are some links for natural remedies of hypothyroidism in dogs. And proper diet appears to be the key! Also Z may have some homeopathic advice.

_http://www.vetinfo.com/natural-remedies-hypothyroidism-dogs.html#b
_http://suite101.com/a/natural-remedies-for-low-thyroid-function-in-your-dog-a337638
_http://peterdobias.com/community/2012/08/holistic-treatment-hypothyroidism-dogs/
 
"If the disease affects only one ear, head tilting and circling will be in the direction of the affected ear"

Zen is tilting in the direction of the ear he had removed. He's also drooling from that side of his mouth only.
Am I right thinking that if this was caused by otitis in the ear he still has, he should be tilting and drooling at the opposite side ?

He's not doing much better yet, he's not falling down anymore but still loses balance easily, can't find a treat on the ground in front of him and has a lot of trouble hearing.
The treatment he was on will be finished tonight and I'll take him to the vet again tomorrow - I have gathered quite a few things to ask her with your help Keit, thank you.
 
Eva said:
"If the disease affects only one ear, head tilting and circling will be in the direction of the affected ear"

Zen is tilting in the direction of the ear he had removed. He's also drooling from that side of his mouth only.
Am I right thinking that if this was caused by otitis in the ear he still has, he should be tilting and drooling at the opposite side ?

Well, I definitely have no knowledge in this area, but from what I was able to gather, both in case of peripheral and central vestibular disease, the head tilt and drooling should be on the side of the affected ear, however paradoxical head tilts were also reported.

You say that his auditory (Eustachian) tube was removed? In case of otitis that is resistant to treatment, usually total ear canal ablation and (tympanic) bulla osteotomy (cleaning out the inner ear) are performed. And if so, the procedure should solve the problem, but in less than 5% complications can occur and lead to vestibular disease and recurrent infection. But I surely can't give you more educated guess to what may be the reason.

_http://keysteps.net/course/info.php?id=135
What complications may be seen?

The potential complications were discussed previously. In reality, although a large number of complications are described for TECA/LBO, it would be wrong to give the impression that these are common, or indeed an expected aspect of the surgery. When the surgery is performed properly, the rates of complication should be very low, with the majority of dogs having very little impact, cosmetic or otherwise, from the surgery.

Facial nerve injury is commonly mentioned in relation to TECA/LBO surgery. Actually, the rates of permanent facial nerve paralysis should be nil, with temporary facial paresis occurring infrequently. This should be the goal for all surgeons undertaking the surgery, and they should not accept a higher frequency simply because it is a difficult surgery.

The one complication which can be difficult, even for experienced surgeons to avoid, is recurrent otitis media. Sometimes, it’s impossible to completely decontaminate the bulla, and grossly visible disease remains at the close of surgery.

Sometimes, there is osteomyelitis affecting the medial bulla wall and complete resection cannot be achieved. In these cases, despite efforts to open the lateral wall as much as possible to facilitate the entry of granulation tissue into the bulla, the exposed lumen quickly become walled off again, and localised infection can therefore persist. These patients may present months, or sometimes a year or so after apparently successful surgery, with signs of head shaking, vestibular disease or other signs of middle ear irritation.

Acute infections, including grossly swollen sides of theface, pyrexia, pain, discharging sinuses or abscess development is less common, and usually occurs when a bulla osteotomy has been performed inadequately, or pieces of cartilage and epithelium have been left after an original surgery.

Good luck with the vet visit tomorrow!
 
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