NeuroFeedback, NeurOptimal and Electroencephalography

The only connection that I was able to find between brain and proanthocyanidins is NAD+.


You can also increase NAD+ with NMN and NR.


You can also get a direct NAD+ treatment.

I Got a $600 Brain 'Reboot' and It Changed My World

It's good to be skeptical about wonder drugs, because often there's nothing wonderful about them at all. So when a finance worker friend of mine told me he'd discovered a miracle treatment that gives him a huge advantage over his colleagues, I was dubious. "No—I'm full of energy every day and feel like a new person!" he promised. "I don't need to drink eight cups of coffee every day now; this is so much better, and I just get a top up every few weeks!"

I suspected he may have just found out about Modafinil, or one of the other study drugs internet psychonauts have already been using for years. But I was wrong. He sent me a link to a pharmacy in South Kensington offering intravenous "Brain Reboot Infusions," which of course sound far too much like something from Minority Report to be genuinely real. But I decided to give my friend the benefit of the doubt and do a little research anyway.

The main ingredient in the intravenous cocktail is nicotinamide adenine dinucleotide, or "NAD+." Discovered in 1906, it's a coenzyme found in all living cells that is "essentially responsible for converting food energy into cellular energy," according to Dr. Mark Collins, consultant psychiatrist at the Priory Hospital, Roehampton.

The internet tells me NAD+ is popular among the "anti-aging community," thanks to a Harvard Medical School study that found it rewound "aspects of age-related demise in mice." It's also supposedly good for: detoxing from alcohol and drugs, increasing energy and focus, reducing chronic fatigue, increasing your metabolism, and improving your cardiovascular health.

It still sounded like bullshit, but the only way I could tell for certain was to put it to the test. I'd quit drinking that particular week, and—as I'd learned online—this treatment could apparently help to mitigate my booze cravings, so the timing was perfect: I booked an appointment for the following day.

Zen Healthcare, just around the corner from Harrods, specializes in the kind of things you might expect a Knightsbridge clinic to specialize in: "bespoke weight loss therapies," travel vaccinations for far-flung locations, botox, "vampire facials," and, of course, Brain Reboot Infusions—which will set you back about $600. (Full disclosure: I got mine for free.)

I arrived a little early, but a Dr. Yassine was there to meet me and explain some of the side effects I might experience while receiving the treatment.

"You will feel your chest tighten and may get a headache," he said. "But this will pass."

I signed some waivers and was escorted to a room where Yassine took my blood pressure. Which, you'll be happy to hear, was normal.

"Are you OK with needles?" he asked.

"Yeah, fine."

Yassine inserted the drip and, a moment later, the "Brain Reboot Cocktail" was flowing through my veins. As he'd warned, I began to feel my chest tighten. Thirty minutes in, I started to wonder what I was doing—my head was aching, the discomfort was becoming kind of alarming, and I was suddenly acutely aware that a foreign substance had by now probably completely flooded my bloodstream. I toyed with the idea of hitting the buzzer Yassine had provided me with should I want to end the treatment, but I decided to stay the course.

Fifty minutes in, I felt a calm sense of positivity envelope my body. Yassine came in and said I had ten minutes left, which flew by. Removing the IV, he asked me how I felt.

"Kinda dreamy," I said.

"A lot of people say similar. Be careful on your way home."

I thanked Yassine more than I needed to. It was time for me to go.

I walked outside, and it hit me: I felt a surge of energy, but no jitters or edginess. My mood had noticeably improved. I felt poised, positive, and pumped-up. I remember thinking, This is awesome, and then saying exactly that out loud. I hopped on the subway, which was as crowded as ever, but for once all the back sweat and the fact it was nearly getting in my mouth didn't bum me out at all.

I woke up the next day at 7 AM and didn't feel horrendous, which is unusual for me. In fact, I felt great. The dreamy feeling had gone, but there was a definite improvement in energy levels, focus, and mindset. This continued throughout the rest of the day, and then for the following eight or so days. But what of its supposed effects on my otherwise unwavering love for beer?

"It's been known for decades that a high dose of vitamin B3—the 'poor man's' way of elevating NAD levels—has a beneficial effect for alcoholics, both in terms of detoxification and, perhaps more importantly, in reducing craving and anxiety levels after detoxification," said Dr. Mark Collins in an email.

And it seems the theory still holds: In all the time I could feel the treatment's effects, I didn't crave the cold embrace of a freshly poured pint even once.

That said, my cravings were just that: cravings. It's not like I was in the midst of a full-blown Stella dependence; I just like alcohol. So to find out how useful NAD+ therapy really is when it comes to drug or alcohol addictions, I asked Dr. Yassine to take me through the theory of how exactly a Brain Reboot Infusion can help someone suffering from withdrawal.

"NAD+ has a significant role in reducing the withdrawal effects by restoring the neurotransmitter balance, which shifts significantly after the drug that's been withdrawn has been removed," he explained. "As a result, the patient experiences almost no withdrawal symptoms whilst and after completing the infusion cycle."

Of course, Dr. Yassine works at a clinic that offers this procedure, so it would make sense for him to talk up NAD+. Still, Dr. Collins—who specializes in addictions and has no real reason to sing the treatment's praises—is also complimentary, if a little cautiously. "I have now witnessed its use in many patients and am very impressed with the short-term results," he said in his email, adding that "what is clearly needed is more research, and in particular longer-term outcome studies."

Dr. Yassine put me in touch with some patients, on the condition of anonymity, to hear how the treatment has worked out for them.

"I've been taking codeine for the last few months," said Jeff*. "It started with a back pain, and I never realized I was going to be hooked up. Then I tried to stop, and it was hell. But having tried NAD+ infusions, stopping codeine has been easier; I didn't feel all the debilitating symptoms I'd experienced earlier."

Ian*, who had been using crack and heroin, had a similar experience.

"I'd be lying if I said the thoughts [about picking up] aren't in my mind, and in my mind often, but that deep 'urge' that addicts will know about isn't there any longer," he said. "I also see a therapist to talk through and figure out why I'm driven to such behaviors, but as of right now, I feel a sense of self-control that I've not felt in a long time. I still have more treatments to go, and I feel I'll always need therapy, but thank God I decided to tell some strangers my deepest problems. Things could have been very different."

Ian's point is important: NAD+ therapy—while seemingly useful, according to everyone I spoke to—is not a panacea. While it may well dull cravings in some patients, it might not for others—and clearly it can't be relied upon exclusively without additional therapy and other forms of treatment.

For me, the treatment did exactly what it said it would, and there are promising signs that it helps with drug and alcohol withdrawal. But as for NAD+'s supposed anti-aging properties, or its ability to improve your metabolism and cardiovascular health, it's very early days. As Dr. Collins pointed out, much more research needs to be done before anything can be said for sure.

 
The interesting thing about ADHD studies with grape seed extract is that it worked on children, but not on adults. And if the connection with NAD+ is true, then it makes sense, because children have more NAD+ than adults, so a little improvement in NAD+ production with grape seed extract might be enough for them but not for adults. So the adults probably won't feel many benefits if they take grape seed extract alone. Fortunately, there are many other things that can also improve NAD+. And,
fortuitously, I was taking a lot of them together, which would explain some of my experiences which I couldn't replicate because I had no idea what was going on. But it seems that things are finally starting to make sense.
 
I found a guy on YT who experiments with different things and also does lab testing. He says that he had no improvement in NAD+ with grape seed extract.

 
In recent years, there has been a lot of research on using the 40 Hz light therapy to stimulate the brain. You can find one review of that research here: Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function

They basically use a stroboscopic, 40 Hz, 50% duty cycle, light for visual stimulation. Which is sometimes also followed by the same 40 Hz audio stimulation. The problem with this method is that it produces a very unpleasant flickering light. But there is one study that showed that the same effect, although less strong, can be produced using the invisible flicker: Novel Invisible Spectral Flicker Induces 40 Hz Neural Entrainment with Similar Spatial Distribution as 40 Hz Stroboscopic Light

There is also a study that shows that cognitive task during this light therapy can improve the outcome: Cognitive tasks propagate the neural entrainment in response to a visual 40 Hz stimulation in humans

We are surrounded by flickering lights that have a negative effect on our brainwaves, but what if some flicker can be used for our benefit?
 
This sounds exactly how NeurOptimal neurofeedback works.

Novel Neurofeedback Technique Enhances Awareness of Mind-Wandering

Summary: Researchers have developed a novel neurofeedback technique based on Pavlovian conditioning that detects when a person’s mind is wandering.

Everyone knows the feeling. You are trying to concentrate on driving or studying, or paying attention in a boring meeting, but suddenly, you realize that you are thinking about something irrelevant to the task at hand.

While mind-wandering is sometimes associated with mental problems such as depression, it also contributes to our creativity. Therefore, what we need is not to avoid mind-wandering, but to learn how to manage it.

The first step to control mind-wandering is to realize that it is occurring. Once we notice it, we are free to stop or to continue it. At ATR, we developed the first method, a neurofeedback technique, to enhance awareness of mind-wandering.

We performed a double-blinded test with 36 participants and demonstrated that awareness of mind-wandering was significantly enhanced after 20 minutes of neurofeedback. Participants were assigned by computer to control and experimental groups and those assignments were withheld from experimenters.

During neurofeedback, artificial intelligence was used to identify mind-wandering of participants performing a task that requires concentration.

In the control group, soft tones were presented at irregular intervals. In the experimental group, those tones were sounded when neurofeedback detected that a participant’s mind was wandering.

However, until debriefing at the end of the experiment, participants in both groups were told that tones were meaningless and were instructed to ignore them.

Since people become aware that their minds are wandering at the time their attention is re-directed back to the external environment, we hypothesized that this novel neurofeedback creates a state in which participants become cognizant of mind-wandering whenever it occurs.

This study had two unique features. First, participants in the experimental group did not know that they had received neurofeedback and they didn’t realize that their awareness of mind-wandering had been enhanced. Second, in conventional neurofeedback, participants obtain rewards when they control their brains well.

In contrast, our neurofeedback employed no rewards or punishments. Instead, it was based on traditional (Pavlovian) conditioning.

This study did not reveal how long effects of this neurofeedback persist, but probably they will not last long. However, future studies will examine whether repeated neurofeedback endures in daily life, and we will also explore training techniques to improve mood and mental problems and to enhance creativity.


Absorption in mind-wandering (MW) may worsen our mood and can cause psychological disorders. Researchers indicate the possibility that meta-awareness of MW prevents these mal-effects and enhances favorable consequences of MW, such as boosting creativity; thus, meta-awareness has attracted psychological and clinical attention. However, few studies have investigated the nature of meta-awareness of MW, because there has been no method to isolate and operate this ability. Therefore, we propose a new approach to manipulate the ability of meta-awareness. We used Pavlovian conditioning, tying to it an occurrence of MW and a neutral tone sound inducing the meta-awareness of MW. To perform paired presentations of the unconditioned stimulus (neutral tone) and the conditioned stimulus (perception accompanying MW), we detected participants’ natural occurrence of MW via electroencephalogram and a machine-learning estimation method. The double-blinded randomized controlled trial with 37 participants found that a single 20-min conditioning session significantly increased the meta-awareness of MW as assessed by behavioral and neuroscientific measures. The core protocol of the proposed method is real-time feedback on participants’ neural information, and in that sense, we can refer to it as neurofeedback. However, there are some differences from typical neurofeedback protocols, and we discuss them in this paper. Our novel classical conditioning is expected to contribute to future research on the modulation effect of meta-awareness on MW.

 
These headphones claim to use the same approach as explained in the previous post, but they don't offer any real-time feedback. Maybe they will add it in the future.

 
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