Ingredients (for a ~100g batch; scale as needed)
- Ivermectin powder: 1-2% concentration (e.g., 1g for 1% cream). Use USP-grade; source from a compounding pharmacy or verified supplier.
- DMSO: 10-20% (e.g., 10-20ml). Pharmaceutical-grade only (99.9% purity); avoid industrial versions.
- Emollient cream base: 70-80g (e.g., unscented lotion, Eucerin, or a simple oil-in-water emulsion like aquaphor or a pharmacist's base). This acts as the carrier.
- Optional additives: Distilled water (to adjust consistency), preservatives (e.g., 0.1% benzyl alcohol), or emulsifiers if the base needs stabilization.
Total: Aim for 100g. Adjust ratios based on desired potency—start low (e.g., 1% ivermectin, 10% DMSO) to minimize risks.Equipment Needed
- Digital scale (accurate to 0.01g).
- Glass or stainless steel mixing bowl/beaker.
- Stirring rod or spatula (non-reactive).
- Gloves, mask, and eye protection (DMSO vapors can irritate).
- Sterile containers for storage (e.g., amber glass jars).
Step-by-Step Preparation
- Prepare workspace: Work in a clean, well-ventilated area. Wear protective gear to avoid skin contact with pure DMSO or ivermectin.
- Dissolve ivermectin in DMSO:
- Weigh 1g ivermectin powder.
- In a small glass container, add 10-20ml DMSO.
- Gently stir or warm slightly (e.g., in a warm water bath at <40°C) until fully dissolved. Ivermectin solubility in DMSO is good, but avoid heat >50°C to prevent degradation. This creates a concentrated solution.
- Mix with cream base:
- In a larger bowl, weigh 80-90g cream base.
- Slowly add the ivermectin-DMSO solution while stirring continuously to ensure even distribution.
- Mix thoroughly (by hand or with a low-speed mixer) for 5-10 minutes until homogeneous. If too thick, add a few ml distilled water.
- Test consistency and potency (optional but recommended):
- Check pH (should be 5-7 for skin safety; adjust with citric acid if needed).
- For potency, a lab assay is ideal—don't skip professional verification.
- Store:
- Transfer to sterile jars.
- Label with date, concentration, and expiration (use within 1-2 months; refrigerate if possible).
- Keep away from light and heat.
Application Tips
- Apply a thin layer to clean, dry skin 1-2 times daily (per professional guidance).
- Patch test first: Apply to a small area and wait 24 hours.
- Wash hands after use; avoid eyes/mucous membranes.
Potential Risks and Considerations