In the "Caricature of Love" thread, it was expressed that there was an interest in binding into books some of the PDFs that were being offered on the forum. I'm glad to see a fellow bookbinder has begun a thread here so I'll just add my thoughts to this thread. The following is some basic information for those who may not be familiar with bookbinding.
I've done some bookbinding before, Japanese, hardbound and paperback binding. For the purposes of PDF-to-book I would recommend either using paperback or hardbound binding because of the amount of pages required.
First of all, what I've done in the past is take all the text from the PDF and transfer it to a document in NeoOffice (open source word editing program for Mac) which has a Brochure printing option. This is a really time consuming task and requires a lot of editing. The purpose of this is to make sure that when you go to print off your book that it will print imposed, 2 pages on the front and 2 pages on the back.
I format my document so that the pages are 13.97cm in width and 21.59cm in height. Top and bottom margins measure 2cm and 3cm respectively. I use a 2.6cm margin for the inside and a 2cm margin for the outside and set up my pages so to that the will be mirrored. The body of the text is Justified.
I've tried some freeware programs that will impose a PDF document but, have not much success, so I've been doing it manually. I'm sure there is a variety of freeware imposition programs available on the web. I have mainly used a duplex printer to print, so I can't say much about the process without one, other than it IS possible to print signatures with a single sided printer (see links).
Take a look at any hard bound books you may have. If you look closely at the spine of the book you will see that there are a number of smaller booklets. Signature printing for books is not in linear order (1, 2, 3, 4, etc.). For example, if you were to print a signature with 8 pages of the book, you will have pages 1 & 8 on the back of the first sheet of paper and pages 2 & 7 on the front. The second sheet of paper will have pages 3 & 6 on the back and 4 & 5 on the front.
Once the signatures have been arranged they are then stitched together. The backboard which will serve as the cover is prepared and the entirety of the signatures is then glued to the spine. Preparing the backboard is an art in itself with the selection of backing papers, book cloth and self-designed dust jackets.
With paperback or perfect bound book covers I would recommend finding a large sheet of card stock (maybe 11x14) that is glossy on one side and matte on the other. You could design your image to be printed and have it printed at a print shop. I don't know if home printers would handle the weight of card stock needed for paperback books. When designing the cover you will have to take into account the dimensions of the front and back of the book as well as the dimensions of the spine. After printing, the card stock can be cut down to the necessary dimensions. I've tried this on my own with little success. My printer kept wanting to add margins to the image, thus resizing it and it didn't appreciate the card stock weight (was dented in the printing process).
Here are some resources I've found to add:
Imposition, Single and Duplex Printing in OpenOffice
http://openoffice.blogs.com/openoffice/2008/03/printing-two-si.html
Grain of paper, punching signatures with awl
http://www.youtube.com/watch?v=hrHi-NhO4GI
Paperback binding
(Nevermind what he says about using Gorilla Glue, I've used PVA and it works fine for paperback and hard-bound)
http://www.youtube.com/watch?v=cbK0mQyj930
Hardbound book process
http://www.csparks.com/Bookbinding/index.xhtml
Ceropegia's Youtube channel- lots of video's on binding hard-bound books
http://www.youtube.com/user/Ceropegia
I'll add some more links as I find them!