mcb
The Living Force
It came back to me -- Loma Linda. Here is one reference from Wikipedia. Also, one of the presenters in the Healthy Mouth Summit (that I linked earlier) remarked that the discoveries made by Leonora in his department at Loma Linda were ignored by the dental school at the same institution.
Some excerpts from the Wikipedia entry:
There is more in the article, and this article is just one reference.
Some excerpts from the Wikipedia entry:
http://en.wikipedia.org/wiki/John_Leonora said:Research Contributions
Gonadotropic hormones. Based on his doctoral studies and subsequent research fellowship, John Leonora initially intended to devote his career to the investigation of gonadotropic hormones.
Dentinal fluid transport. One day he received a telephone call from Dr. Ralph R. Steinman, a dental colleague, who had been studying the flow of dentinal fluid in rats from the odontoblasts in the dental pulp through the dentin using an intraperitoneal injection of the fluorescent dye, acriflavine hydrochloride. He found that in the teeth of rats fed a cariogenic diet the flow of dentinal fluid was markedly reduced. He wondered if some systemic mechanism was involved in this impairment and so decided to contact Dr. John Leonora, as an endocrinologist.
Hypothalamus. This was the beginning of a decades-long collaborative journey. John Leonora first suggested that none of the recognized hormones were plausible candidates for regulating dentinal flow transport (DFT), but that the hypothalamus might well be an alternative hormonal source. Quickly they found that infusing rats with a crude extract from rabbit hypothalami triggered increased DFT activity. This, however, raised the question whether the hypothalamic factor had a direct effect on the teeth or rather had an indirect effect characteristic of other hypothalamic hormones.
Parotid hormone. Assuming that the hypothalamic factor was mediated through one of the major salivary glands, they found that this factor was biologically active when administered to rats with intact parotid glands but was wholly ineffective in rats that had the parotid glands removed. There was no involvement of the other salivary glands. They concluded that the direct regulation of DFT was therefore secreted by the parotid glands and this endocrine function was controlled by the hypothalamus.
...
Suppressive effect of sucrose. Then the research focused on the mechanism by which dietary sucrose suppressed the DFT. Initial studies suggested that the sucrose suppressed the secretion of the parotid hormone. Further studies, however, showed that the sucrose effect occurred indirectly by inhibiting secretion of the hypothalamic parotid hormone releasing factor. Then it was found that the sucrose effect could be effectively reversed by the infusion of the compound carbamyl phosphate through the internal carotid artery. This confirmed that the site of action was within the central nervous system—namely the hypothalamus.
There is more in the article, and this article is just one reference.