DMSO - Dimethylsulphoxide

In his recent newsletter Hartmut Fischer sent a healthy skin tonic recipe: DMSO with NAD+, for skin regeneration.
(I have not tried it yet).

The basis for natural skin mixtures must be free of unwanted additives, such as those found in all industrial mass-produced cosmetics! Here is a simple yet effective skin tonic: mix 30 ml of DMSO Ph. Eur. and 70 ml of aloe water and add 0.5 to 1 gram of NAD+. The concentration of aloe water can be freely selected, depending on whether you want to spray, apply or use the resulting mixture as a ‘pack’, i.e. by varying the viscosity. In order to dissolve the NAD+, it may be necessary to gently heat it to a maximum of 40 °C in addition to stirring. (Translated with DeepL)
 
Here is another recent newsletter article from Hartmut Fischer on ivm, fenben, DMSO and procaine. I´ll post it here in its entirety as the discussion further up was about combining DMSO and ivermectin.

I found the mention of streptococcal infections or sepsis that are mostly overlooked in routine diagnostics, particularly interesting, "which can colonise the endothelium, i.e. the inner walls of blood vessels, and over time lead to a wide variety of symptoms and diseases – AID, MCAS, MC/CFS, COPD, post-vaccination syndrome, long Covid, cancer, etc. However, routine laboratory diagnostics of endothelial cells are not performed!"

In the last part below there are recommendations for the use of a 3 mg ivm-0,29% DMSO solution, a recipe for a fenben-DMSO solution or instead also procaine as a base solution, as was mentioned by Gaby for neural therapy too.

Medicine you can make yourself Newsletter (deepl. translation) [bolded parts, mine]

Ivermectin (and fenbendazole) – Ten years after the Nobel Prize

It could be the title of a novel: ‘Ten Years After’. Exactly ten years ago, in October 2015, half of the Nobel Prize in Medicine was awarded to the two discoverers and researchers of ivermectin. And who got the other half? That's right – it was the Chinese researcher who discovered the effects of the annual mugwort! So 2015 was the year in which two important therapeutic options for the treatment of parasitic diseases were honoured. And there is another parallel: both ivermectin and artemisinin are natural substances! Admittedly, the native active substances were/are then slightly modified to form the approved drugs known today. However, firstly, the underlying avermectins and artemisinin are at least as effective, and secondly, in both cases, the molecules are already very large/complex, so it is rather irrelevant whether a methyl group is exchanged for an ethyl group on the ‘far right, top’ or something similar. Impulse: Just look up both substances on the internet and marvel at their molecular structure – it is our nature that produces such impressive substances and provides them in abundance! How does it do this? Through chemical reactions!

Everything is chemistry – many people are familiar with this phrase, but often fail to grasp its true meaning, asking questions such as ‘is it natural or synthetic?’ when it comes to their extremely amateurish assessment of substances. The absurdity of such a question/statement is enormous, because at the same time we learned in school that plants perform photosynthesis, i.e. they synthesise everything we value in plants! And that is a great deal! The same applies to microorganisms, bacteria, fungi, etc., because they perform biosynthesis! There is only one way to assemble all the molecules needed for life on this planet from the individual building blocks of the universe, and that is through chemical reaction! Synthesis! And in doing so, nature, flora and fauna, is extremely wasteful in order to give us more than we could ever need. It is obvious that not only the bare essentials are produced, but also abundant surpluses in such gigantic quantities that no factory ever conceived by humans could ever match such tonnages. DMSO alone is produced, generated and synthesised in millions of tonnes by marine plankton. Effortlessly.

They produce it with great artistry, i.e. artificially (!), because elements and/or small-molecule platform substances such as CO2 are ‘built’ together in infinitely creative ways through chemical reactions, resulting in the most wondrous molecules, such as ivermectin and artemisinin, which did not exist before. This is a creative, artistic act, similar to the creation of a complex painting from individual colours that did not exist before. This is art, therefore artificial, created through synthesis! No wonder, since plants and microorganisms have unlimited energy, the sun, at their disposal and can produce unlimited ‘waste’ – in the case of plants, this is oxygen ... . So, by asking the superfluous question ‘is it natural or synthetic?’, one thoughtlessly insults nature and despises life! Please take this to heart.

Avermectins, complex macrocyclic lactones, which also include ivermectin, are produced by actinomycetes. The biosynthesis of Streptomyces avermitilis is allowed to run its course, so that fermentation produces, among other things, ivermectin B1a and B1b, which, as mentioned, differ only in a methyl and ethyl group. In this respect, ivermectin is definitely a natural substance, making it suitable for our DMSO & Co. health toolbox. It seems important to mention this, as there is a widespread prejudice that prescription drugs must have been created on a biochemical human drawing board, through molecular modelling.

Back to the headline. So what has happened in these ten years? First of all, it should be mentioned that ivermectin has, of course, been researched for much longer – the awarding of the prize usually takes place with a considerable time lag. Around the mid/late 1970s, Omura and Campbell made the fundamental discoveries. And in general: if I mention this Nobel Prize here, it is not because I endorse award ceremonies or even celebrate them, because as soon as there is competition, as soon as there is something to be won, i.e. as soon as honour and greed come into play, some things can become questionable ... However, based on this date/event and the circumstances, one can guess and understand why ivermectin should become a household remedy today; after all, it has already made it onto the list of essential medicines. And yet much is still unknown, and we will certainly discover further areas of application for this substance in the future.

Primary indications, as can be read everywhere, are ecto- and endo-parasitic infections. It should be emphasised that no (direct) efficacy of ivermectin against bacteria, fungi or ordered macromolecules (known as viruses or prions) has been established, and yet ivermectin has been/is now being used successfully in a wide variety of non-parasitic infections and, beyond that, or precisely because of that, also in tumour diseases. How is this to be understood?

First of all, ivermectin is primarily a veterinary medicine, as it is only officially approved for use in human medicine in Germany for the treatment of scabies and rosacea. In animals (hominids are also mammals ...), however, it is used against a variety of parasitic infections, including ticks – lists of these can be found in abundance on the internet.

An entire book could be written about the question posed here, but in short, there are two issues at stake: Firstly, there is now a convincing flood of evidence that tumour diseases can always be traced back to a causal infection, and secondly, an organism that is “burdened” by parasites (usually completely undetected) is often unable to defend itself against other common bacterial, mycotic or “viral” infections.

A scientific publication discovered by chance (sent to me by a patient) triggered a significant ‘aha’ moment here. A patient case that ostensibly involved streptococcal sepsis, which paradoxically disappeared immediately after ‘emergency treatment’ with ivermectin in the usual dosage. It turned out that the man also had a worm infection (probably for some time before), namely dwarf threadworm: https://pmc.ncbi.nlm.nih.gov/articles/PMC6249898/pdf/13256_2018_Article_1885.pdf

I find this all the more remarkable given that the life-threatening bacterial infection was Streptococcus pyogenes, which I now like to refer to as ‘long scarlet fever’. This bacterium can apparently also colonise the endothelium, i.e. the inner walls of blood vessels, and over time lead to a wide variety of symptoms and diseases – AID, MCAS, MC/CFS, COPD, post-vaccination syndrome, long Covid, cancer, etc. However, routine laboratory diagnostics of endothelial cells are not performed!

As I said, there is already enough material here for an entire book. However, we already have enough arguments to justify the use of ivermectin in our DMSO & Co. health kit, namely:

1. The successful use of ivermectin in non-parasitic infections (including Covid ...) suggests that many people are burdened with parasites and, due to this chronic burden, often react to ‘normal’ infections such as ‘flu’, scarlet fever or infections caused by many other bacteria or routine fungal infections, with significant illness, even life-threatening conditions. Although we should actually be able to cope well with our natural immune defences.

2. Parasites are constantly entering our lives through food (raw food), contact with animals (humans are animals too :-)), nature, etc. For example, the dwarf threadworms, Strongyloides stercoralis, presented in the scientific paper mentioned above, are also transmissible through contact with dogs.

3. Parasitic, chronic foci in particular are capable of causing degeneration and tumour formation in cells/tissues, such as bladder cancer, glandular cancer, etc.

What follows from this? Among other things, that taking ivermectin will probably become very important for prevention. This means simply cleansing the body of (excess) parasites from time to time.

Even if one has a different opinion on the subject of prevention, it is at least imperative to use this substance for a variety of already manifest diseases, as its application is simple and safe. There is talk that ivermectin (in high concentrations) can also activate/occupy GABA and glycine receptors, which would lead to undesirable suppression of the central nervous system. However, we should generally be sceptical about hyped ‘high-dose strategies’ – that is a general recommendation.

Other side effects tend to result from the death of various parasites and are therefore part of the effect.

Now to the practicalities: I use pure ivermectin solution in DMSO with a concentration of 0.29% (www.alchemist.de). Advantages: No undesirable additives, can be dosed very precisely drop by drop, protected in solution and amber glass (ivermectin is sensitive to light and oxidation, like many other lactones).

And above all: we have the direct support of DMSO. Apart from that, ivermectin does not dissolve in water at all.

One gram of the solution contains approximately 3 milligrams of ivermectin, which is the same amount found in commercially available tablets. For tablets, the recommended dosage is between 3 and 12 or 15 mg, depending on body weight. Since the solution also contains DMSO, I halve the otherwise recommended dosage. In my case, that means 2 grams (approximately 2 millilitres) of the solution = 6 mg of ivermectin, which I extract with a pipette.

I fill this small puddle in a glass with water and a dash of freshly squeezed lemon or lime juice (antioxidants) and drink it slowly before breakfast. If I want a higher dose, I drink this mixture a second time in the afternoon, preferably on an empty stomach.

Cost consideration: The nearly 300 milligrams of pure ivermectin in the 100 ml bottle with the 0.29% solution from alchemist correspond to almost 100 commercially available 3 mg ivermectin tablets in terms of substance quantity, for only about €25 at present! Strictly speaking, it corresponds to 96 and a half tablets. So you can easily compare prices on the internet and be amazed to find that just 20 tablets of 3 mg ivermectin from ratiopharm have an RRP of a good €240! Of course, you don't pay this price if you have a prescription, but ivermectin is not usually prescribed by doctors just like that. Yes, there are also foreign sources for Ivermectin tablets, but according to reports, there are also some black sheep among them, and besides, you still don't have pure Ivermectin, but tablets with all kinds of industrial additives in them. The philosophy of the DMSO & Co. health toolbox is different – we use pure substances! Just under 300 milligrams of pure ivermectin, dissolved and protected in DMSO, for around €26 is, in any case, a very inexpensive way to use this natural substance on your own responsibility.

Fenbendazole (a benzimidazole) can be used together with ivermectin or separately. According to a recent study entitled ‘Fenbendazole oral for cancer therapy in humans and animals’ from September 2024, it is also recommended to use DMSO in combination with fenbendazole to make it even more effective! Read more here: Oral Fenbendazole for Cancer Therapy in Humans and Animals

I also purchase fenbendazole from www.alchemist.de, in this case as 30 grams of pure powder, i.e. not pre-dissolved. If you want to use it together with DMSO, you can dissolve the usual recommended amount per application in DMSO, because fenbendazole, like ivermectin, is poorly soluble in water and can be better absorbed together with DMSO.

Furthermore, research into the mechanism of action of fenbendazole has found that it is capable of triggering the reactivation of the p53 tumour suppressor gene. This can be read on the website fenbendazolehelp.org: Unveiling Mechanisms of Fenbendazole in Cancer Treatment

Whenever you hear ‘p53’, you should pay attention, because this is an important factor in connection with all tumour diseases. Interestingly, this effect on p53 has now also been established for procaine – yes, you read that right, good old procaine. Equally popular and inexpensive. Published in the renowned journal Cancer Research.

It states: "Procaine can inhibit the enzyme DNA methyltransferase. This property could be used to reverse paragenetic damage to gene expression. This is particularly interesting in the case of damage to so-called tumour suppressor genes such as p53": https://aacrjournals.org/cancerres/...aine-Is-a-DNA-demethylating-Agent-with-Growth
 
i am currently reading hartmut fischer's book 'the dmso handbook' and would like to try now that my cast is off my wrist and arm. to do an initial test he recommends a 70per cent mix and if any prolonged allergic reaction, liver pains or unpleasant symptoms not to use dmso. these reactions seem extreme but would not using lesser per centage solutions be o.k. excuse my ignorance on this.

i realise the stiffness i have at the moment needs to be exercised to improve movement but hoped maybe dmso would lessen swelling and help the muscles stretch with maybe less pain. at the hospital 3 days ago they just took off the cast and gave me a booklet of exercises to do and to go back in 4 weeks. at 72 i've no idea if the 6 breaks have even started to fuse so i don't want to go full bore against the pain.

when the cast was taken off i expected some pain on the release but the pain was so severe it was just the same as the night i broke it. i was unable to speak for for the 1st 10 minutes. needless to say i'm in a pity me mode at the moment but don't want to do anything silly. i would really be grateful if anyone used to using this substance would give me some advice.

on another note it says the expiry date on my dmso is may 2026. does dmso really have an expiry date.
 
@Tuatha de Danaan Did you break your wrist? I'm sorry if I've missed a post on this somewhere. For bone repair, I'd use Comfrey extract, saturate a gauze pad and apply it topically to the wrist as a poultice. It will help recovery. As for DMSO, if the skin is sensitive, you can dilute the DMSO to a 50:50 ratio with distilled water, if using a liquid DMSO. If using a DMSO creme, most of those are sold with 70% DMSO but they are gentle, and I've never had any skin issues with it.

Well wishes for a speedy recovery! :flowers:
 
on another note it says the expiry date on my dmso is may 2026. does dmso really have an expiry date
It is my understanding that pure dmso does not expire:

What Is The Shelf Life Of DMSO?​

May 28, 2024
The shelf life of pure DMSO is generally indefinite, meaning it can remain stable and effective for many years when stored properly. Here are key points to consider:

Stability: Pure DMSO is chemically stable and does not degrade significantly over time. As a result, it does not have a specific expiration date. This stability is maintained as long as the DMSO is stored in appropriate conditions.

Storage Conditions: For optimal longevity, DMSO should be stored in a cool, dry place away from direct sunlight. It is best kept in high-density polyethylene (HDPE) containers to prevent any potential leaching from other types of plastic (dmso.org.uk).

Manufacturer's Retest Date: Some manufacturers provide a "retest date" rather than an expiration date. This date is usually set 2-3 years after the date of manufacture and serves as a guideline for quality assurance rather than indicating a true expiration (dmso.org.uk).

In summary, pure DMSO does not expire and can be stored for many years without losing its effectiveness, provided it is kept under suitable conditions. (cheezhengchem.com)
 
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