(Peri)menopause

I stumbled upon this homeopathic remedy that seems to help women with hormonal issues and it is called Sepia. A note though, homeopathic remedies are tailored to the individual with specific characteristics and issues, so it may not help women who have another disposition. I took one dose yesterday as I was curious, so I can't tell anything yet.

How to take the remedy see here.

I also found some information on fo-ti (or: he shou wu) which could help manage menopause symptoms and may help increase estrogen.

6. May Help Increase Estrogen and Manage Menopause Symptoms

Due to concerns over using hormone/estrogen replacement therapy, many post-menopausal women are driven to seek alternative sources of estrogen to reduce their symptoms, including herbal remedies. In one study published in the Journal of Clinical Endocrinology and Metabolism, estrogen bioactivity was studied among herbs, including red clover, dong quai, black cohosh, soy, licorice, chasteberry, fo-ti and hops. (8)

Soy, clover, licorice root and hops have a large amount of measurable estrogen bioactivity. The researchers also state, “We discovered surprisingly high estrogen activity in extracts of fo-ti not previously reported.” Soy had the most estrogen activity of all the tested herbs, while fo-ti had the second most (more than licorice, hops and red clover). While more studies are needed to confirm how fo-ti may help reduce menopause symptoms, we would expect that it may work in similar ways as soy — which contains high levels of isoflavones, a substance that mimics estrogen. This can be helpful for managing symptoms tied to decreased estrogen like hot flashes, flushing, low sex drive and night sweats.
 
Gaby posted this article on social media and this root seems to help women in (peri-)menopause and after!

Ashwagandha's benefits for female health have been known for centuries.

Ashwagandha root extract is a powerful adaptogen that helps to reduce stress and anxiety and has been found to promote balanced hormone levels, menstrual health, and fertility.
Discover seven ashwagandha benefits for women and learn why taking an ashwagandha supplement can help to reduce stress and anxiety.

Ashwagandha powder and roots


Seven ashwagandha benefits for female health

Ashwagandha's long-standing use in traditional medicine has ignited considerable scientific interest.

Increasingly more research suggests that ashwagandha can profoundly enhance overall health and may be especially beneficial for female well-being.

Here are seven benefits of ashwagandha for female health.

1. Adaptogen​

Ashwagandha is believed to be one of the most powerful adaptogens, meaning it can enhance the body's ability to adjust to physical and mental stress.

Ashwagandha contains withanolides, a group of more than 40 phytochemicals that can modulate various hormonal, neuronal, and immune functions involved in the body’s stress response.

During periods of stress, your adrenal glands release cortisol, an adrenal steroid-hormone that alters metabolic processes to sustain the body during stressful events such as trauma, exercise, injury, or surgery.

While cortisol plays an essential role in mitigating the physiological effects of stress, chronic stress can lead to imbalanced cortisol levels linked to weak immune defenses, high blood pressure, impaired brain function, and changes in body shape and composition, also known as adrenal body type.

It’s believed that ashwagandha stimulates the activity of gamma-aminobutyric acid (GABA), a calming neurotransmitter that helps to regulate the stress response and directly reduces cortisol levels.

A study published in Cureus found that ashwagandha supplementation significantly lowered elevated cortisol in stressed adults, resulting in improved well-being, better sleep quality, and reduced anxiety levels.

2. Hormonal health

Ayurvedic medicine regularly uses ashwagandha to manage female hormone imbalances.

Chronic stress triggers the release of sex hormone-binding globulin (SHBG), a protein that binds to steroid hormones and decreases cortisol's adverse health consequences.

However, SHBG also binds to estrogen, rendering it unavailable for your cells and tissues, which can cause a knock-on effect on other female hormones, resulting in low progesterone and luteinizing hormone production.

Female hormone imbalances are linked to menstrual issues, mood swings, infertility, skin problems, and low libido.

Ashwagandha’s adaptogenic properties can inhibit excessive SHBG production and support balanced hormone levels, which may explain why this medicinal herb has been found so effective in promoting female health.

3. Menstrual health

Ashwagandha promotes balanced cortisol levels needed for regular and healthy menstrual cycles. It also has potent anti-inflammatory properties that can help to reduce painful menstrual cramps, discomfort, and abdominal swelling.

Ashwagandha has anti-anxiety effects and enhances the body's ability to adapt to rapid hormonal changes at the time of ovulation and shortly before the menstrual period. This has been found to reduce premenstrual syndrome (PMS) symptoms, including breast tenderness, cravings, fatigue, anxiety, mood swings, and irritability.

4. Fertility and reproduction

It’s well understood that chronic stress can negatively impact fertility by interfering with hormone balance and disrupting ovulation.

By reducing stress levels, supporting healthy menstrual cycles, and boosting libido, ashwagandha extract may indirectly promote female fertility.

In fact, research published in BioMed Research International concluded, “Ashwagandha has a positive effect in the treatment of infertility both in male and female.”

5. Postmenopausal health

Ashwagandha may help alleviate postmenopausal symptoms such as hot flashes, night sweats, mood changes, and sleep disturbances by promoting hormonal balance.

It may also counteract the effects of declining estrogen levels during menopause linked to an increased risk of osteoporosis.


While more research is needed to confirm ashwagandha's role in maintaining bone mass, there is evidence that it may positively affect bone health by stimulating the activity of osteoblasts, bone-forming cells responsible for maintaining healthy bone mass.

6. Heart health

Ashwagandha is a rich source of withanolides, highly bioactive compounds with blood pressure-lowering effects.

High blood pressure, in combination with elevated cortisol, can significantly impact cardiovascular function and increases the risk of atherosclerosis, irregular heartbeats, and heart attacks.

“Ashwagandha’s potential to lower blood pressure, stress, and anxiety promotes overall health, which is linked to improved cardiovascular health and a lower risk of heart disease,” explains Dr. Berg.

7. Anti-inflammatory

Ashwagandha contains several phytochemicals with potent anti-inflammatory properties that may help to inhibit the release of pro-inflammatory molecules while, at the same time, stimulating immune cells to release anti-inflammatory compounds.

This may explain why ashwagandha has traditionally been used to manage various inflammatory conditions, including arthritis, asthma, inflammatory bowel disease, eczema, dermatitis, and psoriasis.
 
Any woman who suddenly started having recalcitrant acute pain at around the critical age, from seemingly out of nowhere, whether so-called arthrosis pain or any body part tendinitis, will definitely appreciate the following testimonial/talk:


Recommended referenced article in the video:


This paper refutes 10 common myths and misconceptions, and provides evidence to support what is physiologically plausible and scientifically evident: T is the most abundant biologically active female hormone, T is essential for physical and mental health in women, T is not masculinizing, T does not cause hoarseness, T increases scalp hair growth, T is cardiac protective, parenteral T does not adversely affect the liver or increase clotting factors, T is mood stabilizing and does not increase aggression, T is breast protective, and the safety of T therapy in women is under research and being established. Abandoning myths, misconceptions and unfounded concerns about T and T therapy in women will enable physicians to provide evidenced based recommendations and appropriate therapy.
 
I've just listened to this video which I found to be good for newbies on this topic. It's very short and basic but I thought he made it very simple to understand and provides with some things to continue researching on the topic.


Some points I found interesting:
  • During perimenopause (4-6 years before menopause), progesterone levels decline while estradiol fluctuates, leading to potential estrogen dominance.
  • Progesterone can be given cyclically during perimenopause to balance high estradiol levels. (Like in the last 14 days of the menstrual cycle)
  • After menopause, estradiol replacement is often needed to manage symptoms like hot flashes, but it can cause uterine overgrowth without progesterone.
His recomendations:
  • Before menopause: Progesterone creams are fine for managing symptoms of estrogen dominance, especially when used cyclically.
  • After menopause: Use oral progesterone capsules to protect the uterus from endometrial hyperplasia caused by estradiol replacement. Transdermal creams are not proven enough to provide adequate uterine protection.
 
I mostly find online so called Bioidentical Progesterone creams; is that it or what exactly must I search for?
Thank you!

So far, what I understand is that the ones that say USP progesterone are supposed to be good, but I haven't really tried any of the products yet, so I wouldn't know for sure. A friend gave me one some time ago but I'm still researching a bit before I try. This is the one I have, just as an example: Amazon.com
 
I think it's a good idea to test the hormone levels several days in a cycle to see if levels are deficient. Methods of testing include 10 day saliva and 6 days blood with some on the same days to cross reference, especially days 12 and 21 on a 28 day cycle. If hormone levels are deficient, then bioidentical hormones can supplement.
 
Any woman who suddenly started having recalcitrant acute pain at around the critical age, from seemingly out of nowhere, whether so-called arthrosis pain or any body part tendinitis, will definitely appreciate the following testimonial/talk:

This could explain the effect of testosterone on bone problems:

Our results demonstrate that an androgen (testosterone) must be added for estrogen to stimulate the 25-OH-D3-1-hydroxylase in immature or castrate birds, whereas mature males respond well to estrogen injections alone. Thus, it appears that androgens act as a permissive agent for estrogen stimulation of 1,25-(OH)2D3 synthesis. This may help to explain why estrogen alone will not stimulate medullary bone formation, whereas estrogen plus androgen will. It is of interest that both estrogen and androgen levels are low in postmenopausal women.


It could also explain why Gaby's patient hasn't felt much benefit from vitamin D. She probably doesn't have enough of those two hormones to make the active form of vitamin D.
 
I'm 45, and it's been almost 2 years since my cycle started becoming irregular, but lately it's been all over the place, causing me some hellish days once in a while. I used to be regular all my life with a 30-day cycle.
These are the lengths of the past 12 months: 27-21-28-28-28-24-25-26-31-24-27-32-26
I don't have heat flashes, but I get super tired during SPM (must take 2-3h naps), leg aching (this time it lasted 3 days), and loss of appetite or cravings paired with slow digestion.

I'm going to see my family doctor next week to discuss this. But I wonder if it's better to see a Naturopath for these matters? However, they are quite expensive.

I've seen Gaby's post on Dr. Jonh R. Lee's protocols of low dose natural hormone therapy + the testosterone video. I'll look into this.
Does anyone have anything to add to this topic that could help?
edit: I found this thread too! Perimenopause

I think it's a good idea to test the hormone levels several days in a cycle to see if levels are deficient. Methods of testing include 10 day saliva and 6 days blood with some on the same days to cross reference, especially days 12 and 21 on a 28 day cycle.
If the cycle is irregular and unpredictable, how do we proceed with the testing? I'll ask my doc if he's willing to prescribe the blood tests. I wonder if he will be open to this...
 
These are the lengths of the past 12 months: 27-21-28-28-28-24-25-26-31-24-27-32-26
If the cycle is irregular and unpredictable, how do we proceed with the testing?
For the saliva test, saliva is collected every 2-3 days, starting on day 1 of the cycle: vial 1 days 1-3, vial 2 days 4-6, vial 3 days 7-9, vial 4 days 10-11, vial 5 days 12-13, vial 6 days 14-15, vial 7 days 16-18, vial 8 days 19-21, vial 9 days 22-24, vial 10 days 25-27, and vial 11 day 1 of next cycle.

For the blood test, I think it would be good to try to get 3 consecutive days on or near day 12 that overlap with 2 of the saliva vials, and then 3 consecutive days on or near day 21 that overlap with 2 of the vials. Labs closed on Sundays sometimes get in the way of 3 consecutive days, so then just make it 3 out of 4 consecutive days.
 
I'm 45, and it's been almost 2 years since my cycle started becoming irregular, but lately it's been all over the place, causing me some hellish days once in a while. I used to be regular all my life with a 30-day cycle.
These are the lengths of the past 12 months: 27-21-28-28-28-24-25-26-31-24-27-32-26
I don't have heat flashes, but I get super tired during SPM (must take 2-3h naps), leg aching (this time it lasted 3 days), and loss of appetite or cravings paired with slow digestion.

I'm going to see my family doctor next week to discuss this. But I wonder if it's better to see a Naturopath for these matters? However, they are quite expensive.

I've seen Gaby's post on Dr. Jonh R. Lee's protocols of low dose natural hormone therapy + the testosterone video. I'll look into this.
Does anyone have anything to add to this topic that could help?
edit: I found this thread too! Perimenopause


If the cycle is irregular and unpredictable, how do we proceed with the testing? I'll ask my doc if he's willing to prescribe the blood tests. I wonder if he will be open to this...

The book "What your doctor may not tell you about premenopause" by John R. Lee has been really useful for me learning about hormones and my body.

The USP progesterone cream I've also been using a little over 3 months now seems to be helping my PMS and hot flashes!! The book is definitely worth a read.
 
I’m turning 44 and I have started taking Progest-e which is Ray Peats recipe if I’m not mistaken, progesterone derived from Wild Yam. I have read that low progesterone can be a factor when there is a lot of blood clots in the menstruation. So far it is really helping my mood and energy in the luteal phase.
 
I think it's a good idea to test the hormone levels several days in a cycle to see if levels are deficient. Methods of testing include 10 day saliva and 6 days blood with some on the same days to cross reference, especially days 12 and 21 on a 28 day cycle. If hormone levels are deficient, then bioidentical hormones can supplement.
Im turning 52 this year, last year all of a sudden, after the Aurora in May, it felt like something changed and I developed peri menopause symptoms. But these overlapped with the problems I have had since a child of insomnia and food intolerances, overheating at night etc. I cut my oxalate levels back further and the symptoms have resolved. My cycle went from very regular to stopping for few months, starting up again, then stopping again after another stressor (our landlords put our house up for sale but then we bought it), then just started again. The bleeding pattern is normal. I actually starting to feel better right now than I have ever I as I am actually getting sleep. This has largely been effected by some shifts (after years of work) in my cranial bones.
So what I am saying is any perimenopause symptoms have been entirely foreshadowed by other issues. Which means I am not sure if I should do anything to support myself through this phase and going forward.

From what I’m learning here I think two good resources to start with are John Lee’s book and Hunter’s book on testosterone? It sounds like checking hormone levels is a good plan but I don’t know how you do that when it’s unknown if my cycle will continue or actually have stopped.
 
From what I’m learning here I think two good resources to start with are John Lee’s book and Hunter’s book on testosterone? It sounds like checking hormone levels is a good plan but I don’t know how you do that when it’s unknown if my cycle will continue or actually have stopped.
Testing FSH and estrogen levels will give you an idea if you're in menopause when you skip a few cycles in a row. Otherwise, one year without your cycle=menopause. Estradiol (estrogen) is negligible and FSH is high. You can check your testosterone levels and see if it's near zero or not.
 
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