All about Ivermectin

IT is 2nd time Ms. Kim has Dr. William Makis in recent months but still think it relevant enough to post it here (?) , both about Ivermectin and fenbendazole , menbendazole , cancer and treatment. Interview starts at 22:15 in.

Link @ Rumble
 
I've read some anecdotal reports of topical use of ivermectin on SM and Dr William Makis mentions topical use. Makis says that prescription creams are usually 1% ivermectin, but horse paste is 1.87%. I'm curious about topical use because I usually use black salve to test and treat suspicious skin spots or moles. I made my own black salve up according to the recipe given at the end of the One answer to cancer documentary about a decade ago, however, some of the ingredients have been banned and are increasingly harder to come by. Also if the skin spot or mole shows a hit when black salve is applied, then the process of the salve working to kill it and remove it can be quite uncomfortable.

The most dangerous skin cancer is melanoma, but I've had success with basal cell carcinomas.

2.8. Melanoma​

Melanoma is the most common malignant skin tumor with a high mortality rate. Drugs targeting BRAF mutations such as vemurafenib, dabrafenib and PD-1 monoclonal antibodies, including pembrolizumab and nivolumab have greatly improved the prognosis of melanoma [71,72]. Gallardo treated melanoma cells with IVM and found that it could effectively inhibit melanoma activity [73]. Interestingly, IVM could also show activity against BRAF wild-type melanoma cells, and its combination with dapafinib could significantly increase antitumor activity. Additionally, it has been confirmed that PAK1 is the key target of IVM that mediates its anti-melanoma activity, and IVM can also significantly reduce the lung metastasis of melanoma in animal experiments. Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells [74]. However, NAC reversed the effect of IVM, which indicated that IVM increased TFE3-dependent autophagy through the ROS signaling pathway.

Ivermectin, a potential anticancer drug derived from an antiparasitic drug - PMC

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
Click to expand...

Anyways, I'm curious to know if anyone here has tried topical applications of ivermectin.
 
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