All about Ivermectin

[Ricardo]

IT is 2nd time Ms. Kim has Dr. William Makis in recent months but still think it relevant enough to post it here (?) , both about Ivermectin and fenbendazole , menbendazole , cancer and treatment. Interview starts at 22:15 in.

Link @ Rumble

 

[Ricardo]

IT is 2nd time Ms. Kim has Dr. William Makis in recent months but still think it relevant enough to post it here (?) , both about Ivermectin and fenbendazole , menbendazole , cancer and treatment. Interview starts at 22:15 in.

Link @ Rumble

One example of Dr. William Makis sucesses :

https://twitter.com/x/status/1976304898149892201

 

[Jones]

I've read some anecdotal reports of topical use of ivermectin on SM and Dr William Makis mentions topical use. Makis says that prescription creams are usually 1% ivermectin, but horse paste is 1.87%. I'm curious about topical use because I usually use black salve to test and treat suspicious skin spots or moles. I made my own black salve up according to the recipe given at the end of the One answer to cancer documentary about a decade ago, however, some of the ingredients have been banned and are increasingly harder to come by. Also if the skin spot or mole shows a hit when black salve is applied, then the process of the salve working to kill it and remove it can be quite uncomfortable.

The most dangerous skin cancer is melanoma, but I've had success with basal cell carcinomas.

2.8. Melanoma​

Melanoma is the most common malignant skin tumor with a high mortality rate. Drugs targeting BRAF mutations such as vemurafenib, dabrafenib and PD-1 monoclonal antibodies, including pembrolizumab and nivolumab have greatly improved the prognosis of melanoma [71,72]. Gallardo treated melanoma cells with IVM and found that it could effectively inhibit melanoma activity [73]. Interestingly, IVM could also show activity against BRAF wild-type melanoma cells, and its combination with dapafinib could significantly increase antitumor activity. Additionally, it has been confirmed that PAK1 is the key target of IVM that mediates its anti-melanoma activity, and IVM can also significantly reduce the lung metastasis of melanoma in animal experiments. Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells [74]. However, NAC reversed the effect of IVM, which indicated that IVM increased TFE3-dependent autophagy through the ROS signaling pathway.

Ivermectin, a potential anticancer drug derived from an antiparasitic drug - PMC

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 ...

pmc.ncbi.nlm.nih.gov

Anyways, I'm curious to know if anyone here has tried topical applications of ivermectin.

 

[SevenFeathers]

I'm curious to know if anyone here has tried topical applications of ivermectin.

I am currently experimenting with ivermectin on suspicious looking moles. I've been applying the horse paste for about two weeks now, 2 times a day. So far, not much change. Maybe a little lighter in color.

 

[Ricardo]

topical use of ivermectin cream, on what looks like psoriasis or some infection ?

https://twitter.com/x/status/1981655649864839630

 

[Jones]

I am currently experimenting with ivermectin on suspicious looking moles. I've been applying the horse paste for about two weeks now, 2 times a day. So far, not much change. Maybe a little lighter in color.

Well, one of the benefits of black salve is that you know if it's on skin cancer within 24hrs because you can feel it go to work. It apparently kills the cancer within the first 24hrs, but it can take 3 weeks to remove it and heal the area. It has very little impact on healthy skin and as such it works well to test suspicious spots. Another down side to black salve is that the area where it is applied needs to be covered with a bandaid for the first 24hrs, but bandaids don't always adhere well to some areas and can come off while asleep and the black salve ends up coming off with the bandaid. I've had that problem with my nose and I'm thinking of trying horse paste there.

 

[Gaby]

Intranasal nanoencapsulated ivermectin, outperforming ivermectin in gliomas:

Intranasal Delivery of Ivermectin Nanosystems as an Antitumor Agent: Focusing on Glioma Suppression - PubMed

Glioblastoma presents significant challenges in neuro-oncology due to its aggressive nature, drug resistance, and restrictions imposed by the blood-brain barrier. Ivermectin (IVM), known for its antiparasitic properties, has been highlighted as a promising treatment for tumors and an alternative...

pubmed.ncbi.nlm.nih.gov

Nanoencapsulated IVM significantly reduced the viability of various cancer cell lines, particularly glioma cell lines, which led us to evaluate them in a preclinical glioma model. We implanted adult male Wistar rats with C6 cells. Intranasal delivery of IVM-NC (60 μg/rat/day for 10 days) resulted in a larger decrease in tumor size compared with the group treated with free IVM, along with histopathological improvements. [...]

Furthermore, the effective equivalent dose of IVM (26 μg/kg) in the rat glioma model was lower than the approved human dose for parasitic infections. This study marks the first exploration of IVM delivery to the brain. In summary, nasal administration of nanoencapsulated IVM via nanocapsules presents a promising avenue for targeted therapy against glioblastoma, with potential implications for clinical translation.

Hopefully it will be more readily available and help undo damage by mRNA/lipid nanoparticle COVID era.