I had originally posted this video on
the pyroluria thread last year, but I just watched it again and think it's relevant enough to this thread to repost again here:
I really like this video, because it ties together several things I've been trying to gain a better understanding of: infection, pyroluria, and methylation polymorphisms. I think that anyone who is looking seriously at the infection issue should watch the entire video carefully, but I'll mention a few of the highlights:
Klinghardt says that there are two causes of pyroluria that he's seen in his clinical practice:
- early psychological trauma
- chronic infection
He says that between the two, the latter is more common, but they are not mutually exclusive. He mentions that in cases of chronic infection, microorganisms that have lived with us symbiotically for a very long time without causing serious problems are starting to do so now because of two environmental insults which have increased sharply in the past few decades:
- chemical toxicity
- EMF toxicity
Pyroluria is an epigenetic phenomenon -- it can be passed down from a parent who has experienced one of the initiating factors mentioned above to children as well as grandchildren. Because of this, he hypothesizes that microorganisms trigger epigenetic changes which make their host environment more hospitable -- in the case of pyroluria, these involve enzyme blockages which result in abnormal excretion of zinc, manganese and B6. He also discusses this in the context of Amy Yasko's work on methylation blockages (1:00 and briefly at the end).
This aggressive excretion of zinc and manganese causes the body to substitute less desirable heavy metals as enzyme cofactors. I had thought that it was only possible to substitute a metal which was close to zinc on the periodic table (like nickel), but he says some of the most common substitutions are lead, mercury and cadmium. For this reason, one important part of his protocol involves supplementing with heavy amounts of zinc (250-400 mg), manganese (20-50 mg), and biotin (10 mg). His discussion of the protocol in the video is much more extensive.
Common physical signs of pyroluria are discussed beginning at 55:00:
• China doll look/"Indigo" baby
• Eczema, skin eruptions, fungal infections, herpes virus outbreaks (perioral, index finger)
• Thin fine hair, fine nails, deformed toenails early after birth which gradually self-correct
• Bloated belly
• Don’t like to move (knee/hip/ankle pain)
• Frequently get hurt (“Mr. Bump”) due to ataxia
• Anal itch/frequent parasites
• Stress intolerant
• Difficulty sleeping
• White spots on fingernails
For those with a historical bent, he also has an interesting anecdote toward the end about how the Russian general Korzakov protected his troops with a homeopathic treatment during their battle against Napoleon -- he lost only 5% of his troops, while Napoleon's died in significant numbers.