Connective Tissue Disorders/Ehler Danlos, the ECM and Chronic Issues - MCAS, CIRS, POTS, CFS, IBS, Dystonias, Pain, Proprioceptive Disorders, ETC.!

[Persej]

I remember that Gaby mentioned that coffee gave her pain:

With time, I developed arthritis symptoms after coffee due to the aflatoxins. It didn't happened with organic aflatoxin-free coffees though. The aflatoxins create cross reaction with gluten-like proteins if I remember correctly.

Maybe it's aflatoxins and not caffeine. In my father's village many people have bone pains and that place is famous for high humidity which stimulates mold which creates aflatoxins.

 

[Fluffy]

I remember that Gaby mentioned that coffee gave her pain:



Maybe it's aflatoxins and not caffeine. In my father's village many people have bone pains and that place is famous for high humidity which stimulates mold which creates aflatoxins.

It could be, thought I drink organic it’s already expensive and I’m certain mycotoxin free coffee is even more so, so I’ll just quit.

And this from the article I posted caffeine might just simply be nasty!

Exposure of the fibroblasts to different concentrations of the alkaloid led to the inhibition of the newly synthesized collagen by 48.04% (2.38% ± SD; n=3), 72.90% (3.60% ± SD; n=3), and 92.12% (3.81% ± SD; n=3), respectively

 

[Persej]

Since you mentioned coffee, I tried today to drink again instant coffee with milk and to pay attention to how I would feel. I felt some positive effect on my mind that I don't feel when I drink plain coffee, and it had a strong diuretic effect, that I also don't have when I drink plain coffee. This was happening before, but I never paid attention to it. So I searched to find if it activates PPAR-α, and it does:

Caffeic and Chlorogenic Acids Synergistically Activate Browning Program in Human Adipocytes: Implications of AMPK- and PPAR-Mediated Pathways - PubMed

Caffeic acid (CA) and chlorogenic acid (CGA) are phenolic compounds claimed to be responsible for the metabolic effects of coffee and tea consumption. Along with their structural similarities, they share common mechanisms such as activation of the AMP-activated protein kinase (AMPK) signaling...

pubmed.ncbi.nlm.nih.gov

So it seems that polyphenols from coffee can also activate PPAR-α, but there is a problem with bioavailability with plain coffee. Just like with green tea where I also noticed the diuretic effect when taken with milk.

Cinnamic acid, found in cinnamon, also activates PPAR-α:

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model - PubMed

The response of the lysosomes, the waste clearance machinery of the cell, to different environmental stimuli is coordinated by a gene network with a master regulator Transcription factor EB (TFEB) at the core. Disruption of multiple facets of the lysosomal and autophagic network has been linked...

pubmed.ncbi.nlm.nih.gov