Connective Tissue Disorders/Ehler Danlos, the ECM and Chronic Issues - MCAS, CIRS, POTS, CFS, IBS, Dystonias, Pain, Proprioceptive Disorders, ETC.!

[Persej]

I remember that Gaby mentioned that coffee gave her pain:

With time, I developed arthritis symptoms after coffee due to the aflatoxins. It didn't happened with organic aflatoxin-free coffees though. The aflatoxins create cross reaction with gluten-like proteins if I remember correctly.

Maybe it's aflatoxins and not caffeine. In my father's village many people have bone pains and that place is famous for high humidity which stimulates mold which creates aflatoxins.

 

[Fluffy]

I remember that Gaby mentioned that coffee gave her pain:



Maybe it's aflatoxins and not caffeine. In my father's village many people have bone pains and that place is famous for high humidity which stimulates mold which creates aflatoxins.

It could be, thought I drink organic it’s already expensive and I’m certain mycotoxin free coffee is even more so, so I’ll just quit.

And this from the article I posted caffeine might just simply be nasty!

Exposure of the fibroblasts to different concentrations of the alkaloid led to the inhibition of the newly synthesized collagen by 48.04% (2.38% ± SD; n=3), 72.90% (3.60% ± SD; n=3), and 92.12% (3.81% ± SD; n=3), respectively

 

[Persej]

Since you mentioned coffee, I tried today to drink again instant coffee with milk and to pay attention to how I would feel. I felt some positive effect on my mind that I don't feel when I drink plain coffee, and it had a strong diuretic effect, that I also don't have when I drink plain coffee. This was happening before, but I never paid attention to it. So I searched to find if it activates PPAR-α, and it does:

Caffeic and Chlorogenic Acids Synergistically Activate Browning Program in Human Adipocytes: Implications of AMPK- and PPAR-Mediated Pathways - PubMed

Caffeic acid (CA) and chlorogenic acid (CGA) are phenolic compounds claimed to be responsible for the metabolic effects of coffee and tea consumption. Along with their structural similarities, they share common mechanisms such as activation of the AMP-activated protein kinase (AMPK) signaling...

pubmed.ncbi.nlm.nih.gov

So it seems that polyphenols from coffee can also activate PPAR-α, but there is a problem with bioavailability with plain coffee. Just like with green tea where I also noticed the diuretic effect when taken with milk.

Cinnamic acid, found in cinnamon, also activates PPAR-α:

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model - PubMed

The response of the lysosomes, the waste clearance machinery of the cell, to different environmental stimuli is coordinated by a gene network with a master regulator Transcription factor EB (TFEB) at the core. Disruption of multiple facets of the lysosomal and autophagic network has been linked...

pubmed.ncbi.nlm.nih.gov

 

[Gaby]

instant coffee with milk

Dairy products are DEADLY for people with conjonctive tissue anomalies to the extent that if they persist in consuming those products, they will not recover their health. It also favors an ill psychic hygiene. We came to call it "the dairy demon" as mirth. I noticed it actually depicted the reality pretty good : externally it looks like an uncontrolled addiction, but the energy favored is that one of "take over" or more spirit attachments. Normalization of behavior often is seen with the withdrawal of dairy.

People in this spectrum, and it's very evident in Ehler Danlos, are like the veritable canary in the coal mine.

Not saying this for you, but in general, synthesizing decades of experience witnessing the pattern among vulnerable people. Dairy is the one subject that you can always expect defenders and their multiple narratives to explain it's okay to consume it. Obviously, they're genetically resilient to it, or not: Did Civilization Arise to Deliver a Fix?

 

[Persej]

Dairy products are DEADLY for people with conjonctive tissue anomalies to the extent that if they persist in consuming those products, they will not recover their health. It also favors an ill psychic hygiene. We came to call it "the dairy demon" as mirth. I noticed it actually depicted the reality pretty good : externally it looks like an uncontrolled addiction, but the energy favored is that one of "take over" or more spirit attachments. Normalization of behavior often is seen with the withdrawal of dairy.

People in this spectrum, and it's very evident in Ehler Danlos, are like the veritable canary in the coal mine.

Not saying this for you, but in general, synthesizing decades of experience witnessing the pattern among vulnerable people. Dairy is the one subject that you can always expect defenders and their multiple narratives to explain it's okay to consume it. Obviously, they're genetically resilient to it, or not: Did Civilization Arise to Deliver a Fix?

I understand. My logic is if dairy can help with the absorption of polyphenols, and I can feel the effect of it, then I can go and try other things to see what else can be used to improve the absorption of polyphenols and give me the same effect. I plan to do that, but for now I use dairy as a reference point, because I don't feel the same effect with plain water.