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High Dose Intravenous Vitamin C (and other vitamin infusions)
- Thread starter Laura
- Start date
Thanks, no worries my daughter in law is Polish.
Attached as a PDF, "Response of Peripheral and Central Nerve Pathology to Mega-Doses of the Vitamin B-Complex and Other Metabolites" by Frederich R. Klenner, BS, MS, MD. Journal of Applied Nutrition, 1973
In this paper, Dr. Klenner described how he reversed multiple sclerosis with vitamin infusions. Here're some excerpts.
The protocol of how to effectively treat Multiple Sclerosis. (In two parts, as originally published in 1973.)
***
Importance of Thiamin Hydrochloride in Neurological Diseases
The importance of thiamin in treating Myasthenia Gravis and Multiple Sclerosis cannot be over-emphasized. Two molecules of thiamin hydrochloride in combination with two molecules of phosphoric acid is cocarboxylase. For the reaction to acetyl coenzyme A plus oxaloacetic acid to continue through to citric acid with the release of coenzyme A, cocarboxylase must be present. If this reaction does not take place, due to one of many factors, there will be no coenzyme A present to react with another molecule of pyruvic acid to set in motion the elements necessary for the continuance of the metabolic cycle. In thiamin deficiency, both pyruvates and lactate accumulate in the blood.
Pyruvates also accumulate at the neuro-muscular junction causing cloudy swelling of the distal portion of the nerves. Cocarboxylase, also known as diphosphothiamine, is necessary in the synthesis of acetyl-choline and in the control of its hydrolysis. The activity of choline esterase of serum is also strongly inhibited by cocarboxylase.
The chief chemical factor in both diseases is thiamin hydro-chloride. Other fractions of the B-complex are also essential but in lesser amounts. Myasthenia Gravis is due to genetic fault, most likely involving an intermediate lethal gene or group of genes. Multiple Sclerosis is more complex. The initial pathology is sickness caused by the Coxsackie virus. This virus mimics poliomyelitis, and for many years accounted for thousands of so-called polio cases. This virus, like the polioviruses, can cause paralysis but never permanently...
Early Use of Thiamin Hydrochloride in Neurological Diseases
In the late thirties, Stern1 from Columbia University, was employing thiamin hydrochloride intraspinally with astonishing results in Multiple Sclerosis. He reported taking patients to the operating room on a stretcher, and following 30 mg. thiamin given intraspinally, they would walk back to their room. The response was relatively transient, but it led Stern to believe that Multiple Sclerosis was nothing more than vitamin B1 avitaminosis, the modus operandi being damage to the filter bed of the choroid plexus. Stern also found that the effective dose of vitamin B1, when given in the lumbar subarachnoid space, was too close to the lethal dose as was demonstrated in dogs. Sterns hypothesis was backed by the knowledge that degeneration of the myelin sheaths of peripheral nerves as well as of the ganglion cells of the brain and spinal cord can be produced in experimental polyneuritis. Similar findings are observed in starvation, even when the supply of thiamin appears to be adequate. One school of thought regards the neurological syndrome of polyneuritis as a functional defect concerned with the neurons. From 30 years of observation, I am certain that in Myasthenia Gravis and Multiple Sclerosis, it is not a functional defect, nor is it due to impaired diffusion which would deny to the total metabolism sufficient quantities of the vitamin to satisfy the requirements of the neuro-muscular systems. The problem is supply and demand. In this light, Dr. Leon Rosenberg2 of Yale University Medical School, in working with B vitamins, distinguishes between vitamin-deficiency diseases and vitamin-dependent diseases. He states that the successful treatment of vitamin-dependent diseases requires dosages up to 1,000 times the calculated minimal daily requirement. 1.3 mg. has been established for thiamin hydrochloride which would indicate that in the pathological conditions being considered, the daily requirement would be at least 1300 mg. Moore3, in 1940, published a monograph on the use of high intravenous doses of nicotinic acid for the cure
of Multiple Sclerosis. Moore employed a drug combination called Nicobee. This preparation contained 100 mg. nicotinic acid and 60 mg. of thiamin in each 10cc solution.
Many of the components of the B-complex must also be administered in varying amounts, along with thiamin hydrochloride, since they too exert a dynamic influence in general metabolism. Many believe that the B vitamins are actually metabolic reagents. Hoagland has referred to them as protective catalysts.
Part II: Recommended Treatment Schedule
1) Thiamin hydrochloride: 300mg to 500mg, 30 minutes before meals and bed hour, and during the night if awake. The higher amounts in long-standing cases. This requirement is high, since much is lost through action of gastric juices and loss due to perspiration; 400 mg. daily by needle, given intramuscularly. During summer months this can be given every 12 hours to good advantage. Two to three times each week, and where office access is convenient, 20 mg. per kg. body weight, or at least 1000 mg. is administered intravenously. This is given with 100 mg to 200 mg. Niacin (nicotinic acid) which is available 100 mg. in 10cc ampules. (The concentrated Niacin, available in 30cc vials, must be diluted if employed intravenously.) The intravenous dose is given with the patient in a recumbent
position. A 20cc to 30cc syringe, carrying a one-inch 22-gauge needle should be employed. The injection is given slowly (5 to 7 minutes) holding the syringe with one hand. The usually-employed three fingers of the other hand must be on the patients pulse. An increased pulse rate indicates too fast a flow of the medicine. This indicates the rate of phosphorylization. Thiamin hydrochloride is, indeed, a toxic substance, and anaphylactic reactions have been reported, but I have never seen a case in treating thousands of patients, (not necessarily Myasthenia Gravis or Multiple Sclerosis), in 30 years of clinical observation. I have observed one case of extreme sensitivity in which itching was
present within one minute after an intramuscular injection of 100mg. This was immediately controlled with 5cc Benadryl, IM. It must be remembered that once thiamin hydrochloride is phosphorylated, it is no longer a critical allergic substance, but is cocarboxylase, a necessary but absolutely harmless agent. (My problem has been the preservatives now required by FDA regulations, and they should be removed.) Higher doses of thiamin can be used, but then the dilution factor must be greater.
2) Niacin (nicotinic acid): We recommend 100mg to 3 grams, thirty minutes before meals and at bed hour, and also during the night if awake whichever dose will produce a strong body flush. Niacin dilates the blood vessels, even those that have been compressed by scar tissue, allowing a greater amount of nutrient material to reach the cell laboratory or factor comprising muscles and nerves. This constant, repeated dilatation of the blood vessels acts in the same manner as the dilating urethral catheter to correct constriction. One is chemical, the other is mechanical. Hot fluids taken at the same time as the niacin will enhance the flush. Pyridoxine has been a suggested stimulant. The lack
of constant flushing in Multiple Sclerosis is disappointing but not hopeless. It will require a longer time to achieve results. Many times patients will flush with intramuscular niacin when they fail to flush by the oral route. An occasional patient will experience the sensation of a chill following nicotinic acid flush. This is transient and of no consequence. Food, even jelly beans or a glass of milk, will prevent or minimize the experience. Some patients will flush sometimes and not at other times, even during a single day. If no flush develops within 45 minutes, the dose should be repeated. A delayed reaction of several hours can occur, and should this be superimposed upon a previous medication, the result could be severe. Do not scratch when itching from niacin. Just press the area with your fingers,
or better still, with a cube of ice. Antihistamines will stop the itching and limit the flush, should this be necessary.
Niacin should be given very slowly by the intravenous route in the geriatric patient, with or without cardiac pathology, since it can produce dilatation great enough to effect right-side heart failure.
Myasthenia Gravis patients sometimes attain geriatric status. Vasomotor collapse of peripheral vessels, although rare, can occur. Eight mg. Decadron given IM will reverse this condition.
3) Pyridoxine (Vitamin B6): Lack of this vitamin has been shown to induce microcytic hypochromic anemia and neurologic lesions in dogs and pigs. The term B6 includes not only pyridoxine, but also pyridoxal and pyridoxamine, all three compounds being found in nature. These derivatives have biological activity equal to that of pyridoxine, as demonstrated in rats. Pyridoxine plays a part in the metabolism of unsaturated fatty acids. It is also important in the metabolism of amino acids. Pyridoxal phosphate functions as a coenzyme, and in transamination reactions; 100mg to 200mg is given before meals and bed hour. At least 100mg daily is given intramuscularly.
4) Cobalamin (Vitamin B12): It is thought that vitamin B12 acts as a catalyst in the formation of the purine and pyrimidine deoxyribosides which are present in deoxyribonucleic acid. Technically, B12 is cyanocobalamin. Vitamin B12 with pterylglutamic reduces the requirement for choline essential in the treatment of neurological diseases; 1000mcg. is given three times each week by needle (repository type). The incident of dermatitis from continued use of vitamin B12 by needle is roughly 15%. I have never seen this develop in a patient with Myasthenia Gravis or Multiple Sclerosis. B12 is recognized as a factor in the synthesis of myelin.
5) Ascorbic Acid (Vitamin C): The use of high daily doses of vitamin C will prevent a superimposed illness and will lend itself in metabolism. Ten to twenty grams should be taken daily by mouth in divided doses.
6) Riboflavin (Vitamin B2): A deficiency of vitamin B2 in young animals results in inhibition of growth
terminated by death. The yellow enzyme can, as demonstrated by Warburg and Christian, participate in a series of enzyme reactions involved in the metabolism of carbohydrates. It is capable of transporting hydrogen from reduced coenzyme II, a niacin coenzyme which attacks hexosemonophosphate, regenerating the riboflavin phosphate-protein complex. Riboflavin also takes part in enzymic reactions as a dinucleotide prosthetic group, consisting of riboflavin, two phosphoric acids, ribose and adenine. Riboflavin is very important in the regulatory function of the hormones involved in carbohydrate metabolism. It is classified as a low-energy package; 40mg to 80mg given daily by needle
IM; 25 mg. before meals and bedtime.
7) Vitamin E as d-alpha tocopherol acetate of d-alpha tocopherol acid succinate. The latter is more practical since it is a pure form. Complex biochemical changes in the muscle tissue in chronic vitamin E deficiency are followed by histological lesions characteristic of muscular dystrophy. Deficiency has also been shown to produce demyelinization and distortion of the axon pattern in the spinal cord, giving rise to hypalgesia and progressive paresis. Fatal massive liver necrosis occurs in animals maintained on diets low in vitamin E and sulfur-containing amino acids; 800 international units before meals and bedtime must be adhered to in this treatment.
8) Crude liver: This substance contains factors still unknown but essential in metabolism. Patients with pernicious anemia often show neurological involvement, and are tremendously benefited by liver injections which, of course, contain vitamin B12. Degenerative changes brought on by other factors, therefore, can also be benefited by daily injections of crude liver.
9) Adenosine-5-Monophosphoric acid: One of the purine bases occurring in muscle is adenine. It, along with other purines, exists in various forms. Adenosine polyphosphate is of primary interest in this discussion. The basic structure is adenosine, adenine-9-riboside. This is esterified with phosphoric acid at the 5-position of the ribofuranose, to form adenosine-5-phosphoric acid, also known as adenosinemonophosphate (AMP). Inosinic acid is a commonly occurring breakdown product of AMP, formed by deamination in muscle extract. Myosin displays enzymic activity similar to adenylic deaminase. By attaching further phosphoric acid residues in pyrophosphate linkage, adenosinediphosphate (ADP) and adenosinetriphosphate (ATP) are obtained. ATP, as previously noted, is the energy package essential for life. By adding this to our treatment, we enhance all chemistry dealing with cell metabolism.
10) Choline: Choline is a structural component of fat and nerve tissue, thus has a strong relationship to the phospholipids and to its acetyl ester. Acetylcholine plays an important role in the humoral transmission of parasympathetic and other nerve impulses to effector organs. It also plays a part in transmethylation. Choline serves as a methylating agent in the physiological process guanidoacetic acid to creatine. We give 700mg to 1400mg after each meal and at bed hour.
11) Lecithin: Lecithin is the glyceryl ester of a pair of fatty acids and a substituted phosphoric acid group attached to a choline radical. Choline is one of the products of lecithin, representing about 15% of the molecule. Lecithin placed in water and observed under the microscope, will diffuse out, forming long, curving strands (myelin forms). The hydrophilic nature of the lecithin molecule plays an important part in the structure and properties of cell membranes. It is the lipid used in nerve tissue. We give 1200 mg. Soybean Lecithin after each meal.
12) Magnesium: 100mg. after each meal to supply additional ions for muscle activity. It is an enzyme activator.
13) Calcium Gluconate (10 grain tablets): We give two tablets after each meal and at bed hour to supplement dietary intake for muscle activity. At times, this is given intravenously, one gram twice weekly.
14) Calcium pantothenate: The physiologically active form of pantothenic acid is coenyzme A. Its acetyl derivative (acetyl CoA) is synonymous with active acetate. Metabolic transformations are very complex and involve numerous enzymes and coenzymes. Coenzyme A participates in the acetylation of amines. The pantothenic acid coenzyme plays a vital role in carbohydrate metabolism and acetyl transfer also occurs in the metabolism of fatty acids. We give 200 mg. after each meal and at bed hour.
15) Aminoacetic acid (glycine): Glycine enters into a variety of metabolic functions. It is directly concerned in the synthesis of glutathione, the tripeptide which plays an important part in intracellular oxidation and reduction. Rapport and Katz have shown that when glycine is added to perfused muscle, the oxygen absorption is 40% higher than otherwise, indicating that the presence of this amino acid stimulates the combustion of other tissue constituents. To the body in general, glycine is no doubt most important because of its wide adaptability in the detoxicating process of the body. More than one hundred substances, when fed, are joined in the body with glycine. In the deamination of glycine, three products will be formed: ammonia, carbon dioxide and water. The ammonia from this reaction is then
quantitatively converted to urea. One heaping tablespoon of the powder in a glass of milk four times each day. Much of the oral medication can be taken with this drink.
16) Make certain that the hemoglobin is at least 13 grams.
17) High protein diet with two to three eggs for breakfast.
18) One Theragram-M cap. daily for trace minerals.
19) Dantrium has value for relieving intentional tremor and Symmetrel for relieving stiffness in Multiple
Sclerosis. Dose must be individualized.
20) Zinc gluconate: 10 mg. three times each day has some value in Myasthenia Gravis. Take several hours after vitamin B2.
This treatment works so dramatically in Myasthenia Gravis, that should a given patients physician refuse to administer this schedule, I have this recommendation: One gram thiamin hydrochloride one hour before meals and at bed hour, and during the night if awake. Niacin taken at the same time, and in amounts sufficient to produce a good body flush. Two hundred mg. calcium pantothenate and 100mg pyridoxine before meals and at bed hour. Ten grams ascorbic acid, taken in divided doses. Amino acetic acid: one heaping tablespoon in a glass of milk, four times each day. Naturally, the full schedule will afford more dramatic response.
For a long time it has seemed to me that virus bodies might have the potential to alter their protein coat, and therefore their dimension, and become another virus for another disease. In our long practice, we would see, as I am certain many of you have, chickenpox just before Thanksgiving, mumps by Christmas, red measles in the Spring, and polio or a virus mimicking polio in the Summer. German measles, virus colds, and virus pneumonitis just about any time...
Appendix
Since presenting this paper, we have observed that improvement in all categories is enhanced when the intravenous injection contains 800 mg. to 1000 mg. thiamin hydrochloride, 200 mg. pyridoxine, 400 mg. niacinamide, 100 mg. nicotinic acid. The thiamin hydrochloride solution must be clear. The amount of niacin employed must be calculated from the flush factor of a given patient. The injection is made with a 20cc or 30cc syringe, using a 23G x 3/4 inch or 22G x 1 inch needle. Intravenous medication can be given daily; it should be administered at least twice weekly. Due
to sensitivity possibilities, we always have the patient take the intramuscular injections for three weeks before starting intravenous therapy.
In this paper, Dr. Klenner described how he reversed multiple sclerosis with vitamin infusions. Here're some excerpts.
The protocol of how to effectively treat Multiple Sclerosis. (In two parts, as originally published in 1973.)
***
Importance of Thiamin Hydrochloride in Neurological Diseases
The importance of thiamin in treating Myasthenia Gravis and Multiple Sclerosis cannot be over-emphasized. Two molecules of thiamin hydrochloride in combination with two molecules of phosphoric acid is cocarboxylase. For the reaction to acetyl coenzyme A plus oxaloacetic acid to continue through to citric acid with the release of coenzyme A, cocarboxylase must be present. If this reaction does not take place, due to one of many factors, there will be no coenzyme A present to react with another molecule of pyruvic acid to set in motion the elements necessary for the continuance of the metabolic cycle. In thiamin deficiency, both pyruvates and lactate accumulate in the blood.
Pyruvates also accumulate at the neuro-muscular junction causing cloudy swelling of the distal portion of the nerves. Cocarboxylase, also known as diphosphothiamine, is necessary in the synthesis of acetyl-choline and in the control of its hydrolysis. The activity of choline esterase of serum is also strongly inhibited by cocarboxylase.
The chief chemical factor in both diseases is thiamin hydro-chloride. Other fractions of the B-complex are also essential but in lesser amounts. Myasthenia Gravis is due to genetic fault, most likely involving an intermediate lethal gene or group of genes. Multiple Sclerosis is more complex. The initial pathology is sickness caused by the Coxsackie virus. This virus mimics poliomyelitis, and for many years accounted for thousands of so-called polio cases. This virus, like the polioviruses, can cause paralysis but never permanently...
Early Use of Thiamin Hydrochloride in Neurological Diseases
In the late thirties, Stern1 from Columbia University, was employing thiamin hydrochloride intraspinally with astonishing results in Multiple Sclerosis. He reported taking patients to the operating room on a stretcher, and following 30 mg. thiamin given intraspinally, they would walk back to their room. The response was relatively transient, but it led Stern to believe that Multiple Sclerosis was nothing more than vitamin B1 avitaminosis, the modus operandi being damage to the filter bed of the choroid plexus. Stern also found that the effective dose of vitamin B1, when given in the lumbar subarachnoid space, was too close to the lethal dose as was demonstrated in dogs. Sterns hypothesis was backed by the knowledge that degeneration of the myelin sheaths of peripheral nerves as well as of the ganglion cells of the brain and spinal cord can be produced in experimental polyneuritis. Similar findings are observed in starvation, even when the supply of thiamin appears to be adequate. One school of thought regards the neurological syndrome of polyneuritis as a functional defect concerned with the neurons. From 30 years of observation, I am certain that in Myasthenia Gravis and Multiple Sclerosis, it is not a functional defect, nor is it due to impaired diffusion which would deny to the total metabolism sufficient quantities of the vitamin to satisfy the requirements of the neuro-muscular systems. The problem is supply and demand. In this light, Dr. Leon Rosenberg2 of Yale University Medical School, in working with B vitamins, distinguishes between vitamin-deficiency diseases and vitamin-dependent diseases. He states that the successful treatment of vitamin-dependent diseases requires dosages up to 1,000 times the calculated minimal daily requirement. 1.3 mg. has been established for thiamin hydrochloride which would indicate that in the pathological conditions being considered, the daily requirement would be at least 1300 mg. Moore3, in 1940, published a monograph on the use of high intravenous doses of nicotinic acid for the cure
of Multiple Sclerosis. Moore employed a drug combination called Nicobee. This preparation contained 100 mg. nicotinic acid and 60 mg. of thiamin in each 10cc solution.
Many of the components of the B-complex must also be administered in varying amounts, along with thiamin hydrochloride, since they too exert a dynamic influence in general metabolism. Many believe that the B vitamins are actually metabolic reagents. Hoagland has referred to them as protective catalysts.
Part II: Recommended Treatment Schedule
1) Thiamin hydrochloride: 300mg to 500mg, 30 minutes before meals and bed hour, and during the night if awake. The higher amounts in long-standing cases. This requirement is high, since much is lost through action of gastric juices and loss due to perspiration; 400 mg. daily by needle, given intramuscularly. During summer months this can be given every 12 hours to good advantage. Two to three times each week, and where office access is convenient, 20 mg. per kg. body weight, or at least 1000 mg. is administered intravenously. This is given with 100 mg to 200 mg. Niacin (nicotinic acid) which is available 100 mg. in 10cc ampules. (The concentrated Niacin, available in 30cc vials, must be diluted if employed intravenously.) The intravenous dose is given with the patient in a recumbent
position. A 20cc to 30cc syringe, carrying a one-inch 22-gauge needle should be employed. The injection is given slowly (5 to 7 minutes) holding the syringe with one hand. The usually-employed three fingers of the other hand must be on the patients pulse. An increased pulse rate indicates too fast a flow of the medicine. This indicates the rate of phosphorylization. Thiamin hydrochloride is, indeed, a toxic substance, and anaphylactic reactions have been reported, but I have never seen a case in treating thousands of patients, (not necessarily Myasthenia Gravis or Multiple Sclerosis), in 30 years of clinical observation. I have observed one case of extreme sensitivity in which itching was
present within one minute after an intramuscular injection of 100mg. This was immediately controlled with 5cc Benadryl, IM. It must be remembered that once thiamin hydrochloride is phosphorylated, it is no longer a critical allergic substance, but is cocarboxylase, a necessary but absolutely harmless agent. (My problem has been the preservatives now required by FDA regulations, and they should be removed.) Higher doses of thiamin can be used, but then the dilution factor must be greater.
2) Niacin (nicotinic acid): We recommend 100mg to 3 grams, thirty minutes before meals and at bed hour, and also during the night if awake whichever dose will produce a strong body flush. Niacin dilates the blood vessels, even those that have been compressed by scar tissue, allowing a greater amount of nutrient material to reach the cell laboratory or factor comprising muscles and nerves. This constant, repeated dilatation of the blood vessels acts in the same manner as the dilating urethral catheter to correct constriction. One is chemical, the other is mechanical. Hot fluids taken at the same time as the niacin will enhance the flush. Pyridoxine has been a suggested stimulant. The lack
of constant flushing in Multiple Sclerosis is disappointing but not hopeless. It will require a longer time to achieve results. Many times patients will flush with intramuscular niacin when they fail to flush by the oral route. An occasional patient will experience the sensation of a chill following nicotinic acid flush. This is transient and of no consequence. Food, even jelly beans or a glass of milk, will prevent or minimize the experience. Some patients will flush sometimes and not at other times, even during a single day. If no flush develops within 45 minutes, the dose should be repeated. A delayed reaction of several hours can occur, and should this be superimposed upon a previous medication, the result could be severe. Do not scratch when itching from niacin. Just press the area with your fingers,
or better still, with a cube of ice. Antihistamines will stop the itching and limit the flush, should this be necessary.
Niacin should be given very slowly by the intravenous route in the geriatric patient, with or without cardiac pathology, since it can produce dilatation great enough to effect right-side heart failure.
Myasthenia Gravis patients sometimes attain geriatric status. Vasomotor collapse of peripheral vessels, although rare, can occur. Eight mg. Decadron given IM will reverse this condition.
3) Pyridoxine (Vitamin B6): Lack of this vitamin has been shown to induce microcytic hypochromic anemia and neurologic lesions in dogs and pigs. The term B6 includes not only pyridoxine, but also pyridoxal and pyridoxamine, all three compounds being found in nature. These derivatives have biological activity equal to that of pyridoxine, as demonstrated in rats. Pyridoxine plays a part in the metabolism of unsaturated fatty acids. It is also important in the metabolism of amino acids. Pyridoxal phosphate functions as a coenzyme, and in transamination reactions; 100mg to 200mg is given before meals and bed hour. At least 100mg daily is given intramuscularly.
4) Cobalamin (Vitamin B12): It is thought that vitamin B12 acts as a catalyst in the formation of the purine and pyrimidine deoxyribosides which are present in deoxyribonucleic acid. Technically, B12 is cyanocobalamin. Vitamin B12 with pterylglutamic reduces the requirement for choline essential in the treatment of neurological diseases; 1000mcg. is given three times each week by needle (repository type). The incident of dermatitis from continued use of vitamin B12 by needle is roughly 15%. I have never seen this develop in a patient with Myasthenia Gravis or Multiple Sclerosis. B12 is recognized as a factor in the synthesis of myelin.
5) Ascorbic Acid (Vitamin C): The use of high daily doses of vitamin C will prevent a superimposed illness and will lend itself in metabolism. Ten to twenty grams should be taken daily by mouth in divided doses.
6) Riboflavin (Vitamin B2): A deficiency of vitamin B2 in young animals results in inhibition of growth
terminated by death. The yellow enzyme can, as demonstrated by Warburg and Christian, participate in a series of enzyme reactions involved in the metabolism of carbohydrates. It is capable of transporting hydrogen from reduced coenzyme II, a niacin coenzyme which attacks hexosemonophosphate, regenerating the riboflavin phosphate-protein complex. Riboflavin also takes part in enzymic reactions as a dinucleotide prosthetic group, consisting of riboflavin, two phosphoric acids, ribose and adenine. Riboflavin is very important in the regulatory function of the hormones involved in carbohydrate metabolism. It is classified as a low-energy package; 40mg to 80mg given daily by needle
IM; 25 mg. before meals and bedtime.
7) Vitamin E as d-alpha tocopherol acetate of d-alpha tocopherol acid succinate. The latter is more practical since it is a pure form. Complex biochemical changes in the muscle tissue in chronic vitamin E deficiency are followed by histological lesions characteristic of muscular dystrophy. Deficiency has also been shown to produce demyelinization and distortion of the axon pattern in the spinal cord, giving rise to hypalgesia and progressive paresis. Fatal massive liver necrosis occurs in animals maintained on diets low in vitamin E and sulfur-containing amino acids; 800 international units before meals and bedtime must be adhered to in this treatment.
8) Crude liver: This substance contains factors still unknown but essential in metabolism. Patients with pernicious anemia often show neurological involvement, and are tremendously benefited by liver injections which, of course, contain vitamin B12. Degenerative changes brought on by other factors, therefore, can also be benefited by daily injections of crude liver.
9) Adenosine-5-Monophosphoric acid: One of the purine bases occurring in muscle is adenine. It, along with other purines, exists in various forms. Adenosine polyphosphate is of primary interest in this discussion. The basic structure is adenosine, adenine-9-riboside. This is esterified with phosphoric acid at the 5-position of the ribofuranose, to form adenosine-5-phosphoric acid, also known as adenosinemonophosphate (AMP). Inosinic acid is a commonly occurring breakdown product of AMP, formed by deamination in muscle extract. Myosin displays enzymic activity similar to adenylic deaminase. By attaching further phosphoric acid residues in pyrophosphate linkage, adenosinediphosphate (ADP) and adenosinetriphosphate (ATP) are obtained. ATP, as previously noted, is the energy package essential for life. By adding this to our treatment, we enhance all chemistry dealing with cell metabolism.
10) Choline: Choline is a structural component of fat and nerve tissue, thus has a strong relationship to the phospholipids and to its acetyl ester. Acetylcholine plays an important role in the humoral transmission of parasympathetic and other nerve impulses to effector organs. It also plays a part in transmethylation. Choline serves as a methylating agent in the physiological process guanidoacetic acid to creatine. We give 700mg to 1400mg after each meal and at bed hour.
11) Lecithin: Lecithin is the glyceryl ester of a pair of fatty acids and a substituted phosphoric acid group attached to a choline radical. Choline is one of the products of lecithin, representing about 15% of the molecule. Lecithin placed in water and observed under the microscope, will diffuse out, forming long, curving strands (myelin forms). The hydrophilic nature of the lecithin molecule plays an important part in the structure and properties of cell membranes. It is the lipid used in nerve tissue. We give 1200 mg. Soybean Lecithin after each meal.
12) Magnesium: 100mg. after each meal to supply additional ions for muscle activity. It is an enzyme activator.
13) Calcium Gluconate (10 grain tablets): We give two tablets after each meal and at bed hour to supplement dietary intake for muscle activity. At times, this is given intravenously, one gram twice weekly.
14) Calcium pantothenate: The physiologically active form of pantothenic acid is coenyzme A. Its acetyl derivative (acetyl CoA) is synonymous with active acetate. Metabolic transformations are very complex and involve numerous enzymes and coenzymes. Coenzyme A participates in the acetylation of amines. The pantothenic acid coenzyme plays a vital role in carbohydrate metabolism and acetyl transfer also occurs in the metabolism of fatty acids. We give 200 mg. after each meal and at bed hour.
15) Aminoacetic acid (glycine): Glycine enters into a variety of metabolic functions. It is directly concerned in the synthesis of glutathione, the tripeptide which plays an important part in intracellular oxidation and reduction. Rapport and Katz have shown that when glycine is added to perfused muscle, the oxygen absorption is 40% higher than otherwise, indicating that the presence of this amino acid stimulates the combustion of other tissue constituents. To the body in general, glycine is no doubt most important because of its wide adaptability in the detoxicating process of the body. More than one hundred substances, when fed, are joined in the body with glycine. In the deamination of glycine, three products will be formed: ammonia, carbon dioxide and water. The ammonia from this reaction is then
quantitatively converted to urea. One heaping tablespoon of the powder in a glass of milk four times each day. Much of the oral medication can be taken with this drink.
16) Make certain that the hemoglobin is at least 13 grams.
17) High protein diet with two to three eggs for breakfast.
18) One Theragram-M cap. daily for trace minerals.
19) Dantrium has value for relieving intentional tremor and Symmetrel for relieving stiffness in Multiple
Sclerosis. Dose must be individualized.
20) Zinc gluconate: 10 mg. three times each day has some value in Myasthenia Gravis. Take several hours after vitamin B2.
This treatment works so dramatically in Myasthenia Gravis, that should a given patients physician refuse to administer this schedule, I have this recommendation: One gram thiamin hydrochloride one hour before meals and at bed hour, and during the night if awake. Niacin taken at the same time, and in amounts sufficient to produce a good body flush. Two hundred mg. calcium pantothenate and 100mg pyridoxine before meals and at bed hour. Ten grams ascorbic acid, taken in divided doses. Amino acetic acid: one heaping tablespoon in a glass of milk, four times each day. Naturally, the full schedule will afford more dramatic response.
For a long time it has seemed to me that virus bodies might have the potential to alter their protein coat, and therefore their dimension, and become another virus for another disease. In our long practice, we would see, as I am certain many of you have, chickenpox just before Thanksgiving, mumps by Christmas, red measles in the Spring, and polio or a virus mimicking polio in the Summer. German measles, virus colds, and virus pneumonitis just about any time...
Appendix
Since presenting this paper, we have observed that improvement in all categories is enhanced when the intravenous injection contains 800 mg. to 1000 mg. thiamin hydrochloride, 200 mg. pyridoxine, 400 mg. niacinamide, 100 mg. nicotinic acid. The thiamin hydrochloride solution must be clear. The amount of niacin employed must be calculated from the flush factor of a given patient. The injection is made with a 20cc or 30cc syringe, using a 23G x 3/4 inch or 22G x 1 inch needle. Intravenous medication can be given daily; it should be administered at least twice weekly. Due
to sensitivity possibilities, we always have the patient take the intramuscular injections for three weeks before starting intravenous therapy.
The Mayo Clinic study protocol was designed by Linus Pauling and Ewan Cameron. The Mayo Clinic didn't come close to following the protocols set forth by Pauling. Mayo intentionally scuttled the study. I have a sneaking suspicion that Cameron glommed onto Pauling with promises of a formalized Mayo Clinic study. He was connected. What Ewan Cameron, a psychiatrist, was even doing involved in the C study remains a mystery to me. He was the CIA affiliated mastermind in some of the more odious parts of the MK ULTRA program... as if the whole program wasn't horrifying enough.
I spent the final eight years of my working life as the assistant to the founder/CEO of Alacer Corp, at one time the largest manufacturer of vitamin C products in North America. He designed for Dr Irwin Stone a method of delivering into the body, orally, all eight of the mineral ascorbates which complete the vitamin C complex, as opposed to just sodium ascorbate. He was also working with Pauling and pioneer Canadian vitamin C researcher, Dr. Abram Hoffer. I was privy to the never ending hoops and hurdles that the FDA, as well as the entire medical establishment, were constantly setting up to derail any significant studies or clinical research progress.
Unfortunately, I see nothing in the future whereby the establishment changes tack and embraces vitamin C.
Footnote: When Jay Patrick, the founder of Alacer Corp, died at the age of 92, within a few months Pfizer Pharmaceuticals swooped in and bought the company. At the time of Patrick's death, he was working on a way to stabilize and store an IV solution containing all 8 of the mineral ascorbates, 5 of which are too unstable for long shelf life. Little doubt Pfizer deep sixed that work.
In honor of little Herbie's inspirational story, and to celebrate my 70th YT video, I made a Mass Consumption version:
You can never have too many hedgehog videos.
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We haven't seen him since, and I hope he's out feasting on fat snails now, but whatever he's doing...I'm pretty certain that he was suffering from a tick borne disease and that the vitamin C saved his little life.
Oh, and his name was Herbie:
Such a happy ending, thank you for sharing the story Andromeda!
I watched the video with the dubbing before I read the story, no wonder Herbie was so thirsty if the vitamin C drink was helping him heal! 
Clearly hedgehogs are better at listening to what their bodies need than many people 
In honor of little Herbie's inspirational story, and to celebrate my 70th YT video, I made a Mass Consumption version:
(...)
You can never have too many hedgehog videos.
Agreed, they're total cuties! They used to live in my grandparents' garden when I was little, those tiny noses and shiny little eyes are really adorable
Scottie this video is delicious. You have an excellent voice for little animals, you can become millionaire giving your voice for Walt Disney stories, I am sure. jeje.In honor of little Herbie's inspirational story, and to celebrate my 70th YT video, I made a Mass Consumption version:
You can never have too many hedgehog videos.
Congratulations for the movie. I give an Oscar for the best hedgehog movie.
Here's a good documentary to recommend and/or watch with friends and family members:
An experienced Irish journalist is completely astounded when he hears that his +30 years old friend recovers his health with diet and supplements, so he decides to travel to the Americas to interview several proponents of this way of healing: Sayer Ji, Mercola, Dr. Gaby, the head of the Riordan Clinic, Dr. Levy, Andrew Saul and his daughter, etc...
He chooses to focus on researchers working with the megadosing concept because obviously that is what caught his attention the most.
It is a great documentary introducing this concept of healing and although they cover IV infusions, they mainly highlight the benefit of taking supplements and often a bunch of them like titrating vitamin C to bowel tolerance.
Highly recommended!
Watch That Vitamin Movie | Prime Video
That Vitamin Movie shows that there is a safer, more effective and cheaper way to tackle illness instead of prescription drugs. It reveals a 'hidden' 65-year history demonstrating that vitamins and supplements work. Over 20 of the world's leading nutritional experts give plain and simple advice...
www.amazon.com
An experienced Irish journalist is completely astounded when he hears that his +30 years old friend recovers his health with diet and supplements, so he decides to travel to the Americas to interview several proponents of this way of healing: Sayer Ji, Mercola, Dr. Gaby, the head of the Riordan Clinic, Dr. Levy, Andrew Saul and his daughter, etc...
He chooses to focus on researchers working with the megadosing concept because obviously that is what caught his attention the most.
It is a great documentary introducing this concept of healing and although they cover IV infusions, they mainly highlight the benefit of taking supplements and often a bunch of them like titrating vitamin C to bowel tolerance.
Highly recommended!
I concur with Gaby, this a highly recommended documentary film for watching with family members who may have medical conditions that would benefit from the information contained within. It is a film for the layman, and covers not only Vit C, also a whole host of other vitamins too. It is very easy to watch, and is even quite amuzing at times, yet it gets its message across easily and with force about the benefits of taking vitamins.
I watched that too and I was personally surprised at how many other vitamins can be used in high doses with almost miraculous effects - not just C, but vitamin D and B3, for example. As an introduction to the topic the movie is great, although at points I personally wished they had gone a bit deeper into the science behind the healing mechanism of vitamins. They did explain, however, how vitamin C kills cancer cells, and one of the interviewed even mentioned that it can make cells regress from being cancer cells back into normal cells!
I'd like to share a quote I found in a book about vitamin C. The book is written in Spanish, and has not been translated, but I found the same quote on: DoctorYourself.com - Cancer Therapy: Vitamin C
Actually this is not a quote but an essay, written by Abram Hoffer, who is considered the father of orthomolecular therapy, according to the writer of the book. There are many cases he descibes, but the most interesting is that, this essay motivated many physicians to use vitamin C in their treatments
Actually this is not a quote but an essay, written by Abram Hoffer, who is considered the father of orthomolecular therapy, according to the writer of the book. There are many cases he descibes, but the most interesting is that, this essay motivated many physicians to use vitamin C in their treatments
Fascinating reading!
Yes! And treating psychotic patients - that's amazing!
Can you share the title of the book in Spanish?
