High Dose Melatonin Therapy

Andrian said:
Hi all, I would like to ask you a small advice please, so lately I'm working during the night and I'm able to take melatonin only a couple of days a week when I'm not working. As far as I understood it is not advisable to take the melatonin in the morning though I was still wondering if in my case it will be wise to take it in the morning before going to sleep or better not to? Thank you kindly for your assistance.
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That's how night shift workers are supposed to take it - before going to bed in the morning after the night shift. Hope it helps!
 
anartist said:
I do find it interesting that there is a difference between older and younger people. And I had another thought about the serum levels of melatonin in connection with something Gaby posted earlier. Since the younger supplementers of melatonin don't keep higher serum levels of melatonin, this would account for younger users waking up when their melatonin levels dropped, their bodies interpreting the decrease in melatonin as a signal to wake up. But it does not seem to result in a cortisol increase, if it did then it would be difficult to get back to sleep!?
Although some may have a hard time going back to sleep for that reason? hard to say, but JUST melatonin dropping does not seem to increase cortisol, so there are more signals/information that have to be available for the body to increase cortisol.

What seems to work for me is taking 6mg of melatonin orally a few hours before bed, then taking 5-6mg melatonin sublingually when I go to bed. When I first started taking melatonin at 3mg sublingual years ago, I did feel groggy at times the following morning, and I did have vivid dreams. Now I don't seem to have either reaction. I also take B12 sublingually at the same time, so this probably reduces the effectiveness of the melatonin, but how much? My B12 is high at around 989pmol/L, so I will stop taking it for a while, and keep the melatonin at the same level, and see if there is any change, particularly in drowsiness or dreams.
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Well it has been about two weeks of melatonin only, rather than melatonin and B12 together. I have not noticed much difference but it does seem that I am having better sleep. The very first night without B12 my REM went way down to 0, then bounced back up the following nights going up and down between an hour and 2 hours, and in the last week is pretty solid at 1h45m a night. My deep sleep stayed pretty much the same, averaging an hour a night, but in the past week it has gone down to about 0.75-1.0h per night. There are so many variables in play that it is difficult to assess what affect removing sublingual B12 from my nightly melatonin regime has had, though I can report that while I am not remembering my dreams, I have experienced a dim recall of dreams when awakening which is a change.
I can report something that I have not noticed before which is that last Friday (20Mar) my deep sleep appeared on and off ALL night(1h deep, 1.5h REM), which is very strange as until then, and since, my deep sleep has always occurred in the first part of the night, followed by REM sleep.
 
Since melatonin can protect our DNA from a corona-vaccine
And the doses of melatonin are related to age and young people need less, then I would like to clarify what doses are needed for people aged 20+ years
 
Artem Yalovyi said:
Yes, I saw this chart, but it starts at the age of 40, so I ask for those younger (20-40)
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Read my summary of the book "Melatonin: Breakthrough Discoveries That Can Help You Combat Aging, Boost Your Immune System, Reduce Your Risk of Cancer and Heart Disease, Get a Better Night's Sleep" by Russel Reiter starting here:

cassiopaea.org

High Dose Melatonin Therapy

I finished reading "Melatonin: Breakthrough Discoveries That Can Help You Combat Aging, Boost Your Immune System, Reduce Your Risk of Cancer and Heart Disease, Get a Better Night's Sleep" by Russel Reiter. The book was published in the 90s, but I was amazed of how passionate was the author about...
cassiopaea.org cassiopaea.org

You might need different doses depending on context and your individual reaction.

Melatonin usually has a short life of 30 to 40 minutes. The decline in melatonin levels in your bloodstream will cause your temperature to rise, which your body interprets as a wake-up signal. People who take relatively high doses (10mg), are able to sustain elevated melatonin levels through the night. Others, take a smaller dose of melatonin if they wake up in the middle of the night. Another option is to take a time released melatonin. Nevertheless, the doses that Reiter recommends for people who choose to take melatonin (based on 90s research) are:

Sleep 0.2-10mg
Jet lag 1-10mg
Anti-ageing 0.1-3mg
Shift work 1-5mg
Immune stimulation 2-20mg

The doses that Laura suggested from the other book, looked better. But keep in mind that if there's a virus flying around, you can take 2-20mg to help you fight it off.
 
Hi! I would like to know whether is recommended to give melatonin to small children. I have a 2 year old that never slept great, but with this lock down we have been experiencing for the past 12 days, he sleeps very poorly. I thinks that it is a very stressful situation for him not being aloud to play outside(we live in a flat). Does anybody have any experience with the melatonin or other remedy,maybe homeopathic? Thank you
 
Cristal said:
Hi! I would like to know whether is recommended to give melatonin to small children. I have a 2 year old that never slept great, but with this lock down we have been experiencing for the past 12 days, he sleeps very poorly. I thinks that it is a very stressful situation for him not being aloud to play outside(we live in a flat). Does anybody have any experience with the melatonin or other remedy,maybe homeopathic? Thank you
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I would be very careful with doing it since children in this age usually have much higher levels of melatonin produced in the body than adults. Going outside might be a solution and he doesn't have to play with other children outside if it's not allowed in you region.
 
Cristal said:
We are not aloud to take our son outside. Spain has the worst restrictions...dogs can go out, but children not...
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Melatonin has been used in kids, only like Altair said, they should have higher levels than the average normal already. Make sure he's not been exposed to screens too much, especially in the evening and at nights. There are homeopathic remedies for children as well. If you try melatonin, I would start with half a milligram for a few nights and see if that helps reset his inner clock.

Another thing is to get a red bulb (red light spectrum), like the ones that physiotherapists use. If he gets exposed to that light for 10 minutes or so in the morning, he should have healthier levels of melatonin at night. It substitutes the red light spectrum that he should be getting from the sun.
 
Gaby said:
Melatonin has been used in kids, only like Altair said, they should have higher levels than the average normal already. Make sure he's not been exposed to screens too much, especially in the evening and at nights. There are homeopathic remedies for children as well. If you try melatonin, I would start with half a milligram for a few nights and see if that helps reset his inner clock.

Another thing is to get a red bulb (red light spectrum), like the ones that physiotherapists use. If he gets exposed to that light for 10 minutes or so in the morning, he should have healthier levels of melatonin at night. It substitutes the red light spectrum that he should be getting from the sun.
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Thank you, Gaby. He has very little contact with any screens(communicating with family only). I bought a infrared lamp one month ago, but I didn't dare to use it with him. 100 w Beurer il11. Is this similar to what you recommend?
 
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