I stumbled upon another interesting angle of the MTHFR story. And that is that you can have enough of folate in your blood, but not enough in your brain. That seems to be a common thing in many neurological disorders, including autism. And the reason for that is because some people have folate receptor antibodies that do not allow the folate to go into the brain. Now, the solution that scientists devised is to give such people a huge amount of folate, usually 2 mg/kg (50 mg maximum per child) in order to force the folate to enter the brain. However, there seems to be other options.
One of the option is to supplement the person with vitamin D, because the active version of vitamin D, calcitriol, enhances brain folate uptake. Another option is to switch to a milk-free diet, because consuming milk increases folate receptor antibodies.
One of the option is to supplement the person with vitamin D, because the active version of vitamin D, calcitriol, enhances brain folate uptake. Another option is to switch to a milk-free diet, because consuming milk increases folate receptor antibodies.
A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome - PubMed
In cerebral folate deficiency syndrome, the presence of autoantibodies against the folate receptor (FR) explains decreased folate transport to the central nervous system and the clinical response to folinic acid. Autoantibody crossreactivity with milk FR from different species prompted us to...
pubmed.ncbi.nlm.nih.gov
