New Treatments for Psychological/Brain Disfunction

SummerLite

SummerLite

The Living Force
FOTCM Member
Dr. Wilkenson discribes the successes she's had with new, alternative treatments for psychiatric patients using medications that heal the brain on the biological level reducing symptoms. As a psychiatrist for many years she was disappointed in how her patients weren't progressing with standard treatment and began researching for alternatives. She discovered that people who have undergone significant trauma/stress where producing high levels of glutamate in their brains. which led to cell death and a myriad of psychiatric disturbances. She reasoned that if this process could be interrupted and treated patients might be truly helped. Now after years of using 2 medications which are glutamate modulators, Ketamine and Remotagene, she has seen extraordinary results with some of her most severely affected patients. This treatment is being studied now and she expects this will become a breakthrough treatment for psychiatric conditions in the near future.

I belong to a group that meets once a week for a zoom chat and Dr. Wilkenson is a member of this group. She apologizes for the poor quality of the audio in some places and will have a improved version in the months to come as well as updates on this treatment.

As a side note, she has watched all the videos of people having seizures around the world. She gave her background of having treated and seen many seizures throughout her career and the people raising their arm and turning during a seizure is definitely something new and unexplained in her opinion.

 
Treating the psychological issues using the neuroinflammatory model is interesting, but her choice of medicine for that, Lamotrigine and Ketamine is questionable. There are other anti-inflammatory substances that could be used instead.
 
One way to treat neuroinflammation is through neurosteroids, either directly, or indirectly through nutrients. Here are some examples of nutrients increasing the allopregnanolone:

EGCG: Effects of Epigallocatechin Gallate on Behavioral and Cognitive Impairments, Hypothalamic-Pituitary-Adrenal Axis Dysfunction, and Alternations in Hippocampal BDNF Expression Under Single Prolonged Stress - PubMed

Resveratrol: Resveratrol ameliorated the behavioral deficits in a mouse model of post-traumatic stress disorder - PubMed

Ginsenoside Rg2: The anxiolytic-like effects of ginsenoside Rg2 on an animal model of PTSD - PubMed

Ginsenoside Rg3: The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats - PubMed

The problem with some of them is the still controversial topic of whether they can reach the brain or not. One side of the story is that they need help (other scientists would disagree, hence the controversy). And here are few examples of how can that be achieved with tea polyphenols:

pubmed.ncbi.nlm.nih.gov

Common tea formulations modulate in vitro digestive recovery of green tea catechins - PubMed

Epidemiological evidence suggests a role for tea catechins in reduction of chronic disease risk. However, stability of catechins under digestive conditions is poorly understood. The objective of this study was to characterize the effect of common food additives on digestive recovery of tea...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
Persej said:
The problem with some of them is the still controversial topic of whether they can reach the brain or not. One side of the story is that they need help (other scientists would disagree, hence the controversy). And here are few examples of how can that be achieved with tea polyphenols:

https://pubs.acs.org/doi/10.1021/jf971022g
pubmed.ncbi.nlm.nih.gov

Common tea formulations modulate in vitro digestive recovery of green tea catechins - PubMed

Epidemiological evidence suggests a role for tea catechins in reduction of chronic disease risk. However, stability of catechins under digestive conditions is poorly understood. The objective of this study was to characterize the effect of common food additives on digestive recovery of tea...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
Click to expand...
Basically (AI summary):
  • Plain green tea did not hold up well in digestion: less than 20% of the total catechins were left after the simulated digestion. EGC and EGCG, two of the key catechins, dropped to under about 10% remaining.
  • Adding milk helped a lot: when the tea was half milk (cow’s, soy, or rice), total catechin survival went up to about 52% (cow), 55% (soy), and 69% (rice).
  • Adding vitamin C (30 mg in a typical 250 mL cup) also helped a lot, raising recovery of the four catechins to roughly:
  • EGC: 74%
    EGCG: 54%
    EC: 82%
    ECG: 45%
  • Adding citrus juice (orange, grapefruit, lemon, lime) gave the best results overall, with catechin survival often in the 80–95% range for several of the compounds, and still much higher than plain tea even for the lowest one (ECG at about 30–55%).
    If you drink plain green tea, a large portion of its “good stuff” may be broken down during digestion before your body can use it.
 
I suspect that the same would be valid for coffee polyphenols, although I couldn't find proof for that. It was hard to find it even for green tea because many studies show the opposite results for some reason.

I am wondering if the positive effects that some people report from coffee enemas result from polyphenols not being destroyed during the digestion. Perhaps green tea enemas would be another option for better absorption.
 
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