New Treatments for Psychological/Brain Disfunction

SummerLite

SummerLite

The Living Force
FOTCM Member
Dr. Wilkenson discribes the successes she's had with new, alternative treatments for psychiatric patients using medications that heal the brain on the biological level reducing symptoms. As a psychiatrist for many years she was disappointed in how her patients weren't progressing with standard treatment and began researching for alternatives. She discovered that people who have undergone significant trauma/stress where producing high levels of glutamate in their brains. which led to cell death and a myriad of psychiatric disturbances. She reasoned that if this process could be interrupted and treated patients might be truly helped. Now after years of using 2 medications which are glutamate modulators, Ketamine and Remotagene, she has seen extraordinary results with some of her most severely affected patients. This treatment is being studied now and she expects this will become a breakthrough treatment for psychiatric conditions in the near future.

I belong to a group that meets once a week for a zoom chat and Dr. Wilkenson is a member of this group. She apologizes for the poor quality of the audio in some places and will have a improved version in the months to come as well as updates on this treatment.

As a side note, she has watched all the videos of people having seizures around the world. She gave her background of having treated and seen many seizures throughout her career and the people raising their arm and turning during a seizure is definitely something new and unexplained in her opinion.

 
Treating the psychological issues using the neuroinflammatory model is interesting, but her choice of medicine for that, Lamotrigine and Ketamine is questionable. There are other anti-inflammatory substances that could be used instead.
 
One way to treat neuroinflammation is through neurosteroids, either directly, or indirectly through nutrients. Here are some examples of nutrients increasing the allopregnanolone:

EGCG: Effects of Epigallocatechin Gallate on Behavioral and Cognitive Impairments, Hypothalamic-Pituitary-Adrenal Axis Dysfunction, and Alternations in Hippocampal BDNF Expression Under Single Prolonged Stress - PubMed

Resveratrol: Resveratrol ameliorated the behavioral deficits in a mouse model of post-traumatic stress disorder - PubMed

Ginsenoside Rg2: The anxiolytic-like effects of ginsenoside Rg2 on an animal model of PTSD - PubMed

Ginsenoside Rg3: The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats - PubMed

The problem with some of them is the still controversial topic of whether they can reach the brain or not. One side of the story is that they need help (other scientists would disagree, hence the controversy). And here are few examples of how can that be achieved with tea polyphenols:

pubmed.ncbi.nlm.nih.gov

Common tea formulations modulate in vitro digestive recovery of green tea catechins - PubMed

Epidemiological evidence suggests a role for tea catechins in reduction of chronic disease risk. However, stability of catechins under digestive conditions is poorly understood. The objective of this study was to characterize the effect of common food additives on digestive recovery of tea...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
Persej said:
The problem with some of them is the still controversial topic of whether they can reach the brain or not. One side of the story is that they need help (other scientists would disagree, hence the controversy). And here are few examples of how can that be achieved with tea polyphenols:

https://pubs.acs.org/doi/10.1021/jf971022g
pubmed.ncbi.nlm.nih.gov

Common tea formulations modulate in vitro digestive recovery of green tea catechins - PubMed

Epidemiological evidence suggests a role for tea catechins in reduction of chronic disease risk. However, stability of catechins under digestive conditions is poorly understood. The objective of this study was to characterize the effect of common food additives on digestive recovery of tea...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
Click to expand...
Basically (AI summary):
  • Plain green tea did not hold up well in digestion: less than 20% of the total catechins were left after the simulated digestion. EGC and EGCG, two of the key catechins, dropped to under about 10% remaining.
  • Adding milk helped a lot: when the tea was half milk (cow’s, soy, or rice), total catechin survival went up to about 52% (cow), 55% (soy), and 69% (rice).
  • Adding vitamin C (30 mg in a typical 250 mL cup) also helped a lot, raising recovery of the four catechins to roughly:
  • EGC: 74%
    EGCG: 54%
    EC: 82%
    ECG: 45%
  • Adding citrus juice (orange, grapefruit, lemon, lime) gave the best results overall, with catechin survival often in the 80–95% range for several of the compounds, and still much higher than plain tea even for the lowest one (ECG at about 30–55%).
    If you drink plain green tea, a large portion of its “good stuff” may be broken down during digestion before your body can use it.
 
I suspect that the same would be valid for coffee polyphenols, although I couldn't find proof for that. It was hard to find it even for green tea because many studies show the opposite results for some reason.

I am wondering if the positive effects that some people report from coffee enemas result from polyphenols not being destroyed during the digestion. Perhaps green tea enemas would be another option for better absorption.
 
The same guy who claims to had good results from pregnenalone, also claims to had brain benefits from a supplement that has Hyaluronic acid/Chondroitin/Collagen/Vitamin C mix:


Well, that supplement is supposed to reduce inflammation, so perhaps this neuroinflammatory model does have practical usefulness for brain issues.

Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is mediated, in part, by increased levels of inflammatory cytokines that alter allopregnanolone (AlloP) levels, an important neurosteroid in the brain. We assessed the levels and regulation of AlloP and the effects of AlloP supplementation on cognitive function in 4-month-old and 24-month-old male C57BL/6 mice. With age, the expression of enzymes involved in the AlloP synthetic pathway was decreased and corticosterone (CORT) synthesis increased. Supplementation of AlloP improved cognitive function. Interestingly, interleukin 6 (IL-6) infusion in young animals significantly reduced the production of AlloP compared with controls. It is notable that inhibition of IL-6 with its natural inhibitor, soluble membrane glycoprotein 130, significantly improved spatial memory in aged mice. These findings were supported by in vitro experiments in primary murine astrocyte cultures, indicating that IL-6 decreases production of AlloP and increases CORT levels. Our results indicate that age-related increases in IL-6 levels reduce progesterone substrate availability, resulting in a decline in AlloP levels and an increase in CORT. Furthermore, our results indicate that AlloP is a critical link between inflammatory cytokines and the age-related decline in cognitive function.

pubmed.ncbi.nlm.nih.gov

Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice - PubMed

Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is mediated, in part, by increased levels of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
Click to expand...

Integrating Interleukin-6 into depression diagnosis and treatment

There is growing evidence of a relationship between inflammation and psychiatric illness. In particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such as depression and anxiety. Here we discuss evidence from preclinical and clinical studies examining the role of IL-6 in mood disorders. We focus on the functional role of peripheral and central release of IL-6 on the development of stress susceptibility and depression-associated behavior. By examining the contribution of both peripheral and central IL-6 to manifestations of stress-related symptomatology, we hope to broaden the way the field thinks about diagnosing and treating mood disorders.

Click to expand...

IL-6 Induced by Social Stress Promotes a Unique Transcriptional Signature in the Monocytes that Facilitate Anxiety

Background: Interleukin-6 (IL-6) is elevated in circulation with chronic stress and may contribute to neurobehavioral complications. We have reported that repeated social defeat stress in mice caused recruitment of proinflammatory monocytes to the brain and triggered the onset of anxiety-like behavior. Therefore, the purpose of this study was to determine the role of IL-6 signaling in the peripheral immune response, neuroinflammation, and anxiety following stress.

Conclusions: Here, we show the effects of IL-6 on the transcriptional signature of monocytes in circulation and brain after stress. Overall, robust increases in IL-6 after stress induced a primed profile in monocytes that were recruited to the brain and propagated IL-1-mediated inflammation and anxiety.

Click to expand...

So, basically, all kinds of things that can reduce the inflammation in the body could potentially be also used for psychological issues.
 
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