Schizophrenia – Is it all "just" a matter of diet?
Hello everyone,
As part of my work and research on
autism, I would also like to share some information about schizophrenia. I used the AI
Copilot or
Gemini to research and summarize the information.
I will first briefly discuss the "connection" between schizophrenia and autism before moving on to the main section, based on the contents of the book "
Gut and Psychology Syndrome: Natural Treatment for Autism, Dyspraxia, A.D.D., Dyslexia, A.D.H.D., Depression, Schizophrenia, 2nd Edition" (
Amazon-Link) by Dr. Natasha Campbell-McBride to discusses the possible physiological and pathological causes and possible treatments. This section is also brief and intended to provide a quick overview for what you might want to explore in more detail.
Finally, I'll briefly discuss the physiological and pathological causes of depression and medications that cause it, as depression is considered the early symptom in the course of schizophrenia in the vast majority of cases.
Perhaps this post will be helpful. Feel free to comment here, share your experiences, or provide links to further studies or existing forum posts on this topic.
Schizophrenia and Autism
"Autism and schizophrenia have only been considered separate disorders since the 1980s. Historically, autism was viewed as the childhood variant of schizophrenia."
"The children and siblings of patients with schizophrenia have an increased risk of developing an autism spectrum disorder. This is shown by three case-control studies in the Archives of General Psychiatry. There may also be a connection to bipolar disorder." (
Link to the entire article and
Link to the study)
Diagnostic Overlaps
According to Dr. Natasha Campbell-McBride, schizophrenia is the label psychiatrists tend to put all patients who are difficult to classify.
There is considerable overlap between depression, bipolar disorder, obsessive-compulsive disorder, dyslexia, and schizophrenia. It is not uncommon for a patient to be initially diagnosed with bipolar disorder, only to later be classified as schizophrenic.
Depression is often the only symptom a patient experiences before other symptoms of schizophrenia become apparent.
Family Disposition
Family members of a patient with schizophrenia often suffer from dyslexia, dyspraxia, depression, bipolar disorder, autism, ADHD, and obsessive-compulsive disorder.
Dr. Natasha Campbell-McBride further notes from her experience that, just as with childhood learning disabilities, psychiatric patients don't fit neatly into the "diagnostic schema."
Dr. Natasha Campbell-McBride asks directly: "
Is this because we are failing to recognize an underlying problem that may be causing all these different clinical pictures in different people?"
Conventional Medical Treatment
The only treatment modern psychiatry can offer patients with schizophrenia is antipsychotic medication. The use of these medications is often trial and error, with serious side effects.
Vitamin and mineral deficiencies
Research confirms that deficiencies in vitamins such as nicotinic acid (vitamin B3), B6, B12, B1, folic acid, and vitamin C, as well as minerals such as magnesium, zinc, and manganese, are regularly found in patients with schizophrenia.
Treatment with supplements of B3, B12, folic acid, and vitamin C
The late Canadian physician Abram Hoffer successfully treated thousands of patients with schizophrenia with supplements of B3, B12, folic acid, and vitamin C.
Carl Pfeiffer, an American physician, studied more than 20,000 cases and demonstrated that treating patients with nutritional supplements and diet can be far more effective than taking strong medications.
Connection with the digestive system
Dr. Natasha Campbell-McBride, based on her many years of practical experience, states: "We already know that the answer lies solely in the digestive system."
The French psychiatrist Philippe Pinel wrote almost 200 years ago that the primary seat of mental illness is usually found in the region of the stomach and the small and large intestines.
The US professor Dr. Curtis Dohan spent many years researching the connection between digestive disorders and mental health in patients with schizophrenia. He found that symptoms of schizophrenia could be significantly alleviated by eliminating grains from the diet.
Ireland – Highest Prevalence of Celiac Disease and Schizophrenia
Dr. Natasha Campbell-McBride cites Ireland as an example, where wheat products were not on the menu until the Great Famine of 1845. Prior to that, no cases of schizophrenia or celiac disease had been reported in Ireland. Since the introduction of wheat as a staple food, Ireland has had the highest prevalence of celiac disease and schizophrenia in the world.
Opiates in the Urine of Patients with Schizophrenia
In the late 1970s, it was discovered that gluten from cereal grains and casein from milk can be converted into opiates in the digestive system. These opiates cross the blood-brain barrier and affect the brain. They have been detected in the urine of patients with schizophrenia, depression, and autoimmune diseases.
Connection to Autism
Later, Dr. Reichelt in Norway and Dr. Shattock in Great Britain found the same compounds in the urine of autistic children. It was shown that schizophrenia and autism present with similar symptoms. Both patient groups are unable to digest gluten and casein.
Disturbed Gut Flora and Medical History
The mothers of these patients almost invariably have a disturbed gut flora. A high percentage of patients with schizophrenia were not breastfed, which further compromises their gut flora and immune system.
Physical symptoms such as digestive problems, allergies, eczema, asthma, malnutrition, hyperactivity, dyspraxia, dyslexia, fatigue, irritability, and sleep disturbances appear as early as childhood. These symptoms indicate a disturbed gut flora with nutrient deficiencies and toxicity. According to Dr. Natasha Campbell-McBride's experience, schizophrenia does not arise out of nowhere, but rather has its origin in GAP syndrome.
Pellagra
Dr. Natasha Campbell-McBride points out that there is a certain group of patients with schizophrenia who may not be schizophrenic but suffer from pellagra.
Pellagra is a disease caused by a deficiency of nicotinic acid (vitamin B3). The symptoms are similar to those of schizophrenia: delusions, hallucinations, confusion, depression, irritability, and physical complaints such as dermatitis and chronic diarrhea.
In the past, pellagra occurred primarily in poorer populations who ate a diet primarily consisting of corn.
The Canadian psychiatrist Dr. Abram Hoffer was able to cure many patients simply by administering high doses of nicotinic acid (2–4 g/day) and later supplemented with vitamin C and other nutrients.
Studies on the connection between schizophrenia and the gut microbiome
Alterations of the Gut Microbiota in Patients with Schizophrenia (2024) Shows dysbiosis in schizophrenia patients with a decrease in butyrate-producing bacteria and an increase in pro-inflammatory microbes.
Link Frontiers in Psychiatry
The Gut Microbiome and Schizophrenia: The Current State of the Field (2020) Overview of the current state of research on the gut-brain axis in schizophrenia.
Link Frontiers in Psychiatry
Integrated Analysis of Gut Microbiome, Inflammation, and Neuroimaging (2024) Links gut microbiome changes to inflammatory markers and brain structural changes in schizophrenia.
Link1 or
Link2
Meta-analysis on the efficacy of probiotics in schizophrenia (2024) Demonstrates significant improvement in PANSS scores with Lactobacillus and Bifidobacterium.
Link Springer – European Archives of Psychiatry
Brief profiles of the people mentioned in the book Gut and Psychology Syndrome by Dr. Natasha Campbell-McBride in the chapter on Schizophrenia
Dr. Natasha Campbell-McBride
Born: 1961 (Russia) / Education: Bashkiria Medical University (Neurology), later specializing in nutrition
Books: Gut and Psychology Syndrome (2004) –
Amazon link, Gut and Physiology Syndrome (2020), Vegetarianism Explained (2017), Put Your Heart in Your Mouth (2016)
Official website (
HOME | GAPS )
Dr. Abram Hoffer
Born: November 11, 1917 / Died: May 27, 2009 (Victoria, Canada) / Education: PhD in Biochemistry (University of Minnesota), MD (University of Toronto)
Books: Orthomolecular Medicine for Physicians / Healing Schizophrenia: Complementary Vitamin & Drug Treatments / Niacin: The Real Story (with Andrew W. Saul) / Adventures in Psychiatry
Biography: Wikipedia entry (
Abram Hoffer - Wikipedia )
Collection of his works: Orthomolecular.org (
https://www.orthomolecular.org/history/hoffer/index.shtml )
Dr. Carl Curt Pfeiffer
Born: March 19, 1908 / Died: November 18, 1988 (Princeton, USA) / Education: PhD in Pharmacology (University of Wisconsin), MD (University of Chicago)
Books: Nutrition and Mental Illness: An Orthomolecular Approach to Balancing Body Chemistry (1988) / Mental and Elemental Nutrients (1976) / The Healing Nutrients Within / Twenty-Nine Medical Causes of Schizophrenia
Biography: Wikipedia entry (
Carl Pfeiffer (pharmacologist) - Wikipedia )
Archive of his works:
DoctorYourself.com: Andrew Saul's Natural Health Website
Commonly used medications for schizophrenia and their possible side effects
- Risperidone - Atypical antipsychotic - Weight gain, sedation, elevated prolactin. Increased risk of diabetes and cardiovascular disease.
- Olanzapine - Atypical antipsychotic - Severe weight gain, drowsiness, metabolic disorders. Metabolic syndrome, elevated lipid levels.
- Clozapine - Atypical antipsychotic - Agranulocytosis (life-threatening deficiency of white blood cells), seizures. Regular blood count monitoring required.
- Haloperidol - Typical antipsychotic - Extrapyramidal symptoms (tremors, muscle stiffness), sedation. Tardive dyskinesia (irreversible movement disorders).
- Quetiapine - Atypical antipsychotic - Sedation, weight gain, dizziness. Increased risk of falls.
- Aripiprazole - Atypical antipsychotic - Insomnia, restlessness, headache. Impulse control disorders may occur.
Physical illnesses that can trigger depression
Not every depressive mood is purely psychological. There are a number of physical illnesses that either trigger genuine depression or whose symptoms are deceptively similar.
Hormonal Disorders
Hypothyroidism (underactive thyroid): Fatigue, listlessness, weight gain, depressed mood
Cushing's Syndrome: Too much cortisol can cause anxiety, irritability, and depression
Diabetes Mellitus: Blood sugar fluctuations affect mood and energy
Neurological Disorders
Parkinson's Disease: Depression is often an early symptom
Multiple Sclerosis: Inflammation in the CNS can trigger depressive symptoms
Epilepsy: Temporal lobe epilepsy, in particular, can be associated with depressive episodes
Dementia: Early stages can be confused with depressive symptoms
Infections and Inflammations
Mononucleosis (Infectious Mononucleosis): Can cause weeks of exhaustion and depressed mood
HIV/AIDS: Direct effect on the CNS and psychosocial stress
Post-COVID Syndrome: Many affected individuals report depressive symptoms
Metabolic and Autoimmune Diseases
Anemia (Anemia): Fatigue, difficulty concentrating, and depression
Lupus erythematosus: Autoimmune processes can affect the brain
Liver or kidney failure: Toxins in the blood affect the brain
What else should you consider when experiencing depression?
If depressive symptoms persist for weeks or months, it's unclear why and how they arose, and networking in a forum, relaxation exercises, meditation, and self-improvement work don't bring about any change, then you should:
Run out physical causes
A thorough examination with laboratory tests (e.g., thyroid, blood count, vitamin D, B12) can help identify physical triggers. A deficiency or malfunction – such as that of the thyroid – can directly impact mood and cause depressive symptoms.
Check for neurological disorders
If concentration, memory, or behavior change, there may be a neurological cause behind it – e.g., early dementia, Parkinson's disease, or other brain dysfunctions that initially manifest as depression.
Take sleep disorders seriously
Chronic sleep deprivation or non-restorative sleep (e.g., due to sleep apnea) can massively reduce mental resilience. People who consistently sleep poorly are more susceptible to depression, irritability, and exhaustion.
Have your medications checked
Some medications negatively affect mood – such as beta-blockers, cortisone, certain painkillers, or hormonal medications. A targeted medication history can clarify whether depression might be a side effect.
Consider hormonal changes – especially during sensitive phases of life:
For women:
Menopause (perimenopause and menopause): Estrogen dominance and the drop in progesterone can promote mood swings, sleep disorders, and depressive moods.
Postpartum period: After birth, an abrupt drop in hormones can lead to postnatal depression.
Premenstrual syndrome (PMS) and PMDD: Cycle-related hormonal fluctuations can regularly trigger depressive symptoms.
Perhaps you know of contact points and platforms such as
www.femna.de , which specialize in holistic women's health – particularly in the areas of hormone balance, menstrual problems, menopause, and intestinal health – and would like to share alternative platforms or your experiences.
According to its website, femna.de offers, among other things, for the German-speaking market:
- Laboratory tests for home use: e.g. E.g., hormone status, cortisol profile, intestinal flora – without a doctor's visit
- Individual consultation: Online consultations with health advisors to evaluate test results and create a personalized treatment plan
- Women-specific micronutrients: Dietary supplements tailored to women's specific needs
- Knowledge transfer & education: Blog articles, information materials, and self-help programs for symptoms such as PMS, hormonal acne, or menopausal issues
For men:
- Andropause (testosterone deficiency "in old age"): A gradual decline in testosterone levels can lead to listlessness, irritability, and depressive moods.
- Stress-related cortisol dysregulation: Chronic stress can disrupt hormonal balance and worsen depressive symptoms.
Medications that can trigger depression and depressive moods.
- Antihypertensives: β-blockers, clonidine, α-methyldopa, ACE inhibitors, calcium channel blockers.
- Hormones: Glucocorticoids (e.g., prednisolone), progestins, danazol.
- Pain relievers & anti-rheumatic drugs: Indomethacin, ibuprofen, methysergide, gold salts.
- Antibiotics & antituberculosis drugs: INH, sulfonamides, tetracyclines, metronidazole, nitrofurantoin.
- Antiepileptics: Phenytoin. Clonazepam, hydantoins
- Psychotropic drugs: barbiturates, neuroleptics (in certain cases), amphetamine withdrawal
- Interferons & immunosuppressants: interferon-α, azathioprine
- Contraceptives (the pill)
Medications that can trigger anxiety
- Sympathomimetics (e.g., ephedrine, pseudoephedrine)
- Thyroid hormones (in case of overdose)
- Cortisone preparations (especially at high doses)
- Withdrawal from benzodiazepines – the group of medications that act on the central nervous system and are primarily known for their sedative, anxiolytic, muscle-relaxing, and sleep-inducing effects – can cause severe anxiety.
Medications that can trigger psychosis
- Corticosteroids: can trigger manic or psychotic episodes
- Parkinson's medications: e.g., L-dopa, amantadine
- Antibiotics: e.g., ciprofloxacin, metronidazole
- Interferon therapy: e.g., for hepatitis or MS
- Anticholinergics: can cause delirious states
- Withdrawal from psychotropic drugs: e.g., B. abrupt discontinuation of neuroleptics or benzodiazepines