Schizophrenia

[neonix]

Psychological Disorders and Statin Use: A Propensity Score-Matched Analysis

Psychological Disorders and Statin Use: A Propensity Score-Matched Analysis - PMC

To evaluate the association between statin therapy and risk of psychological disorders including schizophrenia, psychosis, major depression, and bipolar disorder in a military population. Retrospective, observational, population-based, propensity ...

pmc.ncbi.nlm.nih.gov

Despite their effectiveness in lowering cardiovascular morbidity and mortality, hydroxyl methyl glutaryl coenzyme A reductase inhibitors (statins) have been associated with an extremely wide variety of adverse events. Pharmacovigilance groups from different parts of the world have implicated statins as a potential cause of severe psychological adverse events. The New Zealand Center for Adverse Reaction Monitoring (CARM) reported the association of 285 cases of psychological adverse events with statins. Another review of spontaneous adverse events in an Italian database identified 71 psychological adverse events. Adverse events included insomnia, somnolence, agitation, confusion, hallucinations, mood disorders, cognitive disorders, and perception disorders. Case reports, case series, and small randomized controlled studies have linked statin use to the increased risk of psychological disorders, such as violence or depression. The recent FDA warning of cognitive disorders associated with statins has raised additional concerns.

The objective of this study was to determine if statins were associated with an increased risk of psychological disorders, including schizophrenia, psychosis, major depression, and bipolar disorder in a military population that requires a high degree of psychological preparedness.

 

[Alejo]

I just finished making my way through Hidden Valley Road by Robert Kolker, it's a non fiction narrative about the Galvin family, a family of 14, the parents and 12 children out of which 6 were diagnosed with Schizophrenia, it spans from the 1940s until very recently.

The book itself isn't a research or academic book exactly, though it touches upon the academic background of the events it covers for the entire family, it can be pretty devastating but it is well written I thought. The incidence of the disease in the family lead them to be a part of several studies that sought to understand it, it briefly touches on all the theories that were being researched at the time, the treatments available, family and trauma impacts, genetics and so on.

it provides an interesting view of the human dimension of the disease inside of a family. So, I would recommend it.