Second-Oldest Gene Mutation relates Arabs, Turks, and Sephardic Jews but not Ashkenazi Jews
Original paper “Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities“ published in the Orphanet Journal of Rare Diseases can be accessed here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226546/?tool=pubmed
Although gene mutation studies may provide additional evidence for establishing human history, these studies are rare and usually include relatively small number of individuals with known genetic diseases. That may explain why other DNA changes imposed by external forces in certain populations have not been discovered.
Technically it is possible to test some the C’s messages, like first psychopath mutation 50,000 years ago or Jews genetically engineered 130,000 years ago?
A new study has identified a gene mutation that researchers estimate dates back to 11,600 B.C., making it the second oldest human disease mutation yet discovered. http://cancer.osu.edu/mediaroom/releases/Pages/Second-Oldest-Gene-Mutation.aspx Only a mutation seen in cystic fibrosis that arose between 11,000 and 52,000 years ago is believed to be older.
The investigators described the mutation in people of Arabic, Turkish and Jewish ancestry. It causes a rare, inherited vitamin B12 deficiency called Imerslund-Gräsbeck Syndrome (IGS). The researchers say that although the mutation is found in vastly different ethnic populations, it originated in a single, prehistoric individual and was passed down to that individual’s descendents. This is unusual because such “founder mutations” usually are restricted to specific ethnic groups or relatively isolated populations.
Original paper “Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities“ published in the Orphanet Journal of Rare Diseases can be accessed here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226546/?tool=pubmed
I believe this confirms what I read in Laura’s publications. From other references in the article it seems that the idea of separate ancestry between Sephardic and Ashkenazi Jews is landing in the mainstream science.This mutation causes over 50% of the IGS cases among Arabic, Turkish, and Sephardic Jewish families, making it a primary target for genetic screening among diverse IGS cases originating from the Middle East. Thus, rare founder mutations may cause a substantial number of cases, even among diverse ethnicities not usually thought to be related.
After applying the different growth rates, the age was estimated to be between 8,050 years (95% confidence interval [CI] 6,450-11,200 years) and 19,225 years (95% CI: 14,300-28,600 years) for an average of ~13,600 years (~11,600 BC).
If the mutation originated around 11,600 BC it could explain why it is today seen in the peoples of Turkey and Jordan but not necessarily why it is only present in Jews of Sephardic roots.
We have used a series of assumptions to estimate the age range of a founder mutation in AMN that causes IGS. Judging the data conservatively, we believe that the region of origin for the mutation to be in Northern Mesopotamia (today's Eastern Turkey and Northern Iraq) some 13,600 years ago, placing it before the beginning of the Neolithic period (ca. 9,500 BC). Its exclusive presence in Sephardic Jews today could be explained by a common ancestor in an early Semitic population whose descendants contributed to that Jewish tribe as well as the Turkish and Arabic populations we recognize today. The natural history of this mutation is in agreement with recent studies that support a common but complex ancestry between Jews and non-Jews in the Middle East
Although gene mutation studies may provide additional evidence for establishing human history, these studies are rare and usually include relatively small number of individuals with known genetic diseases. That may explain why other DNA changes imposed by external forces in certain populations have not been discovered.
Technically it is possible to test some the C’s messages, like first psychopath mutation 50,000 years ago or Jews genetically engineered 130,000 years ago?