Vitamin D Deficiency

wmu9 said:
I know someone with type II diabetes, and her doctor prescribes D2, not D3. I've never got her to explain why, but it's the doctor's plan and she's not questioning it.
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I had a patient last week whose doctor from the VA (Veterans Affairs) prescribed D2. I told him D3 was much better but it also needed cofactors.

I think most of the prescriptions for vitamin D here in the states are for D2. D2 is less effective at raising vitamin D levels and has a shorter duration of action. And now we know calcifediol is even better but is blacklisted in the USA and Canada!
 
For those in Europe there is this one, reasonably priced:
supplementhub.co.uk

Vitamin D3 2000 IU as Calcifediol - 60 Tablets | VitamoreD

The world's first-ever fast-acting, highly absorbed and vegan Vitamin D3 supplement as Calcifediol. Easy swallow tablets. Vegan Vitamin D3 created from vitamin D rich Algae 3.2 x more potent than any vitamin D supplement in the world 5 x better absorbed in the body.
supplementhub.co.uk supplementhub.co.uk

But lets not forget:
It's particularly helpful for people who are overweight or obese, who have liver issues and/or metabolic pathway dysfunction, and those who have intestinal malabsorption.
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I would imagine people without these issues will do just fine with good ol Cholecalciferol.
Works fine for me.
 
Did a blood test in April because my doctor forced me to do it this year and my Vit D2+D3 score was 25 ng/ml and labeled as 'low', 'insufficient'. That was after having D3 and K2 in liquid drops and some pills for almost 2 years! I was baffled.. I thought quite the contrary, that I was dying for Vit D overdose without knowing LOL! Now I'm taking Vit D in pills and drops regularly. I may take magnesium too, which I've dropped form many months, and see what happens in January or so and then explore new ways if it fails. Thanks for the thread!
 
Chad said:
... In my opinion, when judging ones health, checking specific markers, like vitamin D, is fine - and for some things it may be critical - but it's just as important to be ensuring that ones diet and well being is also optimal; which means good quality, and a sufficient quantity, of animal fats; ...
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Hi, just talked with a guy this morning that was into vit. D issues himself for years and when I asked 'What's the best hour of the day for those pills' he answered that it was as long as you take them after or during a FAT meal, else the vit. D won't be absorbed optimally by the body or at all.

Then he went on on stressing the magnesium and K2 importance, just because vit. D alone could lead to arteries calcification.. a thing I've never read anywhere before.
 
All i can do is give my anecdotal experience. I have been taking 4000 IU a day for four years and, in that time i have climbed up from an absolutely appalling mental state (insomnia, occasional panic attacks and low mental function) into being recognisably myself again. I also made lots of other changes to my diet as well though and, if you are having problems, four years is a long time to wait for to get feedback on just doing just one thing - but my bet would be that vitamin D is vital for mental health and many people really need far more than the official 'daily requirement'.
 
Magrathea said:
All i can do is give my anecdotal experience. I have been taking 4000 IU a day for four years and, in that time i have climbed up from an absolutely appalling mental state (insomnia, occasional panic attacks and low mental function) into being recognisably myself again. I also made lots of other changes to my diet as well though and, if you are having problems, four years is a long time to wait for to get feedback on just doing just one thing - but my bet would be that vitamin D is vital for mental health and many people really need far more than the official 'daily requirement'.
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That is super you have had these gains, Magrathea.

I noticed you have been here since 2019, and for some reason after @Jones in 2020 mentioned it to you (which you must have missed), you were not again directed to make an introductory post, as it is customary for new members to do - see here, Newbies & Important Notices to All Members

Nothing posted about yourself need be elaborate, yet members like to know a little bit about other members, especially how you came here. From your post above, it may be that diet played a role as your evidence above looks back 4-years. If so, well done.

:welcome:
 
Lilou said:
nouveauhealthcare.com

VitamoreD Fast-Acting Vitamin D3 Supplement – Active Form Calcifediol

Vegan Vitamin D3 as Calcifediol. VitamoreD is 3.2 x more potent than generic Vitamin D (10mcg = 2000IU) and it is 5 x better absorbed by the body. VitamoreD is also the safest Vitamin D as you can take less to absorb more. Offers maximum support and comes in small, easy to swallow tablets.
nouveauhealthcare.com nouveauhealthcare.com
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Good news! This company is now able to ship to the US and Canada. And the shipping is free!
 
hlat said:
Is it acceptable with Magnesium Stearate, or should we pass on it?
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It’s certainly better than the other one that Nienna posted that contains sorbitol, titanium dioxide, and red dye #40. And was not cost effective at all.

I guess you’d have to evaluate risk vs benefit. If your vitamin D levels are less than 30, a short course of this to quickly raise it is probably more beneficial than the bit of mg stearate is harmful.
 
Gaby said:
The case study mentioned in the article above never benefited from vitamin D3 supplementation (100000 units per month). It was only calcifediol that improved all her Long COVID/LongVax symptoms, and it might be related to her metabolic issues and her obesity.
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Many things can affect the transformation of cholecalciferol to calcitriol in the body. However, it has been known for a long time that calcifediol is much better than cholecalciferol for raising the calcitriol. That would explain why your patient only benefited from taking the calcifediol and not the D3.

pubmed.ncbi.nlm.nih.gov

Plasma concentrations of vitamin D3 and its metabolites in the rat as influenced by vitamin D3 or 25-hydroxyvitamin D3 intakes - PubMed

Plasma concentrations of vitamin D3 and its metabolites in the rat as influenced by vitamin D3 or 25-hydroxyvitamin D3 intakes
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov

Circulating parathyroid hormone and dihydroxylated vitamin D metabolites after oral 25 hydroxycholecalciferol in infantile rickets - PubMed

Circulating parathyroid hormone and dihydroxylated vitamin D metabolites after oral 25 hydroxycholecalciferol in infantile rickets
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Does that mean that cholecalciferol is completely useless? Well, my current theory is that we can still use cholecalciferol, but just not every day:

Because the serum vitamin D half-life is known to be 15 to 24 hours...

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RECENT estimates based on observations of radio-isotopically labelled cholecalciferol for up to 4 days, suggest that the biological half-life of vitamin D in human plasma does not exceed 50 h.

Long Biological Half-life of Vitamin D3 and its Polar Metabolites in Human Serum - Nature

RECENT estimates1,2, based on observations of radio-isotopically labelled cholecalciferol for up to 4 days, suggest that the biological half-life of vitamin D in human plasma does not exceed 50 h. Conversely, after administration of large amounts of vitamin D, the “vitamin D activity” of plasma...
www.nature.com www.nature.com
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Vitamin D3-3H has been administered intravenously to seven normal subjects, three patients with biliary fistulas, and four patients with cirrhosis. Plasma D3-3H half-times normally ranged from 20 to 30 hours.

JCI - Metabolism of Vitamin D3-3H in Human Subjects: Distribution in Blood, Bile, Feces, and Urine

www.jci.org www.jci.org
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I think that cholecalciferol, calcifediol and calcitriol all send different kinds of signal to the body, and when you take D3 every day those signals are mixed up and your body doesn't know how to handle that properly, so it doesn't produce enough of active form of vitamin D or the vitamin D receptors are not responding properly or whatever. I have a ton of papers to show the circumstantial evidence for that, but none that would prove that directly. So my theory is that you have to wait for the D3 to disappear from your blood in order for calcitriol to do its work. So, one day on, one day off, or something along those lines is what I am suggesting.

It seems that nobody was particularly interested in this subject, even though they have been researching about vitamin D for more than 100 years, and calcitriol for more than 50 years. Luckily for us, the calcifediol is finally approved in the EU as a supplement last year, so hopefully we will get much more options in the near future, although Dedrogyl was available from the 1980s, but not OTC.
 
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