Ma'am, sir,
We are unable, for the time being, to provide individual answers to the many, many questions we are asked. We regret this. In the expectation of an adequate organization, we are sending you a standard answer which covers the essential part of the questions we have been asked so far.
TRANSDERMAL PATCHES containing
Valentonine (VLT) and 6-Methoxy-Harmalan (6-MH)
will be available in Q4 2017
Thank you for your donations, the purchase of the book and the brochure ("The pineal gland and the sleep-wake system"). Therapeutic Applications") and your encouragement.
They will help us to finance, independently, the development of the galenic forms of the patches, in order to make them available to patients as soon as possible. You will be kept regularly informed of the situation by consulting the Josefa Fund website.
As for the 2-tank patches (delivering 100 micrograms of 6-Methoxy-Harmalan, 6-MH, and 400 micrograms of Valentonine, VLT, for Parkinson's and Alzheimer's diseases, and 50 micrograms of 6-MH and 200 micrograms of VLT for sleep disorders and nervous breakdowns), they will be available in 2017 (4th quarter), as indicated at the bottom of the home page of the Josefa Fund website.
Melatonin capsules dosed at 3 mg can be purchased on the Internet, at a price of approximately €25 for 180 capsules (1 capsule dosed at 3 mg taken at bedtime in the evening, to protect the neurons).
On a practical level, the determination of melatonin in blood plasma, taken from 1am onwards, which will allow us to evaluate the secretion of the 3 hormones (MLT, 6-MH, and VLT) by the pineal gland, will take a little more time, as we have to implement the melatonin marker determination method (using a coupling method of mass spectrometry and liquid chromatography, described in our patents) in medical analysis laboratories around the world. However, this delay will not delay the availability of the patches in 2017.
All the information and explanations concerning the discovery of the hormones of the Sleep-Wake System and its therapeutic applications are given in the book and brochure entitled "The pineal gland and the Sleep-Wake System. Therapeutic Applications", available at Amazon.
By September 2017, 10 Letters from Pr Henri Joyeux accompanied by 5 videos co-signed by Pr Jean-Bernard Fourtillan and Henri Joyeux, will have been published. They are dedicated to the therapeutic applications resulting from the discovery of the sleep-wake system:
- Alzheimer's disease (Letter n°138),
- Parkinson's disease (Letter n°139),
- The virtual interviews of Jean-Bernard Fourtillan by Aloïs Alzheimer and James Parkinson (Letters n° 142 and 144),
- Sleep disorders (Letter n° 147),
- Nervous breakdowns (Letter n° 150),
- All benzodiazepines and related drugs are narcotics (Letter N°154)
- Psychosis
- Potential therapeutic applications in perspective.
For more information, and to follow the progress of these new drugs, we recommend that you regularly consult the Josefa Fund's recent publications.
Thank you for your confidence,
Jean-Bernard Fourtillan, Pr Henri Joyeux and their team
Post scriptum
What can be done to improve sleep and mental function in patients with Alzheimer's disease, pending the availability of VLT and 6-MH patches (expected in Q4 2017)?
The 2-tank patches, applied at bedtime and removed in the morning upon awakening, which will deliver 100 micrograms of 6-MH and 400 micrograms of VLT, over an 8-hour period, will not be available, for patients with neurodegenerative diseases, such as Parkinson's and Alzheimer's, before the 4th quarter 2017.
In the interim, these patients may benefit from the administration of Clomipramine (Anafranil® and generics), at a dose of one 10 mg tablet, at night at bedtime.
Neuropsychiatrists have found over many years that Clomipramine improves sleep and cognition in elderly and Alzheimer's patients.
This therapeutic effect can be explained by the fact that this major antidepressant, the leader of IRNs (Noradrenaline Reuptake Inhibitors), induces a noradrenergic stimulation of pinealocytes (cell units of the pineal gland), which results in an increase in the pineal gland's production of the 3 hormones (MLT, 6-MH and VLT); and thus improves sleep, alertness, and cognition.
References: "The pineal gland and the sleep-wake system. Therapeutic Applications" by Professor Jean-Bernard Fourtillan. Book (page 155) and Brochure (page 46).