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[Persej]

I have been feeling moody like I have pms for weeks, melancholy, annoyed at things my partner does that aren’t even annoying worthy (poor dude) . The only thing that’s changed for me is the introduction of PEA.
So I’m going to stop the PEA which has done nothing notable in the 3 weeks I’ve been trying it- except may be making me a pseudo-premenstrual misery machine the whole time.

I’ll report back in after I actually enter then finish the luteal phase in a few weeks

It has been shown in experiments that high dose of Allopregnanolone can have opposite effects of low dose. Perhaps you have enough of it and you don't need more. Here you can see the graph of Allopregnanolone during the menstrual cycle:

Trajectories of Allopregnanolone and Allopregnanolone to Progesterone Ratio across the Six Subphases of Menstrual Cycle - PMC

Background: Allopregnanolone is one of the most studied neuroactive steroids; yet, despite its relevance to neuropsychiatric research, it is not known how it, as well as its ratio to progesterone, varies across all six subphases of the menstrual ...

pmc.ncbi.nlm.nih.gov

If you cannot tolerate PEA at all perhaps you can try Oleoylethanolamide (OEA) which has many similar effects.

 

[iamthatis]

Interesting @Persej
I have been feeling moody like I have pms for weeks, melancholy, annoyed at things my partner does that aren’t even annoying worthy (poor dude) . The only thing that’s changed for me is the introduction of PEA.
So I look up Allopregnanolone so see if has any adverse affects associated.

Ai says

Allopregnanolone, a neurosteroid derived from progesterone,
paradoxically induces anxiety, irritability, and negative mood at moderate, physiological levels (e.g., during the luteal phase), despite being a
GABAA
receptor sedative. This biphasic, inverted U-shaped effect is most common in individuals with Premenstrual Dysphoric Disorder (PMDD).

Key Aspects of the Allopregnanolone Paradoxical Effect:

• Biphasic Action (U-Shaped Curve): While high concentrations (as in late pregnancy or high-dose therapy) and low concentrations produce calming, anxiolytic, or neutral effects, moderate levels (1.5–2 nmol/L) cause adverse emotional symptoms.
• Mechanism of Action: Allopregnanolone acts as a positive modulator of the
  GABAA
  receptor. In specific individuals, it may act on different receptor subunits
  
  rather than calming, lead to paradoxical effects. It is thought to increase amygdala activity (associated with anxiety) at moderate levels, rather than decreasing it.
• Role in PMDD/PMS: The rise of allopregnanolone during the luteal phase (premenstrual) triggers these paradoxical symptoms, with symptoms, mood, and irritability, declining when allopregnanolone levels fall.
• Treatment Approach: Research suggests that using a
  GABAA
  modulating steroid antagonist, such as isoallopregnanolone (Sepranolone/UC1010), can counteract these effects and reduce negative mood in PMDD.
  ScienceDirect.com +4

Contextual Factors:

• Sensitivity Differences: Only 3–8% of the population experiences severe, and up to 25% experience moderate, negative mood changes, similar to the prevalence of PMDD.
• Neurodivergence: Individuals with ADHD, autism, or a history of mood disorders may be more susceptible to this effect.
• Contextual Stress: Chronic stress may play a role in increasing sensitivity to these paradoxical effects.

It’s me again. So I’m going to stop the PEA which has done nothing notable in the 3 weeks I’ve been trying it- except may be making me a pseudo-premenstrual misery machine the whole time.

I’ll report back in after I actually enter then finish the luteal phase in a few weeks

Another way of looking at it is that PEA is changing your physiology, and providing you with an opportunity to do the emotional work. If PEA is clarifying your system, which it probably is, it would also be improving your neuroception. So it may be that what you're now noticing was already there, just another layer of the onion. Generally this is how healing or deprogramming happens, OSIT - not by 'feeling better', but by increasing self-awareness, noticing our BS more, accepting it, and the lessons involved, and struggling with oneself to make the necessary emotional or mental changes. My two cents.