For those of us who do not have a subscription, could you summarize the DMSO protocols (dosage, timing)?
Hi curious_richard, as the forum was down and my post of yesterday was lost (see
here, and a massive thanks and hooray for Scottie that he got it back up again
) i thought I'd post it again.
Okay, so you will have noticed that AMD’s articles on DMSO are very extensive, and if you are interested I definitively recommend reading them, but I thought this provided an excellent opportunity to ask Grok to ‘summarise the DMSO protocols and dosages based on A Midwestern Doctor’s articles on DMSO.’
This is what I got:
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A Midwestern Doctor (AMD), through their Substack articles, particularly "The Remarkable History and Suppressed Potential of DMSO" (August 18, 2024) and "How DMSO Cures Eye, Ear, Nose, Throat and Dental Disease" (October 31, 2024), compiles historical studies, clinical observations, and anecdotal reports on dimethyl sulfoxide (DMSO) for various conditions. Below is a consolidated summary of protocols and dosages for DMSO across these articles, organized by condition or application area. DMSO is FDA-approved only for interstitial cystitis, and most other uses lack standardized guidelines or robust clinical evidence. Use requires extreme caution, pharmaceutical-grade DMSO (>99.99% purity), and professional oversight due to risks like irritation, enhanced absorption of contaminants, and potential side effects. Always consult a healthcare provider or specialist before use.
General Protocols and Considerations
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Source: Only pharmaceutical-grade DMSO (99.99% purity) is safe; industrial-grade products may contain harmful impurities. AMD stresses sourcing from reputable suppliers.
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Dilution: Dilute with sterile saline or distilled water to avoid irritation. Never use undiluted DMSO on sensitive areas (e.g., eyes, mucosa). Avoid plastic containers, as DMSO may leach chemicals; use glass or stainless steel.
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Application: Apply to clean skin or tissues with sterile tools (e.g., swabs, droppers) to prevent contamination, as DMSO enhances absorption. Start with low concentrations and test for tolerance.
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Side Effects: Common effects include garlic-like breath/taste, mild irritation, or stinging. Rare risks include allergic reactions or systemic effects with high doses. Overuse may delay treatment or mask symptoms.
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Contraindications: Avoid in pregnancy, breastfeeding, untreated infections, or with conditions like diabetes or liver/kidney issues without guidance. DMSO may amplify medications (e.g., antibiotics, blood thinners), requiring dose adjustments.
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Dosing Notes: Dosages vary widely due to historical and anecdotal sources. AMD often cites 50–70% for topical use, 5–50% for mucosal/eye/ear applications, and low oral doses (e.g., 1 tsp). Exact amounts are rarely standardized, and protocols depend on practitioner experience.
Eye Conditions
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Conditions: Macular degeneration, retinitis pigmentosa, cataracts, glaucoma, eye strain, post-trauma blindness.
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Dosage/Protocol:
* 5–20% DMSO eye drops (e.g., 20% = 20% 99.9% DMSO + 80% 0.9% saline or distilled water), 1–2 drops per eye, 1–2 times daily.
* Severe cases (e.g., blindness) may use up to 40% DMSO or hourly drops, but only under supervision.
* Example: A glass dropper bottle filled with 20% DMSO solution, applied for weeks/months for cataracts or macular degeneration.
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Notes: Improves microcirculation and reduces inflammation. Historical cases report vision restoration (e.g., retinitis pigmentosa). Apply with clean hands, no makeup/contacts. Contraindicated with artificial lenses. Side effects: temporary stinging, garlic taste.
Ear Conditions
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Conditions: Otitis media, tinnitus, hearing loss, airplane ear (aerositis).
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Dosage/Protocol:
* Otitis media: 30–50% DMSO (≈0.5–1 mL), sometimes with antibiotics, poured into cleaned ear canal, 1–2 times daily. Apply with slight pressure; relief in 10–15 minutes.
* Pain: 50% DMSO with tetracaine (1–2 drops) swabbed on eardrum.
* Airplane ear: 50% DMSO nasal spray (1–2 sprays per nostril, not quantified), or ear drops (0.5 mL).
* Tinnitus/hearing loss: 30–50% DMSO drops (0.5–1 mL), 1–2 times daily, duration varies.
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Notes: Reduces inflammation, enhances antibiotic penetration. A 1967 study showed rapid infection clearance. Avoid in ruptured eardrums unless diluted (e.g., 10%) and external. Sterile application critical. Side effects: garlic odor, mild irritation.
Nose and Sinus Conditions
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Conditions: Sinusitis, aerosinusitis.
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Dosage/Protocol:
* Sinusitis: 30–50% DMSO nasal spray (1–2 sprays per nostril, ≈0.1–0.2 mL), 1–2 times daily, or topical 50% DMSO on sinus areas (1–2 mL, e.g., cheeks), 1–2 times daily. Rare cases used injections (1–2 mL, 30–50%), per Russian studies.
* Aerosinusitis: 50% DMSO nasal spray (1–2 sprays), reported effective in 1967.
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Notes: Calms inflammation, aids antibiotic delivery. Russian study cured pediatric sinusitis in 4–8 days. Sterile sprays essential to avoid infection. Side effects: nasal stinging, garlic odor. Not for chronic cases without oversight.
Throat Conditions
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Conditions: Tonsillitis, throat infections.
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Dosage/Protocol:
* 50% DMSO swabbed directly on tonsils/throat (≈1–2 mL), 1–2 times daily, often with antibiotics.
* Gargling: 20–30% DMSO (e.g., 5 mL in 15 mL water), 1–2 times daily for milder cases.
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Notes: Reduces inflammation, enhances antibiotic efficacy. Evidence is anecdotal from ENT reports. Sterile application critical to avoid bacterial spread. Side effects: garlic taste, throat irritation. Not for severe infections without medical guidance.
Dental Conditions
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Conditions: Periodontal disease, toothache, post-extraction pain, pulpitis, dry socket.
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Dosage/Protocol:
* Periodontal Disease: 50% DMSO (≈5–10 mL swished or 1–2 mL swabbed on gums), 1–2 times daily. A 1969 Polish study improved pain and gum adherence. Some dentists apply 50% DMSO to stabilize loose teeth.
* Toothache: 20–50% DMSO swished (≈5 mL diluted) or swabbed on tooth/gum (0.5–1 mL), 1–2 times daily for temporary relief.
* Post-Extraction/Dry Socket: 50–70% DMSO dropped into socket (0.5–1 mL) or applied to gums/cheek (1–2 mL), 1–2 times daily. Russian study combined with azathioprine (dosage unclear).
* Pulpitis: 50% DMSO swabbed on tooth/gum (0.5 mL), 1–2 times daily, per studies.
* Mouthwash: 10–20% DMSO (5 mL in 20–30 mL water), swished daily for bleeding gums.
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Notes: Reduces pain, swelling, and infection. Portland dentist eliminated post-procedure pain with 50% DMSO. Evidence from small studies and anecdotes, not large trials. Apply to clean tissues. Side effects: garlic taste, gum irritation.
Other Conditions (Non-ENT/Dental)
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Interstitial Cystitis:
* Dosage/Protocol: 50% DMSO (e.g., Rimso-50), 50 mL instilled into bladder via catheter, retained 15–30 minutes, every 1–2 weeks. AMD cites a case with 1 tsp (≈5 mL) oral DMSO in cranberry juice, twice daily, resolving symptoms in two months.
* Notes: Only FDA-approved use. Reduces bladder inflammation.
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Chronic Pain/Musculoskeletal Injuries:
* Dosage/Protocol: 70–90% DMSO topically (1–5 mL) to affected area, 1–3 times daily. Oral: 1 tsp (5 mL) in water, 1–2 times daily for systemic relief.
* Notes: Treats sprains, arthritis, CRPS. Rapid relief reported in 1960s trials.
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Autoimmune/Contractile Disorders (e.g., Scleroderma, Fibrodysplasia):
* Dosage/Protocol: 70–90% DMSO topically (1–5 mL), 2–3 times daily, or oral 1 tsp (5 mL) in juice, 1–2 times daily/weekly.
* Notes: Softens collagen, reduces pain. Anecdotal cases (e.g., scleroderma finger preservation).
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Skin Conditions (e.g., Psoriasis, Lichen Sclerosus):
* Dosage/Protocol: 70–90% DMSO topically (1–3 mL), 1–2 times daily, sometimes with steroids (e.g., 0.25% fluocinolone). Mouthwash (10–20%) for oral lesions.
* Notes: Reduces inflammation, itching. High success for pruritus ani (90%).
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Brain/Spinal Injuries:
* Dosage/Protocol: IV DMSO (1–2 g/kg, historical), or topical 70–90% (5–10 mL) within 90 minutes of injury. Oral: 1 tsp (5 mL) daily for chronic cases.
* Notes: May prevent permanent damage post-stroke/trauma. Limited human data.
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Internal Organ Conditions (e.g., Endometriosis, Ulcers):
* Dosage/Protocol: Topical 70% DMSO on abdomen (2–5 mL), 1–2 times daily, or oral 1 tsp (5 mL) in water, 1–2 times weekly. Ulcers: 10–20 mL 50% DMSO orally/infused.
* Notes: Case reports show pain relief (e.g., endometriosis). Iraqi studies on ulcers.
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Cancer:
* Dosage/Protocol: Topical 70–90% DMSO (2–5 mL) for pain, 1–3 times daily, or IV 10–20 mL 50–70% with other agents. Oral: 1 tsp (5 mL) daily, anecdotally.
* Notes: Enhances chemotherapy, reduces pain. 1967 studies showed remission.
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FWIW, I used DMSO 70/30 for osteoarthritis on foot and knees. On my foot it didn’t do anything, but on my knees it reduced the swelling significantly (though not as impressive as the ginger poultice a la Barbara O’Neill). I also used 70/30 DMSO successfully on a varicose vein on my leg, which reduced it with some 80%. Last week, I got a sensitive molar, and used DMSO on it, again 70/30, and it reduced the sensitivity somewhat. I went to the dentist though and there is large pocket as a result of a wisdom tooth extraction some 8 years ago. She lasered it, but it’s still not good, so I made an appointment for tomorrow. I guess with dosages and protocols, you just have to experiment to find out what works for you.
, however for some reason number 3, How DMSO Cures Eye, Ear, Nose, Throat and Dental Disease, does not show when you click on it, same for the one in the Handbook link you provided.
