High Dose Intravenous Vitamin C (and other vitamin infusions)

[Ant22]

On this forum I found the below post:

We were skeptical when our doctor advised Vitamin C IV therapy to our grandfather, who was diagnosed with advanced liver cancer and given two weeks to live. It's now been 7 months and he's still with us. Vitamin C IV still continues to save his life every day.

We found a supplier of Vitamin C IV Institute Pasteur.

We will share their page maybe someone it is in huge need of Vitamin C IV

vitamincvial.blogspot.com

I followed the above mentioned source described a protocol consisting of vitamin c and sodium bicarbonate, which according to @nature's post above is how you make sodium ascorbate (thank you for the suggestion nature! )

Alternative Cancer Therapy with Mega Dose Vitamin C IV with Sodium Bicarbonate

VITA C IV – Sterile IV Injection
(Mega Dose Vitamin C + Sodium Bicarbonate)
10000MG Ascorbic Acid (Vitamin C) + 4500MG Sodium Bicarbonate
Manufacturer: PharmaLife LABORATORIES
Price: 38USD$/iv bottle 100mL

How to use:
Week 1: 1 x 10 g (1 iv bottle) infusion per day, 3 times per week
Week 2: 1 x 20 g (2 iv bottles) infusion per day, 3 times per week
Week 3: 1 x 40 g (4 iv bottles) infusion per day, 3 times per week
Week 4: 1 x 50 g (5 iv bottles) infusion per day, 3 times per week

IV SALINE SOLUTION BAG (NaCl)
Prices:
IV Saline Solution NaCl 250 mL – 10US
IV Saline Solution NaCl 500mL – 12US$
It can be diluted with Saline Solution as needed!

STERILE DISPOSABLE IV INFUSION SET
- metalic spikes for Vitamin C IV Therapy
Price: 10USD/set

Supplier: Alexandru Calin
(Licensed in Chemistry)
E-mail: order.gerovital@gmail.com
Phone: +40723141550
(whatsapp / viber / telegram)
Bucharest, Romania, EUROPE

This website also provides some testimonials although I can't be sure how credible they are. The first one I came across there was the same one Laura quoted in this post, which means they copied stuff from the internet. I'd prefer to read their own stories but it looks like they only sell vitamin C and accompanying equipment.

More stories they copied from the internet (some do have links to sources): Vitamin C Intravenous IV Drip Therapy for Cancer: CANCER SURVIVOR STORIES

1. Pam Stevens (New Zealand). After just five months of twice weekly treatments together with a broad range of pharmaceutical grade nutritional supplements the patches of cancer in my bones had completely disappeared.

I have survived very aggressive, invasive breast cancer without resorting to chemotherapy, radiotherapy or drugs. Instead my chosen treatment path has been surgery, INTRAVENOUS VITAMIN C and pharmaceutical grade nutritional supplements.

The dose of VITAMIN C I have been on is 82.5 grams - initially twice a week but now once every fortnight. This has been administered since September 2005 and tolerated without any side effects other than thirst while having the treatment.


2. Denise McCabe (US) - (featured on CBS). "you're lucky if you're going to make it a year. That was the prognosis for Denise McCabe after she was diagnosed with breast cancer that had spread to other parts of the body. She started intense chemotherapy which left her debilitated, "I couldn't get off the couch, it was that terrible.

After just a few sessions of VITAMIN C IV, Denise felt better and had a little more energy. And even more importantly, "I started to notice that my cancer markers suddenly started to drop," says Denise.


3. Don C. Hemingway (Canada) "I started Intravenous VITAMIN C (IVC) in July 2005 at 25 gm doses and increased to 50 gm twice weekly but when the PSA tests in September were still increasing, I started searching for more information. I made an appointment to see the Doctors during November. Comprehensive testing indicated that I should be taking 100 gm of IVC at least weekly.

Since I could not be an outpatient, they gave me directions that I could give to a Doctor that was willing to give me the IVC. The PSA test in November at The Center was 22.5 ng/ml of serum.

"I have continued to take 100 gm IVC every 5 or 6 days since November and the PSA tests have been as follows: January 20.32, March 16.36, and May 13.6. The discomfort in the area of the prostate gland has disappeared and the declining PSA test tells me that I am on the right track.

"I have not had any side effects. The side benefits are that I have been able to continue with my regular duties, as well as play hockey and swim with my family and grand-children.


4. Charles C. Mary, Jr., A physician in New Orleans, Louisiana (was practicing IV-C since the times of Linus Pauling Lectures) - Not only does he recommend it for his patients, he has personal experience with the healing properties of ascorbic acid. In 1990 he developed colon cancer. Not wanting to go the traditional route of "cut, poison and burn", he decided to treat himself with megadoses of VITAMIN C IV (ascorbic acid).

Every day, for three months, he took 100,000 milligrams (100 grams) intravenously. Upon the persistence of his family and colleagues he agreed to have a resection of his colon after the vitamin therapy.

Much to the astonishment of the surgical team and pathologists, his cancer was gone- visibly and microscopically.


5. Reagan Houston, MS, PE, Hendersonville, NC United States. "They detail several regimens for various stages of cancer using a low-sugar diet,oral supplements of vitamins C & D (Cod Liver Oil), lipoic acid, selenium,magnesium and copper. For intensive therapy, IV vitamin C and vitamin K3 can be added.

Their regimens may reduce the amount of chemotherapy needed, or, hopefully, eliminate it entirely.

As a ten year survivor of aggressive cancer, I used a similar therapy to obtain complete remission. I never needed nor had surgery, chemotherapy or radiation of any kind".


6. Loretta Hill, 42, of Pittsgrove, Salem County, sits at a faux granite table, facing a TV, chatting with two other cancer patients in the Marlton office suite of family physician Vivienne Matalon.

Each patient is tethered to an intravenous bag of C and other nutrients hung above the table that will take 40 minutes to drip into them. The fee, not usually covered by insurance, is $110.

Hill can't prove that VITAMIN C saved her from colon cancer, but she fervently believes it has.

She was diagnosed in 2001, at age 38, after a sudden bout of rectal bleeding. She had surgery, radiation, two courses of chemo. Six months later, the cancer was back - but had spread to both lungs.

After those tumors were cut out, her oncologist offered irinotecan, which costs about $9,500 a week. But, she says, he held out little hope. He declined to be interviewed.

By then, Hill could barely function, much to the anguish of her husband and 9-year-old daughter.

When she heard about VITAMIN C IV infusions, she figured, "If this doesn't work, at least I'll be in a better position for more chemo."

Today, almost four years later, Hill is in college part time, plays soccer,and has no signs of cancer. Her weekly VITAMIN C dosage has been cut to 30 grams - about 500 oranges' worth - but she has no plans to quit because her only side effects are "fabulous hair and skin."


7. Bill Nath (one of 3 in Levine's study)- Nath consulted experts at four major cancer centers from Wichita to New York. All recommended chemo, radiation, and removal of all or part of the bladder. Total removal would include the prostate, adding risks of incontinence and impotence.

One specialist "said if I didn't remove the whole bladder, I would die," said Nath. "It was pretty traumatic."

Nath ultimately made a choice that seemed suicidal to his wife, friends, and doctors: to keep part of his bladder and forgo chemo and radiation.

Instead, he got 30 grams of VITAMIN C IV twice a week for three months, then every month or two for four years . Today, a decade after his diagnosis, Nath is cancer-free.

Levine, in collaboration with National Cancer Institute pathologists, reexamined, then published Nath's case and two others from Riordan's center.


8. Tami (Parkersburg, WV).

I am doing the IV Vitamin C and have had great results thus far. I was diagnosed Stage 3 breast cancer. I had 8 centimeters removed from first surgery, then 3.6 more second surgery (mastectomy), then some more in a third surgery where I had found a lump in remaining lymph nodes.

Following chemo, which almost killed me, I had a recurrence in the lymph nodes on the opposite side of the original cancer!

At this point I went with the IV VITAMIN C and other IV VITAMINS, supplements and natural diet.

My last tests showed that the recurrence of cancer was gone. My blood labs have been excellent and I am still getting one

Vitamin C infusion a week. I wish more people knew about this.


9. Tricia Thompson, (Canada). He takes Morphine to numb the pain he experiences. After one round of chemo, and a bout in the hospital for illeus (bowel stopped working), he is now to sick to continue chemo at this time.

He started on Intravenous VITAMIN C about 2 weeks ago, 50g 3x a week. He hasn't felt any improvement in his symptoms yet and said he actually feel a bit worse (Feb 21, 2007).

My dad went for his blood work and although his white blood cell count was still up and his red was still low, his cancer marker count ca9-19 went fro 950 to 320.

We understand this is still high, but it's definitely a step in the right direction.


10. Sandra from Chicago, US. I was having Vitamin C IV's once or twice a week for many months (until my veins were shot) and each contained 62.5 grams. (IV administration produces a much higher blood level than oral does). Plus I was supplementing with about 12-14 grams orally on my off days.


11. George received 30 grams (30,000 milligrams) of VITAMIN C IV twice a week for six weeks. X-rays six weeks later showed a marked decrease in the size of the tumors. George continued the injections. Six months later there was no evidence of cancer. Mr. Williams lived a relatively healthy life for another 14 years and died a few years ago of congestive heart failure at the age of 84.


12. The Lord led me to a new doctor who is giving VITAMIN C IV's. I am also on a drink with flaxseed oil/cod liver oil.

Since I started taking these supplements along with VITAMIN C IV, I am so amazed at how good I feel and at how much energy I have. After 10 IV's the doc will do blood work and see the miracle that has taken place....

All Intravenous Vitamin C /714X/Lipoic Acid messages


13. "I personally take Intravenous Vitamin C treatments along with many others that I know who have a variety of cancers and we have experienced many successes. Some are more successful than others because there is much more involved in conquering this disease naturally than just this one treatment as powerful and effective as it is. Diet and supplements are extremely important as well. A strong immune system is the key..".

"..The quickest and most miraculous turnaround that I have witnessed took place with a friend of mine who had terminal prostate cancer and had been given three weeks to live. In just a matter of a few weeks his condition reversed and now more than a year later he is still cancer free. His story is posted on this board under the prostate cancer section.

Intravenous Vitamin C TREATMENT TAKEN BY MY FRIEND FOR HIS TERMINAL PROSTATE CANCER, YOUNG MAN FROM PORTLAND WITH THYMOMA ,YOUNG WOMAN WITH BRAIN TUMOUR , MYSELF AND MANY OTHER SUCCESSES".

All Vitamin C IV / alternative treatments for Stage IV Sarcoma messages


14. "He had about 12 weeks of weekly Intravenous Vitamin C/ IV VITAMINS. Today he has no symptoms of disease.

He feels strong and healthy, takes no pain meds, has resumed all daily activities and his scans reflect this amazing change in his health. The oncologists who did his scans for him told him he should just keep up what he is doing."

All ANY KNOW SURVIVORS/.MIRACLES messages


15. "I was diagnosed 5 years ago with breast cancer. I have been treated for breast cancer using the IVC as my chemo. When I first started my C levels were low and my markers were in the high range. (I had the tumor removed but did not do conventional chemo or radiation). With the IVC's my C levels increased and my Cancer Markers dropped.

My Cancer Markers are now in the very low range of normal.

I continue to do IVC because I have ductal carcianoma insitu (pre cancer or dormant cancer cells)

We don't know how the IVC effects the insitu but by maintaining an optimal level of C in my system if the insitu were to become 'active cancer' then the C would get those cells. The 'side effects' from the IVC are better over all health. I go the The Center in Wichita and am very pleased with how they work with me and for me.

Vitamin C treatment shows cancer promise

More from the same site:

Case Report #1

A case of a 59 year old Hispanic female patient suffering from pancreatic adenocarcinoma metastatic to the liver status post whipple procedure on November 2012. A computed tomography (CT) scan of the abdomen revealed an ill-defined, low attenuation mass at the head of the pancreas, measuring 3.0 x 2.7 cm. The patient was diagnosed in 2012 and completed chemotherapy in May 16, 2013. Her weight at this time was 130 pounds on a 5’7 frame. On presentation, physical examination was notable for scleral icterus and jaundice. She presented cholelithiasis and a laparoscopic cholecystectomy was done. There were no palpable abdominal masses and no hepatosplenomegaly.

A blood analysis and a urinalysis were performed before the intravenous vitamin C treatment was started. Laboratory data showed elevated values of cholesterol (311 mg/dL), triglycerides (430 mg/dL), and carbohydrate AG 19-9 (288 U/mL).

The patient started the intravenous VITAMIN C treatmenton May, 05 2013 and initially received three different doses ofVITAMIN C the first week. The first dose was 25 gr of Vitamin C during 1hour infusion. The second infusion was 50 gr ofVitamin C over a period of 1.5 hr. The third infusion was 75 gr ofVitamin C over a period of 2 hrs. A maximum of 75 gr ofVitamin C was given three times a week over a period of 2 months.

During high doses of intravenous Vitamin C treatment, the laboratory data showed an important progress. Cholesterol and triglycerides values decreased to 266 mg/dL and 196 mg/dL respectively. Laboratory value of carbohydrate AG 19-9 lowered to 36 U/mL (normal range 0-35 U/mL). No other treatment was given during IV Vitamin C therapy.

A whole body PET/CT study was performed on July 05, 2013. Her weight at this time was 140 pounds. The liver appeared enlarge with diffuse FDG activity. No focal areas of abnormal FDG uptake were noted within the hepatic parenchyma. The spleen, adrenal glands and visualized pancreatic portions demonstrate no area of abdominal FDG uptake. According to the PET/CT impression “no hypermetabolic foci to suggest F-18 FDG avid active neoplastic process or metastatic disease at present time.” No adverse side effects were reported by the patient during and after the intravenous vitamin C treatment.


Case Report #2

A case of a 56 year old Hispanic male patient man with a medical history presenting hyperlipidemia, hypertension and diabetes, suffering from pancreatic adenocarcinoma metastatic to the liver status post whipple procedure on January 07, 2014. Metastatic process detected in two of five peripancreatic lymph nodes. A computed tomography (CT) scan of the abdomen revealed a moderately defined mass at the head of the pancreas, measuring 6.5 x 4.5 cm. He arrived to the clinic February 17, 2014 and was weighing 97 pounds in a 5’7 frame. On presentation, physical examination was notable for scleral icterus and jaundice. There were no palpable abdominal masses but hepatosplenomegaly was present. His peripheral laboratories revealed a total bilirubin of 10 mg/dL (normal range 0.3–1.9 mg/dL), whereas the aspartate aminotransferase and alanine aminotransferase were 230 IU/L (normal range 8–48 IU/ L) and 615 IU/L (normal range 7–55 IU/L), respectively. Alkaline phosphatase was elevated at 245 IU/L (normal range 45–115 IU/L).

A blood analysis and a urinalysis were performed before the intravenous Vitamin C treatment was started. Laboratory data showed elevated values of cholesterol (250 mg/dL), triglycerides (320 mg/dL), and carbohydrate AG 19-9 (59 U/mL). Carcino Embryonic Antigen (CEA) 6.5 Ng/mL. Patient decided not to receive chemotherapy.

The patient started the intravenous Vitamin C treatment on February 24, 2014 and initially received three different doses of Vitamin C the first week. The first dose was 25 gr of Vitamin C during 1 hour infusion. The second infusion was 50 gr of vitamin C over a period of 1.5 hr. The third infusion was 75 gr of Vitamin Cover a period of 2 hrs. A maximum of 75 gr of Vitamin C was given three times a week over a period of 6 months.

During high doses of intravenous Vitamin C treatment, the laboratory data showed important progress. Cholesterol and triglycerides values decreased to 170 mg/dL and 180 mg/dL respectively. Laboratory value of carbohydrate AG 19-9 lowered to 20 U/mL (normal range 0-35 U/mL). Carcino Embryonic Antigen lowered to1.45 Ng/mL (normal range < 2.5 Ng/mL). No other treatment was given during IV Vitamin C therapy.

A whole body PET/CT study was performed on August 27, 2014.The liver appeared slightly enlarge with no FDG activity. No focal areas of abnormal FDG uptake were noted within the hepatic parenchyma. The spleen, adrenal glands and pancreatic portions showed no area of abdominal FDG uptake. According to the PET/CT impression “no hypermetabolic foci to suggest F-18 FDG avid active neoplastic process or metastatic disease at present time.” The patient’s weight went up to 145 pounds. No adverse side effects were reported by the patient during and after the intravenous vitamin C treatment.


CASE Report # 3:

A Doctor Speaks:

I notice that many people are using the IV SA (Vitamin C) 50 grams twice a week.

· This dose did not work for me.
· My tumour marker increased!
· In fact, it doubled in three weeks
· and another tumour started to protrude through my abdominal wall.

I increased my dose to 100 grams daily then 125grams every third day. I started the IV Vitamin C the first week of July 2006 and by mid October 2006 my scan was completely clear.

One tumour on the pelvic wall had disappeared and substantial tumours on the colon had vanished, but the small tumour on my abdominal wall is still here but it has almost gone.

My husband is a doctor and we decided to increase to 200grams daily because my ovarian cancer is so aggressive and I was going down hill very quickly. I had got to the stage where I was sleeping all day and had recurrent intestinal blockages.

· Now I take no painkillers at all and I can shop and drive again.
· More importantly, I can look after my four children from 20 to 4 years old.

We did the IV every night in our bedroom using a very fast drip to get the high saturation levels that are needed. A slow drip did not work for me. 100 grams over 2 1/2 hours.

To get the maximum tumour kill we used Vitamins K1&2 or K3. B12 is also important.

Everyone is different.

Mine is an extremely aggressive cancer. My tumour marker can move from 7 to 1200 in two months. My highest figure was 8500.

I usually start the drip in the evening but at times when I have been really scared I have been on a drip round the clock.

Vitamin C is non toxic so you do what you have to do to survive.


CASE Report #4:

His cancer is extremely aggressive and he was too weak for chemotherapy. He started Intravenous VITAMIN C about 2/12 weeks ago 50grms 3x week.

His cancer marker has gone from 650 to 320 in that time. But he is feeling quite sick and weak. His red blood cell count is 3.89, white is 19 and Hmgbl 115.

I was also told that change of diet ( no refined foods, no sugar, no withe flour, rice and coffee BUT lots of raw vegetables and fruits) and giving up bad habits like smoking and social drinking...and also reduction in stress HELPS with this treatment.

 

[Ant22]

One more source: United States Patent: 6284786

This one mentions using vitamin C combined with Alpha Lipoic Acid. Other sources and testimonials also mentioned ALA.

United States Patent6,284,786Casciari , et al.September 4, 2001

Treatment of cancer using lipoic acid in combination with ascorbic acid

Abstract
Lipoic acid and/or its water soluble salt is used to treat cancer, alone or in combination with ascorbic acid (vitamin C). Alone or in combination, it was shown to be effective on in vitro tumors and mouse tumors. The agents can be administered safely, and have been used effectively in case studies.

(...)

What is claimed is:
1. A method for the treatment of cancer in a mammal comprising the steps of:

administering to said mammal a concentration of lipoic acid in an amount effective to slow or stop the growth of said cancer, wherein said cancer is sensitive to lipoic acid.

2. The method of claim 1, wherein said effective amount is 100-25,000 mg/day.

3. The method of claim 1, wherein said effective amount is 300-600 mg/day.

Description

FIELD OF THE INVENTION

This invention relates generally to methods of cancer therapy and particularly the use lipoic acid as a therapeutic agent administered in combination with ascorbic acid. Ascorbate has been shown to be selectively toxic toward tumor cells, but at doses that are too high to be achieved clinically. Both lipoic acid and its water-soluble sodium salt enhance the efficacy of sodium ascorbate against three-dimensional in vitro tumors and in mouse tumors. These agents can be administered safely to patients, and in preliminary trials have been shown to stabilize or resolve disease.

BACKGROUND OF THE INVENTION

The most common methods currently in use for the treatment of cancer include surgery, radiation therapy, and chemotherapy. While these therapies are successful for some forms of the disease, they are far from universally successful in curing cancer. Moreover, traditional therapeutic regimens often cause adverse side effects such as nausea, vomiting, cardiac toxicity, bone marrow suppression, and secondary cancer. Vitamin C (ascorbic acid, ascorbate) has been proposed as an alternative to chemotherapy or as an adjuvant to lessen side effects associated with it. (For the purposes of this application, a reference to ascorbic acid includes the anionic component, ascorbate whether as an acid or one of the pharmaceutically acceptable salt thereof, most notably including sodium ascorbate and calcium ascorbate, any of which are included in a reference to "ascorbic acid" or "ascorbate"). Ascorbic acid has been thought by some to improve immune response and to prevent tumor spreading by strengthening extracellular matrix, but these theories have not as yet been conclusively proven. Clinical trials with ascorbate at doses on the order of 10 g/day were successful in some cases, but not in others. At very high doses, ascorbic acid is preferentially toxic to tumor cells. This preferential toxicity is understood to relate to the ascorbate mediated production of hydrogen peroxide, which is more toxic to tumor cells due to the lower levels of catalase typically present in tumor cells as compared to normal cells. High dose intravenous ascorbate has thus been suggested for the treatment of cancer, as described in U.S. Pat. No. 5,639,787.

Critical to the use of high dose intravenous ascorbate as an anti-cancer agent is the ability to clinically achieve plasma ascorbate levels sufficient to kill tumor cells. Previous measurements of ascorbate plasma levels following intravenous infusion demonstrate concentrations greater than those needed to kill tumor cells grown in monolayer cultures in vitro. However, much higher levels of ascorbate are required to kill tumor cells grown as three-dimensional in vitro tumors. Using the hollow fiber "solid" tumor model, it has been observed that ascorbate concentrations in excess of 500 mg/dL may be required to effectively treat tumors. Currently, the maximum plasma ascorbic acid concentration generally achievable in humans by intravenous infusion is roughly 500 mg/dL, a peak level that drops off sharply over a relatively short period of time. Although ascorbate is relatively innocuous to human patients, the need for higher plasma concentrations demonstrates a need either to safely raise effective plasma levels of ascorbate or to increase the cytotoxic effectiveness of ascorbate toward cancer cells to decrease the required dosage.

SUMMARY OF THE INVENTION

One object of the invention is to provide a method for treating cancer by administering lipoic acid and/or a water soluble salt of lipoic acid. Preferably the lipoic acid is administered at 100-1000 mg/day. More preferably at 300-600 mg/day.

A further object of the invention is to provide a method for treating cancer wherein the lipoic acid or combined therapy is used in combination with another therapy. Preferably the lipoic acid is used in combination with ascorbic acid (vitamin C). Preferably the ascorbic acid is administered intravenously at 15-700 g/week, more preferably 50-200 g/week. The preferred ratio of ascorbic acid to lipoic acid is from about 1:1 to about 3500:1, more preferably from about 10:1 to about 100:1.

A further object of the invention is to provide a pharmaceutical composition for treating cancer in a human or other animal comprising lipoic acid and ascorbic acid in an effective dose. The preferred ratio of ascorbic acid to lipoic acid is from about 1:1 to about 3500:1, more preferably from about 10:1 to about 100:1. Preferably the dose of ascorbate is 2-250 g per infusion per day. Preferably the concentration of lipoic acid is 100-1000 mg.

DETAILED DESCRIPTION OF THE INVENTION

The method of the present invention comprises the treatment of cancer by administering ascorbic acid in combination with lipoic acid in sufficient amounts to achieve a level of concentration in the patient's plasma that is cytotoxic to the cancer cells as demonstrated experimentally using in vitro culture models that mimic the in vivo solid tumor. The basis of the present invention is the discovery, through experimentation, that the concentration of ascorbate required to induce cytotoxicity in an in vitro solid tumor model is significantly reduced when the ascorbate is administered in combination with lipoic acid. Specifically, a ten to one ratio of ascorbate to lipoic acid was found to reduce the ascorbate concentration required to kill fifty percent of the tumor cells treated by roughly a factor of five over that necessary to achieve the same cell killing with ascorbate alone. This was a surprising result, since lipoic acid is a free radical scavenger that has been shown to inhibit ascorbate mediated hydrogen peroxide generation by erythrocytes. The importance of using lipoic acid in combination with ascorbate is that the level of ascorbate required for effective tumor toxicity is reduced to a level that has been successfully replicated in vivo, i.e. in the plasma of patients to whom the combination is administered through intravenous infusion.

Target levels of ascorbic acid and lipoic acid can be set according to the type of cancer afflicting the patient using in vitro studies of cytotoxicity in similar cell lines. More accurate target levels can be achieved by in vitro experimentation of malignant cells taken from the patient if such are available. This invention is not specific to a given ascorbate dose or schedule of intravenous administration. The use of one to eight hour infusions or continuous infusions with the aid of infusion pumps may be indicated. Nor is this invention specific to the vehicle of lipoic acid administration.

Further features and advantages of the present invention will become apparent to those of skill in the art in view of the detailed description of the preferred embodiments which follows when considered together with the attached drawings and claims.

DL-.alpha.-Lipoic Acid (DL-6,8-Thioctic Acid) is a lipophilic antioxidant that can be readily obtained commercially in clinical or research reagent grade. While the lipophilic form is favorable for in vivo use, some in vitro experiments were carried out using a water soluble salt produced from lipoic acid by mixing the acid with sodium bicarbonate in aqueous solution and then drying by lyophilization. For the purposes of this application, a reference to lipoic acid includes both the lipophilic acid and the water soluble salts.

Although other material and method similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described. Example 1 describes toxicity studies that were done on cell monolayers to determine the feasibility of using the combination of ascorbic acid and lipoic acid to treat cancer.

EXAMPLE 1

Toxicity Tests in Cell Monolayers

The toxicity of ascorbic acid and lipoic acid (sodium salt) was tested in immortalized cell monolayers of both tumor and normal tissue origin. In solid tumors, proliferating cells are sometimes more sensitive to treatment than quiescent, non-proliferating cells. To investigate this in cell monolayers, we used sparse plating densities (6 K/well in a 96 well plate) to allow cell proliferation and confluent densities (24 K/well in a 96 well plate) to simulate quiescent cells. Cells were plated in 96 well plates at sparse or confluent densities and then incubated four days in growth medium supplemented with various doses of antioxidants. After incubation, cell numbers were determined by standard calorimetric techniques. Data were analyzed by scaling the cell number at any given antioxidant dose to that of the control and fitting the dose-response data to a sigmoid curve. Values of LC.sub.50, the dose required to reduce cell number by fifty percent relative to untreated controls, were computed from the sigmoid data fit. Results are given in the accompanying table.

Human Cell Types and Densifies Used LC.sub.50 (mg/dL) Line Origin Density Ascorbate Lipoic Acid ECV-304 Endothelial Sparse 149 .+-. 16 127 .+-. 15 Confluent no data no data SW620 Colon Sparse 30 .+-. 4 34 .+-. 2 Adenocarcinoma Confluent 39 .+-. 14 24 .+-. 2 SK-MEL Melanoma Sparse 15 .+-. 2 70 .+-. 20 Confluent 78 .+-. 16 22 .+-. 2 Mia PaCa Pancreatic Sparse 53 .+-. 6 80 .+-. 21 Carcinoma Confluent 308 .+-. 33 109 .+-. 45 MCF-7 Breast Sparse 12 .+-. 1 125 .+-. 31 Carcinoma Confluent 23 .+-. 3 60 .+-. 245

These data indicate that lipoic acid is toxic to cells at high doses; moreover, the LC.sub.50 values for the four tumor cell lines studied (SW620, SK-MEL, Mia PaCa, and MCF-7) tended to be lower than those for the cell line derived from normal tissue (ECV-304), suggesting a greater toxicity toward tumor cells than normal cells. This was a surprising result, since there are no reports of hydrogen peroxide generation by lipoic acid; in fact, lipoic acid has been shown to inhibit ascorbate mediated hydrogen peroxide generation by erythrocytes. There seems to be little dependence of lipoic acid LC.sub.50 on cell density, suggesting that its toxic effect is not dependent upon cell proliferation. In contrast, the data for ascorbate suggest that confluent cells were more resistant.

To determine whether the combination would work on solid tumors, in vitro tests were performed in Example 2.

EXAMPLE 2

Combination Therapy Tests in Hollow Fiber Solid In Vitro Tumors

Experiments combining ascorbate and lipoic acid were carried out using the SW620 hollow fiber solid tumor model. In this in vitro tumor model, SW620 cells grow in three dimensions, forming a cylindrical tumor mass roughly 500 .mu.m in diameter that is similar in terms of microenvironment and proliferative heterogeneity to a micro-region of a solid in vivo tumor. As with solid tumors, drugs must penetrate the inner regions of hollow fiber tumors by diffusion. This model thus provides a more formidable test for drug efficacy than cell monolayers.

SW620 hollow fiber solid tumors were grown as previously described. Briefly, PVDF hollow fibers (500 KD molecular mass cutoff, 500 mm inside diameter with a roughly 100 mm wall thickness, Spectrum Medical Co.) were prepared for cell culture use by soaking them for one week in methanol and then storing them in cell culture medium (RPMI medium supplemented with antibiotics, glutamine, and 10% fetal calf serum). SW620 colon carcinoma cells were prepared in cell culture medium at a concentration of 10.sup.7 cells/ml and injected into the hollow fibers. The fibers were then heat sealed at roughly 2 cm intervals to trap the cells inside them. SW620 hollow fibers were then cultured in Petri dishes for three days. After three days, the hollow fibers are transferred to stirred medium either by moving them to spinner flasks containing 50 ml cell culture medium stirred at 150 rpm by a magnetic stirrer or by transferring them to six-well plates placed on an orbital shaker at 150 rpm. Cell culture medium was replenished on days three and six. On day eight or nine, SW620 hollow fiber tumors were transferred to twenty-four-well plates containing cell culture medium supplemented with various doses of ascorbate and lipoic acid or lipoic acid sodium. After one or two days incubation on an orbital shaker, the hollow fiber tumors were rinsed and the cells were extruded out of the fibers with trypsin. The cylindrical tumor cell mass was exposed to trypsin while pipetting up and down to form a single cell suspension. Cell culture medium was then added to stop trypsin action. Surviving fractions were determined as previously described. Briefly, cells were transferred to ninety-six-well plates at a concentration of 5000 cells per well and incubated for six days. The surviving cell population was then measured using the SRB colorimetric assay. Surviving fraction was expressed as the ratio of the SRB staining at a given dose to that for cells from untreated hollow fiber tumors.

The effect of lipoic acid on SW620 hollow fibers was analyzed using dose-response curves for SW620 colon carcinoma tumor cells grown for nine days as hollow fiber tumors and treated for 48 hours with sodium ascorbate alone or in combination with lipoic adic. Lipoic acid concentrations of 5 mg/dl or 20 mg/dl were tested. The surviving fractions without ascorbate (denoted SF .sub.o) were analyzed along with the doses of ascorbate required to reduce the surviving fraction to half the SFlhd o value, denoted LC.sub.50. Standard deviations for SF.sub.o and LC.sub.50 values were analyzed by the curve-fitting program KaleidaGraph (Synergy Software). In this experiment the lipoic acid concentration was kept constant while the ascorbate dose was varied. It was clear from these data that lipoic acid itself, at the two concentrations tested, exhibited a toxic effect against tumor cells grown in three dimensions; moreover, lipoic acid amplified the toxic effects of ascorbate, causing reductions in surviving fraction at much lower doses than for ascorbate alone. The LC.sub.50 value for ascorbate in the presence of 20 mg/dL lipoic acid was roughly half that in the absence of ascorbate, and the difference was statistically significant. This effect on ascorbate efficacy was not expected a priori. The ability of lipoic acid to scavenge free radicals that would otherwise be converted by ascorbate to hydrogen peroxide might suggest a protective effect rather than a toxic one. Lipoic acid, like other lipophilic antioxidants such as vitamin E, may recycle ascorbate from the reduced dehydroascorbate form. However, the effect of this recycling is uncertain: while recycled ascorbate may increase cytotoxicity due to increased hydrogen peroxide generation, any cytotoxic effects generating from the actions of ascorbate oxidation products will be reduced. Thus, the mechanism of lipoic acid's enhancement of ascorbate toxicity is unknown, though it may aid in killing quiescent cells that are resistant to ascorbate, as suggested by the cell monolayer data above.

Additional tests were carried out by varying the lipoic acid concentration with the ascorbate concentration while using a 100:1 ratio of ascorbate to lipoic acid (to yield a lipoic concentration from 5 to 10 mg/dL at the LC.sub.50). The effect of lipoic acid in series of experiments was to again decrease the ascorbate LC.sub.50 against SW620 hollow fiber tumors by roughly a factor of two. Since in vitro experiments with lipoic acid were limited by its hydrophobic properties, we used the hydrophilic sodium salt to lipoic acid to provide higher ascorbate to lipoic acid ratios. Specifically, a 10:1 ratio of ascorbate to the sodium salt of lipoic acid was tested against SW620 hollow fiber tumor cells. Dose response curves for SW620 colon carcinoma tumor cels grown for 9 days as hollow fiber tumors and treated for 48 hours with sodium ascorbate alone or in combination with the sodium salt of lipoic acid were prepared. In the combination treatment, the lipoic acid to ascorbate ratio was 1:10. Data from three replicate experiments were pooled. The doses of ascorbate required to reduce the surviving fraction to half the control value were denoted as LC50. Standard deviations on LC50 values were estimated by the curve-fitting program kaleidaGraph (Synergy Software). The results, suggest that lipoic acid sodium at this ratio can reduce the ascorbate LC.sub.50 by roughly a factor of five, from 490 mg/dL in the absence of lipoic acid to 90 mg/dL in the presence of lipoic acid. The importance of this result is indicated by comparing the concentrations of ascorbate required for cytotoxicity in hollow fiber tumor to the doses that can be obtained in blood plasma during intravenous infusion. A plasma ascorbate concentration of 490 mg/dL is much more difficult to achieve and sustain than a value of 90 mg/dL.

To determine the feasibility of in vivo administration of the combination therapy, in Example 3 serum levels were determined after intravenous administration.

EXAMPLE 3

Studies of Ascorbate Pharmacokinetics: Implications for the Present Invention

Pharmacokinetic measurements and compartmental analysis were used to determine the potential relevance of lipoic acid and ascorbate combination therapy in the clinic. A seventy-five year old Caucasian male with diagnosed metastatic prostate cancer was infused intravenously with 65 grams sodium ascorbate in sterile water over an eighty minute period. Blood samples were taken at regular intervals over a twenty-four hour period, frozen, and then analyzed for ascorbate content using a colorimetric assay. The ascorbate plasma concentration was analyzed in a prostate cancer patient given a 60 gram intravenous infusion of sodium ascorbate over an 80 minute period. Plasma ascorbate levels measured over a 24 hour period were fit to a two compartment, four parameter pharmacokinetic model of ascorbate uptake and clearance from plasma and tissue. The following parameter values were obtained: K.sub.x =0.124 min.sup.-1, K.sub.1 =0.124 min.sup.-1, K.sub.2 =0.038 min.sup.-1. The plasma volume V.sub.p, was fixed at 30 dl. A peak plasma value of 460 mg/dL was obtained, but it quickly diminished with time. Since levels might be sustained longer with continuous infusions, the two-compartment model was used, and hypothetical plasma ascorbate curves were computed for the case of continuous twenty-four hour infusions of various ascorbate doses. Predicted plasma ascorbate levels from a two compartment, four parameter pharmacokinetic model of ascorbate transport and clearance in blood. Plasma vs. time curves are given for five different infusion doses: 25, 50, 75, 100, and 125 grams per day. The infusion rate, G(t), is set to various values as shown in the figure. Infusion is modeled as continuous. Parameter values for the compartmental model are as follows: K.sub.x =0.124 min.sup.-1, K.sub.1 =0.124 min.sup.-1, K.sub.2 =0.038 min.sup.-1. The plasma volume, V.sub.p, was fixed at 30 dl. A phase one clinical trial is currently under way to assess the safety of continuous ascorbate infusions, and is currently near completion. Doses up to 50 g/day were tested and found safe. From the modeling results in EXAMPLE 3 this dose is expected to produce plasma concentrations of roughly 52 mg/dL after twenty-four hours. Based on the data in EXAMPLE 2, SW620 hollow fiber tumor cells exposed to 52 mg/dL ascorbate for forty-eight hours would have a surviving fraction of greater than ninety percent; in contrast, the same tumor cells exposed to the same ascorbate dose combined with lipoic acid would have a surviving fraction of only sixty percent.

Thus, dose-response data with hollow fiber in vitro tumors, combined with pharmacokinetic data and modeling, suggest that ascorbate is toxic at clinically achievable doses when lipoic acid is used in combination with it. Therefore, tests were performed in an in vivo cancer model.

EXAMPLE 4

Toxicity Tests in a Murine Tumor Model

Lipoic acid alone or in combination with ascorbate (a 10:1 ascorbate to lipoic acid ratio) was tested against mouse tumors at the Beijing institute. C57 mice were divided into groups of twenty and inoculated by B16 melanoma cells subcutaneously. After forty-eight hours, treatments were administered once every other day for a five week period by subcutaneous injection near the tumor site. Tumor size was measured on days ten, seventeen, and twenty-four of treatment. The tumors in mice treated with lipoic alone or in combination with ascorbate were significantly smaller than those in the control group. Data at day twenty-four are given in the accompanying table:

Treatment Group Relative Tumor Size Animal Survival Control 100% 14/20 (70%) Lipoic Acid Alone 60% (p < 0.01) 18/20 (90%) Lipoic Acid and Ascorbate 51% (p < 0.01) 13/20 (65%)

Lipoic acid was toxic to mouse tumors with or without ascorbate, although animal survival rates were better for the combination. While the results for lipoic acid alone are surprising, the experiment overall confirms the utility of using lipoic acid as an anti-cancer agent in combination with ascorbate. Therefore, in the following case studies, combination therapy was initiated.

EXAMPLE 5

Case Studies Using the Combination Therapy

Case Study #1:

A sixty-five year old Caucasian female began treatment at our clinic on Dec. 1, 1998. In the previous year she was diagnosed by her oncologist as having low-grade small-cell malignant lymphoma with the involvement of the bone marrow. The circulating platelet count is a good indicator of metastatic burden in the bone marrow, as the expected course for this disease is for an unremitting decline in circulating platelet levels. Indeed, the patient indicated in her correspondences with our clinic that her platelet counts had fallen from 239,000 to 160,000 in the six months immediately prior to the commencement of lipoic acid therapy. She was placed on a regimen of 300 mg Lipoic Acid daily along with other nutritional supplements to accommodate her nutritional deficiencies. Two months later, She was started on intravenous vitamin C therapy, at 50 grams twice per week. Six months after her first visit, her ascorbate dose was increased to 75 grams twice per week. The patient's platelet levels remained relatively stable during the course of treatment: her counts never went below 100,000 as normally expected with this type of cancer. Six months after initiating lipoic acid treatments, her platelet count was stable at 190,000.

Case Study #2:

A 70-year-old Caucasian male was diagnosed with pancreatic cancer on Dec. 3, 1996. He opted to undergo traditional chemotherapy in January 1997. One tumor marker for pancreatic cancer is a carbohydrate antigen known as CA-19-9. The patient's antigen level decreased initially after the first chemotherapy treatment; however, by October, 1997, the his CA-19-9 level had increased to a value of 7,400 units/mL serum. At that time he was placed on a regimen of 15 grams intravenous vitamin C, given two times weekly and 300 mg oral lipoic acid, taken two times per day, as well as other nutrient supplements that the patient was deficient in. One month later his dose of Vitamin C increased to 25 grams two times per week. Within two months the patient's antigen level had dropped to 3,200 units/mL serum. At that time his dosage of Vitamin C was increased incrementally 30 grams, 50 grams, and finally 75 grams. In January, 1998, the patient opted to stop chemotherapy while continuing lipoic acid and ascorbate treatments. The levels of CA-19-9 however continued to fall. In March 1998, the patient's CA-19-9 was 700 units/ml serum. The patients CA-19-9 levels during the time course of treatment with ascorbate and lipoic acid decreased. The levels of CA-19-9, a pancreatic cancer marker, expressed as units per mL of serum, were analyzed with time. Lipoic acid was given orally at a dose of 300 mg administered twice daily. Ascorbate was given intravenously at an initial dose of 15 grams per week. This dose was incrementally increased to 25 grams twice per week, one month after the onset of therapy, and thereafter was incrementally increased to 30, 50, and finally, 75 grams twice per week. The patient discontinued ascorbate and lipoic acid therapy in March 1998, after six months of treatment. He died four months later.

Case Study #3:

A 53-year-old Caucasian male was diagnosed with colorectal cancer with liver metastases, and underwent surgery to remove the largest of the liver metastases. The patient was started on low dose 5-fluorouracil chemotherapy, intravenous vitamin C, and oral lipoic acid. He was also given various nutritional supplements to combat diagnosed deficiencies. The vitamin C dose was gradually increased to 100 grams, administered twice weekly by intravenous infusion. He continued therapy until March 1998, when he was declared to be cancer-free. On his last follow-up in December 1998, the patient was still cancer-free.

 

[Ant22]

In this post of mine Dr Hoffman was quoted as a source of information provided in the article. I'm not sure if it's the same person but I found a Dr Hoffman who administers vitamin C for cancer: Intravenous vitamin C for cancer

He uses dosages up to 100,000 mg (100 grams) per day and the article provides further reference to 200,000 mg (200 grams) per day in infusions lasting 4-12 hours several times a week. I bolded those dosages in the quoted text below.

The article also describes a case of vitamin C being rejected as an ineffective cure, but this was done based on oral administration. Interestingly enough, the person who made that claim got cancer later in life himself.

For more than 20 years, the Hoffman Center has been using high-dose vitamin C drips in its cancer support protocols. The initial impetus was from Linus Pauling who, together with Ewan Cameron, pioneered the use of high-dose C in cancer in the 1960s.

Now, there’s new interest in this modality for fighting cancer based on new, exciting research under way at the National Institutes of Health.

Cameron and Pauling found that vitamin C helped cancer patients live about four times longer than cancer patients not given vitamin C. They administered high-dose vitamin C in the form of sodium ascorbate given orally and intravenously to treat more than 1,000 cancer patients.

Nonetheless, vitamin C for cancer suffered a setback when Dr. Charles Moertel of the Mayo Clinic, an arch foe of nutritional therapies for cancer, sought to disprove Pauling’s thesis. But he did not follow the Pauling/Cameron instructions or regimen.

Moertel selected a cohort of terminal colon cancer patients who had not responded to all forms of conventional treatment, including surgery, chemo and radiation, and administered 10 grams of vitamin C to them orally. When the patients failed to demonstrate improved survival over patients not receiving vitamin C in the study, Moertel pronounced the vitamin C/cancer hypothesis defunct.

Moertel failed to note that the benefits achieved by Pauling and Cameron’s patients were obtained via both IV and oral C. He ultimately succumbed to cancer himself years later.

Alternative practitioners, meanwhile, sought to resurrect IV vitamin C as a tool in the treatment of cancer, but not until recently has serious academic research resumed.

Dr. Hugh Riordan of Kansas treated hundreds of cancer patients with doses of vitamin C up to 200,000 mg (200 grams) per day in infusions lasting 4-12 hours several times a week. He compiled a series of case histories documenting impressive responses but passed recently, before his work was generally acknowledged.

His protegee, Dr. Jeanne Drisko, Director, KU Integrative Medicine, has undertaken a series of clinical trials to validate the benefits of IV vitamin C in cancer. An FDA approved trial is now underway.

Research at the National Institutes of Health is beginning to suggest that vitamin C deserves another chance to find its niche in the arsenal of anti-cancer therapies. Studies now suggest that even high dose vitamin C given by mouth is poorly absorbed. Blood levels “max out” at doses of 500 mg given several times during the day.

But vitamin C given intravenously is another story. When delivered in a “drip,” much higher concentrations of C can be attained. At these higher concentrations, vitamin C has different characteristics than if given orally. While oral vitamin C boosts immunity and assists tissue repair, it is too weak to do much to kill or inhibit cancer cells. But at high doses delivered directly into the bloodstream, it may act to increase levels of hydrogen peroxide deep in the tissues where cancer cells lurk. Peroxide-mediated killing is one of the white blood cells’ key mechanisms for fighting infection and cancer.

Research currently under way has shown that high concentrations of vitamin C can stop the growth or even kill a wide range of cancer cells. Only intravenous administration of vitamin C can deliver the high doses found to be effective against cancer.

IV vitamin C, when administered by a trained, experienced physician, is safe and well-tolerated, even at doses as high as 100,000 mg (100 grams) per day. Proper blood tests must be done to ensure that it is well-tolerated, and the patient must be monitored. Doses must be gradually adjusted upward. Not all patients are candidates for IV vitamin C. Vitamin C can be safely administered even while patients are undergoing chemo and radiation; in fact, the FDA-approved trial at the University of Kansas Medical Center explicitly permits the co-administration of vitamin C with conventional treatments.

Intravenous vitamin C remains one of the key modalities employed by the Hoffman Center in support of recovery from cancer, and it is hoped that additional research, now under way, will further document its benefits.

 

[beetlemaniac]

I spoke to the doctor I mentioned earlier about his normal protocols for IV Vitamin C;

For General Wellness:
- 15 - 30 g Sodium Ascorbate once a month
- Optional: Include CoQ10, Glutathione, Collagen, Vit. E, ALA, Magnesium, B-Complex

For Cancer:
- An initial intensive phase with 30 - 60 g Sodium Ascorbate a day
- Infused daily for 5-7 days, then a break followed by a reassessment after 2 or 3 weeks
- Optional nutrients above are provided by default to attack the problem from multiple angles

For Viral infections (such as Dengue and HPV):
- 30g Sodium Ascorbate daily for 3-5 days

He generally does the above in combination with other things which of course would include diet. I know that he has some other therapies available like Ozone, FIR, and some new Russian-made system which sends red light through the veins.

There's so much information out there and the gist of it is that many seem to be recommending upwards of 100g IVC daily. I'm not sure if this doctor does such high doses, but I could ask him if it ever was necessary in some cases.

As a side note: I find it really curious that Vitamin C can be useful in cases of Schizophrenia, as in Gaby's post:

–Schizophrenia: Dr. Klenner reminds us of Hoffer and Osmond’s work with niacin and Vitamin C back in the early 1950’s. Six to 8 grams of C a day made the niacin work. One schizophrenic took one gram every hour for 48 hours and was completely recovered for six months with no further treatment. These megadoses halved the suicide rate. It has been demonstrated that schizophrenics burn up C ten times faster than the normal population.

I've restarted taking Vitamin C and I seem to be getting more control over my thinking - go figure, it could be a placebo.

 

[Oxajil]

A Myer’s cocktail is a Nutritional IV Therapy. It is named so after Dr. John Myer and is commonly misnamed a ‘Meyer’s cocktail.’

It is unknown what the true “Myer’s cocktail” was, as there was no written account of the exact treatment. Patients of John Myer reported that he used a 10-mL syringe to perform a slow vitamin push of various nutrients into the vein. Today, IV nutrient therapy or IV vitamins is used interchangeably with the name Myer’s cocktail and consists of various different vitamins and minerals in combination to treat specific diseases. The Myer’s cocktail is now done in an IV bag, rather than a vitamin push from a syringe. The patient receives more hydration and nutrients this way. Common nutrients found in IV vitamin therapy are:

Ascorbic acid (vitamin C)
B complex
Magnesium chloride
Calcium chloride

I found a clinic not too far away that provides the 'Myer's cocktail' through IV: Dr. Mulder's clinic. It's also possible to add other stuff, including glutathione! It's a bit pricey (cocktail costs 100 euros), but I might give it a try next year. I'm going to ask if vit C IV would be possible, as they do provide vit D or magnesium or B12 IV separately (which cost only 30 euros).

 

[beetlemaniac]

This study that Gaby posted some time ago in the Vitamin C thread about it's dual antioxidant and oxidating effects was interesting and I thought it was worth reposting here. In summary, in the treatment of cancer, Vitamin C has dual effects depending on whether the cell is healthy or cancerous. For healthy cells, it acts as an electron donor and thus is antioxidative, whereas for cancer cells it helps with the generation of hydrogen peroxide which is oxidative. Here's the post.

 

[nicklebleu]

Read this interesting article about vitamin C in relation to cancer treatment. Apparently iron plays an important role in damping or abolishing the vitamin C effect (hydrogen peroxide)


Link to the article: Depletion of Iron From Tumor Cells Prior To Vitamin C Therapy - LewRockwell LewRockwell.com

It is widely known that mega-dose vitamin C transiently produces hydrogen peroxide, an oxidant, to selectively kill cancer cells. In the late 1970s Linus Pauling and Ewan Cameron were first to report of success utilizing intravenous vitamin C to produce 1-year survival among 22 percent of otherwise hopeless cancer patients (chemotherapy at the time was far less effective). Subsequent studies concluded oral vitamin C could not possibly reach adequate blood concentrations of vitamin C to produce hydrogen peroxide (cancer cell killing effect) even though the data from that study ran contrary to the conclusions drawn. [Knowledge of Health 2016]

Thereafter Steve Hickey and Hilary Roberts posited a dynamic flow theory of ascorbate (vitamin C) therapy that addressed the fact vitamin C is rapidly excreted and its oral absorption is drastically reduced when consumed in mega-doses. Therefore, Hickey and Roberts posed intermittent oral administration of vitamin C to maintain high blood levels sufficient to exert a cell killing (cytotoxic) effect in cancer cells. [Journal Orthomolecular Medicine Vol. 20, 2005] Liposomal vitamin C further increases vitamin C delivery inside cells to potentially effect a cure.

These revelations have led to a renaissance in the use of vitamin C for cancer. [Knowledge of Health, 2016]
Now another breakthrough in the scientific understanding of vitamin C therapy for cancer is being reported. Researchers in Japan report extracellular iron (outside cancer cells) decomposes hydrogen peroxide generated by vitamin C. The inhibition of cancer cell growth via vitamin C (hydrogen peroxide) is completely blocked by the presence of iron. [Scientific Reports 2018] This was demonstrated in leukemia cells (cancer of the blood) in a lab dish. Given that most of the iron stored in the body is bound to hemoglobin in red blood cells, it is understandable why iron plays such an important role in leukemia.

The anti-cancer effect of vitamin C is completely abolished by iron. Iron serves as a growth factor for tumor cells. With this new understanding, researchers employed iron-binding molecules prior to vitamin C treatment with demonstrable anti-cancer effects. An iron-chelating (key-lay-ting) drug, or donation of blood to reduce iron load, or a low iron diet (in humans, avoidance of red meat) increased the cell-killing effect of vitamin C. A reduction of iron combined with vitamin C infusions worked synergistically (more than additively) to the point where detection and invasion by tumor cells was completely eliminated. Iron storage (ferritin) was dramatically reduced by the above measures and then vitamin C-activated hydrogen peroxide killed off cancer cells readily. Researchers conclude this approach produces a “novel anti-leukemic effect.” [Scientific Reports 2018] The idea of utilizing a natural iron chelator, such as IP6 (phytic acid or phytate) derived from rice bran, prior to oral vitamin C therapy now needs to be put to the test. The comparative iron chelating properties of various natural iron chelators is presented in the chart below. It reveals IP6 as a superior iron chelator even over EDTA which is often employed by clinicians who perform chelation therapy.

The prospect of home cancer therapy looms as neither IP6 rice bran extract nor vitamin C are toxic or induce acute side effects. A regimen of IP6 (up to 1600 mg is orally absorbed) followed by a vitamin C chaser is proposed.
The advantage of home vitamin C therapy is that intravenous vitamin C infusions cannot practically or economically be administered on a daily basis at doctor’s offices. Cancer rages unchecked in between chemotherapy or even intravenous vitamin C infusions. Daily oral iron chelation with IP6 rice bran followed by oral vitamin C therapy (3000 mg vitamin C as ascorbic acid four times a day), or as an alternative, liposomal vitamin C, may prove to be a safe and novel way of introducing self-care to cancer therapy. Be aware, home-made mixtures of lecithin + vitamin C produce emulsified ascorbate but not the microscopic lipid bi-layered delivery system defined as a liposome. [Whole Foods Magazine Aug. 2018]

 

[Fester]

That's a New Zealand story and program - though I don't doubt the same thing goes on here.

Not so much scientific study, but plenty anecdotal stuff around the internet about using injectable vitamin C for snake bite in animals - dogs and farm animals. It can be an subcutaneous or intramuscular injection - but apparently it can really sting so the animal will tolerate the injection if they are extremely unwell, but fight it as they improve. At that point it's suggested that you swap over to oral preparations. Injectable vitamin C sold at produce/stock feed outlets and some online veterinary supplies sites. They use a size 18 needle because the vitamin C is kind of thick.

I haven't seen it used in this fashion, or personally met anyone who has, though I know that one of the tracking clubs used to keep it on hand in case.

If you end up with a loved one sick and in the same battle with hospitals, it might be a consideration to sneak an injection in yourself!

Example of online supply:
JS Enterprise

Here's also a paper written by Dr Wendell Bellfield, a veterinarian - he was the first to consider using Vit C for treating infectious diseases in animals.

http://www.mv.helsinki.fi/home/hemila/animals/Belfield_1967.pdf

The doc attached below is by Pat Coleby - an Aussie farmer who first started collecting stories of vit C as a snake bite cure and writing about it.

Thank you so much for sharing this! I had no idea, and I'm shocked! This is something that every Aussie should know, being as we're only missing number 4 out of the twenty deadliest snakes in the world here...

Also there was a newspaper article I saw briefly the other day talking about how at times the doctors don't administer enough antivenom and the victim has died from residual venom still active.

 

[Jones]

@Fester, It seems that dogs that are treated with antivenin usually end up dying of cancer within a few years of being treated - that's one of the reasons that many latched on to the idea of having injectable vitamin c on hand. I know of a Labrador and Aussie Shepherd breeder that lives on a beef cattle property that had lost a number of dogs to either snake bite or cancer within a few years of the antivenin treatment. I also know an agility trainer that had two dogs bitten within a year of each other and both died within 2 years from cancer after being treated.

We didn't know back then about using vitamin c for treating cancer, so we could have tried it with these dogs.

 

[Cosmos]

Stay with me, there are good reasons why I'm posting the following here. It will become clear as you read on.

I've researched the topic of Vitamin C delivery to the body a while now with a particular emphasis on making "Liposomal Vitamin C" at home, especially for serious and acute health issues.

Early on I started to realize though, while looking at all kinds of recipes on making it and scientific articles, both from lay persons and professionals in science and the brands manufactures who sell Vitam-C as Liposomal products, that there is a great deal of confusion about this topic and everyone basically seemed to have different opinions about what Liposomal really is and if it can be made with simple tools at home at all, without many facts being available.

At the end of this gathering of data I basically concluded that there isn't really any proof that the simple recipes people on the net provide via ultrasonic cleaning apparatuses and the like do produce Liposomal products and thought it is rather likely that what is actually produced there is an emulsion, which is something quite different. See more about that below .

So I started to make the "Lipo-Vit-C" myself with various methods and recipes from the Net, while trying to also use a rather "strong" ultrasonic unit. There is also a wild discussion what amount of power is really needed and what waves, amplitudes, Herz etc. have to be used to produce Liposomes.

Then I also looked very casually into some of patented recipes that involve alcohol in the process from companies who claim to create Liposomes and then basically realized, what I started to assume already, that the process itself for producing them is probably far more difficult and maybe involves a number of complex chemical guidelines that also depend on temperature, mixing time etc.

Having had quite a bit personal experience in applying a bit more complex chemistry to produce a desired outcome in the past, I knew that what sounds so simple could be rather difficult in reality. I also tried to use two simple chemical methods, of which I found one on the internet and the other one after talking to friends, to find a way to "easily determine" what I actually produced at home, since I wanted some concrete data, which no one seemed to provide on the net, on what I was actually producing, aka. Liposomes or something else like an emulsion.

The idea most commonly used on the net is Natron and trying to see what chemical reaction the produced product has to it, compared to simple vitamin c, dissolved in water. The other one was using Iodine, since I knew that it dissolves (becomes invisible) when it comes in direct contact with Vitamin C. Tried both and wasn't sure what to make of the results, since I thought, there are probably more variables at play and it isn't that simple. The basic idea floating around the net is that Natron shouldn't react, or much less strongly, when it comes in contact with Lipo-C, compared to normal Vit-C (producing a less bubbly reaction or delayed bubbly reaction) and that this than is supposed to be "proof" that we have Liposomes.

Turned out that this couldn't convince me of anything really in either direction, since again I thought this is a bit oversimplified and missing some concrete data I was yet unaware of. While doing all of that, I also came across the idea of bioavailability and how Vit-C Liposomes seem to be far superior in that regard but again not really knowing what this means and how it applies to it.

Recently I did new batches of "home made Lipo-Vit-C", and made a simply bowl experiment, calculated how much Vit-C should be in what I swallowed and seeing how my body reacts to it, thinking that the body might react far less, bowl movement wise, if it is "Liposomal". So I took a rather large dos is in one go (of about 12 grams of Vit-C dissolved and prepared in this amount of "homemade liposomal Vit-C"), just to see the reaction.

After an hour or so my bowls reacted, but far less serverly as I expected, so my assumption was that indeed, at least some significant amount of that Vit-C must have changes into Liposomes or something like that. In the end of all of this I came to the conclusion that what you would really need is a electron microscope or a lap that can look at it in this way, otherwise you can't be sure at all.

Fast forward to today, I watched a three part series in german from a guy who started out doing the Lipo-Vit-C at home as well and in the course of those three videos (and years in between) encountered many of the same questions and confusions I described above, about what is actually produced in those homemade recipes, coming to the same tentative result as I have, that Lipo-C might indeed be something different that can't be produced at home so simply.

In one of those videos a guy linked the following presentation about Lipo-Vit-C from Thomas E. Levy, MD, JD, which described many of the same problems and finally lit a number of light bulbs about that topic in me, which seems to be in accordance with my observations and others on the net.

Not only is Levy doing a great job in finally explaining clearly what Liposomes actually are and what not, but also how true Liposomal products, which are very specific in their membrane forms and sizes to even be able to do miracles in the body, seem to clearly surpass even Intravenous-Vit-C, for very logical reasons. He also talks about what bio availability really means and that this is also rather complex. He states quite clearly, and I think he is right, that home made "Lipos" are not Lipos, but emulsions of Micells which makes a huge different in what it can and can not do. Lipos vary in size from 100 - 500 nanometers (and can't be produced with those homemade lipos recipes) and Micells are of at least one order in magnitude bigger size around 1000+ Nanometers and have quite another, one layered shell structure, which has its limits to pass through and interact with the body.

Lipos can pass, do to their size and at least doubled layered structure, in which the core has a payload of the material (in this case Vit-C) that needs to be delivered, right through the gut into the blood stream and extra and even intracellular structures. Micells on the other hand, do to their larger size and only one layered structure, without an inner core , can only go to the lymphatic sytem for example, but not really farther than that; aka not anywhere near to cells. What he does say though, which seems to be in accordance with what I have gathered so far, is that homemade "Lipo-C" which should be properly called "Mico-C" in my opinion, is indeed far more effective that normal vitamin C. So I think it is a good idea to use it instead of normal Vitamin C. He also explains why it is comparing apples with oranges when science papers try to determine the effectiveness of Intravenous Vit-C in comparison with Lipo-C, by studying the blood levels. Very interesting!

I highly reccomed watching this in full, since he brings up so many interesting facts and results, also about Intravenous-Vit-C compared to Lipo-C, that I think it is a must watch in that regard. He also mentions his Multi-C-Protocol, which I think is the best we can do for serious cases at the moment and not only that. The most important component is Lipo-C in there. Here is the Protocoll from the video and I think the normal Vit-C for the bowl tolerance barrier could be substituted by homemade Mico-C.

I think this is the best Protocol we have available at this point, that you can use pretty much against anything, including cancers, infections, inflammatory diseases and even mundane stuff etc, VERY EFFECTIVELY, varying the amounts and specifics according to the given need...

The Multi-C Protocol:



By now I'm also rather convinced that some, if not many, especially the cheap brands, of Lipo-Vit-C providers, actually provide you with Mico-C-Emulsions rather then Lipo-C. If a brand does not clearly state what makes their product Lipo, like Nanometer sizes between 100 and 500, lab results, facilities and Patents that are used, and their stuff is rather cheap on top, it could very well be that it is not Lipo. I guess there are also legal loopholes some of those companies use to promote their products as "Lipo", while in fact what they sell are cheap Emulsions (you can do at home) for huge profits as "Lipos".

On the other hand, I think, a couple of brands have enough credibility and concrete things to back up their claims, to be fairly certain that it is Lipo. Unfortunately they are usually pretty expensive, which is largely do to the high production cost in labs and they usually contain alcohol. I heard somewhere that if you would like to buy some of the ultrasonic equipment they use to produce lyposomes at home, you would need at least 17.000 € or so to buy it and a lot of space for the machine. That was just a radome claim however, so I'm not sure.

At this point, discovering more and more about the truly miraculous improvements Vit-C, most especially in Lipo form, seems to provide for pretty much any circumstance and need, I do wonder though how much money exactly and what methods one could use to at least try to built a working Lipo lap at home.

Maybe there are indeed cheaper solutions out there, that the manufacturers keep under raps, that one could build to produce that stuff? It is certainly worth the effort, if something like that could be possible.

 

[SunEterna]

Hello there.
In Germany, they do it in a clinic.
My aunt who has a liver cancer gets these injections.
The Dr is called, Dr Nigro. Here's the link: Welcome to your naturOPATHIC Practice

Peace.

 

[Cosmos]

I just posted a follow up on my post above in another thread about Vit-C and more specifically about Liposomal Vitamin-C. Here it is:

Do-it-yourself liposomal nutrients

 

[Persej]

I just posted a follow up on my post above in another thread about Vit-C and more specifically about Liposomal Vitamin-C. Here it is:

Do-it-yourself liposomal nutrients

That would explain why I never felt any benefit with homemade liposomal Vitamin C.

I started the sodium ascorbate enema protocol, since I had some positive experience with the oral Vitamin C. And I got some very strong reactions on it. One of it is that I feel a lot of movement in my intestines, followed by loose stools, even though I am using a very small dose - about 1 gram in 50 ml of water. It could be some kind of die-off effect, I guess, because I got diarrhea the first time that I drank the Vitamin C. After that first time I stopped having the same effect, but I was still feeling bloated deeper in my intestines after I eat something.

I also found a very interesting article that says that some people might have a problem with oral intake of Vitamin C because their gastro-intestinal bacteria might eat the Vitamin C before absorption can take place: https://jb.asm.org/content/jb/44/1/75.full.pdf

 

[Jones]

More censorship - I just tried to go to the health-matrix website to share an article on liposomal vitamin c and it's recipe and I'm getting 403 Forbidden access messages from safari, duckduckgo and dog pile search engines.

 

[Gaby]

More censorship - I just tried to go to the health-matrix website to share an article on liposomal vitamin c and it's recipe and I'm getting 403 Forbidden access messages from safari, duckduckgo and dog pile search engines.

My website is down since at least yesterday. I tried to access the historical record of vitamin C that I compiled years ago and got this message:

Forbidden You don't have permission to access /index.php on this server. Additionally, a 403 Forbidden error was encountered while trying to use an ErrorDocument to handle the request.

Hopefully it will come back soon.