Laura's Stem Cells

[PERLOU]

Merci Laura de partager vos nouvelles... Quel bonheur de savoir que votre santé est meilleure de jour en jour...
Cependant, n'en faites pas trop, ni trop vite, soyez raisonnable et reposez vous bien...
De tout cœur avec Vous...

Thank you Laura for sharing your news ... What a joy to know that your health is better day by day ...
However, do not overdo it, neither too fast, be reasonable and rest well ...
Wholeheartedly with you...

 

[maxtree]

Wonderful news, you are getting better step by step ! Thanks for sharing

 

[Christine]

Very good news Laura,
It's funny because on the night of August 20-21 I dreamed of you, you were thin. I rarely remember my dreams but when it is clear it is either a message that I have to understand where a premonitory dream.

 

[worldbridger]

I guess I should report since I've noticed some additional changes/improvements. But maybe this goes in the infrabed thread? Dunno.

Anyway, as ya'll know, when I got home, I was taking a number of meds to keep everything running smooth while the stem cells did their work. The odd thing is, that once I started using the infrabed, like within three or four days, all the meds were making my system totally out of whack, especially the victoza which was controlling my insulin and which had given me so much relief.

I was so messed up that I took a couple of days to get off everything and clear out with big doses of vitamin c. Then, I proceeded with the infrabed alone.

Well, a big test soon came: a birthday with treats... and I partook. NO problems at all with anything. I even lost a little weight overnight which was unheard of.

Then, yesterday, I partook of another small goodie and the same thing happened. Well, something strange happened actually; a half hour after eating some sweetened figs with a nut crumble on top, I suddenly got so hot I could feel waves of heat just radiating away. I even started sweating a bit. I realized that never in my life has eating produced heat as it does for many people who just burn off their calories instead of storing them, but here it was happening to me. So, I figure my mitochondria are working and that has been one of my big problems: mitochondrial dysfunction.

Anyway, again, I dropped a half kilo overnight.

One of the things I've been doing since the stem cells - and it doesn't seem difficult - is eating only between 9/10 in the morning and 4 in the afternoon most days. That amounts to intermittant fasting because it is about 17 to 18 hours that I go without eating after my last meal of the day.

One other thing to note: I was feeling well enough that I was starting to sit at my desk to work, but after three or four days of that, the leg started swelling and hurting again so I'm back to the chaise and the laptop on a lapdesk. It's not optimal for working because I don't have two screens which really help when editing and such, but it works okay once I get used to it. I think it is going to take the full six months to get that leg/knee completely healed/rebuilt.

But, in general, my mood is better despite the horrors of the world "out there", I'm better able to cope with it; and I am pretty much free of pain.

So, step by step...

Glad (and a little bit envious) to here that you are "pretty much free of pain", after all these years can you believe it?

 

[RedFox]

That's really awesome news Laura!

 

[hesperides]

What makes me jump for glee is if your mitochondria is coming back to life again, how many more ailments aren´t there that might say bye bye to their hostage, besides some more annoying kilos

As far as I remind, never did I see you so full of hope regarding your health, this in itself is such a fantastic outcome after sooo many years of research in the medical stuff and much more.

 

[Laura]

Glad (and a little bit envious) to here that you are "pretty much free of pain", after all these years can you believe it?

I'm still keeping my fingers crossed and, of course, I can't do a lot right now so there's no stringent testing. But at least I get around a little and don't suffer agonies as was the case before.

I think there are some things that helped a LOT initially, well before the stem cells could be considered to have kicked in, three drugs, in fact: pentoxifylline, vinpocetine, and procain, all three of which I received by IV infusion daily at the clinic, and I continued to take the pentox and vinpocetine. These last two really help the circulation and oxygenation of tissues and I will take them again if I notice the least bit of swelling. I think pentox is a miracle drug - no wonder they don't use it in the West, it works too well.

So, those three things really knocked it all out immediately, and now the infrabed and red light seems to be very effective although obviously, by now, the stem cells are doing something!

 

[Konstantin]

Great news Laura. I am glad that you feel much better. I hope that your condition will improve even more.

 

[Learner]

That's all really great news, Laura!! Thank you for sharing! Good to hear that you got meds that actually work in a powerful way for you and that now the infra-bed continues to support the kicking-in of the stem-cells, so you can kick-off the meds one by one Further recovery as speedy as it can be

Have you thought about contacting the clinic about the infra-bed possibility if it continues working well for you, for them recommending it to other patients as well?

 

[nature]

Glad (and a little bit envious) to here that you are "pretty much free of pain", after all these years can you believe it?

I'm still keeping my fingers crossed and, of course, I can't do a lot right now so there's no stringent testing. But at least I get around a little and don't suffer agonies as was the case before.

I think there are some things that helped a LOT initially, well before the stem cells could be considered to have kicked in, three drugs, in fact: pentoxifylline, vinpocetine, and procain, all three of which I received by IV infusion daily at the clinic, and I continued to take the pentox and vinpocetine. These last two really help the circulation and oxygenation of tissues and I will take them again if I notice the least bit of swelling. I think pentox is a miracle drug - no wonder they don't use it in the West, it works too well.

So, those three things really knocked it all out immediately, and now the infrabed and red light seems to be very effective although obviously, by now, the stem cells are doing something!

Very good news!

Pento was used for arteriopathy of lower limbs (to improve oxygenation of limbs) and in brain senescence (to improve memory). It has been removed because it was not efficient. In sudden deafness another drug is frequently used, derived from ginkgo biloba, but has no real effect. It's a vasodilatator too. Maybe these drugs are usefull if combined with stem cell therapy? In any cas, they're not efficient alone, that's why they are not used anymore.

 

[Laura]

Pento was used for arteriopathy of lower limbs (to improve oxygenation of limbs) and in brain senescence (to improve memory). It has been removed because it was not efficient.

I rather think it was removed because Big Pharma can't make money off of it. It really works! And on many things too numerous to mention. Gaby did a lot of research on it and was very surprised to see how many applications it has.

In sudden deafness another drug is frequently used, derived from ginkgo biloba, but has no real effect. It's a vasodilatator too. Maybe these drugs are usefull if combined with stem cell therapy? In any cas, they're not efficient alone, that's why they are not used anymore.

I think that is quite wrong for reasons stated above. My tinnitus has been seriously reduced as a result of the Pento and Vinpocetine, and the effect was noticeable within a few days of the first infusions. My left leg went from being literally blue - cyanotic - to normal and warm within 4 days.

So, I wouldn't be so fast to toss it out without taking the time to read the research.

 

[Gaby]

Pento was used for arteriopathy of lower limbs (to improve oxygenation of limbs) and in brain senescence (to improve memory). It has been removed because it was not efficient.

Or maybe that is what they would like us to believe. In Spain it is still used for arteriopathy and there are thousands of papers published on pentoxifylline. It is sort of Big Pharma's wonder drug. It is extremely cheap and has a safety track record of decades.

What is even more intriguing is that scientists don’t know why or how pentoxifylline works, but it seems to be working in a number of debilitating conditions.

From McCarty MF, O’Keefe JH, DiNicolantonio JJ. Pentoxifylline for vascular health: a brief review of the literature. Open Heart 2016;3: e000365. doi:10.1136/openhrt-2015-000365

Pentoxifylline for vascular health: a brief review of the literature

...pentoxifylline may have potential for slowing the progression of atherosclerosis, stabilising plaque, reducing risk for vascular events, improving the outcome of vascular events, dampening the systemic inflammatory response following cardiopulmonary bypass, providing symptomatic benefit in angina and intermittent claudication, enhancing cerebral blood flow in patients with cerebrovascular disease while slowing progression of vascular dementia, improving prognosis in congestive heart failure, and aiding diabetes control.

They are describing all sorts of mechanisms of actions for pentoxifylline, but still, it is clear that it is not a standard anti-inflammatory or circulation drug. It also decreases fibrotic lesions, making pento a cheap alternative in conditions that are very debilitating.

From http://dx.doi.org/10.1016/j.bjoms.2016.12.006

Pentoxifylline – a review of its use in osteoradionecrosis

Pentoxifylline has been used to treat complications related to fibrosis for over 20 years. Formerly used to treat those after radiotherapy such as osteoradionecrosis (ORN), it is now being tried for medication-related osteonecrosis of the jaw (MRONJ), which can occur after prolonged use of bisphosphonates. We review theories on the formation of fibrosis in patients with ORN, discuss the pharmacology of pentoxifylline and vitamin E, and report published outcomes. To our knowledge no prospective randomised controlled trial has investigated the benefits ofthese agents in cases of ORN, but reported outcomes in many published case series are encouraging.

From, doi: 10.1111/1755-5922.12076

Pentoxifylline in Heart Failure: A Meta-Analysis of Clinical Trials

A meta-analysis evaluating pentoxifylline versus placebo in HF suggested a significant nearly fourfold decrease in all-cause mortality in the pentoxifylline group.

From, Adv Ther DOI 10.1007/s12325-017-0547-2

Repurposing Pentoxifylline for the Treatment of Fibrosis: An Overview

Recently, the effectiveness of pentoxifylline in the treatment of fibrosis via attenuating and reversing fibrotic lesions has been demonstrated in several clinical trials and animal studies. As a result of the limited availability of antifibrotic agents in the long-term treatment of fibrosis that can attenuate and even reverse fibrotic lesions effectively, it would be of particular importance to consider the potential clinical utility of pentoxifylline in the treatment of fibrosis. Thus, this paper discusses the evolving roles of pentoxifylline in the treatment of different types of fibrosis.

From Indian Dermatol Online J. 2017 May-Jun; 8(3): 218–220. doi: 10.4103/2229-5178.206119

Successful Treatment of Generalized Granuloma Annulare with Pentoxifylline

Generalized granuloma annulare has a protracted course with only rare spontaneous resolution. It comprises 8–15% of all the cases.[3] Diabetes has been reported in 21% of generalized granuloma annulare.[4] Laboratory abnormalities such as hyperlipidemia, hypergammaglobulinemia and presence of circulating antinuclear antibodies have been observed.[4] Investigations of our patient did not reveal any of these abnormalities except for high blood sugars. As described earlier, the histopathological changes in our patient were typical of interstitial granuloma annulare, which is the most common pattern reported in generalized granuloma annulare.[4]

Generalized granuloma annulare is poorly responsive to therapy. Because our patient had an unsatisfactory response to multiple treatment options, pentoxifylline was given which showed a striking response.

Pentoxifylline is a phosphodiesterase inhibitor which is commonly used in intermittent claudication. Its dermatological uses include Raynauds phenomenon, livedoid vasculopathy, necrobiosis lipoidica and venous ulcers. Even though the drug has been in use since many decades, novel indications are emerging even in recent times.

Pentoxifylline has been successfully used in generalized granuloma annulare by Rubel et al.[5] and Patrascu et al.[6]

The exact mechanism of action of pentoxifylline in granuloma annulare is not known. We postulate that, in granuloma annulare, pentoxifylline, probably with its TNF alpha blocking action, inhibits macrophage activation, and hence the granulomatous inflammation. Moreover, with its anti-inflammatory action, it may also reduce the vasculitis occurring in granuloma annulare.

With its favorable toxicity profile and familiarity among dermatologists, pentoxifylline may be a good choice for this difficult to treat and distressing condition. We report this case as resolution of lesions of granuloma annulare with pentoxifylline has rarely been reported.

I was surprised to hear that Laura was going to receive pentoxifylline infusions. One of the doctors at the clinic said it as a matter of fact due to Laura's bad circulation back then. I was surprised to realize that something as simple as that could help. In my mind it was only for intermittent claudication and that was that. Networking works!

Pentoxifylline is also used as a painkiller. It has had results as a topical agent in combination with other things such as capsaicin. Better than taking opioids!

I'll attach some of the papers.

 

[Gaby]

Pento in necrosis of the jaw.

 

[Gaby]

Pento and its effect in fibrosis.

Pento in heart failure.

 

[munaychasumaq]

Fantástico to know Laura you are recovering little by little.Wonderful news!! I am wondering how are Andromeda and Galatea regarding their health?