The Cheapest, Quickest, and Most Effective Treatment for CIU
So, it’s been a while since I posted, mainly because it’s been quite a while since I’ve had a flare up of CIU (Chronic Idiopathic Urticaria). I’ve been fortunate that a once daily Zyrtec and a vitamin regimen has been enough to keep mine under control. I’ve experimented with skipping a dose, but have never gotten more than 36-48 hours without early symptoms appearing that sent me running for a Zyrtec. A week ago I had the worst flare up I’ve had in years. Strangely it was just on my scalp this time. After a lot of thinking, reading, and experimenting, I think I understand what brought it on and how to treat it for good.
A few weeks ago I learned that I have a MTHFR gene mutation following a comprehensive metabolic blood workup. Apparently a lot of people have it. There are two different kinds. You can have MTHFR 677, 1298, or both, and either can be homogeneous or heterogeneous, meaning you either have a gene from one parent or both. There are a number of ailments now believed to be associated with these two mutations, including neurological conditions. Fortunately I only have 1298ac which is heterogeneous. So basically, the body just doesn’t utilize folic acid very well. If you have 677 and it’s homogeneous, you’ve got to take a purer form of folic acid that your body can actually use known as methyfolate, since your body cannot convert folic acid into methylfolate on its own. If you are heterogeneous or just have 1298 like I do, your body can use folic acid but perhaps not efficiently, so methylfolate can also be beneficial. Niacin also slows down the process of converting folic acid to methylfolate. I was taking high dose Niacin for 4 months trying to correct my lipid profile. Taking Niacin and methylfolate at the same time is like trying to drive with one foot on the gas and one on the brake. The symptoms I was experiencing primarily was low energy and brain fog later in the day. Since dropping the Niacin and taking methylfolate and methyl-B12 daily that improved pretty quickly.
One of the primary effects of a 1298 mutation is the ability of the body to rid itself of toxins. So gradually over time you accumulate a lot of toxins stored in the body that are not removed efficiently. In addition to toxins the methylfolate process in the body plays a part in histamine management. Histamine is very important in the body for a lot of reasons including brain function, but as you CIU sufferers know it’s the cause of the hives. It got me thinking about whether my CIU was attributed to toxins in the body and poor histamine control due to the MTHFR mutation. The treatment for this is to take methylfolate and methyl-B12 but high dose Vitamin C, Vitamin D, and Milk Thistle are especially helpful in detoxing the liver and causing it to release fatty deposits storing toxins. So I tweaked my vitamin regimen again adding Milk Thistle also.
About the same time I changed up my vitamins I switched to a Low Carb High Fat ketogenic diet. That’s unrelated to CIU but an effort to correct my lipid profile and high risk factors for heart disease and pre-diabetes. Since I wasn’t snacking as much during the day, for some reason I wasn’t drinking as much water as I had been. Also since cutting out all processed food and not eating out as much, I was eating mostly fats, meat, and home cooked veggies which were much lower in sodium. Mix in a couple weeks of high stress with a new job plus dehydration and I had a full blown raging flare up of CIU. Taking double doses of Zyrtec did not help at all. After reading someone’s post in a forum about chronic dehydration and allergies, I started putting the pieces of the puzzle together. I think the detoxing regimen was kicking in and releasing toxins but the lower water intake wasn’t allowing me to flush the toxins from the body or maybe just caused the hives directly. So here’s what I did next…
I started drinking a lot of water, at least 80 ounces a day. As you can imagine, I made frequent trips to the bathroom. I realized water was not enough. I had to add sodium to help retain fluid to correct chronic dehydration. Once I increased my intake of sea salt and continued drinking at least 80 ounces of water a day, by day 4 the hives were going away and barely came back on day 5. On day 6 no hives symptoms at all. Day 7 I skipped the Zyrtec altogether. I may take it tomorrow if there are any symptoms to taper off the dose gradually every other day.
Chronic dehydration is tricky to notice because you stop being thirsty after a while. Your body adapts in part by increasing histamine, raising blood sugar, cholesterol, you name it. By re-hydrating all of those come down naturally. So now I’m wondering if my CIU outbreak 4 years ago was really the result of chronic dehydration, toxicity, or both. I’ll continue taking the methylfolate and vitamin regimen and drinking a LOT of water for other health reasons as well, but I’m betting the hives do not return. If you’re struggling with CIU and have exhausted all other options, this is a cheap one to try by drinking water and eating salt. Get your blood tested for MTHFR mutations also if that doesn’t help you. I hope this helps at least a few others as it did me.