Some cigarettes have a "kick" containing 35 times more "freebase" nicotine - the most addictive form - than others, researchers have found. The findings could help rate the addictiveness of different brands, they say.
"Free-base" nicotine is a particularly potent form of the naturally-occurring tobacco drug because it is in an extremely volatile, uncombined form. This means it can be much more rapidly absorbed by the lungs and brain than nicotine derivatives such as nornicotine or its salts.
The new study is the first into the amount of "free-base" nicotine contained in common brands of cigarettes and found wide-ranging differences. The researchers at Oregon Health and Science University used a laboratory smoking device and a gas chromatograph-mass spectrometer to collect and analyse smoke from 11 brands of cigarettes. The study measured the first three puffs of smoke from each cigarette.
"Measurements ranged from about one per cent free-base nicotine in the first few puffs to 36 per cent for a specialty US brand," says lead researcher James Pankow. "One type of Marlboro, the leading US brand of king-sized filter cigarettes, contained about 10 per cent free-base nicotine."
Crack cocaine
Previous research has shown that a drug's addictiveness is influenced by the speed at which it is delivered to the brain and absorbed into and from the blood stream.
"The study shows that the modern cigarette does to nicotine what crack does to cocaine," says addiction expert Jack Henningfield, at the Johns Hopkins University School of Medicine. The notorious addictiveness of smoking crack results from the vapourised cocaine reaching the brain almost immediately.
Ian Jones, a nicotine expert at Bath University, UK, adds: "Free-base nicotine is the most damaging form because it is the optimal configuration for binding to the nicotine receptors in the brain, heart and rest of the body. If the binding efficiency is increased, it means the concentration of nicotine at the receptors is higher and so it is very addictive."
"The first few puffs are the most important in terms of addiction, because nicotine reaches the brain within seconds," Jones told New Scientist.
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_http://biopsychiatry.com/nicotine/freebase-nicotine.html