Iodine and Potassium Iodide

[Persej]

I remember that some people reported crying, either awake or during the sleep, while taking iodine. That never happened to me while taking Lugol, but it did while taking the combination of blue iodine and vitamin D. It doesn't happen if I take just the blue iodine. I spent a lot of time trying to find some connection between iodine and vitamin D and I finally found reports from several people which you can find here:

SOME NOTES ON OUR PRESENT KNOWLEDGE AND IGNORANCE OF THYROID FUNCTION - PMC

pmc.ncbi.nlm.nih.gov

I will start again with such combination and see what will happen.

I also found a possible explanation of my experience with iodine and phospholipids. A combination of iodine and cholesterol is used for the visualization of some steroid-hormone-producing glands, like adrenals and ovaries, because such glands readily absorb iodocholesterol. So it seems that different forms of iodine go to different places.

Leydig-cell tumor of the ovary: Visualization using 131I-19-iodocholesterol scintigraphy - European Journal of Nuclear Medicine and Molecular Imaging

A Leydig (Hilus)-cell tumor of the ovary was diagnosed in a 54-year-old woman with severe hirsutism and virilization. This case is unique in that (1) it was diagnosed in a postmenopausal female 24 years after ovarian irradiation for sterilization, and (2) the tumor was successfully localized...

link.springer.com

 

[Persej]

Since we want to push iodine into other glands apart from thyroid, and thyroid loves to take as much of iodine as possible, and that there is already a method for diverting iodine away from thyroid, such as the case with nuclear accidents where people take potassium iodide to block the uptake of radioactive iodine into the thyroid, and since I already have a form of iodide which is in my experience very mild to thyroid, which is blue iodine, I was wondering if taking the blue iodine prior to taking Lugol or tincture of iodine is the best way to saturate our body with iodine? That is what I'm going to try next.

And this was a bad idea. I woke up with a very fast heart rate. Luckily, I knew what was going on, so I quickly drank the salted water and the heart rate reduced after some time. This was the first time that I experienced such reaction from taking the iodine. This reaction of iodine overload of thyroid was caused because I didn't take the salted water because I wanted to see if taking the blue iodine would push Lugol's iodine into other parts of my body. But that didn't happen, they just both got into my thyroid.

So I did a little research about salt and iodine:

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www.sciencedirect.com

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academic.oup.com

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academic.oup.com

And it seems that salt is very good at removing the iodine from our bodies. So if you are using high amounts of iodine, you should increase the salt intake, or you will overload your thyroid with iodine. Another thing that removes iodine from our bodies, and probably other halogens, is bicarbonate. It's not as good as salt, but it can help.

But there are things which can reduce uptake of iodine into the thyroid, and those are acetic acid (found in vinegar) and lithium carbonate.

 

[Steph_rivers]

And this was a bad idea. I woke up with a very fast heart rate. Luckily, I knew what was going on, so I quickly drank the salted water and the heart rate reduced after some time. This was the first time that I experienced such reaction from taking the iodine. This reaction of iodine overload of thyroid was caused because I didn't take the salted water because I wanted to see if taking the blue iodine would push Lugol's iodine into other parts of my body. But that didn't happen, they just both got into my thyroid.

So I did a little research about salt and iodine:

Loading…

www.sciencedirect.com

Loading…

academic.oup.com

Loading…

academic.oup.com

And it seems that salt is very good at removing the iodine from our bodies. So if you are using high amounts of iodine, you should increase the salt intake, or you will overload your thyroid with iodine. Another thing that removes iodine from our bodies, and probably other halogens, is bicarbonate. It's not as good as salt, but it can help.

But there are things which can reduce uptake of iodine into the thyroid, and those are acetic acid (found in vinegar) and lithium carbonate.

That's such a coincidence that you mention this now. I've been doing 36 hour fasts every other day and on my fasting days I consume quite a hefty amount of electrolytes (sodium chloride, potassium chloride, magnesium citrate, and sodium bicarbonate). When I feel low energy I take 1 drop of 2% lugols and almost immediately feel better. Makes me wonder if I'm displacing a lot of Iodine during those times, and this is why some people get thyroid issues when going on long fasts?

 

[Persej]

When I feel low energy I take 1 drop of 2% lugols and almost immediately feel better. Makes me wonder if I'm displacing a lot of Iodine during those times, and this is why some people get thyroid issues when going on long fasts?

It could be. During the fast, the thyroid uptakes less iodine, probably to conserve energy in the body, and when you combine that with those electrolytes which increase the removal of iodine from the body, you can get iodine depletion.

 

[Persej]

Perhaps the connection between iodine and vitamin D lies in calcium?

In vivo experiments using a calcium deficient or a normal diet, proved that calcium enhance iodine entry and concentration into the thyroid gland of the rat and the intra-thyroidal T4 pool, T4 level in serum was also increased. Peripheral metabolism of T4, serum TSH levels and pituitary TSH contents were unaffected. Calcium has a local regulatory function on the thyroid gland.

[In vivo regulation by calcium of thyroid metabolism of iodine in rats] - PubMed

In vivo experiments using a calcium deficient or a normal diet, proved that calcium enhance iodine entry and concentration into the thyroid gland of the rat and the intra-thyroidal T4 pool, T4 level in serum was also increased. Peripheral metabolism of T4, serum TSH levels and pituitary TSH...

pubmed.ncbi.nlm.nih.gov

In vivo, in the rat, in nutritional experiments, calcium accelerated iodine entry into the thyroid and augmented the concentration of iodine in the gland (1). These data are compatible with the hypothesis of Ca2+ acting on the thyroid as in "stimulus-secretion coupling" where the cation promotes extrusion of the contents of exocytotic granules (2). The whole set of experimental data from the in vivo work (1, 3) fit into the view that Ca2+ might increase the velocity of iodine entry into and the concentration of iodine in the thyroid by promoting exo cytosis of non iodinated thyroglobulin; and so do data from in vitro experiments in the literature, provided the statement: "Ca2+ is required for the in vitro TSH stimulation of 131I transfer from the intrathyroidal iodide pool into thyroglobulin" (5) is inverted into: "Ca2+ is required for the TSH stimulation of the transfer of Tg into the sites of its iodination"; these are located in the lumen of the follicle (4). The transfer of Tg (= exocytosis) was shown to be limiting factor to the acceleration of iodine binding by TSH, in vivo (6).

[The stimulation by calcium of the thyroidal iodine metabolism fits into the scheme of "stimulus-secretion coupling" (author's transl)] - PubMed

In vivo, in the rat, in nutritional experiments, calcium accelerated iodine entry into the thyroid and augmented the concentration of iodine in the gland (1). These data are compatible with the hypothesis of Ca2+ acting on the thyroid as in "stimulus-secretion coupling" where the cation promotes...

pubmed.ncbi.nlm.nih.gov

In vivo experiments, in the rat, using diets deficient in calcium, or sodium or both ions, proved these cations to regulate the thyroidal iodine metabolism. Calcium enhanced iodine entry into the thyroid and the intrathyroidal iodine and T4 pools. T4 level in serum was also increased by calcium. Sodium enhanced iodine entry and secretion. The two cations have local regulatory functions on the thyroid gland and do not affect TSH levels in serum and the hypophysis. The effects of calcium and sodium are interdependent, sodium deficiency suppressed the effects of calcium and the effects of sodium were significantly limited by calcium deficiency. Results from chromatography of the thyroid extracts and data from the literature are compatible with the hypothesis of calcium enhancing iodine entry and accumulation into the thyroid gland mainly through an effect on exocytosis of thyroglobulin, the was this ion enhances exocytosis of protein in stimulus-secretion coupling. An addition to this theory is pur forward in order to reconcile with it the whole set of experimental data obtained with the two cations, in vivo and in vitro, on thyroidal iodine metabolism.

[In vivo regulation by calcium of the thyroidal iodine metabolism and its modulation by sodium, in the rat (author's transl)] - PubMed

In vivo experiments, in the rat, using diets deficient in calcium, or sodium or both ions, proved these cations to regulate the thyroidal iodine metabolism. Calcium enhanced iodine entry into the thyroid and the intrathyroidal iodine and T4 pools. T4 level in serum was also increased by calcium...

pubmed.ncbi.nlm.nih.gov

 

[Persej]

A couple more articles about connection between calcium and thyroid.

https://www.acpjournals.org/doi/10.7326/0003-4819-7-9-1080

https://www.acpjournals.org/doi/10.7326/0003-4819-48-6-1300

Calcium and metabolism of I-131 in rats and homogenates of rat thyroid - PubMed

Calcium and metabolism of I-131 in rats and homogenates of rat thyroid

pubmed.ncbi.nlm.nih.gov

Calcium interaction with bovine thyroglobulin: stoichiometry and structural consequences of calcium binding - PubMed

Gel filtration studies show that the thyroglobulin (Tg) molecule (dimer) binds from 18 to 50 Ca2+ ions. At pH 7.5 Tg binds 18 Ca2+ ions with a Kd of 1.3 x 10(-5) M, and 50 Ca2+ ions with a Kd of 5.5 x 10(-4) M. The binding of calcium to bovine thyroglobulin increases the absorption band of...

pubmed.ncbi.nlm.nih.gov

The effect of calcium on thyroid function - Enlighten Theses

 

[Vajra91]

Reporting on my current experience. I've been supplementing with 10-12 drops/day of 5% lugol for about a month now (plus cofactors, although I keep forgetting about the salted water). Started with a fairly high dosage, but I felt confident given my past experience with it. No particular effects yet, except (again) for some tiny, white, slightly painful but definitely tolerable "growths" inside my nose. Happened the first time I tried the protocol too, several years ago, but they seem to be smaller and less painful this time, at least for now. Kinda look like small warts.
Maybe a papillomavirus reactivated by the iodine? I have been suffering from the occasional recurring warts on the bottom of my feet for years, coming back at least once or twice a year.
Half-tempted to increase the dosage and try nuking any infection out of existence.. But maybe I should give some more time to the slow(ish) and steady approach? I am uncertain.

 

[neonix]

Natural antagonist of iodine is vitamin C. When you take too much vitamin C you may need more iodin. If you take too much iodine you may need more vitamin C. But you shoudn't take iodine and vitamin C at the same time.

 

[Persej]

One thing that I noticed ever since I started taking iodine is the subtle energy that I sometimes feel in my palms and feet. After my hyperthyroid reaction a few days ago, I stopped taking iodine for a few days, then slowly started taking just the blue iodine. I had no bad reaction. But yesterday I took a drop of vitamin D and today I feel again that energy in my palms. It seems that there is some kind of positive connection between vitamin D and iodine.

A possible connection:

TSH-stimulated increases in calcium uptake and calmodulin levels in thyroid cells - PubMed

This is the first report to show that polypeptide hormone increases cellular calmodulin contents. In cultured porcine thyroid cells, 6 days' exposure to TSH (above 0.02 mU/ml) increased cellular calmodulin contents. Six days' exposure to TSH also increased calcium uptake in thyroid cells. This...

pubmed.ncbi.nlm.nih.gov

The inhibitory effects of calmodulin antagonists on TSH-stimulated thyroid hormone release by mouse thyroid lobes - PubMed

Calcium ions have been shown to play a mojor regulatory role in the release of various hormones from a wide variety of endocrine organs. More recently, in vitro evidence suggests that a calcium-binding protein, calmodulin, is also involved in the release of many hormones. So we examined the...

pubmed.ncbi.nlm.nih.gov

A role for intracellular calcium and calmodulin in the release of triiodothyronine from human thyroid-cell monolayer cultures - PubMed

Human thyroid cells in monolayer responded to acute stimulation by TSH with an increase in the secretion of T3. This process appeared to be dependent on a rise in the cytosolic calcium concentration since the antagonist of intracellular calcium mobilization, TMB-8, was found to inhibit the...

pubmed.ncbi.nlm.nih.gov

 

[Tauriel]

Can I also ask you how you applied it externally to make the old patches of psoriasis disappear? You say it took a couple of weeks, but do you remember the amount and frequency?

lso, do you or anyone know if appling it on the scalp would be safe? I'm already suffering from the beginning of androgenetic alopecia (or so I was told by a dermatologist)

Hi Vajra91,
I'm not active on here anymore so I just saw this.
With today's knowledge I wouldn't recommend external application on psoriasis spots. What I described was a one-time-only-experiment and it really gets to the skin and affects it in a negative way.
For sure I wouldn't recommend application on the scalp.

All in all the psoriasis disappeared over the course of six years that I've been taking iodine.
I stopped taking it this spring- just now started to take 1-2 drops once a week.
Hope I could be of help.

 

[Vajra91]

Hi Vajra91,
I'm not active on here anymore so I just saw this.
With today's knowledge I wouldn't recommend external application on psoriasis spots. What I described was a one-time-only-experiment and it really gets to the skin and affects it in a negative way.
For sure I wouldn't recommend application on the scalp.

All in all the psoriasis disappeared over the course of six years that I've been taking iodine.
I stopped taking it this spring- just now started to take 1-2 drops once a week.
Hope I could be of help.

Thank you very much Tauriel.
Yeah, I've experimented a little as well. Topical application seemed promising at first but ultimately proved a little too aggressive on psoriasis with no outstanding benefit, so I'm limiting myself to oral intake as well.

Glad to know that taking it in the long run continued to prove useful for psoriasis as well.
And congratulations on your success keeping it at bay, of course. Hopefully I'll get to that point too, eventually.
Thank you your answer

 

[Ricardo]

Psoriasis may well be synergistic with parasites , ivermectin may well help you @Vajra91 in this case.

https://twitter.com/x/status/1958149525563920542

 

[Vajra91]

Psoriasis may well be synergistic with parasites , ivermectin may well help you @Vajra91 in this case.

https://twitter.com/x/status/1958149525563920542

Huh... That's something I had never properly considered for some reason. I guess I always assumed that I would somehow notice a parasitic infection one way or another.. Diet aside, I've heard of possible connections with yeasts, some viral or bacterial infections... But sure, parasites would also trigger the immune system.
I've had a pretty comprehensive stool test with no signs of infection aside from e. coli o157, which I treated with an antibiotic, seemingly succesfully, but.. Who knows..
If iodine and dmso (as soon as I start dmso anyway, hopefully soon) should fail to make a difference in a reasonable timeframe, ivermectin would well be worth an attempt, I guess.
Thank you Ricardo! That's something I might have never thought about on my own