Is Coffee Good or Bad for you?

Re: Coffee bad aswell?

Foxx said:
hesperides said:
You can also add lima, lemon, mandarine and/or orange peel to water and let it boil for a while, then add your tea. From time to time, I also mix some vainilla powder or cinnamon in my tea with xylitol or stevia. Very yummy! You can also boil green tea together with mint leaves.

The green and mint tea sounds like a good combination, but boiling either of them will make them bitter, whereas steeping them at certain temperatures below boiling won't.

The fruit peel combinations sound tasty as well :)

Thanks for your advise, Foxx. It´s really welcome because I never used to drink tea before starting the diet and sure need some tips like yours. Will try soon tomorrow as suggested.
 
Re: Coffee bad aswell?

SeekinTruth said:
Black or green tea (with or without butter) and a bit of stevia and xylitol is great on occasion. Also, as mentioned, cocoa. I drink cocoa with cocoa butter and grass fed butter with stevia and xylitol and a pinch of salt every morning. It's also great with coconut oil.

Black or green tea are very good but to my taste, Oolong tea is just totally delicious. And there is a lot of varieties of Oolong tea.

And in the summer, you can make a iced tea with your oolong leaves.
 
Re: Coffee bad aswell?

Melatonin,
If you were not aware, there are many natural "teas", located all over the globe that you can get for free & have beneficial properties. I am not aware of your living location, & it is not important to me for trying to share some ideas with ya. But everywhere there are these plants that you can utilize at no cost to you, but for perhaps a bit of "research time".
I offer for example: Pine needle tea made from the new needles (Springtime is best but all year is good.) of most pine trees & has a lot of Vitamin C. & most find the taste to be pleasant. Staghorn Sumac( non poisonous), makes a tea from the red berries that also contains Vit C. & tastes a bit like lemonade. Chaga mushrooms from Birch trees is another type of tea that is said to contain anti- cancer properties. Labrador tea is a plant that grows in Northern climes that is good too. There are many to list, these are but a few. If you are interested more info can be found by looking in "Field guides", such as the Petersons' guidebooks & the like. Many are available at local libraries. There is also quite a bit to be found on this info, right on the internet, if you choose to look. I am just trying to offer you some alternatives, like some of the others, & am in no way trying to influence you or anyone. This is just something I thought was apropos to this topic & I was trying to help out a bit.
:)

Hope you find a drink that you enjoy!
:)
 
Re: Coffee bad aswell?

Thanks for the info MnSportsman. :)
I will keep it in mind for the future. Currently im more than happy with "Twinnings" fruit teas. The best tasting ones being Nettle and Peppermint, and Sweet Fennel. :)
 
One thing that came up in discussion here lately is the fact that all coffee studies have been done on people eating carbs as a large part of their diet. There are NO studies of the effects of coffee on a person on a Ketogenic Diet.


A new article by Dr. Hyman:


Is Coffee Bad Or Good For Your Health? Two Experts Debate
by Mark Hyman, MD

Coffee is the magic elixir that keeps America humming. Before indoor plumbing was available and potable water was everywhere, Americans drank beer for breakfast and all through the day, resulting in a slow start to our nation’s prosperity.

Then the coffee bean was discovered in the 1800s. Caffeine and coffee replaced alcohol and beer and the industrial revolution was off to a great start. Perhaps it is no coincidence that the Internet boom and technology revolution started at the same time as Starbucks. It helped America focus!

It is certainly why I started on coffee during medical school. Everyone else was doing it, and it seemed a great way to help me cram for anatomy and biochemistry exams. But I quickly noticed a droop every afternoon: my brain shut down, my eyes became heavy and I could only “cure” it through another cup of coffee.

During my emergency room days I would power up with a quadruple espresso and work from 11:00 p.m. to 7:00 a.m. Just like a drug addict, I needed more and more just to stay barely functional. My sleep was difficult, more interrupted and less restful, and I woke tired and need my “fix” of java.

So I decided to “detox” and kick my drug habit. After a few days of headache and total exhaustion, I felt renewed energy, woke up alert and ready to embrace the day, and felt steady energy all day long. My sleep deepened, and the low-grade irritability and anxiety I felt disappeared. I realized I was living on borrowed energy.

The truth is that not everyone responds to caffeine the same way. Some metabolize coffee differently than others. Our detoxification pathways are genetically determined. That is why some people have one cup in the morning and can’t sleep for days and others can have a double espresso after dinner and hit the pillow and fall into deep sleep.

The gene involved is called CYP1A2. You can get a lab test to find out if you have trouble detoxifying. The good news is some may be better than others at tolerating caffeine and may be able to enjoy that coffee.

But there are many reasons for us to take a second look at our national coffee habit and obsession. Americans sleep about 1.5 hours less a night than 100 years ago, at great detriment to our cognitive function and health.

Coffee has a lot to do this with the wide-ranging health impact of sleep deprivation on our health, including heart disease, obesity, type 2 diabetes and cancer. To learn more about this link read, Lights Out, Sleep, Sugar and Survival.

There are some benefits of coffee. Coffee is the single biggest source of antioxidants in the American diet. Researchers claim it can prevent Parkinson’s and ward off Alzheimer’s, type 2 diabetes, and depression. It can help with focusing and reading and may make you more productive.

So why don’t we just put it in our water supply?

First, coffee is a drug. And using it recreationally is certainly fine, or for the occasional pick me up when you just couldn’t get enough sleep. But there is a dark side of coffee and caffeine.
It is addictive. It requires you to drink more and more to get the same “high” and eventually is needed just to feel “normal.” Headaches, exhaustion, and other biological signs of withdrawal put it clearly in the camp of addictive drugs.
It stimulates the release of dopamine, which helps us focus, pay attention, and remember. But it depletes those neurotransmitters over time and loses its effectiveness.
It stimulates the release of stress hormones including adrenalin and cortisol. This may lead to palpitations, anxiety, insomnia, and even spikes in blood sugar and insulin.
It increases homocysteine (increasing risk for heart disease, depression, cancer, and dementia) and depletes vitamins and causes mineral loss, including magnesium the relaxation mineral.
It causes urinary excretion of calcium and contributes to osteoporosis.
It can cause diarrhea, reflux and heartburn.
It may interact with common medications such as Tylenol, causing liver damage.
Coffee increases risk of stillbirths and iron deficiency in mothers and babies.

Occasional use of addictive legal drugs such as alcohol, sugar, or caffeine cause no harm, but regular, habitual use and addiction may cause significant risk. But more importantly, it has a negative effect on the quality of life for many who drink it — they sleep poorly and are more tired and irritable and anxious.

For something that is supposed to give you more energy, it usually offers only a brief lift with increasingly diminishing returns. The surprising thing many former coffee drinkers discover is that they have more energy, not less, when they finally kick the habit. Try a drug holiday — you might be surprised at the lift you get, much better than coffee.

The OTHER SIDE



It's been linked to decreased risk of skin and prostate cancers. It might lower depression risk in women. It could protect you from Type 2 diabetes. It might stave off Alzheimer's disease and Parkinson's disease. And it tastes good.

Uh, where do we sign up?

Over the past few years, a body of scientific evidence has built up pointing to the many health benefits of coffee. No wonder more than 50 percent of Americans enjoy a daily java fix. But before you grab a celebratory cup of joe (or seven), consider this: Coffee is also an addictive stimulant that could come with enough side effects to give some experts the jitters.

We sensed a serious debate, er, brewing. And so we asked HuffPost Wellness Editor Dr. Patricia Fitzgerald and HuffPost blogger Mark Hyman, M.D., to break down both sides of the coffee debate.

Dr. Patricia Fitzgerald Wellness Editor, The Huffington Post; doctor of acupuncture and Oriental medicine; nutritionist; author

Sometimes I think coffee is so enjoyable, it seems like it has to be bad for you. Hot, delicious, with the little stimulating kick of caffeine -- how could it not be? And yet it's true: For most people, regular, moderate coffee consumption is not harmful to your health.

In fact, one of the best parts of my job is getting to tell a person that he or she doesn't have to give up their morning cup of coffee. As a clinician, a significant part of my day with patients involves nutritional counseling, which means I often find myself encouraging people to eat less sugar, more vegetables, and fewer processed foods -- a necessary but sometimes challenging process! But, for most people, that morning cup of Joe can stay. And often, the look in their eyes when I tell them they don't have to give it up is priceless.

I don't suggest that people can keep drinking coffee simply for the pleasure it brings (though, enjoyment and health are far from antithetical), but also a spate of recent studies have shown that drinking a couple cups of coffee a day just isn't bad for you. According to an article in the American Journal of Clinical Nutrition, "Our results suggest that coffee consumption is not harmful for healthy adults in respect of risk of major chronic disease." Coffee drinkers don't have a higher rate of heart disease or cancer -- or any other major health problems.

And not only that, but there's lots of evidence to show that coffee is actually good for you. The same article in Clinical Nutrition finds that coffee drinkers have a lower risk of diabetes. Other research has show that coffee can lower your risk of several kinds of cancer, including prostate and skin cancer -- and a can lead to a very modest reduction in almost a dozen other types of cancer.

A recent study out of the University of South Florida and University of Miami found consuming higher levels of caffeine (which came from coffee among those tested) is linked with a delayed onset of Alzheimer's disease. In fact, drinking coffee has even been suggested to increase longevity.

And there's evidence that coffee has mental health benefits as well. The results of one study suggested, "Women who consume two to three cups of caffeinated joe per day had a 15 percent lower risk of depression than non-coffee drinkers."

Another study pointed to decreased stroke risk among women who regularly consumed coffee,

and a recent study pointed to decreased risk of heart failure among those who fulfill their jones for java.

The abundance of studies supporting the benefits of coffee can actually be supportive to our health, because it reduces the stress around a habit that we may have erroneously believed was not good for us. It's nice to have some relief from the "food police." When our chosen rituals can be enjoyed without guilt, there is a benefit to our emotional health. Additionally, the benefits of coffee can extend beyond what the studies show, to the psychological, societal and cultural benefits of the world's most popular beverage.

For millions of people, the morning's first cup of coffee is a comforting and much-looked-forward-to ritual, one that can make dragging yourself out of bed and commuting to work a little bit more bearable -- maybe even add a bit of joy. (And, as recent studies have shown, smiling is good for your health too!)

A good cup of coffee can lead to sensory delight. Obviously, the taste of a good cup of coffee is without parallel -- but even a bad cup of coffee has its charms. The appeal of coffee, however, is not limited to a single sense.

The strong, distinct aroma of coffee -- released from grinding beans or even just walking by a coffee shop -- also brings pleasure, which increases dopamine in your brain (which has been correlated with happiness and health). The sight of a coffee shop can often bring a feeling of relief. There's an element of touch: gripping a hot cup of coffee on a brutal winter's day, or the chill of a delicious iced coffee (more appropriate on days like the ones most of us have been having).

And for true enthusiasts, even the sound of the beans grinding can invoke delight, as can the whirring of a milk-steamer or the barista's chatter. Perhaps even on a larger level, the sound of a potential suitor finally asking, "Would you like to meet for coffee?"

That social element of coffee is unparalleled. Coffee appeals to our sense of serving and being served. Offering someone a cup of coffee and receiving a cup of coffee has become kind of a universal symbol of hospitality

Coffee shops can be inspiring gathering places -- one of the few public spaces we have left. People gather in groups to chat, meet for first dates, or sit quietly and read. They host music shows, hang local artists' work, and are places to hang fliers, advertise apartments for rent or look for missing cats.

Like all things, coffee is best enjoyed in moderation (more notes on how to do that below, but the key word in the sentence might be "enjoy," since providing enjoyment is what coffee does best!

How to keep your coffee consumption healthy:

Before you order that extra large triple latte, keep in mind that more experts agree it is best to limit your intake to one to two cups a day. Use common sense -- some people are sensitive to caffeine and should limit or choose decaf. Too much caffeine can contribute to insomnia, nervousness, anxiety, gastrointestinal issues, and heart rhythm concerns. Pregnant woman and those with blood pressure issues should check with their doctor. Also, excess sugar and cream in those fancy coffee drinks are not recommended.

Tips for healthy coffee:

1) If choosing decaf, go for Swiss water process decaf vs. the chemical solvent process.

2) It is best to choose organic coffee when possible. Conventionally-grown coffee is a heavily sprayed crop.

3) If you are watching your cholesterol levels, use paper coffee filters to remove chemicals responsible for elevated cholesterol.

GO TO THE ORIGINALS FOR the LINKS!
 
And here is another:

http://www.bodybuilding.com/fun/mahler11.htm

MM: Recently at t-mag, there was some discussion regarding the negative effects that caffeine might have on insulin activity. What are your thoughts on this?

DE: The research he quoted is accurate but only under limited conditions. What needs disputing is the underlying philosophy. Insulin resistance has a negative connotation to it just like ketones because both conditions were first observed in diabetics and have been, ever since, considered very negative responses tied tightly to disease. It is one thing to study man the "carbohydrate-eater/diseased-man" and an entirely different thing to study man the "fat-eater/man-not-diseased." One cannot extrapolate the findings in one group to the other, yet it is done all the time. So now what would benefit one group is extrapolated to benefit the other. This is very poor science. It is likely that consuming caffeine along with carbs is a bad idea just as consuming carbs w/o caffeine is a bad idea. Of course, an even worse idea is to eat few carbs for a couple of days and then to load carbs for a few days, and, as well, to starve and then to eat a lot of food in one meal along with carbs. All of these are bad actions. But, on the other hand, if you consumed caffeine along with a low-carb diet, it would enhance the fat burning process, the ideal condition of man


In considering this, keep in mind what Dr. Hyman has pointed out above:

Dr. Hyman said:
The truth is that not everyone responds to caffeine the same way. Some metabolize coffee differently than others. Our detoxification pathways are genetically determined. That is why some people have one cup in the morning and can’t sleep for days and others can have a double espresso after dinner and hit the pillow and fall into deep sleep.

The gene involved is called CYP1A2. You can get a lab test to find out if you have trouble detoxifying. The good news is some may be better than others at tolerating caffeine and may be able to enjoy that coffee.

Plus, there is the leaky gut issue. One needs to remove ALL such elements for a long period for gut healing to take place.

But, the bottom line is: perhaps coffee in moderation is okay for those people who STAY on the KD and who are already advanced in gut healing and healing of other conditions related to carb/grain/dairy/veggie consumption?

Just leaving it open.
 
Well, I've never been a coffee drinker but I followed a link to "BulletProof" coffee (Upgraded coffee beans blended with grass fed butter and MCT oil) from reading Dr. Kruse's site and this guy, Dave Asprey, concludes that one of the worst things about the majority of coffee beans are the mycotoxins and molds on the beans. He also sells this Upgraded Coffee but he does list citations on the dangers of mycotoxins in coffee.

Here's a link: http://www.bulletproofexec.com/coffee/

...and a snippet from: http://www.bulletproofexec.com/why-bad-coffee-makes-you-weak/

Why Bad Coffee Is Bad For You
Sometimes your taste buds know best.

You don’t like the taste of bad coffee for the same reason you don’t like the taste of gasoline: your body is telling you it’s toxic.

The data on coffee consumption goes back and forth. Some studies show health benefits, while others show negative outcomes. This might seem confusing, but the reason is simple: bad coffee is bad for you, and scientists suck at differentiating types of coffee when they run studies on coffee.

Studies on coffee and health don’t control for processing methods or the source of the beans. This means the coffee beans are almost always contaminated with mycotoxins. Mycotoxins are damaging compounds created by molds which grow on coffee beans (among other things). These compounds cause all sorts of health problems like cardiomyopathy, cancer, hypertension, kidney disease, and even brain damage. They also make your coffee taste bitter, like it needs sugar.

Some types of coffee have more mycotoxins than others, which is why you see some studies showing a benefit to drinking coffee, and others showing negative health outcomes. The problem isn’t coffee per se, it’s the mold on your coffee. It even can vary by individual batch, especially for large coffee producers. (like ones with big ugly green logos on every street corner)

Mycotoxins are in almost all low quality brands of coffee. One study showed that 91.7% of green coffee beans were contaminated with mold. This is before they were processed, which allows even more mold to grow. Another study showed 52% of green coffee beans and almost 50 percent of brewed coffees are moldy. Coffee is easily one of the largest sources of mycotoxins in the food supply.

As the researchers concluded,

“…regular coffee consumption may contribute to exposure of humans to OA (ochratoxin).”

Ochratoxin A is bad news. It hits your kidneys, causes cancer, and messes up your immune system. Trust me, I know. I’m an ochratoxin canary, having lived in a house with ochratoxin-generating toxic mold that caused some serious damage to my immune function and autonomic nervous system. (If I can be Bulletproof with all that going on, so can you!)

So just to open it up a bit further... maybe moderate coffee intake on the KD diet after gut healing has taken place would be okay as long as the coffee beans are well-sourced and free of mycotoxins.
 
Just thought I'd give a bit of an update on the coffee experiment. Things seem to be going well on this front. I've sourced a good place not too far from me that imports the green coffee beans, triple washes them to remove any mold and then roasts them on the premisis. They have varieties from all over the world, so there's lots to explore. Their decaf is swiss water method and they say removes 99% of the caffeine! This means I can enjoy it in the evening too, as it hasn't disturbed my sleep :)

My usual routine is to wake up, make some breakfast and then brew some coffee. I buzz about 80 to 100 grams of butter into about 750mL of coffee with an imersion blender. Then in the afternoon, or evening on the days I work, I do the same thing with decaf coffee after dinner. I'm finding this to be a great way of getting more fat into my diet. I've been having issues going overboard on the fat in my meals and it making me quite nautious. I think I've vomited more in the last couple of months than I did my whole life leading up to this (that's probably an exaggeration, but it doesn't feel like it!). But with the butter coffee I'm having no such issues. I've lessened the amount of fat in my meals by a little bit, which feels much more comfortable to me.

The caffeine buzz is familiar and pleasant, and seems to sharpen my mental state and increase my reflexes. But it doesn't really seem to have much of a downside compared to my previous coffee habit. I keep waiting for that inevitable crash in the afternoon, but it never comes. The buzz just kind of lessens in intensity until it's gone. No crash, no plunging blood sugar levels leading to extreme hunger, no jitters and no gut-rot. I'm thinking there really is something to the idea that coffee for fat burners is different from coffee for sugar burners, because it certainly seems different from my previous experience. It doesn't seem to cause a strong adrenal response. Hard to tell for sure, though.

One thing I have noticed is that I seem to be physically clumsier, although I can't be sure this is attributable to the coffee since I seem to go through clumsy phases periodically. One thing I have noticed is that I seem to have reflexes fast enough to recover from my clumsy moves more readily than without the coffee enhancement. For example, the other day I knocked a container of whey protein off a shelf at work with my elbow but quickly caught it before it could hit the ground. It was an impressive move (well, it impressed me, anyway). I guess it remains to be seen whether this clumsy period subsides as it usually does or if it sticks around. This would be a good indication of whether it's caused by the coffee or not.

Anyway, that's my update. As you can probably tell, I'm loving this experiment. I think coffee is one of the things I've missed most with all the dietary changes, and I'm overjoyed now that it's back :D
 
dugdeep said:
I've been having issues going overboard on the fat in my meals and it making me quite nautious. I think I've vomited more in the last couple of months than I did my whole life leading up to this (that's probably an exaggeration, but it doesn't feel like it!). But with the butter coffee I'm having no such issues. I've lessened the amount of fat in my meals by a little bit, which feels much more comfortable to me.

Have you been drinking bone broth with meals? Especially with breakfast? That's a great way to increase fat consumption without reaching the point of overdoing it.

I can't repost the following article because it's blocked by some anti-copy/paste software function, but it sounds interesting, FWIW.

Coffee could aid bowel functions after surgery

http://www.nutraingredients.com/Research/Coffee-could-aid-bowel-functions-after-surgery

Consumption of coffee could be cheap and safe way to help to speed up and improve the bowel functions of people after surgery, according to new data.

Like dugdeep, I've had similar positive results to with coffee over the past ten days I've been drinking it. Dang, it just feels so right! But as we know, that doesn't mean much in itself and we could yet be playing havoc with our insulin levels. We shall see I guess.
 
Kniall said:
dugdeep said:
I've been having issues going overboard on the fat in my meals and it making me quite nautious. I think I've vomited more in the last couple of months than I did my whole life leading up to this (that's probably an exaggeration, but it doesn't feel like it!). But with the butter coffee I'm having no such issues. I've lessened the amount of fat in my meals by a little bit, which feels much more comfortable to me.

Have you been drinking bone broth with meals? Especially with breakfast? That's a great way to increase fat consumption without reaching the point of overdoing it.

Yes, I've been trying to do bone broth at least once per day. In fact, I think this may be how I went overboard on the fat a couple of times. Once I actually loaded up on fatty bone broth at breakfast since I knew I wasn't going to be able to eat again until the evening. I took a nap later that day and woke up 20 minutes later with some of the worst nausia I've ever experienced and this was hours and hours after breakfast.

[quote author=Kniall]
I can't repost the following article because it's blocked by some anti-copy/paste software function, but it sounds interesting, FWIW.

Coffee could aid bowel functions after surgery

http://www.nutraingredients.com/Research/Coffee-could-aid-bowel-functions-after-surgery

Consumption of coffee could be cheap and safe way to help to speed up and improve the bowel functions of people after surgery, according to new data.
[/quote]

Very interesting. Especially the part about it not being related to caffeine. My own bowel motility seems to have improved with this experiment, although I'm still not going every day. I'll give it more time to see how this plays out.

[quote author=Kniall]
Like dugdeep, I've had similar positive results to with coffee over the past ten days I've been drinking it. Dang, it just feels so right! But as we know, that doesn't mean much in itself and we could yet be playing havoc with our insulin levels. We shall see I guess.
[/quote]

It does feel right! I've been in a positive mood all week from this. I'm sure it's chemical, but none the less it feels good!

Regarding insulin, I don't think the coffee causing insulin release, at least from what I can tell. I'm not noticing any blood sugar effects at all (no crashing or hunger or anything like that). In sugar-burners, coffee causes cortisol release and cortisol raises blood sugar to support the stress response by mobilizing glucagon (which in turn releases glycogen and starts gluconeogenesis) so that there's a ready fuel source for the muscles to respond in fight or flight mode. Usually this is followed by a crash as insulin packs all the glucose into the cells and you're left with low blood sugar. I wonder, and this is pure speculation, that if in fat-burners, because glucose is not the preferred fuel, if it actually increases fat burning instead. Maybe rather than cortisol causing blood sugar to rise, it mobilizes fats (or maybe ketones) in order to fuel the stress response.

A lot of unknowns in that, but it's a maybe :)

Edit - posted prematurely; added a sentence and corrected spelling
 
dugdeep said:
It does feel right! I've been in a positive mood all week from this. I'm sure it's chemical, but none the less it feels good!

I hate to be the "fun killer" but I'd caution such a joyous reaction. It's been my first hand experience that any food I "love" is really bad for me and that pleasure rush is usually a compensation for the damage the food is doing. So, I'd tread carefully there, but that's just me...
 
anart said:
dugdeep said:
It does feel right! I've been in a positive mood all week from this. I'm sure it's chemical, but none the less it feels good!

I hate to be the "fun killer" but I'd caution such a joyous reaction. It's been my first hand experience that any food I "love" is really bad for me and that pleasure rush is usually a compensation for the damage the food is doing. So, I'd tread carefully there, but that's just me...

I sure hope that never applies to bacon!! :P
 
LQB said:
anart said:
dugdeep said:
It does feel right! I've been in a positive mood all week from this. I'm sure it's chemical, but none the less it feels good!

I hate to be the "fun killer" but I'd caution such a joyous reaction. It's been my first hand experience that any food I "love" is really bad for me and that pleasure rush is usually a compensation for the damage the food is doing. So, I'd tread carefully there, but that's just me...

I sure hope that never applies to bacon!! :P

If you get a 'joyous buzz' from it, it might!
 
anart said:
dugdeep said:
It does feel right! I've been in a positive mood all week from this. I'm sure it's chemical, but none the less it feels good!

I hate to be the "fun killer" but I'd caution such a joyous reaction. It's been my first hand experience that any food I "love" is really bad for me and that pleasure rush is usually a compensation for the damage the food is doing. So, I'd tread carefully there, but that's just me...

Point taken. I'm continuing to watch for negative effects, but so far haven't found any. Maybe I'll give it a rest for a couple of days just to see how it goes.
 
Yesterday I read a small notice in a magazine about the role of chlorogenic acid that is found in coffee.
Pretty interesting stuff, so I had to look it up. Here are a few quotes:

_http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032718
Chlorogenic acid (CGA) has been shown to delay intestinal glucose absorption and inhibit gluconeogenesis. Our aim was to investigate the role of CGA in the regulation of glucose transport in skeletal muscle isolated from db/db mice and L6 skeletal muscle cells. Oral glucose tolerance test was performed on db/db mice treated with CGA and soleus muscle was isolated for 2-deoxyglucose transport study. 2DG transport was also examined in L6 myotubes with or without inhibitors such as wortmannin or compound c. AMPK was knocked down with AMPKα1/2 siRNA to study its effect on CGA-stimulated glucose transport. GLUT 4 translocation, phosphorylation of AMPK and Akt, AMPK activity, and association of IRS-1 and PI3K were investigated in the presence of CGA. In db/db mice, a significant decrease in fasting blood sugar was observed 10 minutes after the intraperitoneal administration of 250 mg/kg CGA and the effect persisted for another 30 minutes after the glucose challenge. Besides, CGA stimulated and enhanced both basal and insulin-mediated 2DG transports in soleus muscle. In L6 myotubes, CGA caused a dose- and time-dependent increase in glucose transport. Compound c and AMPKα1/2 siRNA abrogated the CGA-stimulated glucose transport. Consistent with these results, CGA was found to phosphorylate AMPK and ACC, consistent with the result of increased AMPK activities. CGA did not appear to enhance association of IRS-1 with p85. However, we observed activation of Akt by CGA. These parallel activations in turn increased translocation of GLUT 4 to plasma membrane. At 2 mmol/l, CGA did not cause any significant changes in viability or proliferation of L6 myotubes. Our data demonstrated for the first time that CGA stimulates glucose transport in skeletal muscle via the activation of AMPK. It appears that CGA may contribute to the beneficial effects of coffee on Type 2 diabetes mellitus.

_https://www.google.fi/url?sa=t&source=web&cd=8&ved=0CFkQFjAH&url=http%3A%2F%2Fwww.jimronline.net%2Fcontent%2Ffull%2F2007%2F81%2F0872.pdf&ei=rNp8UPzmDLGM4gSIuIBg&usg=AFQjCNG4WteLlg2soupZ4NnhaboptCS-qA
The results from a clinical study performed in 12 healthy volunteers with different coffee products containing glucose show that instant coffee enriched with chlorogenic acid induced a reduction in the absorption of glucose of 6.9% compared with the control. No such effects were seen with normal or decaffeinated instant coffee. In a second, comparative, randomized, double-blind, 12-week study we investigated the effect on the body mass of 30 overweight people, compared
with normal instant coffee. The average losses in mass in the chlorogenic acid enriched and normal instant coffee groups were 5.4 and 1.7 kg, respectively. We conclude that chlorogenic acid enriched instant coffee appears to have a significant effect on the absorption and utilization of glucose from the diet. This effect, if the coffee is used for an extended time, may result in reduced body mass and body fat when compared with the use of normal instant coffee.

_http://www.ncbi.nlm.nih.gov/m/pubmed/14522730/
CONCLUSIONS: Differences in plasma glucose, insulin, and gastrointestinal hormone profiles further confirm the potent biological action of caffeine and suggest that chlorogenic acid might have an antagonistic effect on glucose transport. Therefore, a novel function of some dietary phenols in humans may be to attenuate intestinal glucose absorption rates and shift the site of glucose absorption to more distal parts of the intestine.

So it does seem that coffee might actually be beneficial as long as you don't consume any carbs. One thing that is still puzzling me is how the whole receptor/synapse thing is affected by coffee. I don't know if I remember it correctly, but doesn't the 'caffeine molecule' fit into one of the types of receptors, inhibiting 'tiredness molecules' from attaching? (Sorry for the lack of proper scientific terminology)

I've been recently experimenting with coffee, adding butter. So far I've only noticed it to be beneficial, it helps to get things done, a little like acetylcholine. I'm not sure how long I'll continue, but right now with an increased work load at work it seems like a blessing.
 
Back
Top Bottom