Re: Ketogenic Diet - Path To Transformation?
[quote author=http://www.healing-arts.org/children/autism-overview.htm] Alan Friedman and colleagues have pioneered the potential role of DPP IV deficiency in autism.
Some have gone so far as to suggest that DPP-IV deficiency may explain all of the abnormalities seen in autism. Dipeptidyl peptidase IV (DPP-IV) is a serine peptidase that removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided the penultimate residue is proline.
The only known enzyme to break down casomorphine, dipeptidyl peptidase IV or DDP-IV, appears to be absent or reduced in autistic children. The gene for this enzyme is distal to other suspected autism genes on 2 and Q of 7 and is expressed in the kidney, the small intestine, the liver, the blood-brain barrier, and has involvement in T-Cell activation.
{the gene is expressed in all these organs, plus the BBB and our immune system... these are the same places we deal with when we talk about iron} Also found in the urine were undigested food particles, suggesting a leaky gut syndrome.
Mice with the a defective casomorphine enzyme gene will die if not on a gluten free diet. Later we will discuss the possible role of glutein and cassein in autism, and the elimination of these substances from the diet as a treatment.
The toxicity of gluten and cassein may result from the lack of DPP IV. Thus, DPP deficiency may be important in explaining opioid excess.[/quote]
Jeanne Brohart blames vaccines for her son's autism. She has a lot to say about iron (in addition to other toxic heavy metals).
[quote author=Jeanne Brohart http://www.autismhelpforyou.com/Redefining%20The%20Role%20Of%20Insulin.htm]
Children with autism are known to be very deficient in B6. Do these children with autism crave grains because they provide “some” B6 – even if in very limited amounts due to processing issues? Do they crave milk because it provides calcium (known to inhibit iron absorption)? Do they experience a hallucinogen effect because of the stress involved in these disorders? Certainly, a “numbing” of sorts as would be provided via a natural opiate effect could affect one’s memory of painful and/or traumatic events. Again, more interesting questions.
Note that B6 is also tied to approximately 100 enzymes functions [91] and that enzyme dysfunction as it relates to casein and/or gluten breakdown also very much appear to be a problem area not only for children with autism [99] but for persons with schizophrenia [100, 101] and dementia [102] as well.[/quote]
I once read that a woman was having Alzheimer-like symptoms, and the doc gave her a jab of B6 (or was it B12? can't remember) and she was perfectly fine after that.
More from Jeanne Brohart
[quote author=http://www.autismhelpforyou.com/anemia.htm]Hemoglobin is not iron! Unfortunately physicians prescribe iron to anemic people who test with low hemoglobin. Yes, the patients are anemic, but the iron is collecting in storage instead of going into hemoglobin. These people are iron-loaded.
They need iron removed despite the anemia. The anemia should be treated with B vitamins, especially B12, B6 and folic acid. {exactly the things that are added to modern gluten foods by manufacturers, incidentally. Jeanne also speculates
Note that casein kinase 1 is involved in dna repair and that the very things which contain gluten - grains - are sources of something else that is critical to these children - Vitamin B6. Could this be part of the reason why these children were craving milk and gluten products... for the potential benefit they may derive from milk and vitamin B6 - in spite of the fact that they had issues digesting foods like milk and grains because of compromised immune systems.
}
<snip>
As Roberta Crawford of the Iron Overload Diseases Association has stated, a person would have to be on a starvation diet to be "iron deficient". Thus, it is much more likely that "anemia" in autism and Alzheimer's is more likely the result of IRON LOADING anemia!
Also, disorders such as autism and Alzheimer's are very much tied to vitamin B deficiencies.
“A deficiency of vitamin B6 can result in anemia that is similar to iron deficiency anemia” [33].
Thus... is it "anemia" that we should be diagnosing in these patients or vitamin B deficiency? Another very interesting question![/quote]
[quote author=http://www.ncbi.nlm.nih.gov/pubmed/16189201]
Clusters of phosphoserine residues in cow milk caseins bind iron (Fe) with high affinity. Casein inhibits Fe absorption in humans, but protein hydrolysis lessens this effect. Phosphopeptides from different caseins gave conflicting results on Fe absorption; release of phosphate residues by intestinal alkaline phosphatase could be a key point of that metabolism.
<snip>
The differences in protein composition between cow and breast milk, which does not contain alpha-casein, could explain some of their differences in Fe bioavailability.[/quote]
Another -
[quote author=http://www.sigmaaldrich.com/catalog/product/sigma/c4032?lang=en®ion=US]
Clusters of phosphoserine in casein
chelate iron and reduce its bioavailability. Partial enzymatic digestion of casein unmasks phosphorylated residues to alkaline phosphatase,
permitting dephosphorylation and increasing the bioavailability of iron.[/quote]
Which reminds me of the Jews
[quote author=http://en.wikipedia.org/wiki/Milk_and_meat_in_Jewish_law]Mixtures of milk and meat (Hebrew: בשר בחלב, basar bechalav, literally
"meat in milk") are prohibited according to Jewish law.[/quote]
How do I connect the dots here... Maybe back in the days when bloodletting was common, cultures that ate dairy did so to chelate iron? (if that is even possible)
Or, does iron overload somehow cause gluten to have the effect it does, so our guts become leaky and the casein that escapes into our bloodstream carries iron with it... and dephosphorylation of that casein will release the iron.
If we stay clean for so long and expect our guts to have healed, and we
still react to casein, then the reason may be that we can't digest casein properly (or take too long to digest it). Then, we can speculate that it's because we are deficient in the enzyme DPP-4. And why are we deficient? Probably has to do with iron loading.
Also, DPP-4 inhibitors are used to treat type-2 diabetes. Here's how it works
Note that DPP-4 inhibits incretin, meaning that DPP-4 indirectly helps
raise blood glucose. I don't know how this relates but here's something from Jack Kruse
[quote author=http://www.jackkruse.com/cpc4-evolutionary-friend-or-foe/]When we see this occur it suggests that some aspect of trait that causes a disease today likely helped our ancestors in our past to survive. In the case of diabetes,
high blood glucose levels allows a person to deal better with extreme cold because it lowers the freezing point of blood! It is natural antifreeze that allows life to exist in the cold.
<snip>
To make Ice wine in late harvest around frost time, a grape begins to protect itself by rapidly reducing its water content and by raising its sugar content. It tries to eliminate water when it gets cold. Now maybe you understand why you have the urge to urinate when you begin to use cold thermogenesis? You transiently are dumping water and raising your blood glucose levels just like a grape.
But what happens in you is with longer adaptation you BG level drop as your fat mass shrinks. You eventually lose all your glucose stores and eventually just burn fat to survive. Humans have this ability as we evolved.....but the Neanderthals likely did not. Why you may ask?
Do ever wonder why they never won out in evolution against us? Modern science still struggles to figure out why? Could it be they could not become diabetic to survive the cold of the ancient past?[/quote]
Btw, ice wine = Eiswein. As in
Q: Can you comment on Pannonia in general? Is it in any way significant? This lake Neusiedl?
A: Eiswein: Eisenstadt.