nicklebleu said:
I wonder what the interaction would be between grain/ dairy and coffee consumption (as in our culture these two things very often go hand in hand) - being that the arousal reaction to decaf coffee would be stronger in people eating a lot of grains, thus stimulating their opiate receptors on a much greater scale. This would lead to a quicker and heavier withdrawal reaction to quinides.
OMG you're right! I didn't think of that. Constant overdose of opioids (gluten) > brain adapts by having less opioid receptors > small dose of quinides is enough to block all those receptors lol.
But I think the quinide-insulin connection is also significant.
[quote author=http://www.coffee-makers-et-cetera.com/coffee-health.html]Among the antioxidants in coffee is a compound called quinine.
Quinine increases the body's sensitivity to insulin. Along with other antioxidants like
chlorogenic acid and tocopherols and minerals like magnesium (all of which are also found in coffee), quinine helps metabolize glucose as well.[/quote]
Americans love their coffee-and-donut. Coffee helps them out with donut's blood glucose spike, so coffee-drinking could be a subconscious habit. My housemate-with-MS subsists on glucose alone, and she drinks a lotta coffee.
[quote author=http://www.sciencedaily.com/releases/2007/08/070821143629.htm]"
Roasting is the key factor driving bitter taste in coffee beans. So the stronger you roast the coffee, the more harsh it tends to get," Hofmann says, adding that prolonged roasting triggers a cascade of chemical reactions that lead to the formation of the
most intense bitter compounds.
Using advanced chromatography techniques and a human sensory panel trained to detect coffee bitterness, Hofmann and his associates found that coffee bitterness is due to two main classes of compounds:
chlorogenic acid lactones (A.K.A. quinides) and phenylindanes, both of which are antioxidants found in roasted coffee beans. The compounds are not present in green (raw) beans, the researchers note.
(Everybody knows quinine—the famous malaria cure—is bitter, right? This whole article is saying quinides produced from the roasting process are the sole reason that coffee is bitter.)
"We've known for some time that the chlorogenic acid lactones are present in coffee, but their role as a source of bitterness was not known until now," Hofmann says. Ironically, the
lactones (A.K.A. quinides) as well as the phenylindanes
are derived from chlorogenic acid, which is not itself bitter.[/quote]
I think humans have, evolutionarily or genetically, learned to associate bitterness with poison. Poison can be "good", meaning it can have medicinal value. (Like carnivorous animals using plants as laxatives.) Surely, bitterness is how the Quechua people identified cinchona bark to have medicinal properties (unless the Lizzies told them directly). Modern "coffee" is just that—quinine medicine! The carb-guzzlers who down coffee everyday are self-medicating. Subconsciously, they seek out that bitterness, because the bitterness tells their sick bodies it's medicine.