Ares
Jedi Master
Carbon Monoxide Research
quote from
"The Health Benefits of Tobacco"
http://www.amazon.com/Benefits-Tobacco-William-Campbell-Douglass/dp/9962636450
http://www.ncbi.nlm.nih.gov/pubmed/12006181
another study:
If CO and NO are neurotransmitters, then minute dosages of these gases may indeed be beneficial? The standard trick to attack here is to make a general blanket statement "CO is deadly to humans", (which is true), but is also very misleading in context.
As the author William Campbell of the book cited above says
quote from
"The Health Benefits of Tobacco"
http://www.amazon.com/Benefits-Tobacco-William-Campbell-Douglass/dp/9962636450
Now the given reference does not work, But a little digging of the role of CO and NO on the web and this is what I found - this may be the source of the quote above:Carbon monoxide is a by product of tobacco smoke. A report indicates low levels of CO may help victims of heart attacks and strokes
CO inhibits blood clotting, thereby dissolving harmful clots in the arteries. The researchers focused on CO's close resemblance to Nitric Oxide (NO) that keeps blood vessels from dilating and prevents buildup of the detritus of clotting. The researchers commented" Recently NO has been elevated from a common air pollutant...to an [internal] second messenger of utmost physiological importance. Therefore, many of us may not be entirely surprised to learn that CO can... rescue the lung from [vascular] injury," reports the researchers.
The extrapolation from this is that cigar smoke can relieve ischemic heart disease through the minute amounts of CO present.
Ref: http://193.78.190.200/10b/cm.htm
http://www.ncbi.nlm.nih.gov/pubmed/12006181
Cross talk between carbon monoxide and nitric oxide.
Hartsfield CL.
Cardiovascular Pulmonary Research Laboratory, Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA. cynthia.hartsfield@UCHSC.edu
Abstract
Carbon monoxide and nitric oxide are two endogenously produced gases that can act as second messenger molecules. Heme oxygenase and nitric oxide synthase are the enzyme systems responsible for generating carbon monoxide and nitric oxide, respectively. Both carbon monoxide and nitric oxide share similar properties, such as the ability to activate soluble guanylate cyclase to increase cyclic GMP. It is becoming increasingly clear that these two gases do not always work independently, but rather can modulate each other's activity. Although much is known about the heme oxygenase/carbon monoxide and nitric oxide synthase/nitric oxide pathways, how these two important systems interact is less well understood. This review attempts to define the current known relationship between carbon monoxide and nitric oxide as it relates to their production and physiological function.
another study:
Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes
by L. Xue *, G. Farrugia * , † , ‡, S. M. Miller *, C. D. Ferris § , ¶, S. H. Snyder § , ‖ , *, and J. H. Szurszewski * , †
Abstract
Nitric oxide (NO) and carbon monoxide (CO) seem to be neurotransmitters in the brain. The colocalization of their respective biosynthetic enzymes, neuronal NO synthase (nNOS) and heme oxygenase-2 (HO2), in enteric neurons and altered intestinal function in mice with genomic deletion of the enzymes (nNOS Δ/Δ and HO2 Δ/Δ) suggest neurotransmitter roles for NO and CO in the enteric nervous system. We now establish that NO and CO are both neurotransmitters that interact as cotransmitters. Small intestinal smooth muscle cells from nNOS Δ/Δ and HO2 Δ/Δ mice are depolarized, with apparent additive effects in the double knockouts (HO2 Δ/Δ/nNOS Δ/Δ). Muscle relaxation and inhibitory neurotransmission are reduced in the mutant mice. In HO2 Δ/Δ preparations, responses to electrical field stimulation are nearly abolished despite persistent nNOS expression, whereas exogenous CO restores normal responses, indicating that the NO system does not function in the absence of CO generation.
If CO and NO are neurotransmitters, then minute dosages of these gases may indeed be beneficial? The standard trick to attack here is to make a general blanket statement "CO is deadly to humans", (which is true), but is also very misleading in context.
As the author William Campbell of the book cited above says
Much has been said about CO found in tobacco smoke. CO in sufficient amounts is deadly; there is no doubt about that. [But] So is cobra venom and botulinum toxin, but tiny amounts have been found effective in certain conditions. CO has also been found to have significant medical benefits in tiny amounts. Its the new (to most people) science of hormesis.
It is interesting to note that public health doctors think its OK to dose you on a continuous basis with fluoride in your water, even though the highly toxic fluoride is cumulative in your tissues, including your brain - whereas CO is not. But 'everyone knows' CO is a deadly gas (which it is) and so it cannot be used in any amount for medical purposes, which is contrary to the basic pharmacological principle and knowledge.
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