Lights Out by T.S. Wiley and Bent Formby said:THE MAN WITH TWO BRAINS
It is your central nervous system in the form of your brain and gut that responds to your endocrine system. Your hormones report changes in your HPA axis to your immune system, which uses cytokines or neuropeptides to direct all traffic with regard to homeostasis. The immune system is much more than bone marrow or spleen, peyer's patches or thymus cells. Even the lymph system is only a part of what we call the immune system. Those sites are actually just factories for the production of white cells, lymphocytes, or the now infamous T cells. About eighty percent of the full force of your defensive immune system resides in your intestines or gut. This makes sense, since most toxins will enter through your mouth.
Even though we're led to believe that the immune system is our defense system, nothing could be further from the truth. The immune system i5 planetary, not individual. Our hormonal interface with the world in the form of the HPA axis means that the immune system is really "the mar behind the curtain" working the knobs and dials that make the broil-seem so competent. The elements of the immune system—gut, skin, fa: lymph, brain, and glands—all recognize, communicate, memorize, rear_ and even plan to survive earth changes that have been timed into or.: programming by millennia of experience. These capabilities mean that the immune system is as sentient, on its own, as you think you are.
It also makes sense that eighty percent of the immune system is locate in the gut because the gut was your original brain. As we slithered across rock, pre-"head brain," the neurotransmitters we know, like dopamine serotonin, and norepinephrine, and hormones like adrenaline and insulin ran The Project from your midsection.
The real clue to the overwhelming power and control the immune system has comes in the realization that it is completely mobile, so like free thinking individual you perceive yourself to be. The immune system within is, at least, your equal. Your immune system controls your behavior by controlling neurotransmitter activity. All immune cells have receptors to read both neurotransmitters and hormones controlling energy regulation and sex hormones. By the same token, the immune expressions called cytokines are active in your gut and your brain and your fat base and gonads.
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JUST CHILL
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Mammals in cold climates sleep for months at a time, or hibernate, to slow metabolic processes during food scarcity and darker days. Cooling us down in the dark, melatonin does antioxidant work, times ovarian and testicular function, and revs up the immune system for the next waking period, when we must keep harmful microbes out from behind the front lines.
Sleep is the biggest immunological defense scheme we've come up with yet, because not only does it defend us against other organisms in our environment, it defends us against starvation by the insulin-melatonin system. Insulin is produced only when your body senses sugar or stress. Since stress is heralded by cortisol, and cortisol is elevated as long as you're bathed in light, circadian rhythmicity, or day-night cycles, along with carbohydrates, control your insulin production. Light-and-dark cycles control insulin so you can store fat for hibernation, or dormancy. Long days meant the end of summer and food supply. The short sleep cycles of long days translate hormonally into an increased need for carbohydrates to store fat and cascade other hormones to put you to sleep. Carbohydrate craving is a precursor to sleep that we all still respond to every night that we're up late. Hibernation "drives" drive us to eat ice cream or have a glass of wine after a long day. Remember, a midnight snack is never a hard-boiled egg.
That last thing you think about, the last thing you want to eat before surrendering the light, is always any kind of sugar you can get your hands on.
Insulin secretion is controlled by the food you eat, but the food you want is controlled by your immune system responding to perceived seasonal variation in the light. When your body and brain need sleep to maintain immunity and reproductive capacity, melatonin and prolactin must surge. We even have melatonin receptors on our ovaries and testes that "read" light-and-dark cycles.
Melatonin is a potent antioxidant that, along with prolactin, controls immunity while you sleep. Without sleep, you become defenseless and autoimmune. Your immune system, too, like every other mechanism of life, is comprised of a sacred duality. Th1 and Th2 cells stand on that board on the log as the two halves of your immune function. [...]
I'll continue later on, almost done though.