Ascorbic acid (vitamin C)

More info on dehydroascorbic acid:

_http://en.wikipedia.org/wiki/Dehydroascorbic_acid

Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid. It is actively imported into the endoplasmic reticulum of cells via glucose transporters. It is trapped therein by reduction back to ascorbate by glutathione and other thiols.[1] Therefore, L-dehydroascorbic acid is a vitamin C compound much like L-ascorbic acid...

Although there exists a sodium-dependent transporter for vitamin C, it is mainly present in specialized cells, whereas the glucose transporters, most notably GLUT1, transport Vitamin C (in its oxidized form, DHA)[2] in most cells, where recycling back to ascorbate generates the necessary enzyme cofactor and intracellular antioxidant...

Vitamin C accumulates in mitochondria, where most of the free radicals are produced, by entering as DHA through the glucose transporters, GLUT1. Ascorbic acid protects the mitochondrial genome and membrane.[2]

Vitamin C does not pass from the blood stream into the brain, although the brain is one of the organs which has the greatest concentration of vitamin C. Instead, DHA is transported through the blood–brain barrier via GLUT1 transporters, and then converted back to ascorbate.[7]

Dehydroascorbic acid has been used as a vitamin C dietary supplement.[8]

As a cosmetic ingredient, dehydroascorbic acid is used to enhance the appearance of the skin.[9] It may be used in a process for permanent waving of hair[10] and in a process for sunless tanning of skin.[11]

In a cell culture growth medium, dehydroascorbic acid has been used to assure the uptake of vitamin C into cell types that do not contain ascorbic acid transporters.[12]

As a pharmaceutical agent, some research has suggested that administration of dehydroascorbic acid may confer protection from neuronal injury following an ischemic stroke.[7] The literature contains many reports on the antiviral effects of vitamin C,[13] and one study suggests dehydroascorbic acid has stronger antiviral effects and a different mechanism of action than ascorbic acid.[14] Solutions in water containing ascorbic acid and copper ions and/or peroxide, resulting in rapid oxidation of ascorbic acid to dehydroascorbic acid, have been shown to possess powerful but short-lived antimicrobial, antifungal, and antiviral properties, and have been used to treat gingivitis, periodontal disease, and dental plaque.[15][16] A pharmaceutical product named Ascoxal is an example of such a solution used as a mouth rinse as an oral mucolytic and prophylactic agent against gingivitis.[16][17] Ascoxal solution has also been tested with positive results as a treatment for recurrent mucocutaneous herpes,[17] and as a mucolytic agent in acute and chronic pulmonary disease such as emphysema, bronchitis and asthma by aerosol inhalation.[18]
 
Here's a good summary from a 2011 patent application (for a stable DHA solution for oral and external skin application) _http://www.faqs.org/patents/app/20110046216

Patent application title: STABLE COMPOSITIONS OF DEHYDROASCORBIC ACID
Abstract:

Stable liquid compositions containing the oxidized form of vitamin C known as dehydroascorbic acid are provided. The compositions comprise dehydroascorbic acid and a pharmacologically acceptable liquid organic polyol solvent for said dehydroascorbic acid, wherein said polyol solvent comprises about 50% or greater of the total weight of said composition. The compositions are useful as dietary supplements, skin-enhancers, concentrates, or research solutions.

[0003]2. Prior Art

[0004]Ever since the elucidation of the chemical structure of vitamin C in the mid-1930's it has been known that vitamin C occurs naturally as two different compounds, namely, ascorbic acid (AA) and an oxidized form of AA called dehydroascorbic acid (DHAA). It also is known that AA and DHAA are unstable compounds. In aqueous solutions, some factors which affect the rate of their destruction include the pH of the solution, and exposure to various metal ions, heat, light and air. It also is known that DHAA is considerably less stable than AA when subjected to comparable conditions. `Deutsch J C. Dehydroascorbic acid. Review Journal of Chromatography A, 881 (2000) 299-307 ` (Deutsch), incorporated here by reference, states en-equivocally "DHA is more reactive and unstable in solution than AA." Therefore, as a supplement to the diet, or as an ingredient of a topically applied product such as a skin lotion, AA has been the preferred chemical form of vitamin C because of its greater stability. In fact, we do not know of any commercially available dietary or topically applied product wherein DHAA specifically has been utilized as a substantial source of vitamin C.

[0005]Also known is that solid AA is far more easily dissolved in water than is solid DHAA, as noted in `Pecherer B J. The Preparation of Dehydro-L-ascorbic Acid and its Methanol Complex. Am Chem Soc 73 (1951) 3827-3830` (Pecherer) and `Koliou E K and Ioannou P V. Preparation of dehydro-L-ascorbic acid dimer by air oxidation of L-ascorbic acid in the presence of catalytic amounts of copper(II) acetate and pyridine. Carbohydrate Research 340 (2005) 315-318 ` (Koliou) which are incorporated here by reference. To prepare aqueous solutions of DHAA from the solid form requires prolonged mixing at temperatures well above 37 degrees centigrade. Thus solutions of DHAA are much more difficult to manufacture than solutions of AA. Also, since the conditions to solubilize it efficiently do not exist in the gut of human or other animals, substantial doubt exists about whether the dry, solid form of DHAA can be absorbed when ingested. These are also reasons why DHAA has not been utilized as the source of vitamin C for dietary supplements or topical products.

[0006]Around the same time as the chemical structures of AA and DHAA were elucidated in the mid-1930's, the antiscorbutic properties (ability to prevent the disease called scurvy) of both compounds were recognized and generally accepted as being equal or nearly so. The oxidation of AA to DHAA was shown to be reversible both in vitro and in biological systems, so the equivalence of the two compounds could easily be attributed to simple interconversion within an organism. Although a few early investigators did note some peculiar differences in the biological utilization of these two compounds, at least as essential dietary ingredients for humans and certain other species, AA and DHAA were generally considered bioequivalent. The dietary supplement and skin care product industries developed their products using AA (and various more stable derivatives of AA) because of the stability and solubility issues with DHAA, and DHAA has essentially been ignored and forgotten in these industries.

[0007]Since the mid-1930's, the volume of research in vitamin C has been enormous, and it is possible that no single subject in the field of biology has been the focus of more research and more scientific journal articles than vitamin C. And since about the mid-1990's, many new discoveries about DHAA have been made. Among these discoveries, those of particular pertinence to the present invention include those which demonstrate that, although the two compounds are equivalent in their antiscorbutic properties, AA and DHAA are not "bioequivalent" in any broad definition of the word. Specifically it is known today that AA and DHAA are absorbed by different mechanisms in the gut; that they accumulate differently in the various tissues of an animal when ingested; that they are absorbed into living cells by completely different mechanisms utilizing different receptors on the cell surface; that the cells of certain important tissues of the human body (e.g., brain) have a very high concentration of vitamin C but completely lack cell surface receptors for AA; that DHAA is absorbed into cells by the same receptors as glucose, which are present on every cell in the human body; that in human skin cells, DHAA is absorbed up to 5 times faster and to levels 2 times higher than is AA; that DHAA is almost instantly converted into AA once it has been absorbed into a cell; that both AA and DHAA have antiviral effects in vitro against viruses that cause disease in humans such as HSV-1 (herpes simplex virus type 1 that causes oral herpes and can cause genital herpes), influenza virus, and poliovirus; and that DHAA has much stronger antiviral effects than does AA. Literature that supports these statements, and is incorporated here by reference, includes `Savini et al. Dehydroascorbic acid uptake in a human keratinocyte cell line (HaCaT) is glutathione-independent. Biochem J 345 (2000) 665-672 ` (Savini) and `Furuya et al. Antiviral effects of ascorbic and dehydroascorbic acids in vitro. Int J Mol Med 22 (2008) 541-545` (Furuya).

[0008]Thus it can be seen that a solution of DHAA for oral ingestion or topical application, while being a source of vitamin C much like numerous other available products that contain AA, also can provide specific benefits and uses unavailable in any other product on the market today. What is needed is a stable liquid solution of DHAA in an orally and topically acceptable medium. .....

From measured data in the patent, DHA (in water) decomposes at the rate of about 5% per day. Propolene glycol (or glycerol) apparently prevents this decomposition. Among the ultimate decomposition products is oxalic acid.
 
Mineral Ascorbates: I don't know if this has been mentioned on this thread or not, but according to Dr W D Kelley, http://www.themetabolicinstitute.com/ about one in four people cannot tolerate straight ascorbic acid and should take the mineral ascorbates instead (calcium ascorbate etc). When Linus Pauling came out with his Vit c research in the '70s, I started taking ascorbic acid and it would just totally knock me out. Mineral ascorbates don't do that. FWIW
 
denekin said:
Mineral Ascorbates: I don't know if this has been mentioned on this thread or not, but according to Dr W D Kelley, http://www.themetabolicinstitute.com/ about one in four people cannot tolerate straight ascorbic acid and should take the mineral ascorbates instead (calcium ascorbate etc). When Linus Pauling came out with his Vit c research in the '70s, I started taking ascorbic acid and it would just totally knock me out. Mineral ascorbates don't do that. FWIW

Ascorbic acid doesn't knock me out but it sure cleans me out, and it doesn't take much. I would call that intolerance. I take small amounts of sodium ascorbate instead (along with a few other supplements, for multiple issues). I still have a bottle of ascorbic acid powder, and I add a couple of grams of it to my Epsom salt baths. It doesn't bother me that way.
 
Megan said:
Horseofadifferentcolor said:
We take vit. pills...

Be careful with that. The information I have been seeing is that taking vitamin pills can be worse than doing nothing. You can easily overdose on specific micronutrients, especially if you are taking other supplements. There is a balance of nutrients that comes from eating whole foods. When you take multivitamins you can end up with imbalances that result in toxicity.

See for example _http://chriskresser.com/9-steps-to-perfect-health-4-supplement-wisely and the articles linked there.

Kresser said:
Be selective with your supplementation.

Multivitamins have become increasingly popular: half of Americans currently take one. But is this a good idea? Most studies show that multivitamins either provide no benefit, or may even cause harm. A study in the Archives of Internal Medicine showed that multivitamins have little to no influence on the risk of common cancers, CVD or total mortality in postmenopausal women. A now infamous meta-analysis in the Journal of American Medical Association, which looked at over 68 trials with 230,000 pooled participants, found that treatment with synthetic beta carotene, vitamin A and vitamin E may increase mortality.

The problem with multivitamins is that they contain too little of beneficial nutrients like magnesium, vitamin D and vitamin K2, and too much of potentially toxic nutrients like folic acid, calcium, iron and vitamin E. This means that multivitamins can actually cause nutrient imbalances that contribute to disease. Another problem is that multivitamin manufacturers often use the cheapest possible ingredients, such as folic acid instead of natural folate – the consequences of which we discussed above.

Thanks Megan,
I agree with the fact that imbalences creat problems and I completley agree that synthetics are worthless. I dont trust a word of what the American Medical Association has to say.I bet the study they did was for folks taking centrum silver :evil: We currently take magnesium maltrate before bed and in the morn take B-complex(I know it helps me),krill oil(having a hard time finding safe fish), Potassium, and D3. The supplements I buy are pretty pricey and raw so I have been under the impression I was on the right track, but I am always open to feed back. Have others stopped taking all vitamins?
 
Horseofadifferentcolor said:
... I agree with the fact that imbalences creat problems and I completley agree that synthetics are worthless. I dont trust a word of what the American Medical Association has to say.I bet the study they did was for folks taking centrum silver :evil: We currently take magnesium maltrate before bed and in the morn take B-complex(I know it helps me),krill oil(having a hard time finding safe fish), Potassium, and D3. The supplements I buy are pretty pricey and raw so I have been under the impression I was on the right track, but I am always open to feed back. Have others stopped taking all vitamins?

I have stopped at times, although right now I am taking a small dose of D3 as an experiment, and C in conjunction with other supplements. I cut out the multivitamins perhaps a year ago as I learned about the problems with them, including the "good quality" one that I was taking at the time. The main thing to "take" seems to be high-quality meats including organ meat, pastured eggs, and such, and to limit cooking temperatures.

B complex is something I have often seen recommended, and something I have taken in the past. I can't say, though, that taking or not taking a vitamin supplement has ever made any noticeable difference for me, other than in my grocery bill. Minerals are a different matter.
 
As a possible associated side note, while reading "Idle No More" background of stories over the last few days, something came up there that lead to the following on Vit C. I've not found yet any measurable values for its contents, yet it is interesting and actually remembered this from reading "The Edible Wild" or another similar book decades ago. The link here shows a protester in the north drinking what he calls "Spruce Root Tea" (see @ 1:15 in video).

_http://www.cbc.ca/player/News/TV%20Shows/The%20National/ID/2327138596/

Searching this out directly has not result in a match (yet), however, it did came up with Spruce Needle Tea and here is a link from Wiki with a brief snip and a similar Norwegian link:

Note: this Tea must be made from the new growth needles, not the old.

Spruce Tea said:
Food and medicine

The fresh shoots of many spruces and pines are a natural source of vitamin C.[6] Captain Cook made alcoholic sugar-based spruce beer during his sea voyages in order to prevent scurvy in his crew.[7][8] The leaves and branches, or the essential oils, can be used to brew spruce beer.

The tips from the needles can be used to make spruce tip syrup[clarification needed]. In survival situations spruce needles can be directly ingested or boiled into a tea.[9] This replaces large amounts of vitamin C. Also, water is stored in a spruce's needles, providing an alternative means of hydration[clarification needed]. Spruce can be used as a preventive measure for scurvy in an environment where meat is the only prominent food source[clarification needed].

_https://en.wikipedia.org/wiki/Spruce#Uses

Think some clarification on meat and vitamins needs to be added as noted in the quote.

Norway Spruce:

_http://en.heilkraeuter.net/herbs/norway-spruce.htm

Kind of intrigued about the Spruce Root, if it has the same properties of Vit C - i'll keep looking.
 
Laura said:
_http://www.infoisus.com/naturalhealtharchives/grouppekurosawa.com/blog/2006/02/how-to-make-your-own-dehyd_114115275209892585.htm

How to Make Your Own Dehydroascorbic Acid
I would like to thank my colleague Dr. Will LaValley, M.D. of Austin Texas for stating the obvious. Simple hydrogen peroxide can oxidize vitamin C to DHA. Therapeutically, we have NO interest in vitamin C. We are only interested in DHA, a molecule which activates different biochemical pathways than vitamin C.

Ascorbyl palmitate should NEVER be taken as capsules. The AP is not soluble in water and will not be absorbed into the body UNLESS the AP is dissolved in fat. The oil industry developed AP as an anti-oxidant for oils. It was never meant to be taken in capsule form.

Bottom line.

We want to consume DHA but not vitamin C. Further, we want to prevent DHA from being converted back to vitamin C in the tissues.

We can purchase 500 grams of vitamin C for $20. See the home page of the GK website and the reference to the bulk supplement supplier.

Consider the following protocol.

10 grams of vitamin C can be converted to 10 grams of DHA by using common 3% hydrogen peroxide. Use fresh hydrogen peroxide, not the stuff that has been in your medicine cabinet for the last 2 years. Dissolve the 10 grams of vitamin C in water. It will not dissolve completely. You can also use vitamin C esters, calcium ascorbate, which are more soluble. Unfortunately, these products are more expensive and are not available in bulk form.

Slowly add the 3% hydrogen peroxide to the semi dissolved vitamin C. Forming will occur as the hydrogen peroxide interacts with the vitamin C.

I conducted the following experiment. I ground up ten 500 mg vitamin C pills in a mini-grinder. I added about 2 ounces of water to the vitamin C and its pill fillers, and stirred it for about a minute. If you use pure vitamin C without the pill fillers, its alot easier than grinding up pills.

To the 5 grams of vitamin C in 2 ounces of water, I added one teaspoon (measuring teaspoon) of 3% hydrogen peroxide. Forming occured for about 5 seconds and stopped. I added some small additional amounts of hydrogen peroxide, but forming never occured again. So, a teaspoon of hydrogen peroxide seems to neutralize 5 grams of vitamin C into DHA, our goal. I probably could have used less hydrogen peroxide, but who cares.

Then I drank it. Vitamin C is an acid and causes stomach problems for some people. When the powder vitamin C is neutralized with hydrogen peroxide, it has a tart taste but nothing more. Just drink it down. No stomach upset at all.

I tried this exactly as instructed here, but it did not work. Pure Ascorbic Acid powder with fresh 3% Hydrogen Peroxide liquid does not react at all -- not if concentrated, not if diluted, not when cold and not when hot, I tried all of these combinations.

I drank a minuscule sip of the mixture but it was very bad to my stomach. Basically, the unmodified Hydrogen Peroxide began to foam in my stomach and probably killed a lot of useful bacteria. I felt nauseous for half an hour. No wonder they put the warning on the label: "Do not drink"
 
Data said:
I tried this exactly as instructed here, but it did not work. Pure Ascorbic Acid powder with fresh 3% Hydrogen Peroxide liquid does not react at all -- not if concentrated, not if diluted, not when cold and not when hot, I tried all of these combinations.

I drank a minuscule sip of the mixture but it was very bad to my stomach. Basically, the unmodified Hydrogen Peroxide began to foam in my stomach and probably killed a lot of useful bacteria. I felt nauseous for half an hour. No wonder they put the warning on the label: "Do not drink"

Didn't I mention using baking soda which is what we did? It works fine.
 
Poking around looking for more stuff to toss in the pot here: (Obviously, I'm interested in autoimmune conditions since I have one and so do several other members of my family).

The Ascorbate Effect in Infectious and Autoimmune Diseases

Robert F. Cathcart, M.D.
127 Second Street, #4
Los Altos, CA 94022
650-949-2822
http://www.orthomed.com


The vitamin C effects are all the usual effects of the usual small doses of vitamin C and also the effects of the moderate and usual high doses of the vitamin C. The ascorbate effect is where massive doses of vitamin C are used where we are mostly throwing away the vitamin C for the electrons carried. With massive amounts of ascorbate it is possible to neutralize the massive amounts of free radicals generated mostly by the damage to mitochondria of infectious diseases, allergies, and injuries. Under most conditions the electrons carried by free radical scavengers come from the metabolism of glucose in the mitochondria. The amount of electrons from this source, when the mitochondria are not damaged, are sufficient when we are well to neutralize the free radicals of living. However, when we are sick and especially where the mitochondria are damaged, the free radicals overwhelm the mitochondrial ability to make electrons available. In these cases vitamin C in massive amounts can be the source of the necessary numbers of electrons to eliminate most of the free radicals of diseases. The ordinary doses of vitamin C, vitamin E, beta carotene, etc. cannot suffice. Any inflammation is evidence that the free radicals have not been adequately eliminated.

In 1969, I discovered that the amount of ascorbic acid tolerated orally without loosening of stools (a benign diarrhea) was somewhat proportional to the free radical toxicity of the condition being treated. The sicker a person was, the more ascorbic acid they would tolerate orally without it causing diarrhea. In a person with an otherwise normal GI tract when they were well, would tolerate 5 to 15 grams of ascorbic acid orally in divided doses without diarrhea. With a mild cold 30 to 60 grams; with a bad cold, 100 grams; with a flu, 150 grams; and with mononucleosis, viral pneumonia, etc. 200 grams or more of ascorbic acid would be tolerated orally without diarrhea. The process of finding what dose will cause diarrhea and will eliminate the acute symptoms, I call titrating to bowel tolerance.

When at the peak of the cold it is possible to take 100 grams of ascorbate in divided doses in 24 hours, I call it a 100 Gram Cold.

Sodium ascorbate intravenously never causes diarrhea in any dose. The diarrhea of ascorbic acid taken orally is caused by a hypertonic situation in the rectum. Intravenous sodium ascorbate actually increases bowel tolerance to ascorbic acid orally if administered at the same time.

The ascorbate effect is a threshold effect. Symptoms are usually neutralized when a dose of about 90% or more of bowel tolerance is reached with oral ascorbic acid. Intravenous sodium ascorbate is about 2 ½ times more powerful than ascorbic acid by mouth and since for all practical purposes huge doses of sodium ascorbate are non toxic, whatever dose necessary to eliminate free radical driven symptoms should be given.

The mathematical formulas that describe redox potential involve logarithms. Logarithms go low, low, low and then rapidly go high. The ascorbate effect acts at a threshold dose as would be anticipated from the logarithms in the formula when a reducing redox potential is forced into the oxidized tissues involved in the disease.

Example or the Common Cold

Most people have had the experience of feeling that they are catching a cold one evening but then wake up the next morning all well. What has happened here is that either antibodies from a previous cold wipe out the virus, or the white cells in the nose and throat destroy the virus by phagocytosis. These white cells need a little vitamin
C to perform phagocytosis. If the virus damages enough mitochondria in the nose and throat to produce enough free radicals to destroy all the vitamin C then the white cells shut down and that is when you wake up knowing you will be sick for a week or so. A condition of acute induced scurvy exists in the nose and throat.

Small doses of vitamin C taken as a maintenance dose will prevent a certain percentage of colds because this acute induced scurvy is harder to induce.; Once the free radical cascade is induced in the nose and throat small and moderate doses of vitamin will not cure the cold. However, moderate doses will prevent the spread of the acute induced scurvy into the sinuses, ears, and bronchial tubes so complications will be prevented. It is interesting to note than moderate doses by reducing the free radicals systemically will slow down the production of new antibodies; therefore, the basic, uncomplicated mild disease, unsick condition, will last a little longer than an uncomplicated untreated cold.

However, if massive doses, (usually bowel tolerance doses of ascorbic acid will suffice, but not always, sometimes intravenous sodium ascorbate is necessary) are driven into the nose and throat sufficient to neutralize the free radicals and eliminate the acute induced scurvy in the nose and throat, the white cells come out fighting mad and destroy the virus.

Humeral Immunity Reduced by Massive Amounts of Ascorbate

Massive doses of ascorbate augment cellular immunity while reducing humeral immunity. Clinically, the affinity of antibodies for their antigen is augmented by free radicals or an oxidative redox potential. I hypothesize that the single disulfide bond that holds the light chain of the antibody to the heavy chain is strengthened in an oxidative redox potential. Single disulfide bonds similarly hold all the other receptor sites of the immune system together.

I further hypothesize that the immune system receptor sites are under some normal stress and that under a reducing redox potential there is more of a tendency for the disulfide bond to break into two sulfhydryls which incapacitates the antigen bonding site. This would be a simple, neat mechanism whereby the humeral immune system would be turned off when there was no injury to the body. Any injury to cells would damage mitochondria, produce free radicals, induce an oxidative redox potential and turn on the immune system. While it appears from all the scientific work done on the immune system, its turn on is more complicated than this hypothesis, this hypothesis would explain many of the clinical effects of massive doses of ascorbate.

This hypothesis would explain why symptoms of hay fever, asthma and anaphylaxis are blocked or ameliorated by massive doses of ascorbate. It is pointed out that when a person is given penicillin or other antibiotics, they are sick and have oxidative redox potential in various parts of the body. This oxidative redox potential turns on the antibodies and the penicillin, or etc., can be recognized as a foreign body. In my experience, massive doses of ascorbate given along with penicillin prevent the anaphylactic and other allergic reactions to penicillin.

Ascorbate Treatment of Viral Hepatitis

In my experience acute viral hepatitis, A, B, C, non AB, etc., are all cured by massive amounts of ascorbate given over a few days intravenously. Chronic viral hepatitis is a different story. It is such a different story that something other that just a continuing viral infection must be going on. I think it is possible that chronic liver damage releases chemicals from the interior of the liver cells that cause an autoimmune like situation to be turned on. Chronic hepatitis, like that diagnosed as chronic hepatitis C, can be vastly ameliorated by continuing high doses of ascorbic acid by mouth, alpha lipoic acid (thank you Bert Berkson), selenium, vitamin E, silymarin, and strict restriction of sugar.

Chronic Fatigue Syndrome

I practiced medicine in Incline Village, Nevada between 1970 and 1980. There I saw many mononucleosis and bad flu cases. All responded to massive doses of ascorbate. I never saw an acute viral disease develop into chronic fatigue. Shortly after I left Incline, the chronic fatigue syndrome was identified by Dr Paul Cheney in 1983. A friend, the dentist in Incline, told me that none of my old massive vitamin C takers got chronic fatigue syndrome. I admit that this observation is not hard science but it is interesting.

Chronic fatigue syndrome is ameliorated by continuing bowel tolerance doses of ascorbic acid but these patients must be worked up for candida, parasites, food and chemical sensitivities, hypothyroidism, T4 resistence, etc., and treated appropriately. The nutritional program should include no sugar, low carbohydrates, elimination of all foods they are allergic to, chemicals, zinc, manganese, chromium, selenium, cod liver oil, vitamin E, multiple Bs, sometimes IM B12, folic acid and multiple Bs, along with the massive doses of C.

Ebola and Other Hemorrhagic Fevers, Nipah Virus and Etc.

All of these diseases produce massive amounts of free radicals. These hemorrhagic fevers are examples of probably 500 gram diseases. These diseases are so toxic, produce so many free radicals, that they rapidly produce not only a localized acute induced scurvy but a systemic induced scurvy. Shortly. collagen fibers begin to break down and bleeding is induced throughout the body. These cases must be treated with massive amount of sodium ascorbate intravenously immediately at the beginning of the disease. The rate of administration should be rapidly increased until the fever and other acute symptoms are diminished. My guess at a starting dose would be at a rate of at least 240 grams of sodium ascorbate per 24 hours. Do not be cheap. Give them vitamin E, B vitamins, zinc, manganese, chromium, selenium, EPA, DHA, etc. I have never treated a hemorrhagic fever case.

SARS is just another flu virus, possibly more toxic than most flues so give them intravenous sodium ascorbate. Probably 120 grams of sodium ascorbate intravenously per 24 hours would do it but give more according to the symptoms. I have treated at lease a thousand cases of flu and never so much as hospitalize one case.

Distemper and Kennel Fever

Although dogs are ascorbate producing animals, it is possible that a very toxic disease will overcome their ability to produce ascorbate. Wendell Belfield, DVM, of San Jose, CA has been curing dogs of distemper and kennel fever for 20 years with massive doses of sodium ascorbate intravenously. The dog just needs to be helped out for a few days with the intravenous and then he takes over himself.

Poliomyelitis

The first physician who used massive amounts of sodium ascorbate intravenously on serious viral diseases was Fred Klenner, M.D. of Reidsville, North Carolina. He published curing 60 cases of polio out of 60 cases with intravenous C. See Southern Medicine and Surgery, July 1949, p. 209. The whole article is on my website http://www.orthomed.com/polio.htm

Bacterial Infections

Bacterial infections cause symptoms, suppress the immune system, and cause allergic reactions to antibiotics by way of free radicals. While these diseases should be treated with the appropriate antibiotics, they should also be treated with massive doses of ascorbate. Massive doses of ascorbate clinically seem to broaden the spectrum of activity of antibiotics against resistant bacteria.

Autoimmune Diseases

My experience with some autoimmune diseases, particularly lupus, is that ascorbate in massive doses is very helpful. The following is my theory as to why. This theory involves many simplifications and probably some ideas that turn out inaccurate but are a way of thinking about the problem of autoimmune diseases that explain the role of massive doses of ascorbate. It also gives the patient a theory with which to listen to their body to figure out their biochemical individuality as related to a treatment of their disease.

Any disease that has symptoms of inflammation, which are mediated by free radicals, cannot help but be benefited by eliminating those free radicals as much as possible with massive doses of ascorbate. When you use enough ascorbate, throwing away the vitamin C for the electrons carried, it is a matter of chemistry, not necessarily medicine, that the free radicals will be neutralized.

The immune system is very complex but to use the example of antibody exclusion, antibodies are made by B cells in utero and after. When a new B cell develops it takes on a random combination that determines the shape of the receptor site of the antibody it makes. These B cells try to match chemicals on the surface of cells. When an immature B cell matches something it dies. When a mature B cell matches something, it multiplies and produces antibodies of that shape. This is called antibody exclusion and is one of the reasons why antibodies do not ordinarily attack a person’s own cells. When the person is 100% well, their antibodies will not attack the person’s own cells. However, when a person is sick, making many free radicals, these free radicals increase the affinity of the antibodies for their antigen and may cause the antibodies to fit some shape which is not a perfect fit but a close fit.

One of the purposes of antibodies is to mop up dead or diseased cells. Remember that the antibodies and the B cells making them are extracellular and only have tried to fit shapes on the surfaces of cells. Antibodies could fit some of the chemicals in the interior of cells. Therefore, when a cell leaks, for whatever reason, certain chemicals from the interior of cells, certain antibodies may attack that cell.

The other thing is that certain injuries like from chemicals, etc., may alter the shape of chemicals on the surfaces of cells. This, especially in the oxidative redox potential of the injured area, may cause the cross reaction of antibodies on these changed cells.

So, now an infection, allergy, injury, chemical reaction, etc.;, may cause damage to cells and cause antibodies to attack. For example, suppose the person has a condition, like candida, EBV, HHV6, and various other stresses, that results in the release of lots of free radicals, These free radical up regulate the immune system. It is obvious that massive doses of ascorbate at this point may down regulate the immune system by eliminating free radicals in such a way as that the following may be prevented.

First step

The person may have a hidden or not so hidden allergy to something like milk. The immune system may then produce antibodies to milk that are similar in shape to the chemicals on the surfaces of the synovial lining of joints. The shape would not be exact because antibody exclusion would have prevented the formation of B cells making that shaped antibody. However, if the shape is close enough, with the increased affinity of antibodies in this oxidative redox potential situation, the antibodies will attack the synovial lining of the joints. Maybe some previous injury to the joint or some stress increases the oxidative redox potential in a particular joint and that joint becomes inflamed first.

At this early point, in this example, an absolutely milk free diet may stop all this. Massive doses of ascorbate would obviously help by reducing the oxidative redox potential. I saw a patient 3 months ago who had a diagnosis of rheumatoid arthritis by a local immunologist 10 years ago. She, on her own, discovered when she ate no red meat or milk products that the arthritis went away. She has been in total remission for 10 years. The immunologists I know were not interested in discussing the case.

Second step

With this injury to the synovial cells, they start leaking chemicals from their interior to the outside where antibodies can match them. In the possible case being discussed, the autoimmune reaction may take on a life of its own and perpetuate itself even though the person stops any milk. Antibodies build up in numbers and their affinity increases because of the increasing oxidative redox potential. Then, if other joints have not been involved before, they may become involved now because maybe some of the chemicals from the interior of the cells are on the surface in minute amounts but never before enough to cause a noticeable reaction. Now with the increasing numbers of antibodies and the increased oxidative redox potential, more joints become involved.

At this point, the case is not so easy to put into remission but it may be that massive doses of ascorbate, maybe even intravenously, plus eliminating the original problem (in this case milk) may throw the person into remission.

Other Problems

I find that most of the time other problems such as candida, and other food and chemical sensitivities, and leaky gut frequently get involved. All of these have to be treated. Antiyeast programs, no sugar, low carbohydrate diet, elimination of all things the patient is sensitive to, support with large amount of vitamins, minerals, essential fats, and amino acids are necessary. With Sjögren’s syndrome use in addition primrose oil. Bio-identical hormones, especially progesterone, can be helpful in osteoporosis.

I want to make special mention of nightshades (tomatoes, potatoes, egg plant, red, green, and yellow peppers, paprika and tobacco). Nightshades should be eliminated in everyone who has osteoarthritis of the fingers but they can be involved in other arthritis also. There is a relatively common genetic weakness in the ability to digest a toxin within the nightshades especially manifesting itself as one ages. If there is a genetic tendency to get lupus or rheumatoid arthritis, these diseases can be triggered by nightshades. I have seen this several times in lupus patients. The immunologists I know are not interested in this.

If standard medical treatments are used such as prednisone, methyltrexate, etc., massive doses of ascorbate plus other nutrients may augment their effects and reduce side reactions. It never hurts with any disease to eliminate as many of the free radicals as possible and reduce the oxidative redox potential.
 
Chronic fatigue syndrome is ameliorated by continuing bowel tolerance doses of ascorbic acid but these patients must be worked up for candida, parasites, food and chemical sensitivities, hypothyroidism, T4 resistence, etc., and treated appropriately. The nutritional program should include no sugar, low carbohydrates, elimination of all foods they are allergic to, chemicals, zinc, manganese, chromium, selenium, cod liver oil, vitamin E, multiple Bs, sometimes IM B12, folic acid and multiple Bs, along with the massive doses of C.


I don't do the IM B12, but do take the rest except for high doses of C.

The only food I have not been able to eliminate long enough would be coffee/decaf. That happens to be my kryptonite. (I thought it was cherry pie, but I was wrong.)

I'm having rumbling with just the first packet of the 1000mg Lipo C. I'm going ahead with the second packet anyway, since its not clear whats going on yet.

It does not taste very good, but holding the nose gets you past that. ;)
 
More links to stuff about dehydroascorbic acid:

http://ajcn.nutrition.org/content/63/5/760.short

Here you can buy 25 grams of the stuff for over 400 bux: _https://www.goldbio.com/Dehydroascorbic-acid-P5298-C76.php

This one is very interesting particularly in view of potential viral plagues, etc:

http://www.spandidos-publications.com/ijmm/22/4/541

Antiviral effects of ascorbic and dehydroascorbic acids in vitro

Authors: Ayami Furuya, Misao Uozaki, Hisashi Yamasaki, Tsutomu Arakawa, Mikio Arita, A. Hajime Koyama

Affiliations: Division of Virology, Department of Cellular and Molecular Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama 641-8509, Japan

Doi: 10.3892/ijmm_00000053

Pages: 541-545

Abstract:

In the present study, ascorbic acid weakly inhibited the multiplication of viruses of three different families: herpes simplex virus type 1 (HSV-1), influenza virus type A and poliovirus type 1. Dehydroascorbic acid, an oxidized form of ascorbic acid and hence without reducing ability, showed much stronger antiviral activity than ascorbic acid, indicating that the antiviral activity of ascorbic acid is due to factors other than an antioxidant mechanism. Moreover, addition of 1 mM Fe3+, which oxidizes ascorbic acid to dehydroascorbic acid and also enhances the formation of hydroxyl radicals by ascorbic acid in the culture media, strongly enhanced the antiviral activity of ascorbic acid to a level significantly stronger than that of dehydroascorbic acid. Although both ascorbic acid and dehydroascorbic acid showed some cytotoxicity, the degree of cytotoxicity of the former was 10-fold higher than the latter, suggesting that the observed antiviral activity of ascorbic acid with and without ferric ion is, at least in part, a secondary result of the cytotoxic effect of the reagent, most likely due to the free radicals. However, the possibility that oxidation of ascorbic acid also contributed to the antiviral effects of ascorbic acid exists, in particular in the presence of ferric ion, since dehydroascorbic acid exhibited a very strong antiviral activity. Characterization of the mode of antiviral action of dehydroascorbic acid revealed that the addition of the reagent even at 11 h post infection almost completely inhibited the formation of progeny infectious virus in the infected cells, indicating that the reagent inhibits HSV-1 multiplication probably at the assembly process of progeny virus particles after the completion of viral DNA replication.
 
Laura said:
Data said:
I tried this exactly as instructed here, but it did not work. Pure Ascorbic Acid powder with fresh 3% Hydrogen Peroxide liquid does not react at all -- not if concentrated, not if diluted, not when cold and not when hot, I tried all of these combinations.

Didn't I mention using baking soda which is what we did? It works fine.

I found out that Ascorbic acid + Sodium bicarbonate = Sodium ascorbate, which is different from Dehydroascorbic acid. However, both are a kind of oxidized form of Vit. C, and both have higher bio-availability.

I looked for information about a possible home-synthesis of Dehydroascorbic acid, but found nothing. The only reference to an easy way to make it yourself was the link posted earlier, which seems to come from Dr. Stephen Robert Martin, who died at age 62. But as I said, I had no success with Hydrogen Peroxide (maybe I did something wrong).
 
It seems that getting dehydroascorbic acid's benefits are likely even if AA is used due to vitamin C's metabolism in the body:

_http://www.tomlevymd.com/book_preview/chapter4.html

Vitamin C as ascorbic acid is first metabolized to oxidized ascorbic acid, or dehydroascorbic acid (DHAA). Whenever vitamin C first contributes two electrons to another compound while performing its major responsibility as an antioxidant, DHAA is immediately produced. Other antioxidants and some enzymes can promptly regenerate DHAA back to the potent, unoxidized ascorbic acid (Long and Carson, 1961; Basu et al., 1979; Rose and Bode, 1992; Bode et al., 1993). However, when this regeneration does not occur, further metabolic breakdown of vitamin C can take place. The primary metabolic pathway of vitamin C is as follows (Davies et al., 1991):

Vitamin C (ascorbic acid) to DHAA
DHAA to diketogulonic acid
Diketogulonic acid to lyxonic acid, xylose, threonic acid, or oxalic acid (oxalate)

Oxalate, or oxalic acid, is a major metabolite of vitamin C after it is utilized and fully broken down in the body. Oxalate is considered a true metabolic "end product" because there is no evidence that mammalian tissues further utilize it or break it down any further (Hagler and Herman, 1973). Since the primary constituent in most kidney stones is calcium oxalate (Jayanthi et al., 1994), many conventional doctors have simply concluded that significant vitamin C supplementation will lead to kidney stones. For this reason alone, it would seem that many patients are still warned by their physicians that vitamin C supplementation "might" cause problems and increase their chance of developing a kidney stone. However, there exists a large amount of literature from respected research centers that indicates otherwise. In patients with known kidney disease, some reasonable cautions are in order. However, a healthy person who avoids dehydration and ingests even very large amounts of vitamin C does not need to have any concern about kidney stone formation. In fact, there is a strong suggestion in some studies that regular supplementation of vitamin C actually decreases the chances of kidney stone development.

[...]

akenouchi et al. (1966) noted that about 80% of vitamin C administered to human subjects was eliminated as dehydroascorbic acid, the oxidized form of vitamin C. They concluded that the metabolic breakdown of vitamin C in humans does not necessarily have to follow the entire sequence down to oxalate. They also noted that as the vitamin C dose is increased, urinary excretion of diketogulonic acid increased. This is a clear indication that further oxidative breakdown of the diketogulonic acid to oxalate does not have to occur for a metabolic breakdown product of vitamin C to be excreted.

This one is very relevant:

http://www.ra-infection-connection.com/AA-Cancer.htm

Vitamin C Cancer Treatments

Oral Liposomal AA (L-AA) has significantly higher blood adsorption and 98% vs. the ~20% transfer effectiveness for plain AA powder. L-AA has ~5 times the transport effectiveness that was achievable before. The gut to blood transfer no longer has a practical upper limit because the loose bowel phenomenon does not happen when AA is surrounded by Lecithin, a lipid emulsifier. The Lecithin also facilitates the transport of the AA to lipid membrane microbes where it can be oxidized and the dehydroxy ascorbic acid (DHA) produced can be readily ingested by the microbes in place of sugars they crave. The ingested DHA kills sugar-eating microbes and cancer cells. But the AA level must be high enough. Now it can be.

Optional microbe killing lipids like vitamins [A, E, & D], EGCG, coconut oil, capric & caprylic acids [anti-yeast], palmitic acid [butter], and olive oil can be included in the Lecithin lipid mix. Xylitol (a healthful sugar alcohol) that has anti-bacterial and anti-yeast properties can be used as a sweetener.

The levels of blood AA concentration that was historically found effective (by Klenner, Cathcart, and others) against bacteria and viruses in the blood was achievable only with continuous sodium ascorbate IV supplemented with oral AA. The sessions could take several days to weeks and were both inconvenient and expensive. Only a few doctors provided these services. Many doctors remained skeptical of their value because of flawed AA effectiveness studies. These treatment modalities were a real bother.

We can now produce consistently high blood AA by intake of several grams of oral L-AA every hour during waking hours for a period of days in an outpatient mode of treatment. The presence of the doctor is no longer necessary, just like it is not needed for most prescribed drugs.

L-AA is anti inflammatory by its nature; at high enough dosages it acts like an antibiotic plus antiviral plus anticancer chemo drug, with very few side effects. The history of this AA treatment is described below. What is new is the high blood active AA levels can be achieved by oral intake alone. To further improve this AA treatment, ketosis (See Atkins low carb diet induction) should be invoked. Xylitol should be used in place of sugar to force sugar using bacteria and yeasts to die back and gene shift to using Xylitol in place of sugar. The gene shift greatly reduces the pathogenicity of the microbes and yeasts. See our AA Ketonic Protocol discussion. A video shows how to make your own L-AA.

Those of you with Lyme's disease or Morgellons might be very interested to check that ketonic protocol out.
 
I didn't even try it with peroxide because I didn't want to be drinking it. So, it becomes sodium ascorbate? Well, that's good enough. It made up well in the liposomal solution.
 

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