About Ketosis and AA protocols.
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How Low-Carb Ketosis + AA + Antibiotic Fats + Nutrition + Anti-Inflammatories Potentiate Antibiotic Protocols:
In order to maximize the kill percentage one needs a protocol that has multiple factors. The following conceptual formulas illustrate how the combined protocol factors work in theory.
The combined survival fraction is the product of the survival fractions of the several lethal elements.
If kill percentage is K%, define kill fraction as 0 < Kf <1 by K%/100.
Survival fraction: Sf = 1- Kf and Kf = 1- Sf.
Sf = (Sf1) x (Sf2) x (Sf3) x (Sf4) x….
Sf = (1-Kf1) x (1-Kf2) x (1-Kf3) x (1-Kf4) x….
By using multiple antibiotics or adjuvants that have different principles of operation one can multiply the effectiveness, and reduce the chance of developing antibiotic resistance.
SfAntibiotics = (SfAntibiotic1) x (SfAntibiotic2) x (SfAntibiotic3) x (SfAntibiotic4) x ….. Combined Antibiotics
SfAntibiotics = (1-KfAntibiotic1) x (1-KfAntibiotic2) x (1-KfAntibiotic3) x (1-KfAntibiotic4) x …..
SfTotal = (SfAntibiotics) x (SfAntibiotic-Fats) x (SfAA) x (SfAnti-Inflammatories) x ….. Combined Protocol
SfTotal = (1-KfAntibiotics) x (1-KfAntibiotic-Fats) x (1-KfAA) x (1-KfAnti-Inflammatories) x …..
S%Total = 100 x SfTotal
In order to minimize the survival percentage one uses more factors and tries to minimize each survival factor. Where replication occurs one tries to block the success of it, by targeting the factors leading to its success and reducing the odds by functional changes in the in vivo environment. One kill factor is Ketosis. John Ely describes the mechanism of glucose ascorbate antagonism (GAA) and Aggressive Glycemic Control (AGC). See note below: 14
Many other Kfs are Anti-microbial antibiotics.
One is sugar or nutrient starvation. One is tryptophan starvation. 15 One is molecular spoofing. One is neutralizing a spreading factor. One is microbe <to/from> immune-cell signal blocking, by immuno-suppression. Several are a mineral antagonist, salt/silver/zinc. Many are eating anti microbial foods. Many are vitamin and nutritional deficiency related. Many are spices and herbs like olive and aloe vera. There will be more specific new ones that we will discover in the future, and old forgotten ones we will find in the various nations’ medical archives and learn how to implement.
AA (Ascorbic Acid = vitamin-C) Actions:
AA has two effects. One is to make it more difficult for the invaders to penetrate their target cells that they use for replication. The other acts inside the cell when ROS- oxidized AA kills the invaded cell with its compromised mitochondria. The effect of anti inflammatories is also multiple. One is to reduce the signaling of the microbe to the target immune cells that they would invade. This slows the replication. Another is to turn off the generation of the ROS that converts antioxidant AA to the oxidized for Dehydro AA (DHA). A third is to reduce the formation of plaques, granulomas, lesions, and calcium nodules that wall off and protect the microbes from the antibiotic.
Reactions are competitive and depend on concentrations:
Chemical reactions depend on the concentration of the various molecules. The uptakes into cells for sugar and for DHA are competitive. If the sugar concentration is much greater than that of AA then most of the uptake will be of sugar, feeding the microbe cellular invaders. If the blood is starved for sugar and DHA is present in high concentration, then the cells are more likely to uptake the DHA. This is to say that sugar interferes with the action of AA (= DHA) acting as a initiator of invaded-cell death. So the effectiveness of AA is improved by the low sugar Ketosis mode. It is worsened by hypoglycemia and diabetes.
Similarly, the action of the Antibiotic fats, the monoglycerides of the saturated tropical oils of the palm plants are in proportion to their concentration. Since the nation’s diet prefers some fats above others, starving the body of saturated palm fats reduces several natural antibiotics that have been shown to help control both bacteria and viruses. COPD and bacteria caused plaque is likely to be made worse by too little palmitic and lauric fatty acids. The attempt to reduce cholesterol is misguided and it leads to labeling saturated fats as bad when the opposite is true.
Jarish Herxheimer reaction (Herx):
Antibiotics kill cellular microbes and create Jarish Herxheimer reaction with reactive oxygen species ROS: H202 and NO. When active vitamin C (Ascorbic Acid) molecule meets ROS molecule they react to disable the oxide and this makes the oxide/oxidizing form of AA, called Dehydro AA (DHA). The antioxidant, active form of AA neutralizes toxins of the Herx reaction and it is a powerful histamine reducer. As ROS levels drop the histamine levels also drop. “Large” amounts of AA are eaten frequently, Start with 3-6+ grams as often as every two hours. Effective dosage for a Herx condition is about 24 grams per day or more. Google [Cathcart Titration to Bowel Tolerance].
How to tell the AA dosage you need:
If your gut does not get loose, you need to take more AA. If gut gets loose from eating the AA, you are taking too much or too often. If you are sick, with high levels of AA intake, you should feel a reduction of the feelings of sickness. If sickness symptoms come back: pain, itch, ague, etc, then you are out of AA and you need to eat more of it, immediately. Since AA is stored in the lenses of the eyes the degree of focus accuracy may fluctuate with systemic AA depletion. Some persons know that when their eyes go out of focus, it indicates that they are low on AA and need to eat more.
You can increase AA intake and effectiveness by making and using Liposomal AA. Combine powdered AA, Water, Lecithin, [and coconut oil] in a blender. Following this an ultrasonic cleaner is used to micro-homogenize the AA. This makes oral Liposomal AA which is more effective than IV AA. One gram of this AA is said to be equivalent to 7 grams of sodium ascorbate IV AA. The combined encapsulated AA passes thru the gut more readily and it also is more bioactive in the body. See the video: How to make Liposomal AA. See the list of all the Vitamin C Foundation Videos.
Microbes need sugar and body can work without much sugar at all:
Normal body cells do not need much sugar for energy; they can also use fats and proteins. But cancer cells, microbes and infected cells need a lot of various microbe specific sugars. AA does not get imported into cells very much, but DHA goes into cells in very much greater amounts. But this happens only if you are eating a lot of active AA to start with, and are not eating much sugar.
Ketosis: how to induce it and test for it:
Benign ketosis (<15-30 grams of carbohydrates per day), see Atkins Diet induction phase; it really lowers blood sugars. You can get ketone test strips at any pharmacy to test if you are in the ketosis state. You may notice your breath smells like nail polish remover. This is because you have a little acetone in your blood. Acetone is in nail polish remover.
With ketosis: Liver stops converting glucose to fats for storage. Liver switches to use fats and your cells’ mitochondria in the Krebs cycle burns the fats extracted from your blood. Lipid HDL and LDL drop into the “normal” range. Ketosis starves system of sugars. Starches we eat are converted to sugars. So ketonically low carbs means very low sugar in our blood.
Microbes invade cells: red and white blood cells; epithelial and tissue cells; especially, they invade immune cells chemically-signaled to kill and eat them.
Microbes in chronic, persistent infections invade your epithelial cells and your immune cells, among others, in certain organs that specific microbes have matching molecular “hooks” to attach to. They use hyaluronic acid Lysase, an enzyme that dissolves your cell walls, to penetrate your cells and to inject their DNA or RNA into their target cells.
Inside invaded cells, microbial genetic recipes cause the mitochondria to work differently and to dysfunction. The microbe parts steal CoQ10 the energy oxidizer molecule and sugar from your cells and you feel tired. If you take more Co enzyme Q10 to make up for this you will feel almost normal. The invaders need sugar and CoQ10. But your cells can live by converting Fats and Proteins into the acetyl CoA that is actually the fuel. The invaders --- bacteria, viruses and fungal forms eventually replicate and kill the cell to get out. We have seen striking pictures of their exit.
How Ketosis changes the cells’ functions:
Ketosis:
In the absence of sugars, DHA (oxidizing form of vitamin C) takes sugar’s place. This means that an oxidizing molecule is imported and the microbe components try to use it as fuel. This does not work and it kills the mitochondria and the infected cells and the microbes that import it. The invaded cells’ microbes’ parts can work with certain sugars, but cannot burn fat or protein as well. So the cell dies.
Cell Wall Deficient (CWD) bacterial invaders and infected cells need lots of sugar. Soft drinks and refined starches provide this. So see the Dr. Atkins diet materials for the low carbohydrate diet’s induction stage rules to make sure you have somewhat less than 15 to 30 grams of carbohydrates and are not eating any of the forbidden food elements or eating too much.
You need enough DHA to act as if it was sugar, and the cells normally metabolize a very large number of grams of sugar. So you need to swallow the AA as if it were food. We usually do not eat this much of vitamin C, by far. We should not get it as a food component (like fruit juice) because it comes with too much sugar. But if you think of pure AA as a sugar replacement food that you need, then 30 to 150 grams per day of AA is not much if it were meat or candy.
CWD bacteria of various species and strains prefer strain-specific sugar molecules. High Fructose Corn Sugar, (HFCS) is a mix of several sugars and nourishes most varieties of CWD bacteria. There is a lot of HFCS in soda drinks and in junk food. Instead, your diet should be meats, fats, and natural fibrous vegetables that have low sugar and starch content.
See the web for Atkins Diet recipes and foods and how to limit the amounts you can eat. You must maintain a strict low carbohydrate diet, to stay in ketosis mode. No bread, potatoes, rice, pasta, breakfast foods, pastries, pies, donuts, corn, carrots, yams, starchy beans, pasta, etc. Perhaps your intake is about 500 calories/day. You can eat meat, fats, un-breaded fish, shellfish, a little cheese, but no milk, buttermilk, cottage cheese and ice cream. No condiments that contain sugar. Read all the labels and insure the number of grams of carbs is in the range for the Atkins diet induction. You can stop the ketosis after your symptoms stop and you no longer need to lose weight. When on Atkins diet, vitamin supplementation is necessary.
How cells use energy: Citric Acid (Krebs) Cycle
Cells use a molecule called ATP for energy. It is made in a recycling reaction loop called the Krebs cycle (Aka, citric acid cycle) that uses as its “food” a super versatile enzyme, Acetyl-CoA, made from Fats, Carbohydrates or Proteins by a process called catabolism by mitochondria in cells. In the liver, with ketosis ongoing the cells convert fats to glucose, the primary sugar the body cells need. Too much dietary citric acid may promote bacterial growth.
Catabolism takes place in cells’ mitochondria to convert fats and produce Acetyl-CoA. Then the Krebs cycle reactions use Acetyl-CoA to make ATP, the cell energizer fuel that drives all the other cells’ anabolic, energy-consuming reactions.
In the mitochondria, CoQ10 is the oxidizer and Acetyl-CoA is the fuel and NADH (Coenzyme-1) is the helper enzyme, so called spark plug. So in all cells from muscles to brain, deficiency of CoQ10 will limit the cells’ energy use. Your body needs about 500 mg of CoQ10 per day, made by the mevalonate chemical pathway, where cholesterol, CoQ10 and Heme is made.
When you get older you do not make enough CoQ10 and may need supplements. If you have chronic intracellular infections, and we all do, then you need CoQ10 supplements. The mevalonate pathway is blocked by statins. Statins really starve the body’s cellular (nerve and muscle) regeneration process by limiting cholesterol, CoQ10 and Heme, a component of hemoglobin. Heme is used in blood cells to transport oxygen throughout the body. Cholesterol is the source of our sex hormones and is needed to keep nerves and muscles healthy and to rebuild them as needed.
So
if you starve the carbs, then the Acetyl CoA fuel sources become fats and protein, and your cells work. But microbes prefer non-glucose sugars so ketosis starves them and they suck up DHA that is an oxidizer, not a food. That further starves the cell and oxidizes the mitochondria. This kills the invaders’ CWD L-forms and also kills the invaded cells that have ingested microbial DNA. This blocks intra-cellular microbe replication. Because of their sugar preferences certain microbes are more sensitive to ketosis than others. So avoiding of HFCS and dietary sugars is best.
Nutrition Factors:
According to Mary Enig: The cause of heart disease is excess refined vegetable oils and hydrogenated (Trans) fats; excess refined carbohydrates: sugar and white flour; mineral deficiencies: magnesium, iodine, selenium; deficiencies of natural unrefined vitamins: A-complex/B-complex/C; deficiencies of antioxidants like vitamin E complex; and the disappearance of dietary antimicrobial fats: animal fats (butter) and tropical oils: coconut, red palm and palm kernel oils.
One could also add Lysine, Proline and Carnitine deficiencies. AA + Lysine è Carnitine, needed for muscle and tissue health. Lysine is anti viral, especially for the human Herpesvirus family: HHV1&2 (HSV=cold sores), CMV, EBV, H. zoster = Chicken pox and shingles, etc. L-arginine promotes HHV growth. See Pauling protocol for heart disease. Excess lysine and low arginine spoofs the microbes molecule building process.
Tropical Oils contain: Saturated fatty acids---Lauric, Palmitic, Caprilyic, Myristic; CoQ10; tocopherols and tocotrienols (vitamin E variants); and antiviral vitamin A variants. Our packaged vitamins A & E are monomolecular not a natural mix and do not have all the many process-dependent, unique shapes we need. Natural, gently refined tropical oils are not heated excessively, not bleached, not oxidized and not hydrogenated; they are made that way for the nutrition trade. They contain the wide spectrum of molecular shapes you may need in ways that go beyond our simplistic theoretical knowledge of their actions.
The saturated fatty acids do not oxidize easily or turn rancid rapidly. Rancid fats are toxic. If rancid or hydrogenated (trans) fats were used to make cholesterol some resultant molecules produced would be toxic to nerves. Statins cause cholesterol starvation, opening the way for toxic oil variant molecules to take the place of the missing cholesterol, leading to nerve and muscle cell dysfunctions and cell replacement molecule errors that shorten our life by increasing our aging rate.
Tropical oils are very readily used as fuel, they pass the blood brain barrier, and they dissolve the CWD membrane to kill CWD forms and viruses system wide. Monoglyceride forms of Lauric, Caprilyic, Palmitic, Myristic are antimicrobial. Lauric and Palmitic are most essential to systemic anti microbial health. Daily 2 to 3 tablespoons of tropical fats: coconut, red palm oil, and palm kernel oil or a mix of the three to get all the natural nutrients with the widest range in molecular shapes. We will use the active shapes and burn the others. A case history below shows Alzheimer’s improvements.
Antiviral Omega 3 oils are also essential to health. They come from fish and cod liver oil, along with vitamin A. They normalize and lower excessively high allergic immune responses. Omega 6 oils are also essential. However, Omega 6 oils may add to inflammation and have antimicrobial effects. This can be used to enhance the microbe killing factors. Most doctors avoid prescribing the O-6 oils because of the induced Herx like immune upsurge. Instead of avoiding O-6 they should be in the diet and the AA anti oxide intake should be increased to neutralize the increased inflammation. The best way to get the natural O-6 (9%) and O-9 (Oleic=~83%) is from natural foods (sunflower seeds) rather than extracted refined oils. One effective way is from eating a modest amount of sunflower (O-6) and flax (O-3) seeds as a snack, several times a day without missing a day. See nutritional components of sunflower seeds. See Case History sunflower seeds at the end of the list of personal case histories.
Vitamins A, B6, B12, C, D, E are related to dependencies and infections. Vaccine induced high vitamin A dependency has been demonstrated as an allergy-related cofactor in Autism. Active allergic responses rapidly deplete ascorbic acid (AA) which is vitamin C. Vitamin D is essential to immune system activity. Too low vitamin D contributes to a depressed immune system.
Herx Management:
Because this protocol depends on ROS to convert AA to DHA, totally suppressing the antibiotic initiated Herx reactions by use of immune-suppressing drugs defeats the purpose of generating DHA to kill infected cells. However for very severe inflammatory conditions, the following measures can help to reduce the severity of the Herx reactions. Cortisone and prednisone can reduce inflammation, granulomas, scleroses, lesions, plaques and microbe (viral) replication. Benicar, an angiotensin release blocker (ARB) can block the cytokine cascade inflammation flare and allow increased antibiotic dosages. TNF blockers also stop inflammation. Granuloma formation walls off TB bacteria and protects them from antibiotics. So anti inflammatories functionally and statistically potentiate antibiotic actions.
During the Ketonic protocol, eating patient specific allergy-producing foods, like peanuts or other foods known to turn on immune system may be used if the Herx reaction does not rise to the level needed to convert AA to DHA. An experienced physician who will work closely with you over the period of administration, best can handle managing the proper balance of inflammation and immune suppression. Fire and forget is not the mode of treatment. In the absence of the physician, every hour, you have to learn to listen to the feelings of pain, tingling and irritation to sense the action of the foods and medicines and learn which combinations improve things and which changes make things worse.
Time cycling the antibiotics:
Time cycling the antibiotic is useful because the microbes
CWD forms switch forms within minutes in vitro and in vivo to protect themselves from the antibiotic. Lyme CWD forms roll up in tight balls, then unroll later. If a two-day on/off/on/off antibiotic cycle is used each cycle reduces the population by an assumed 30%, after 20 cycles (40 days), the Sf20-cycles = 1/(1-.3)20 = .0006.
When this is combined with other protocol elements like Lauric acid to attack microbes’ membranes and palmitic in the lungs to reduce immune signaling, the total reduction can be dramatic.
Immune suppression and antibiotics work well together because the sclerotic plaques wall off the microbes and protect them. The immune suppression increases the kill percentages and speeds. Prednisone or TNF blockers alone used as an antibiotic adjuvant with conventional TB antibiotics showed a reduction of relapse rate from ~30% to ~2%.
A side comment on histamine:
Antihistamines might seem to be helpful in severe Herx reactions, but with the high AA blood levels of this protocol, there should be very little histamine produced. High histamine is a result of the combination of AA depletion and NOS, not a cause of it. With high ROS and not on the high AA protocol,
toxins and allergies and acute infections cause AA depletion. When AA levels get below .7 mg/100 ml the histamine levels start to increase exponentially. See the graph in this hyperlink. Histamine is toxic in high levels. Histamine food poisoning (e.g, from decomposed tuna or certain bacteria in cheese) is evidenced by a red skin flush over most of the upper body.
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