The Living Force
Some clinical info on Iodine and Candida (there is some info on people using iodine for anti-candida treatment, but I can't find any more clinical info on that yet so will leave posting for the moment).
Background: Candida species have become a major opportunistic pathogen causing recurrent oral thrush and oesophageal candidiasis in patients with HIV/AIDS in Kenya. This has resulted in repeatedly high use of expensive anti-fungal drugs(ie Contrimazole, Amphotericin B and Nyastatin) which most of these patients cannot afford full dose. This has resulted in the development of Candida strains resistant to common antifungals in the community. Due to this, Kibera Based Health Care(KCBHC), which cares for the sick at home decided to look for cheap and effective drugs to manage this problem. Methodology: Patients with recurrent oral thrush under the care of KCBHC were grouped in two. One group was managed with 2% Povidone Iodine mouth gurgle, the other was managed with Contrimazole or Nystatin which are routinely used. Healing effects, recurrence and development of oesophageal candidiasis and disappearance of mouth odour were monitored over two years. Results: The patients on Iodine healed within 10 days and mouth odour disappeared. Gurgling of Iodine whenever patients felt signs of recurrence prevented serious recurrence and development of oesophageal Candidiasis. Those on antifungals also healed within 10 days but continued having mouth odour. Some developed serious recurrent oral thrush which degenerated to oesophageal candidiasis. The medical cost of care using Iodine was very low compared with antifungal care. Conclusions: Povidone Iodine mouth gurgle is effective and cheap therapy for managing recurrent oral thrush and prevents it from degenerating to oesophageal candidiasis on HIV/AIDS patients.Through seminars this treatment has been passed to other CBHC groups who have also found it to be cheap and effective treatment. This is reducing the use of antifungal drugs in the community. The antifungal drugs are used for serious systemic infections. In the long run we might reduce the emergence of the antifungal resistant candida strains.
In vitro susceptibility of Candida albicans to four disinfectants and their combinations.
AIM: The aim of this study was to evaluate the susceptibility of seven strains of Candida albicans to four disinfectants: iodine potassium iodide, chlorhexidine acetate, sodium hypochlorite and calcium hydroxide. In addition, all possible pairs of the disinfectants were tested in order to compare the effect of the combination and its components. METHODOLOGY: Filter paper discs were immersed in standardized yeast suspensions and then transferred to disinfectant solutions of different concentrations and incubated at 37 degrees C for 30 s, 5 min, 1 h and 24 h. After incubation the filter paper discs were transferred to vials with PBS and glass beads that were then vigorously shaken for dispersal of the yeast cells. PBS with resuspended yeasts was serially diluted 10-fold. Droplets of 25 microL from each dilution were inoculated on TSB agar plates and incubated in air at 37 degrees C for 24 h. The number of colony-forming units was then calculated from appropriate dilutions. RESULTS: C. albicans cells were highly resistant to calcium hydroxide. Sodium hypochlorite (5% and 0.5%) and iodine (2%) potassium iodide (4%) killed all yeast cells within 30 s, whilst chlorhexidine acetate (0.5%) showed complete killing after 5 min. Combinations of disinfectants were equally or less effective than the more effective component. All C. albicans strains tested showed similar susceptibility to the medicaments tested. CONCLUSIONS: This study indicates that sodium hypochlorite, iodine potassium iodide and chlorhexidine acetate are more effective than calcium hydroxide against C. albicans in vitro. However, combining calcium hydroxide with sodium hypochlorite or chlorhexidine may provide a wide-spectrum antimicrobial preparation with a long-lasting effect.