Re: Ketogenic Diet - Path To Transformation?
This is what I've come up with so far on lactic acid. I don't think I will pursue this any further.
http://www.sott.net/articles/show/228186-Your-Brain-On-Ketones-How-a-High-fat-Diet-Can-Help-the-Brain-Work-Better said:
(For those interested in nitty gritty details - babies are in mild ketosis, but very young babies seem to utilize lactate as a fuel in lieu of glucose also - and the utilization of lactate also promotes the same use of acetyl-CoA and gives the neonates some of the advantages of ketoadaptation without being in heavy ketosis.)
If one drops carb intake and begins working out, the muscles will be producing lactic acid. Now there will be a surplus of lactic acid and glucose will be conserved. It seems to me, after my reading that lactate mainly acts as an intermediate support fuel between carb restriction and ketoadaption, but only if one works out during the carb restriction, and not for long.
1: Lactate as a fuel seems to have some of the benefits of ketones:
lactate "may exert a strong action over GABAergic networks in the developing brain, making them more inhibitory than it was previously assumed" (http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2009.06506.x/pdf) "We demonstrate that in the neonatal brain, Em and EGABA strongly depend on composition of the energy substrate pool. Complementing glucose with ketone bodies, pyruvate or lactate resulted in a significant hyperpolarization of both Em and EGABA, and induced a radical shift in the mode of GABAergic synaptic transmission towards network inhibition." This seems to be saying that lactate, as well as ketone bodies, has the opposite effect of glutamate. From Psyche's synthesis: "Studies on cultured rat neonatal cortical neurons revealed that beta-hydroxybutyrate and acetoacetate prevented neuronal cell death induced by glutamate." Lactate seems to have a similar effect.
2: Lactate is used as well as protein for gluconeogenesis. But, if GNG is only increased by several % during ketosis and is mostly constant, does it matter whether the source is coming from protein or lactate? I read in one place that most GNG occurs from lactate, so can one conserve protein, and simplify our dietary protein dilemma by consuming a nutrient the liver prefers over protein for GNG?
So maybe lactic acid plays a minor role in ketogenesis if one works out, or consumes it outright.
As a cooking aid, I realized a good way of comparing vinegar and lactic acid would be to compare their respective salts, as that would be
how they act in a bone broth. Generally, acetic acid salts have more industrial uses, whereas lactic acids salts are more commonly used as preservatives and flavorants. According to Wikipedia:
Acetates:
Magnesium acetate can cause inflammation and is suggested to be handled with gloves. Is this what the magnesium in bone broth becomes when it is dissolved by added vinegar?
Potassium acetate is used as a food preservative and pH regulator. It is used to treat diabetic ketoacidosis.
Sodium acetate is typically added to processed foods as a seasoning.
Calcium acetate is used to treat hyperphosphatemia as it binds to phosphates in the diet, and causes upset stomach. It is also a food additive.
Lactates:
Magnesium lactate is used as a mineral supplement, and as an acidity regulator in foods.
"Potassium lactate is commonly used in meat and poultry products to extend shelf life and increase food safety as it has a broad antimicrobial action and is effective at inhibiting most spoilage and pathogenic bacteria."
Sodium lactate is used as a food preservative, acidity regulator and bulking agent in foods.
Calcium lactate is used in food as a baking powder. It is most commonly used as an antacid and can also be used to treat calcium deficiencies, because it can be absorbed at various pH's and so does not need to be taken with food.
In conclusion, it seems using vinegar (acetic acid) might dissolve the minerals out of bones,
but they may not be in a useful form, or may even be inflammatory. Calcium and magnesium especially, and these are big parts of bone broth. Lactic acid has more broad uses in the body, and
it's salts are used for supplementation of calcium and magnesium. This makes me think of malic acid, which comes before lactic acid in malolactic fermentation. I know that magnesium malate and calcium citrate malate are supposed to be very effective supplements. However malic acid does not have salt forms of sodium or potassium.
Lactic acid is the result of lactofermentation and is easily made at home in the form of sauerkraut, sourdough and cultured milk products. None of us would eat most of these things, especially those seeking to eliminate all carbs. Cultured butter is one potential source. Stick of butter in the bone broth?