Re: On smoking, cancer, nicotine and big pharma
I haven't been following this thread till just recently and wanted to interject a clarification on what was posted way back on page 11 in regards to Zebra's post about Niacin.
zebra said:
When a smoker becomes "hooked" on ciggarettes the nicotine does something. The nicotine basically kicks the vitamin B3 out of you're body and takes its place. The vitamin B3 also known as Niacin, Niacinamide or Nicotinic Acid is usually craved for when in cigarette form containing a derivitive-nicotine. Many people are not getting enough nutrition through what they consume and B3 is one of those essentials. Naturally if you are lacking or not getting enough and do try smoking, chances are you will probably continue. After all you just found a source of Niacin, ahem, nicotine;)
I'm assuming anyone reading this thread has already read SOTT article titled "Aliens don't Like to Eat Humans Who Smoke"
http://www.sott.net/signs/anti-anti-smoking.htm, and does cover how "nicotine does something".
However, I've often wondered if there was a correlation between nicotine and nicotinic acic (niacin) just because of the similar sounding names. After re-reading the Sott article again, I decided to look up niacin in the
PDR for Nutritional Supplements by Sheldon Saul Hendler, PhD, MD, (etc.) and found this interesting background on Niacin. As an introductory note, in the PDR it states: "nicotinic acid and nicotinamide have identical vitamin activities,
but have very different pharmacological activities."
Nicotinic acid was first discovered as an oxidation product of nicotine, and thus the origin of its name. In fact much of the confusion caused by the use of the term niacin for both nicotinic acid and nicotinamide, as well as for nicotinic acid alone, was created by the attempt to dissociate nicotinic acid from its nicotine origins. Niacin, via its metabolites, is involved in a wide range of biological processes, including the production of energy, the synthesis of fatty acids, cholesterol and steroids, signal transduction, the regulation of gene expression and the maintenance of genomic integrity. Nicotinic acid, in pharmacological doses, is used as an antihyperlipidemic agent. [raising HDL-cholesterol (good ones) and lowering LDL-cholesterol (harmful ones) and triglycerides.]
I'm not trying to make the connection that nicotinic acid is a metabolite of inhaled nicotine; it would seem that nicotine's benefits outlined in the SOTT article, may only be closely related to nicotinic acids biologic activity.
And in response to the second part of Zebra's post, ...
zebra said:
If someone really wants to quit and TRULY has the want and will, try taking vitamin B3. Hold on now...Niacin should not be taken if you have heart problems(I believe) or high blood pressure, simply because it stimulates you're circulatory system (amoung many other great things!) It will make you flushed in the face and sometimes all over. Tingling sensations may be experienced.
Niacinamide does not have the side effect of making you flushed.
I'd like to chime in with the following:
Actually, most of the niacin studies cited in the PDR were done on cardiovascular patients. One study included survivors of myocardial infarction, receiving
1 gram doses of nicotinic acid, three time a day, in combination with clofibrate and was found to significantly decrease total and cardiac mortality (by 26%).
Another study done on men, 40-59 who had undergone coronary artery bypass, who were given nicotinic acid in combination with colestipos showed significantly decreased disease progression in some and significantly increased disease regression in some others, compared with placebo.
More recent studies continue to produce positive results for nicotinic acid. in one of these, it was shown to inhibit vascular oxidative stress, redox-sensitive genes and monocyte adhesion to human aortic endothelial cells, providing evidence for the inhibition of vascular inflammation and presence of anti-atherosclerotic properies independent of, and in addition to, its lipid-modulating effects.
The PDR also has the following precautions:
high doses of niacin (nicotinic acid)(1 gram is nearly 1000 times the amount of RDA, with is 16 mg for men over 19 yoa) should be taken only under the supervision of a physician.
High dose nicotinic acid is contraindicated in those with hepatic dysfunction, unexplained elevations of serum aminotransferases, active peptic ulcer disease and arterial bleeding. High dose nicotinic acid may negatively affect glucose tolerance. Liver toxicity has been noted more frequently in the slow-release form of niacin, but occurences are noted as mild and manageable. There is many drug interactions listed as well, which common sense should dictate discussing niacin supplementation with the physician prescribing the medication beforehand.
Also from the PDR regarding the "niacin flush", as well as the "nicotine rush", I would suppose:
Nicotinic acid can cause vasodilation of cutaneous blood vessels, resulting in increased blood flow, principally in the face, neck and chest. [producing the niacin flush. This may in part explain its benefit for cardiovascular patients, which is similar to the effects of nitro tabs]....
The flushing effect of nicotinic acid is transient and tolerance to this effect occurs with continued administration of the vitamin. The flushing effect, as mentioned above, is prostaglandin mediated, and tolerance results from reduction in prostaglandin levels with continued administration.
My husband sometimes, not all the time, flushes taking a liquid multi containing only 20mg of nicotinic acid. (His bottom gets a cute pink blush
)
We've found he can avoid this by taking it after/with a small meal.