AUTOIMMUNE DISEASES CAUSED BY AN INFECTION?

Clarithromycin destroys biofilms and enhances bactericidal agents in the treatment of Pseudomonas aeruginosa osteomyelitis.

Abstract

In this study, the effect of clarithromycin on the destruction of bacterial biofilm in Pseudomonas aeruginosa osteomyelitis was investigated. Foreign body-related osteomyelitis caused by ceftazidime-sensitive Pseudomonas aeruginosa was produced in the tibias of 26 rats. After osteomyelitis was verified on Day 14, 10 rats had ceftazidime (1500 mg/kg/day) given subcutaneously, and 10 rats had ceftazidime given subcutaneously and clarithromycin (100 mg/kg/day, two 50-mg/kg doses every 12 hours) given orally; three rats formed the control group. After a treatment period of 20 days, the tibias and the foreign bodies were removed, cultured, and examined by electron microscopy. The number of microorganisms growing on the bone tissue in the group receiving combined treatment was significantly lower than in the other groups. The number of microorganisms growing on the foreign body in the group receiving only ceftazidime was significantly higher than that of the group receiving combined treatment. Electron microscope examination revealed that the biofilm layer was eradicated in the group that had combined therapy; however, biofilm formation was evident on the foreign body in the group receiving only ceftazidime. Clarithromycin enhanced the activity of concomitantly used bactericidal agents by destroying biofilm on the surface of the materials.

_http://www.ncbi.nlm.nih.gov/pubmed/15662320

Quickly found other studies:

Efficacy of clarithromycin on biofilm formation of methicillin-resistant Staphylococcus pseudintermedius (_http://www.biomedcentral.com/1746-6148/8/225)
A Subinhibitory Concentration of Clarithromycin Inhibits Mycobacterium avium Biofilm Formation (_http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529245/)

Found this information in this article _http://www.pharmateca.ru/ru/archive/article/8006 (in Russian). The article suggests that Clarithromycin can eradicate biofilms regardless of which bacteria have formed it. Clarithromycin is allegedly the only known antibiotic with ability to destroy biofilms. Check English references at the end of the article.
 
Cross posting for reference:

RedFox said:
Wanted to pick up a potential nugget I just found in relation to the following:

treugolnik said:
Lucerne is alfalfa, indeed. In Russian alfalfa sounds like lucerne, and alfalfa is associated with the brand — Alfalfa. There is an interesting excerps:


Session 29 November 2001


Q: In other words, when an event occurs, as in a "measurement," or a "change," in terms of macrocosmic quantum changes, it is like a phase transition of a certain collection of matter units in terms of living beings? Living beings as whole units, can "survive," so to say. I have in mind that it's almost like a decision in your life. When you make a decision, it's like a shift in your consciousness. And when you are looking at a macrocosmic quantum transition, it's almost like a decision, in a sense. And on one side of it, you come to that moment, and you make the decision, and on the other side of that moment - which, in a certain sense, the moment of measurement is immeasurable - and on the other side of it, everything is different. Not only is it so, that on the other side of the measurement is everything different, like with an atom, when an event occurs, something is gained or lost, or has moved its position or momentum or something, some significant difference exists in the state of the atom after this moment of measurement. And this significant difference is what I am trying to get at. (A) Probably what you have in mind is something like "transiting to 4th density, what really happens?" (L) Yeah.
A: "Happens" is not quite the proper term, more like "becomes."
Q: (A) Becoming is creating something completely new. "Happen" means that things change, move, regroup. But "become" means...
A: Yes.
Q: Is there anything that we are supposed to do regarding this upcoming transition?
A: Yes.
Q: Can we know what it is?
A: Not yet!
Q: Is there anything we ought to be doing to prepare ourselves that we are not doing?
A: A little more attention to physical energy levels would be helpful.
Q: Which of course, suggests that physical energy is important and will be needed in some way.
A: Remember to utilize alfalfa with spiraling.

[...]



Session 22 October 2008

Q: (L) Yes, they are circles. The next thing we come to is that I
discovered that alfalfa, in fact, a very particular type of alfalfa, does,
indeed, grow in the German highlands. And, in fact, this alfalfa was
brought via a route that you described... as France, Spain, Canary
Islands, and Morocco. I was asking about this story of the purported
travels of Mary Magdalene, and you said that the people were not
important, that the message was. You then said that the 'artifacts
hold the key' and listed this sequence of places. I found a paper on
the subject of alfalfa which described this exact route of the spread
of alfalfa and it's value in farming because it literally replenishes the
ground it is grown in. So, it seems that you were describing the route
of the alfalfa plant. Can you comment on this?

A: Now that you have found this out, perhaps you should research
the properties of this mineral Rich in alfalfa and what it does for the
body of homo sapiens??

Q: (L) That is an interesting thing. Alfalfa was named as the 'father
of foods,' and was grown, primarily for, interestingly, horses! And,
we have chevin and the 'Horse of God.' Anyway, one of the primary
areas where this particular type of alfalfa was grown happens to be
in Baden, right next door to this Horselberg... right off the banks of
the Rhine. There is a valley there. Clover is, of course, a variation of
alfalfa, and 'dale' is a depression in the ground. Could this be right
there next to the location of the Lorelei rock off the Rhine?

A: Closer, and what of the four leaves?

Q: Yes, indeed. I will work on that.

[...]

https://books.google.co.uk/books?id=5IC6--3zhXMC&pg=PA64&lpg=PA64&dq=alfalfa+mineral+composition&source=bl&ots=-mQmoOw3Ny&sig=ub8dGdltPv7IW_6Jmml63ULa6B4&hl=en&sa=X&ved=0CCMQ6AEwATgKahUKEwiepuDhgfvGAhXTB9sKHZt8DxU#v=onepage&q=alfalfa%20mineral%20composition&f=false
Alfalfa Studies:
A study of the boron content of alfalfa was made after available evidence indicated a possible boron deficiency in certain areas of the state (26). Rather wide sampling established ranged from 18 to 56 ppm on untreated soils in Kansas.
Table V illustrates the effect of added fertilizer on boron content of alfalfa. With added lime and phosphorous, the increased yield of alfalfa results in a lowered boron content. Thus boron becomes a limiting factor in the growth of alfalfa under these conditions. It is desirable therefore in these low-boron areas to add this element to the soil, especially when other fertilizers are to be added.

http://www.quantumagriculture.com/node/218
‘Lucky’ Clover
Clover, which might otherwise be highly desirable because of its ability to unlock calcium and feed nitrogen fixing microbes, is far more seriously affected by boron loss than grasses, even though both may be stunted in a boron deficient paddock. Because boron is necessary for sap pressure and sap pressure is required to carry calcium, amino acids and other nutrients to where cell division occurs in plants, then clover may either be severely stunted by overgrazing during drought, or it may die out altogether. On the other hand I happened to encounter a cattle and horse operation in North West Victoria where capeweed was doing a brilliant job of bring boron (along with sulphur, calcium and nitrogen) back into the topsoil after a period of drought and severe overgrazing. The cell division was proceeding so well that not only were the clover leaves quite large, there were numerous four and five leaf specimens. Presumably four leaf clovers are considered ‘lucky’ because they are a sign of robust soil fertility and good cell division, which can only occur where boron is sufficient.

rrraven said:
Q: (Chu) Is there anything we should improve or change in our candida/detox diet?
A: You are all doing well. Search transcripts for clues about minerals and secrets.
minerals and secrets mentioned together in transcripts 970719
A: Trace minerals interact with deeply held secrets.
and 981205
Q: (L) What about the clay and the montmorillonite, and the
connection of the clay TO the montmorillonite, and what you
once said about trace minerals unlocking secrets in some
way?
A: Yes.
Q: (L) Yes what? (A) How much should we drink?
A: No.
Q: (L) We shouldn't drink it?
A: Be vague, we vague.
Q: (L) Is this montmorillonite the objective of the clues about
tritium? The fact that tritium pointed to this clay, and that this
clay is situated in the Rhineland, among other select sites, and
alfalfa possibly grows there. Is this where the clue was
supposed to lead us?
A: The question is about the mind, spirit and body, and what
happens hence.
Q: (L) Well, what I am trying to get to here is: is it useful for
us to ingest this montmorillonite? Will it assist in this
mind/body/spirit connection?
A: What is more to the point is who was assisted before, how
and why.
Q: (L) I don't get it. Maybe it is because I am so tired, but I
am hitting a blank on that.
A: You must be, as the obvious is quite oblivious!
Q: (A) We are not getting anything about this mineral... who
was assisted before, how and why... (F) I can figure that out!
(L) Well, go ahead! (F) If this clay is in Germany, and if the
implication is that the mineral causes some sort of beneficial
effect, perhaps, in antiquity, somebody was using it for that
reason. (L) Is F**** right on this?
A: Yes, he is.
[..]

Montmorillonite may have been close.....
https://books.google.co.uk/books?id=pEnxBwAAQBAJ&pg=PA241&lpg=PA241&dq=montmorillonite+boron+content&source=bl&ots=MOWgsDfnNN&sig=1dMFwjeJVfc3sDyMpscfehphjek&hl=en&sa=X&ved=0CD8Q6AEwBWoVChMI2cLUt4r7xgIVYi_bCh2G4wge#v=onepage&q=montmorillonite%20boron%20content&f=false
B. Factors Affecting Boron Adsorption-Desorption by Soil Constituents

1. Boron Adsorbtion as Affected by Boron Concentration and Water Content

boron adsorption by clays, hydrozy-aluminium, or soils increases with solution boron concentration showing a curve concaving downward (Figure 1). Equilibrium amounts of adsorbed boron on montmorillonite and soils as a function of the solution-to-adsorbent ratio, the water content does not affect the boron-adsorbent interaction (Keren and Mezuman, 1981; Mezurman and Keren, 1981). This fact is useful in prediction of boron distribution between the liquid and solid phases in soil during wetting and drying cycles (see also III.O).

2. Soil pH is one of the most important factors affecting boron uptake by plants. Studies by Peterson and Newman (1976) and Gupta and MacLeod (1977) have shown that a negative relationship between soil pH and plant boron occurs when soil pH levels are higher than 6.5. Since the plants obtain their boron from the soil solutions (Hatcher et al., 1959), these results indicate that boron distribution between liquid and the solid phase is strongly dependent on soil pH.
It has been reported by several investigators (Bingham et al., 1971; Hingston, 1964; Keren and Gast, 1983; Keren et al., 1981; Mezuman and Keren, 1981' Sims and Bingham, 1967) that increased pH enhances boron adsoption on clay minerals (montmorillonite, illite, kaolinite), hydroxyl-Al, and soils, showing a maximum in the alkaline pH range. Olson and Berger (1946) reported that alkalinization (pH > 7) of a soil increased it's capacity to adsorb boron, and this additional additional adsorbed boron could be released by acidification of the original soil pH.

Therefore stomach acid would release boron from montmorillonite.

So looking back on the thread, I noticed that my google results had brought up something slightly different. That is the same 'borax conspiracy' but instead of talking about high doses of borax, it talks about boron tablets.
Given borax is generally quite toxic, this is a particularly interesting diversion!

Posting the relevant part
http://www.checktheevidence.com/pdf/Borax-Txt.pdf
[..]The Arthritis Cure of Dr Rex Newnham
In the 1960s, Rex Newnham, PhD, DO, ND, then a soil and plant scientist in Perth, Western Australia, developed arthritis. Conventional drugs did not help, but he realised that plants in that area were rather mineral deficient. Knowing that boron aids calcium
metabolism in plants, he started taking 30 mg of borax a day, and in three weeks all pain, swelling and stiffness had disappeared.
Health and medical authorities were not interested in his discovery, but improving arthritis sufferers were delighted. Eventually he had tablets made containing 3 mg of boron, and only by word of mouth he sold 10,000 bottles a month. When he asked a drug company to market the tablets, it indicated that this would replace more expensive drugs and reduce profits. It so happened that it had representatives on government health committees, and arranged that in 1981 Australia instituted a regulation which declared boron and its compounds to be poisons in any concentration. He was fined $1,000 for selling poison, and this successfully stopped his arthritis cure in Australia.2
Subsequently, Dr Newnham published several scientific papers on borax and arthritis. One paper covered a double-blind trial in the mid-1980s at the Royal Melbourne Hospital, which showed considerable improvement in 70 per cent of those who completed the trial; only 12 per cent improved on a placebo.3 He also found that the traditional sugarcane islands have very low soil-boron levels due to long-term heavy use of chemical fertilisers. lamaica has the lowest level, and the arthritis rate is about 70 per cent; he noted that even most dogs were limping. Next comes Mauritius, with very low boron levels and a 50 per cent arthritis rate. The daily boron intake in these countries is less than 1 mg/day. The USA, England, Australia and New Zealand generally have
average soil-boron levels, with an estimated intake of 1-2 mg of boron and an arthritis rate of about 20 per cent. All spas reputedly curing arthritis have very high boron levels. These are also high in Israel, with an estimated daily boron intake of 5-8 mg and an arthritis rate of only 0.5-1.0 per cent.
Bone analysis showed that arthritic joints and nearby bones have only half the boron content of healthy joints, and synovial fluid that lubricates joints is boron deficient in arthritic joints. After boron supplementation, bones were much harder than normal. With additional boron, bone fractures healed in about half the normal time in both humans and animals. Dr Newnham once saw a baby girl, aged nine months, with juvenile arthritis, and borax cured her in two weeks.
Dr Newnham wrote that, commonly, people can get rid of their pain, swelling and stiffness in about one to three months. Then they can reduce treatment from three boron tablets to one tablet (each 3 mg) per day as a maintenance dose. He also stated that patients with rheumatoid arthritis often experienced a Herxheimer! reaction and that this is always a good prognostic sign. They must persevere, and in several more weeks the pain, swelling and stiffness will be gone.4,5
The Herxheimer reaction is an early aggravation of symptoms with increased pain due to toxins released by killed Candida and mycoplasma. I was surprised that this fungicidal effect is already present at such a low dose. It is equally surprising that
also about 30 per cent with osteoarthritis experienced a Herxheimer reaction, suggesting that the border between osteoarthritis and rheumatoid arthritis is rather fluid. In longstanding and resistant cases, use other antimicrobials in addition.
[..]

So an important question, does boron kill these things?
Most of google is full of the 'borox conspiracy' stuff, which is not helpful (I want medical papers) - and I think is a diversion. Bit of a needle in a haystack this one.
 
Altair said:
Clarithromycin destroys biofilms and enhances bactericidal agents in the treatment of Pseudomonas aeruginosa osteomyelitis.

Abstract

In this study, the effect of clarithromycin on the destruction of bacterial biofilm in Pseudomonas aeruginosa osteomyelitis was investigated. Foreign body-related osteomyelitis caused by ceftazidime-sensitive Pseudomonas aeruginosa was produced in the tibias of 26 rats. After osteomyelitis was verified on Day 14, 10 rats had ceftazidime (1500 mg/kg/day) given subcutaneously, and 10 rats had ceftazidime given subcutaneously and clarithromycin (100 mg/kg/day, two 50-mg/kg doses every 12 hours) given orally; three rats formed the control group. After a treatment period of 20 days, the tibias and the foreign bodies were removed, cultured, and examined by electron microscopy. The number of microorganisms growing on the bone tissue in the group receiving combined treatment was significantly lower than in the other groups. The number of microorganisms growing on the foreign body in the group receiving only ceftazidime was significantly higher than that of the group receiving combined treatment. Electron microscope examination revealed that the biofilm layer was eradicated in the group that had combined therapy; however, biofilm formation was evident on the foreign body in the group receiving only ceftazidime. Clarithromycin enhanced the activity of concomitantly used bactericidal agents by destroying biofilm on the surface of the materials.

_http://www.ncbi.nlm.nih.gov/pubmed/15662320

Quickly found other studies:

Efficacy of clarithromycin on biofilm formation of methicillin-resistant Staphylococcus pseudintermedius (_http://www.biomedcentral.com/1746-6148/8/225)
A Subinhibitory Concentration of Clarithromycin Inhibits Mycobacterium avium Biofilm Formation (_http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529245/)

Found this information in this article _http://www.pharmateca.ru/ru/archive/article/8006 (in Russian). The article suggests that Clarithromycin can eradicate biofilms regardless of which bacteria have formed it. Clarithromycin is allegedly the only known antibiotic with ability to destroy biofilms. Check English references at the end of the article.

Reading about this drug is kinda scary.
 
Laura said:
NSD said:
After totally 2000 mg of Metro and 900 mg Allo divided in few doses i got Flu but cant be sure is it from treatmeant.

Chin pain never had but now is first time.

Um, exactly what do you mean divided in a few doses? Is the amount right for your weight? Do you have enough to do up to 8 cycles and doxy for 6 months?

The "chin pain" sounds like it is part of the whole stiff neck thing that is one symptom of serious Herx reaction.

Divided in three days. Wanted to go slowly, was a bit scared of medications. My weight is about 77 kg. If i need i think that i can buy it. Here is not expensive.

Yea that strange pain in chin and my stomach stop to work a bit.

Want to add that i am almost every day on rollerblades sometimes i make about 30 km. Hope that is not problem for treatment? If someone have advice of some kind please add and thanks in advance.
 
NSD said:
Laura said:
NSD said:
After totally 2000 mg of Metro and 900 mg Allo divided in few doses i got Flu but cant be sure is it from treatmeant.

Chin pain never had but now is first time.

Um, exactly what do you mean divided in a few doses? Is the amount right for your weight? Do you have enough to do up to 8 cycles and doxy for 6 months?

The "chin pain" sounds like it is part of the whole stiff neck thing that is one symptom of serious Herx reaction.

Divided in three days. Wanted to go slowly, was a bit scared of medications. My weight is about 77 kg. If i need i think that i can buy it. Here is not expensive.

Keep in mind that if you DO have a proving reaction, you can't just quit or you will be in worse condition than you were before. If you start, you must proceed through the entire protocol otherwise you are harming yourself. I thought that was pretty clear.

NSD said:
Yea that strange pain in chin and my stomach stop to work a bit.

Not unusual. You after the metro cycle, as we have described in detail, you MUST replenish your beneficial bacteria and continue doing this throughout the treatment.

I've managed to keep my digestive tract going with higher doses of vitamin C which are also helpful.

NSD said:
Want to add that i am almost every day on rollerblades sometimes i make about 30 km. Hope that is not problem for treatment? If someone have advice of some kind please add and thanks in advance.

PLEASE READ THE ENTIRE THREAD AGAIN!!!!!!!!!!!!!!!!!!!!!!!!!

Why are you on rollerblades every day? You cannot do this treatment without allowing for plenty of rest and downtime!
 
Thanks for quick answer.

I am reading every day trying to understand all and will do again.

Almost every day for about 2 hours and i have enough sleep and rest but if that 2 hours is problem i will stop.

I know must replenish my beneficial bacteria so i buyed Bifidum and will take it, once in that three days i took 5gr of vit C.
 
JEEP said:
Hmmm, I very recently opened an article about 'Stephen Crohn, dubbed 'The Man Who Can't Catch AIDS' in 1996 ... he was resistant to H.I.V. and AIDS has committed suicide, aged 66' - and I cannot find the link in my history. The article also referred to the health caretakers who were immune to the Spanish Flu as well as the unlikelihood that this Stephen Crohn would commit suicide - simply doesn't make sense.

Did he die of a broken heart? This article seems to imply that he did.

http://articles.latimes.com/2013/sep/21/local/la-me-stephen-crohn-20130922
 
Laura said:
Altair said:
Clarithromycin destroys biofilms and enhances bactericidal agents in the treatment of Pseudomonas aeruginosa osteomyelitis.

[...]

Reading about this drug is kinda scary.

Yes, in the protocol, it is left as a last possible resource because it has too many side effects. It is a dangerous drug.
 
Latest update on brain-eating amoeba:

http://www.pulseheadlines.com/braineating-amoeba-st-bernard-parishs-water-supply/3051/ said:
‘Brain-Eating’ Amoeba found again in St. Bernard Parish’s Water Supply

For the second time in two years, residents from Louisiana, New Orleans, are threatened by a potentially deadly Amoeba, commonly known as the “brain-eating” Amoeba. Louisiana Department of Health and Hospitals (DHH) confirmed the presence of Naegleria fowleri Amoeba in the water supply.

Older articles on SoTT
http://www.sott.net/article/266338-Deadly-brain-eating-amoeba-found-in-Louisiana-parishs-water-supply
http://www.sott.net/article/281857-Girl-dies-from-one-in-a-billion-brain-eating-amoeba-infection

I'm still catching up on the thread, I hope the article above isn't too off topic now. Very exciting stuff! I thought the ketogenic diet would solve all my health problems but I'm finding many issues like difficulty coping with stress, trouble breathing, and anxiety, feeling like I'm unable to progress. Also will check out MTHFR mutations.
 
NSD said:
Hope that is not problem for treatment? If someone have advice of some kind please add and thanks in advance.

Make sure to not only read the entire thread, but also the attached papers. The metronidazol papers quoted explain what to expect from this protocol regarding Herx reactions. For instance, waking up one day and not been able to go to work is something that can happen. I'm glad you can roller-blade!

It is a good reminder for people to make sure the information on this thread is fairly well understood before embarking on this experiment. Antibiotics can be cheap and easily accessible, that doesn't mean you should just jump in with the protocol. Support from a health care provider is desirable, in case something goes really wrong.

Doing a blood test before the protocol would be the responsible thing to do as well. Imagine if you have impaired kidney function or a sluggish liver. That is the kind of info you should know before taking antibiotics for such a long time.

FWIW!
 
I can't seem to find the thread(s) about mycoplasma being developed as a biological weapon. No matter what search parameters I use (different terms, match all words, match any words, search all or some boards etc., etc.) nothing relevant comes up. The thing I can't understand is why this current thread doesn't come up in the search results when many key words used in it are in the search?


This thread keeps growing fast and remains very interesting. I still need to catch up with some of the links here though. That book on Lyme disease and Rife therapy posted by Aragorn sounds like it might be worth looking into. I might buy that one too. What I was reminded of was that the C's seemed to imply that a Rife machine can do more than kill pathogens (like help restore normal function to body systems, maybe from certain frequencies, etc.), but I'm not sure. Anyway, catching up on this thread daily is taking the better part of my forum activity.

Oh, and the boron connection being brought back into the conversation is another good clue....
 
Gaby said:
NSD said:
Hope that is not problem for treatment? If someone have advice of some kind please add and thanks in advance.

Make sure to not only read the entire thread, but also the attached papers. The metronidazol papers quoted explain what to expect from this protocol regarding Herx reactions. For instance, waking up one day and not been able to go to work is something that can happen. I'm glad you can roller-blade!

It is a good reminder for people to make sure the information on this thread is fairly well understood before embarking on this experiment. Antibiotics can be cheap and easily accessible, that doesn't mean you should just jump in with the protocol. Support from a health care provider is desirable, in case something goes really wrong.

Doing a blood test before the protocol would be the responsible thing to do as well. Imagine if you have impaired kidney function or a sluggish liver. That is the kind of info you should know before taking antibiotics for such a long time.

FWIW!

Thanks for advice! Yea i am a bit quick at reading and like i want to read all from once but miss many good points in thread.

I can maybe because illness is not serious yet and have strength to avoid hard reaction from medications but by time that can change to worse.

I've read a bit about stiff neck and there are many causes between sport injuries, wrong sleeping to Meningitis infection.

Is now late to make blood test?
 
SeekinTruth said:
I can't seem to find the thread(s) about mycoplasma being developed as a biological weapon. No matter what search parameters I use (different terms, match all words, match any words, search all or some boards etc., etc.) nothing relevant comes up. The thing I can't understand is why this current thread doesn't come up in the search results when many key words used in it are in the search?

Hopped over to SOTT for a search there and found this

http://www.sott.net/article/155150-BioWarfare-Mycoplasma-The-Linking-Pathogen-in-Neurosystemic-Diseases

It´s not a forum thread but at least it´s something.

Hope this helps a bit. :)
 
Laura said:
If Cranberry juice helps destroy adhesion, then D-mannose should also be a big help.

"Research is showing that – although cranberry juice is filled with what I believe are too many sugars that can lead to other potential health problems – cranberry EXTRACT is another story altogether. Recent studies suggest that components found in cranberry extract may work the same way as cranberry juice.*

That means you're getting two ingredients to help support urinary tract health instead of just one with D-Mannose.*"

products.mercola.com/d-mannose/
 

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