AUTOIMMUNE DISEASES CAUSED BY AN INFECTION?

[luke wilson]

NSD, before you go about nuking tour body, you should know as much as you can! You only have 1 body... And the stuff being discussed hear to me appears that if you go into it without the proper level of knowledge, you may have some serious prices to pay down the line.

 

[aragorn]

Thanks Aragorn for looking into the Rife information -- I haven't had a chance to catch up on everything you've posted about it yet, but look forward to doing it as soon as I can. Have you considered registering on the Rife forum? There may be some things worth checking out there -- we just have to remember it's a private forum, so we can't quote from it directly (although we can probably summarize findings).

Yeah, I thought about joining the forum, perhaps I'll do it!

I just placed an order on the first book by Rosner, the one called "When antibiotics fail, Lyme disease and Rife machines". Even if it's in some things a bit out of date, I liked the overview he gives on the rife machines, the different models, and other related things, too. Plus, there's a good list of references at the end.

After all this reading, one thing I can say with 75% certainty, is that if one would like to try "rifing therapy" with best efficiency, the way to go would be to use the magnetic field option and not contact methods, like zapping and Bob Beck's blood purifying unit with alternating current. The reason is (as you can read below in the quotes), that "zapping the blood" only takes you so far, it can't properly reach places like joints, lymphs, brain, etc. This means, that the best options are machines that are built according to Rife's original models, i.e. using plasma tubes, or the so called Doug Coil (a coil operating at different frequencies, creating a magnetic filed). You know, reading all those patents and also main stream research papers related to this, are slowly making me convinced that this Rife therapy (the real Rife stuff) is working, and worth a try. As I now understand it (and that might change), IF we follow this path of operation, the thing to do would be the following:

- destroy the shielding of the dormant critters, e.g. the biofilm (not sure if this can be done with rifing), some "free-swimming" critters could be destroyed directly by rifing
- lure the dormant critters to become active (not all at the time!), I'm not sure what would do this
- then using the right frequencies, and magnetic field options, kill them with a Rife machine

One of the questions that I still haven't figured out is: since some of the critters like mycoplasma don't have a cell wall, their electrical properties are probably different, too. Would they still respond to frequency/current targeting? Like Rosner said in his newest book, there might be properties in rifing that we still don't know about (perhaps Rife himself knew more than we know?). For instance, there is at least one research paper that talks about how T-cells (our warrior cells) use electrical current to destroy invaders. Perhaps rifing also energizes the T-cells, making them more effective?

Another thing that bothers me, is that there is no way to scan/analyze the body for the resonances, i.e. the critters that are present. On the market there's the so called F-scan, but it seems to be a total scam. So, doing rife therapy, you must try out different frequencies, without exactly knowing what you should target. Many users say, though, that they do feel when the frequency is on target, that "something is happening". On the other hand, if it takes 30min to use a couple of different frequencies, it would still be worth it, if it helps with the chronic condition.

#

Here are some quotes from Rosner's first book, that I thought were useful as food for thought. I guess the information on the antibiotics is out of date, but the points he make could still be valid. Again, I hope the author is okay with so many quotes from his book!

Excerpts from When Antibiotics Fail: Lyme Disease and Rife Machines

Antibiotics

Antibiotics are the treatment of choice in ”early” Lyme Disease and aggressive antibiotic therapy can be a useful weapon in all stages. Many people do improve, or even recover, using antibiotics. However, many people do not. […] The problem is not that antibiotics are completely ineffective; instead, they are usually only effective enough to help a person recover to a certain point, after which there is a stalemate between the infection and the person. This story is consistently seen among Lyme Disease sufferers: They get better and sometimes stable with antibiotics, but they can never quite get well. And, the most ominous problem is that those who get better on antibiotics often relapse when the drugs are discontinued. So most people stay on them for months or years. Because antibiotics are toxic when used in high doses, long term, this is not an ideal scenario.

Bacterial resilience when challenged by antibiotics

[…] All bacteria attempt to survive in adverse conditions. Ability to survive in adverse conditions is the reason bacteria are a threat to human health in the first place: The human immune system is the most advanced bacterial defense system that exists – it creates the harshest of adverse conditions for invading bacteria – yet, against all odds, some pathogenic bacteria can survive (and even proliferate) in the body. […] Antibiotics use a method of action to create adverse conditions for invading bacteria. For example, some antibiotics’ method of action is to inhibit bacteria from manufacturing their much needed cell walls (such as cephalosporin antibiotics like Rocephin, and penicillin antibiotics like amoxicillin). Other antibiotics bind to certain parts of bacteria in an attempt to prevent new proteins from being manufactured (such as macrolide antibiotics like Zithromax and Biaxin, and the new ketolide antibiotic Ketek). Antibiotics do not magically enter the body and kill bacteria – a specific process must take place for the pink pills to be anti-bacterial.

But this process does not always happen. Bacteria are experts in survival. Lyme Disease bacteria particularly have an amazing ability to rapidly and efficiently detect, and mutate in defense against, antibiotics. When this happens, antibiotics become completely ineffective. The sobering reality that pink pills do not always kill bacteria renders the glorious invention of the 20th century, our super-powerful antibiotics, just another tool that sometimes works and sometimes doesn’t.

[…] Antibiotics are not the only threat survived by Lyme Disease bacteria. The bacteria can survive starvation, nutrient deprivation, elevated temperature, increased oxygenation, being frozen, hydrogen peroxide, and pH changes. As a matter of fact, Lyme Disease bacteria can survive MOST adverse conditions encountered in the human body and in nature. Unfortunately, most modern Lyme Disease therapies rely on antibiotics or other adverse conditions to treat Lyme Disease. That’s why modern Lyme Disease therapies can fail, and even sometimes make a person worse. You just can’t beat these bacteria at the survival game. They win.

The ideal therapy must kill the bacteria without creating an adverse environment that the bacteria can detect as a threat (Rosner 2005, 15-16).

Antibiotics do not reach all deep, sequestered areas of infection

The reason antibiotics do not reach all areas of infection is that they are delivered (either orally or intravenously) via blood. Blood does not deliver antibiotics to all parts of the body in sufficient concentrations to kill the spirochete.

There are two reasons for this:

First, some parts of the body, such as joints and cartilage, receive minimal blood flow in comparison with other blood-rich parts of the body. Lyme Disease colonies can become established in these areas.

Second, the brain (where the Lyme Disease infection is often worst) is protected from foreign antibiotic chemicals carried in blood. The brain has what is referred to as a blood-brain barrier, which ensures that most foreign substances stay out of the brain, even if they are allowed to circulate to other parts of the body. Most oral antibiotics only reach the brain in one-tenth the concentration they reach other parts of the body. LLMDs know that antibiotics must reach the brain to be effective, so they administer much higher doses in an attempt to get them past the blood-brain barrier. But high doses of antibiotics wreak havoc on the rest of the body.

Antibiotics and other treatments delivered via blood are also hindered in reaching the infection because of various blood problems often occurring in Lyme Disease sufferers. Many LD patients have excessive inflammation, hypercoagulation, increased presence of fibrogen, poor circulation, and other blood-related problems. These problems compound the difficulty of getting the drugs or herbs where they are needed. Experts theorize that the LD bacteria intentionally create excess inflammation to prevent proper immunological function and blood flow (see Benicar therapy in Chapter 8). So, even an antibiotic capable of avoiding the LD defense mechanism would not be an ideal therapy. First, the bacteria would quickly mutate out of susceptibility to the antibiotic and second, the antibiotic would not reach the infection in sufficient quantities needed to deactivate the bacteria. […] Natural and herbal antibiotics can cause the same problems as pharmaceutical antibiotics. They threaten the spirochete and activate the spirochetal defense mechanism, and they also require blood to be distributed which means they do not successfully reach all areas of infection. Some natural antibiotics have side effects as well (Rosner 2005, 22-24).

[…]Not only can the spirochete convert to a dormant cyst form, it can also undergo a morphological change into a bacterial form known as the cell wall deficient form (also called variant form, or L-form). This form can be much more difficult to diagnose and treat than the spirochete form. This form is also less susceptible to antibiotic therapy. By this point you may be impressed with the LD organism’s knack for survival, but it gets even more amazing. When a single spirochete converts to cyst form to survive a harsh environment, as many as FIVE new spirochetes can re-emerge from that single cyst when that single cyst finally does re-activate. You attack a single spirochete with antibiotics, the spirochete converts to cyst form to survive, you stop taking antibiotics, and up to FIVE intact, viable spirochetes emerge!

Wow, these guys are truly evil!

LD spirochetes have also been seen under the microscope shuddering rapidly and shedding many tiny granules, or blebs, from their bacterial structure when they are threatened with antibiotics. These granules are hypothesized to have the ability to grow up to be fully functional spirochetes when the antibiotic is discontinued and when the environment again becomes favorable. So attacking a single spirochete with antibiotics can result in dozens of new spirochetes via granule and cyst reproduction.

As you can see, engaging the spirochete’s defense mechanisms by threatening the infection with antibiotics is dangerous. You will kill some of the bacteria but you will also force a significant number of the bacteria to resort to behavior that will aid the infection in proliferating and worsening. This situation is seen clinically when people who were treated with antibiotics relapse after cessation of antibiotic therapy. They become much sicker than they were before antibiotics were used. Although it is possible for a person to recover after the infection has become more entrenched due to antibiotic use, a full recovery takes longer and is more difficult (Rosner 2005, 18).

Chapter 3: Five solutions created by rife machine treatment

Solution 1: all deep, sequestered areas of infection are accessible

The ideal treatment cannot rely on blood to distribute it because this would not allow penetration to sequestered areas of infection. The treatment must also reach the brain effectively. The brain is highly protected from foreign chemicals by the blood-brain barrier, so reaching the brain is no small task.

This characteristic of rife machine treatment is intriguing. The behavior of electromagnetic fields renders the body’s hard-to-reach places easily accessible. The EM field produced by a rife machine to deliver the treatment is not shielded by any of the materials in the human body. While antibiotics are limited by blood distribution and the blood-brain barrier, EM fields are not limited at all. Rife machine treatments do not require blood for delivery. When the body is near a rife machine emitting an EM field, the field penetrates the body in its entirety. Rife machines can reach every area of the body effectively including skin, blood, tissue, bones, brain, etc.

After spending years, thousands of dollars, and using toxic IV antibiotics to treat the infection in the brain, now it is possible to treat the brain with ease. The blood-brain barrier is not a factor with rife machine therapy. The blood-brain barrier prevents entrance of foreign substances into the brain but does not prevent entrance of EM fields.

Solution 2: all strains of spirochete can be killed

Since bacterial resistance forms rapidly to most (herbal or pharmaceutical) antibiotics, the ideal treatment must have sustainable killing power. If the infection can mutate and become resistant then the treatment will not provide long term results. Rife machines operate by vibrating (oscillating) an object at such rate as to cause its destruction. The target rate of vibration, or MOR (mortal oscillatory rate), depends on the structure of the organism. There are theoretically MORs for all micro-organisms: amoeba, bacteria, viruses, fungi, parasites, etc. As a matter of fact, there is potentially an MOR for every physical object.

As said, there might be other mechanisms than frequency involved that make the Rife technology effective.

LD is one infection particularly susceptible to modern rife machines. Spirochetes […] are narrow, elongated and relatively symmetrical due to their spiral shape. Therefore, resonance more easily destroys spirochetes than compactly shaped microorganisms like viruses and most fungi. […] This also accounts for why rife machines work better against the spirochete form of LD than the cyst or variant forms, which are more compact microorganisms. As a matter of fact, research indicates that modern rife machines only work on the spirochete form of LD, not the variant and cyst forms. […] Spirochetes come in different shapes and sizes. […] [this] can easily be accommodated by changing treatment frequencies slightly.

The obvious question is: what about when the bacteria are in variant and cyst form, and are not susceptible to rife therapy? Because antibiotics are the main cause of spirochetes converting to cyst/variant organisms, if antibiotics are avoided the bacteria remain in spirochete form. Or, if the bacteria are already suppressed to dormant cyst and variant forms due to previous antibiotic therapy, then the rife machine treatment protocol indicates that antibiotics are to be discontinued when rife machine therapy is initiated. This will result in removing the adverse conditions created by antibiotics. Eventually all dormant forms of the disease will convert back to spirochetes (as part of their natural life cycle) and become susceptible to rife therapy.

In his newest book, he makes the point that the "waiting game" is not enough, we need to force these critters to activate

Solution 3: the LD defense mechanism is not activated

Avoiding activation of the LD defense mechanism is the core goal of an ideal treatment approach. This is where most therapies fail – most therapies are a direct chemical or environmental threat to the infection that results in activation of the bacterial defense mechanism. Rife machines ”silently” attack the LD spirochete and kill it stealthily without triggering its defense mechanism. Rife machines are the only known therapy the spirochete is incapable of detecting, adapting to, or mutating in defense against. The ability for rife machine technology to accomplish this is based on the fact that the LD spirochete has only evolved the ability to sense and defend against physical threats, including chemicals (antibiotics), heat, pH changes, freezing, starvation, etc. The organism is fully capable of surviving these challenges. The organism has not developed the ability to defend against resonant frequencies or electrical current. The LD infection has never encountered these types of challenges in nature, and has thus not evolved (or adapted) to survive them. By using resonant frequencies and electrical current, we can attack the LD spirochete with a weapon it has never encountered before and is thus incapable of defending against.

Experiments have shown that spirochetes in a petri dish or test tube react quickly to the introduction of antibiotics via changed bacterial activities and formation of blebs, granules and cysts. Experiment have shown that spirochetes in a petri dish or test tube do not change their bacterial activities and do not convert to variant and cystic forms when exposed to resonant frequencies. Thus when rife therapy is used the bacterial load is reduced without the treacherous results of activating the bacterial defense mechanism. This attack strategy can only be accomplished when antibiotics are NOT IN USE. Antibiotics cause the infection to revert to variant and cyst forms that are not susceptible to rife machine treatment. Rife machines work by [when] drawing out the infection from its suppressed, defensive, dormant position (Rosner 2005, 33-37).

 

[LQB]

Just received this from the Green Pasture folks:

GcMAF for the treatment of cancer, autism, inflammation, viral and bacterial disease
by David Noakes

Human GcMAF, otherwise known as Vitamin D binding protein macrophage activating factor, holds great promise in the treatment of various illnesses including cancer, autism, chronic fatigue and possibly Parkinson's. Since 1990, 59 research papers have been published on GcMAF, 20 of these pertaining to the treatment of cancer. 46 of these papers can be accessed through the GcMAF web site.

GcMAF is a vital part of our immune system which does not work without it; and is part of our blood. GcMAF stimulates the macrophage element of the immune system to destroy cancer cells. It also blocks the supply of nutrients to cancer cells by stopping blood vessel development to the site (anti-angiogenesis). Cancer cells are weakened and starved, making them more vulnerable to attack by the GcMAF stimulated macrophage system. Research has shown macrophage activation and stopping diseased blood vessel development can also help in various neurological diseases such as Parkinson's, Alzheimer's, rheumatoid arthritis, inflammatory conditions, and diabetic retinopathy.

In the case of autism, Dr. James Bradstreet has so far treated 1,100 patients with GcMAF with an 85% response rate. His results show a bell curve response with 15% of the patients showing total eradication of symptoms and 15% showing no response.

In addition, experimental and clinical evidence confirms that GcMAF shows multiple powerful anti-cancer effects that have significant therapeutical impact on most tumors including breast, prostate, and kidney. GcMAF is created in the body by the release of two sugar molecules from a GcProtein molecule.

However, tumors release an enzyme known as Nagalase. Nagalase degrades GcProtein to the point it is unable to become GcMAF. Since GcMAF only lives for about a week in the body, without continuous conversion of GcProtein the stores of GcMAF are depleted rapidly in the presence of Nagalase. However, Nagalase can only destroy GcProtein and not GcMAF. Thus the introduction of external GcMAF through injection into the body has been shown to be effective.

GcMAF has no side effects of its own, but in under 10% of cases the immune system, which will be rebuilt in just three weeks, can produce considerable side effects in autistic children. The treatment consists of an injection with a tiny diabetic sized syringe once a week. The duration depends on the severity of the disease. Research also reveals that in cancer cases that are stage I and II, the success rate approaches 90% inside 6 months. Nagalase and immune system levels can be measured in the blood and thus offer a marker for cancer and other diseases.

In conclusion, GcMAF restores the energetic balance in the cell. Cancer cells driven by sugar metabolism become healthy oxygen driven cells, so tumor cells no longer behave as parasitic organisms. GcMAF stimulates macrophages to consume the cancer cells and cells invaded by viruses. This stimulation of the immune system and the anti-angiogenetic effect surrounding the tumor is beneficial in cancer and several neurological disorders like autism, chronic fatigue, Parkinson's, and Alzheimer's, and it is available to the general public.

The following testimonials are from the gcmaf.eu web site:


Autism
Hello Dr. Bradstreet, After 13 weeks of the GCMAF, we are happy to report that she continues to have tremendous gains in all areas. Increased socialization and speech, better performance in the school as well as community settings, decreased tantrums and less vocal protests, she is able to change activities and transition to non preferred tasks. It has been absolutely amazing, all her therapists, teachers, other parents have remarked about her good behavior in public places (for example, grocery stores, department stores such as Nordstrom's, Macy's, The Zoo, Bowling, the library, parks and playgrounds. In the past, we never went to these places in fear of her stimming, or her behavior (45 minute tantrums). Now, she surprises us as well as others with her appropriate comments and follows direction very well. Before she would only eat one thing (french fries) and now she eats everything including vegetables!!!!! I've sent some pictures to show her progress. We are so excited to see what more phenomenal things are in the future to come!


Ovarian and lung cancer
I first contracted cancer in the form of a granulosa cell tumour in 2005. After 2 operations and 3 months of chemo by January 2010 it had reached stage 4 and had spread from my ovaries to my lungs. After that scan in January I was told the chemo had failed, my 5 tumours were still growing, given Tamoxifen hormone, told I had between 3 months and 2 years left to live, and sent on my way.

I started taking GcMAF at the age of 56 on 16th May 2010; the only feeling or side effect I have from GcMAF is I felt almost from the beginning that I had my old energy back and was feeling much better and fitter in myself. After 8 weeks of taking only GcMAF and Tamoxifen I went for a scan. This showed all tumours had shrunk, the four in my lungs were now hardly noticeable and that the aggressive tumour in my pelvis had shrunk from 7.4cm to 4.1 cm. This is a significant decrease in size.

The stand-in consultant was very excited, and said these were excellent results. As I did not know her, and she did not ask, I did not tell her why.

On the 21st Oct I had another scan; the improvements continued; the secondaries appeared to be merely scar tissue, and the pelvic tumour had shrunk to 3.5 cm

In the winter my improvements seemed much slower; we now know because GcMAF needs normal vitamin D levels. But I've just got back from a wild month in Australia and Thailand, the sunshine should have done wonders for my vitamin D levels, and for my next scan. I will keep you updated. But I am over the moon and feel better than ever. And yes, you can phone me if you like. Gail in London.


Breast cancer
"I have the opportunity to treat patients from all over the World and the addition of GcMAF for my cancer patients is truly adding a new dimension not previously available to us. Recently I have been following a 42 year old women who had already undergone surgery, radiation and chemotherapy for stage IIIB breast cancer. I obtained a nagalase test through ELN (Holland) and it returned in the very elevated range of 4.20nmol/min/mg (normal reported by this lab does not exceed 0.95). Her other tumor markers were not elevated, but her PET scan demonstrated a likely metastatic site in the hip bone.

After discussing her options the patient wanted to try GcMAF therapy prior to considering more radiation or chemotherapy. After 6 weeks of GcMAF 100ng/week subcutaneous injections (much like a shot of insulin) her repeat nagalase test returned at 2.10 (a 50% reduction). All of her other tumor markers remain negative and she is taking the dose of Vitamin D3 required to optimize her blood levels (9000 iu/day). It is too soon for her PET to be repeated but we will follow this soon to determine the course of the bone metastasis. The nagalase test may be a more sensitive marker for tumor burden than other more accepted blood tests. GcMAF given via simple patient administered once weekly injections is clearly able to reduce the nagalase level dramatically over a short period of time. In previous published studies, nagalase response to GcMAF was correlated with reduction and eventual elimination of cancer. This is an encouragement to us all and I will keep you posted on the patient's progress."

For more information please visit First Immune GcMAF or contact David Noakes at:

First Immune GcMAF
Clos de Balade 21
1140 Evere
Brussels, Belgium
Phone +44-7781-411-737

 

[aragorn]

Fascinating discussion with Bryan Rosner and the "Royal Rife of our time", Doug, who invented the coil machine:

http://<iframe width="420" height="..._g" frameborder="0" allowfullscreen></iframe>

 

[Altair]

Cross posting for reference:

Session 29 November 2001
Q: Is there anything that we are supposed to do regarding this upcoming transition?
A: Yes.
Q: Can we know what it is?
A: Not yet!
Q: Is there anything we ought to be doing to prepare ourselves that we are not doing?
A: A little more attention to physical energy levels would be helpful.
Q: Which of course, suggests that physical energy is important and will be needed in some way.
A: Remember to utilize alfalfa with spiraling.

[...]

So an important question, does boron kill these things?
Most of google is full of the 'borox conspiracy' stuff, which is not helpful (I want medical papers) - and I think is a diversion. Bit of a needle in a haystack this one.

Small correction: in the original session script (http://cassiopaea.org/forum/index.php/topic,18647.msg176214.html#msg176214) C's used the word "spirulina" and not "spiraling". Some studies regarding boron:

The importance of boron nutrition for brain and psychological function

Abstract
Boron (B) nutriture has been related to bone, mineral and lipid metabolism, energy utilization, and immune function. As evidence accumulates that B is essential for humans, it is important to consider possible relationships between B nutriture and brain and psychological function. Five studies conducted in our laboratory are reviewed. Assessments of brain electrical activity in both animals and humans found that B deprivation results in decreased brain electrical activity similar to that observed in nonspecific malnutrition. Assessments of cognitive and psychomotor function in humans found that B deprivation results in poorer performance on tasks of motor speed and dexterity, attention, and short-term memory. However, little support was found for anecdotal reports that supplementation with physiologic amounts of B helps alleviate the somatic and psychological symptoms of menopause. Parallels between nutritional and toxicological effects of B on brain and psychological function are presented, and possible biological mechanisms for dietary effects are reviewed. Findings support the hypothesis that B nutriture is important for brain and psychological function in humans.

_http://link.springer.com/article/10.1007/BF02783144

Dietary boron, brain function, and cognitive performance.

Abstract

Although the trace element boron has yet to be recognized as an essential nutrient for humans, recent data from animal and human studies suggest that boron may be important for mineral metabolism and membrane function. To investigate further the functional role of boron, brain electrophysiology and cognitive performance were assessed in response to dietary manipulation of boron (approximately 0.25 versus approximately 3.25 mg boron/2000 kcal/day) in three studies with healthy older men and women. Within-subject designs were used to assess functional responses in all studies. Spectral analysis of electroencephalographic data showed effects of dietary boron in two of the three studies. When the low boron intake was compared to the high intake, there was a significant (p < 0.05) increase in the proportion of low-frequency activity, and a decrease in the proportion of higher-frequency activity, an effect often observed in response to general malnutrition and heavy metal toxicity. Performance (e.g., response time) on various cognitive and psychomotor tasks also showed an effect of dietary boron. When contrasted with the high boron intake, low dietary boron resulted in significantly poorer performance (p < 0.05) on tasks emphasizing manual dexterity (studies II and III); eye-hand coordination (study II); attention (all studies); perception (study III); encoding and short-term memory (all studies); and long-term memory (study I). Collectively, the data from these three studies indicate that boron may play a role in human brain function and cognitive performance, and provide additional evidence that boron is an essential nutrient for humans.

_http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566632/

Boron as antibiotic

Discovery of a Novel Class of Boron-based Antibacterials with Activity against Gram-negative Bacteria

ABSTRACT

Gram-negative bacteria cause approximately 70% of the infections in intensive care units. A growing number of bacterial isolates responsible for these infections are resistant to currently available antibiotics and to many in development. Most agents under development are modifications of existing drug classes, which only partially overcome existing resistance mechanisms. Therefore, new classes of Gram-negative antibacterials with truly novel modes of action are needed to circumvent these existing resistance mechanisms. We have previously identified a new a way to inhibit an aminoacyl-tRNA synthetase, leucyl-tRNA synthetase (LeuRS), in fungi via the oxaborole tRNA trapping (OBORT) mechanism. Herein, we show how we have modified the OBORT mechanism using a structure-guided approach to develop a new boron-based antibiotic class, the aminomethylbenzoxaboroles, which inhibit bacterial leucyl-tRNA synthetase and have activity against Gram-negative bacteria by largely evading the main efflux mechanisms in Escherichia coli and P. aeruginosa. The lead analogue, AN3365, is active against Gram-negative bacteria, including Enterobacteriaceae bearing NDM-1 and KPC carbapenemases as well as Pseudomonas aeruginosa. This novel boron-based antibacterial, AN3365, has good mouse pharmacokinetics and was efficacious against Escherichia coli and P. aeruginosa in murine thigh-infection models, which suggest this novel class of antibacterials has the potential to addresses this unmet medical need.

_http://aac.asm.org/content/early/2013/01/03/AAC.02058-12

There is evidence from several laboratories that dietary boron plays a role in immune function in a variety of organisms. The boron-containing antibiotic boromycin... was recently found to be a potent anti-human immunodeficiency virus (HIV) antibiotic, acting by (in part) still unknown mechanisms.

_https://books.google.de/books?id=Al8-rzgMqWoC&pg=PA6&lpg=PA6&dq=boron+antibiotic&source=bl&ots=erELbvtklQ&sig=yJKWT06RJZsJSFKwG199goJA88E&hl=de&sa=X&ved=0CFsQ6AEwBmoVChMIuvX2k_X7xgIVhVUUCh2JwACT#v=onepage&q=boron%20antibiotic&f=false

_https://books.google.de/books?id=bffjBwAAQBAJ&pg=PA29&lpg=PA29&dq=boron+containing+antibiotics&source=bl&ots=YBSRTgEQI_&sig=6_r0XTiMgLrNTorB79tmiQbIkeM&hl=de&sa=X&ved=0CH0Q6AEwCWoVChMIvqWUnff7xgIVx_xyCh31FAZ0#v=onepage&q=boron%20containing%20antibiotics&f=false

Natural and Synthetic Small Boron-Containing Molecules as Potential Inhibitors of Bacterial and Fungal Quorum Sensing

6. Boronic Acids As Inhibitors of Bacterial Enzymes

Many bacteria use QS signaling systems to synchronize target gene expression and coordinate biological activities among a local population.N-acylhomoserine lactones (AHLs) are one family of the well-characterized QS signals in Gram-negative bacteria, which regulate a range of important biological functions, including virulence and biofilm formation.19,20 Several groups of AHL-degradation enzymes have recently been identified in a range of living organisms, including bacteria and eukaryotes. Expression of these enzymes in AHL-dependent pathogens and transgenic plants efficiently quenches the microbial QS signaling and blocks pathogenic infections. A range of bacterial species which use AHL molecules as QS signals to regulate different biological functions, including production of virulence factors and biofilm formation of human pathogens, have been discovered.8–10,19,20 Several groups of AHL-degrading enzymes have recently been identified in a range of living organisms, including bacteria and eukaryotes. Expression of these enzymes in AHL-dependent pathogens and transgenic plants efficiently quenches the acceleration of the QS signal and blocks pathogenic infection.8–10 Proteins capable of degrading these autoinducers have been called “quorum-quenching” enzymes, can block many QS dependent phenotypes, and represent potentially useful reagents for clinic, agricultural, and industrial applications. The most characterized quorum-quenching enzymes to date are the AHL lactonases, which are metalloproteins that belong to the metallo--lactamase superfamily.94The finding that many pathogens rely on cell-to-cell communication mechanisms, known as quorum sensing, to synchronize microbial activities essential for infection and survival in the host suggests a promising disease control strategy, i.e. quenching microbial quorum sensing or in short, quorum quenching. Results obtained over the past few years have demonstrated that quorum-quenching mechanisms are widely conserved in many prokaryotic and eukaryotic organisms.95 These naturally occurring quorum-quenching mechanisms appear to play important roles in microbe-microbe and pathogen-host interactions and have been used, or served as lead compounds, in developing and formulating a new generation of antimicrobial agents.

Well, you probably have to read the whole paper... (in attachment). Source: _http://www.researchgate.net/publication/49696183_Natural_and_Synthetic_Small_Boron-Containing_Molecules_as_Potential_Inhibitors_of_Bacterial_and_Fungal_Quorum_Sensing

 

[NSD]

NSD, before you go about nuking tour body, you should know as much as you can! You only have 1 body... And the stuff being discussed hear to me appears that if you go into it without the proper level of knowledge, you may have some serious prices to pay down the line.

Trying and thanks all for concern and guide. I am not so smart as i want to be :)

Hope i am on right track....

 

[truth seeker]

I can't seem to find the thread(s) about mycoplasma being developed as a biological weapon. No matter what search parameters I use (different terms, match all words, match any words, search all or some boards etc., etc.) nothing relevant comes up. The thing I can't understand is why this current thread doesn't come up in the search results when many key words used in it are in the search?

Not sure if this is what you're looking for, but I found these:

Mycoplasma fermentens(a bioweapon) - Often Overlooked In Chronic Lyme Disease

Re: Morgellons: Controversial disease doctors refuse to treat

Re: Chemtrails? CONtrails? Strange skies...

 

[wattsup]

Video explaining how autism, cancer, .... Have been introduced in altering the auto immune system.

Link: _https://youtu.be/cALgIHETMDU

 

[Altair]

EDTA Inhibits Biofilm Formation, Extracellular Vesicular Secretion, and Shedding of the Capsular Polysaccharide Glucuronoxylomannan by Cryptococcus neoformans


ABSTRACT

The fungal pathogen Cryptococcus neoformans can grow as a biofilm on a range of synthetic and prosthetic materials. Cryptococcal biofilm formation can complicate the placement of shunts used to relieve increased intracranial pressure in cryptococcal meningitis and can serve as a nidus for chronic infection. Biofilms are generally advantageous to pathogens in vivo, as they can confer resistance to antimicrobial compounds, including fluconazole and voriconazole in the case of C. neoformans. EDTA can inhibit biofilm formation by several microbes and enhances the susceptibility of biofilms to antifungal drugs. In this study, we evaluated the effect of sublethal concentrations of EDTA on the growth of cryptococcal biofilms. EDTA inhibited biofilm growth by C. neoformans, and the inhibition could be reversed by the addition of magnesium or calcium, implying that the inhibitory effect was by divalent cation starvation. EDTA also reduced the amount of the capsular polysaccharide glucuronoxylomannan shed into the biofilm matrix and decreased vesicular secretion from the cell, thus providing a potential mechanism for the inhibitory effect of this cation-chelating compound. Our data imply that the growth of C. neoformans biofilms requires the presence of divalent metals in the growth medium and suggest that cations are required for the export of materials needed for biofilm formation, possibly including extracellular vesicles.

_http://aem.asm.org/content/78/22/7977.full

Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era

[...]

Chelating Agents

Metal cations, such as calcium, magnesium, and iron have been implicated in maintaining matrix integrity (Patrauchan et al. 2005; Raad et al. 2008). Consistent with this observation, chelating agents have been shown to destabilize biofilm architecture besides interfering with bacterial membrane stability (Donlan 2011). For example, sodium citrate inhibited biofilm formation by several Staphylococci species in vitro (Shanks et al. 2006). In addition, tetrasodium-EDTA eradicated biofilms in an in vitro biofilm model and on explanted hemodialysis catheters (Kite et al. 2004; Percival et al. 2005), whereas disodium-EDTA, in combination with tigecyclin or gentamicin, reduced biofilm formation by Staphylococcus species and P. aeruginosa on Hickman catheter segments in vitro (Bookstaver et al. 2009). Raad et al. showed efficacy of a combination of minocycline and disodium-EDTA against biofilms in vitro or on explanted catheter tips, as well as in the treatment of catheter-related bloodstream infections in three different patient studies (Raad et al. 1997, 2003). A minocycline-EDTA solution was also successfully used to prevent indwelling implantable-port infections in children with cancer; no port infections or other adverse effects were observed in patients whose ports were flushed with the monocycline-EDTA solution, whereas 21% of the patients in the untreated control group developed infection (Chatzinikolaou et al. 2003). Moreover, reduction of catheter-related bloodstream infections was observed in hemodialysis patients after treating catheters with minocycline-EDTA (Bleyer et al. 2005; Feely et al. 2007).

[...]

_http://perspectivesinmedicine.cshlp.org/content/3/4/a010306.full

 

[Sol Logos]

It may be unrelated so with that disclaimer this popped up on my Facebook feed and it sounded interesting in light of all this. So I thought I'd share in case there's something to it that might be helpful. The article has a bit of pop culture feel to it btw.

About 25 years ago, the famous American doctor Hulda Clark came to an life-changing discovery that significantly changed the course of development of modern medicine.

She Cured 20.000 People from CancerHulda Clark has managed to heal more than 20.000 patients who were suffering from cancer and other similar diseases. The basis of each of her treatments was the elimination of parasites that exist in the human body. Clark is convinced that the basic cause for the development of every untreatable disease is the same – parasites.

She found many old recipes and designed some new recipes that helped thousands of people eliminate these dangerous microorganisms which ultimately lead to cancer cure as well as healing of other dangerous diseases.

Dr. Clark is also known as a biophysicist, philosopher and author and co-author of many different books dedicated to alternative medicine. She graduated at the University of Saskatchewan in Canada where she studied medicine. After that, she got MA in biology.

Finally in 1958, she got doctorate degree in physiology from the University of Minnesota.

However, this is not where Dr. Clark stopped upgrading her knowledge.

That’s why in 1988 she was able to design a technology that can scan the body for pathogenic microorganism presence. This discovery led to the creation of the device known as Syncrometer.

Thanks to the Syncrometer, people can detect microorganisms and other potentially dangerous substances in the body in a fast and precise manner. This device is relying on detection of resonance. In case you didn’t know, everything around us comes with its frequency.

If we use frequency in the right way, we can easily detect viruses, parasites and bacteria in human and animal bodies. Thanks to this device, Dr. Hulda Clark concluded that the leading cause of many so-called untreatable disease are the parasites found in the body.

Five years later, in 1993, Clark presented a new book called The Cure for all Cancers. This book comes with a thorough explanation about the link between Fasciolopsis buski parasite and cancer. This particular type of parasite can be noticed in every person suffering from cancer. Once the parasite is removed from the system, the cancer is gone. This was the reason why Hulda Clark created a unique anti=parasite recipe that includes black walnut, cloves and wormwood.

With the help of this remedy, users can eliminate more than 100 different types of parasites. It was proven that this powerful combination can eliminate fully-grown parasites, but what is even more interesting it can eliminate the eggs and larva created by these parasites too. Dr. Clark has also designed a special anti-parasite program that has healed thousands of people from “incurable” diseases and cancer.

Bioresonance Zapper:
She didn’t stop there and continued her research. After a while, she presented a brand new method which involved the use of bioresonance zapper. Zapper is an electronic device that works with the help of micro-currents and in this way it is capable of elimination of bacteria, viruses and parasites.

It is good to know that a huge number of doctors were aware that microorganisms can’t live in an environment with specific frequency and this is something they knew before Dr. Clark introduced the method. They have conducted many studies in which they have successfully eliminated bacteria and viruses by exposing them to different frequencies. The good news is that although these frequencies are deadly to microorganisms they are perfectly safe for the human body.

Scientists have developed a new field of science called Bioresonance Medicine based on this finding. This type of alternative medicine is part of conventional medical practices in some countries like Russia for example.

...

_http://www.healthandlovepage.com/bioresonance-zapper/

 

[shijing]

Thanks, Altair, for finding that information about EDTA -- it seems the biofilm/heavy metal connection might be worth following up on. Here's an interesting interview from Tick Talk Ireland:

http://www.ticktalkireland.org/biofilms.html

Biolfilm is often talked about in Lyme disease. This is a mass including all 3 forms of the borrelia bacteria (for a view of Biolfim go to: http://www.youtube.com/watch?v=a4uNDWdChM8 )

This article discusses biolfilm in autism but also refers to Lyme and MS:

Dissolve Biofilms With Fibrinolytic Enzymes:
A Novel Approach to Chronic Infection in Autism Spectrum Disorders

An Interview with Peta Cohen, M.S., R.D., founder of Total Life Center in Northern New Jersey. Cohen specializes in treating children with autism using a biomedical / nutritional model. Cohen received her Masters in Clinical Nutrition from New York University and has been a Defeat Autism Now! practitioner for the past ten years.

Focus: You have evolved a highly successful strategy to treating chronic bacterial infections and biofilms that involves some new insights and relies in part on fibrinolytic enzymes like nattokinase and lumbrokinase. I understand you are working with autism experts like Anjum Usman, M.D. and functional medicine pioneers to get the word out on your new insights.

Cohen: I do a tremendous amount of testing and assessing the children through urine and fecal analysis. What got me so interested in nattokinase and lumbrokinase was the concept of what a biofilm infection actually is. If you do a medline search on biofilms and platelet aggregation, fibrinogen, and fibrin, boom, it’s there right in your face. Bacteria build biofilms by first aggregating together, and then rapidly weaving this protective web or matrix around them. They build a polymeric matrix. It’s a sticky, gluey, mucus-y goop and it’s got fibrin in it to give it an intact structure. The bacteria recruit fibrinogen to create fibrin as part of that matrix. At that point they can shed their outer membrane, which has the proteins that serve as antigens and as a target of the missile of the immune system. They’re very protected. They’re very crafty in creating a way to survive and procreate and hide from the immune system.

Focus: Why are they protected, and how does that impact our health?

Cohen: They’re protected because they’ve built this matrix but are still alive, still fermenting and metabolizing and leaching toxins into the bloodstream, although they may have a reduced metabolism compared to active, acute infection. Because of the biofilm they can no longer be reached by an anti-infectious agent or even the immune system. And because of the biofilm you may not find evidence of the infection in the fecal matter when you do stool cultures. For years, I knew from organic acid testing, from the short-chain fatty acids and metabolites the children were excreting, that they carried these infections. Yet when I did a stool culture I did not find the bugs.

Focus: When you began to work at dissolving the biofilms, did you find the bugs?

Cohen: Oh yes! But I found something else that was just as fascinating, something nobody was thinking about. Think about what that biofilm might really be made of. The biofilm matrix has a horizontal and a vertical weave. It’s standard knowledge that biofilm bacteria sequester calcium, magnesium and iron to help build that matrix. Minerals give the biofilm integrity—as if you’re building a wall. You don’t only want bricks, you want cement. To address this, first you use fibrinolytics to help dissolve the fibrin, then you use EDTA to chelate out the minerals. And guess what? We started getting huge dumps of toxic metal. Now why is that? I think the answer points to something so huge, whether we’re dealing with autism or lyme disease or multiple sclerosis or lupus or even cancer.

Focus: Why were the kids dumping toxic metals when you began to degrade the biofilms?

Cohen: Well, think about it. These are all positively charged cations, that’s why EDTA is able to chelate them well. Mercury, and copper, and other heavy metals are also positively charged. Why would the bug preferentially insert calcium or magnesium? It could use any positively charged metal. This has been the most fascinating part of my year-long work on biofilms. As we degraded this biofilm matrix and liberated these bugs, not only did the organic acid levels get higher—one child bounced into the 400’s—but the kids started to dump metals into the bowel. I felt like I’d exposed these little terrorists in a cell.

Focus: So the metals and the bugs are both in the gut?

Cohen: Right. At an Autism One Conference in Chicago last May, one researcher presented his proton analysis of brain tissue, attempting to verify the presence of mercury in the brains of autistic children, and he couldn’t find it. Yet he still found evidence of activation of the microglia (a type of glial cell that acts as the first and main form of active immune defense in the central nervous system) as a consequence of toxic metals. So where are these metals? I’m suggesting they are in the biofilm, along with the bugs, in the gut. If the biofilm wasn’t using toxic metals, along with common minerals, to build the biofilm, then why all of a sudden do I get these huge dumps of metals on stool tests?

Focus: What exactly is your therapy and what sequence do you use?

Cohen: I start with enzymes like nattokinase and lumbrokinase, as well as other mucolytic enzymes, to get the best, broad fibrinolytic effect. Dr. Usman feels nattokinase is particularly good at degrading strep biofilms and I think that strep is a very big player in these childrens’ health. I will run strep titers and they will be extraordinarily high. And these children—and certainly some adults as well—will manifest strep as a comorbid infection that has significant implications for neurological function. They will have very OCD type tendencies, and sometimes almost psychotic outbursts. There isn’t a precise, sudden onset with obvious symptoms.

Focus: How much do you recommend?

Cohen: Remember, these patients are very young; some are just a few years old. So I will recommend half a capsule of each, two times a day. That would be a 50 milligram capsule of nattokinase, and a 20 milligram capsule of lumbrokinase. First do the enzymes along with EDTA, then thirty minutes later, add in an arsenal of antimicrobials. I use formulations containing berberine, artemisinin, citrus seed extract, black walnut hulls, artemisia herb, echinacea, goldenseal, gentian, tea tree oil, fumitory, gentian, galbanum oil, oregano oil, neem, and pharmaceuticals as well when necessary, such as Vancomycin, Diflucan, Gentamycin. I use a different one every day. Then an hour later you come in with the binders to help mop up the debris. I use chitosan, citrus pectin, a special bicarbonate formula, organic germanium, chlorella and others. I also use buffering agents, such as buffered vitamin C, since when the body is destroying bacteria it becomes acidic. Minerals must be assessed, and repleted when necessary. I test bloodwork and “pees and poos” (urine and stool) every two months to monitor the process.

Focus: Enzymes, EDTA, antimicrobials, binders, and buffering agents. What are the clinical results?

Cohen: They’re fantastic. It’s like the missing piece. I had one little autistic boy who lives in the city who is loaded with viruses and infections and is now almost fully recovered. His mother used to complain about the terribly high levels of copper in his bloodstream and that his hair was like a copper mattress. We measured the hair but there was a marginal amount of copper in it. He was not eliminating. As we got into the thick of the biofilms his copper blew out of his body in his stool, for months and months. He’d been loaded with copper. I’ve had other children struggling for ages to get mercury out, and out it came.

Focus: It sounds like this approach would work for any chronic illness in which chronic infection plays a role.

Cohen: Yes, I think biofilms are a huge missing piece in Lupus, Lyme Disease, Multiple Sclerosis and any autoimmune-type chronic infection. You have to ask, what compels the immune system to maintain this state of dysfunction? Ask yourself, how could an organism perceived by the immune system as foreign survive its presence? Either something has corrupted the immune system, or the organism has transformed itself in a way that the immune system can’t find it. That’s what the biofilm does. I believe it’s one of the biggest medical issues we’re dealing with today.

 

[RedFox]

That's really interesting Shijing.
So it looks like EDTA is going to be really useful. Combined with it sequestering iron that the pathogens need to grow it should help a lot.
It also potentiates antibiotics (see here).

 

[Altair]

NAC Reduces Biofilm Formation

Germ gangs, otherwise known as biofilms, indicate that a “call to war” is linking bacteria together in a hostile mode that attacks the human host. A new study shows that NAC (N-acetyl-cysteine)1 can reduce biofilm formation by 62% - a rather astounding finding for a nutrient.

The researchers tested NAC against a wide variety of problematic bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebseilla pneumoniae, Pseudomonas aeruginosa and Proteus vulgaris. Once these organisms form biofilms they are often resistance to antibiotics and very difficult to get rid of. Too bad NAC wasn’t tested against Candida albicans biofilms, as I bet it works on them too.

The precise mechanism of how NAC works its anti-biofilm magic is unknown. NAC is an important antioxidant that fuels the production of cellular glutathione. NAC is known to dissolve mucous and is an excellent respiratory support nutrient. Low levels of NAC reduce the functionality of immune troops that patrol mucosal surfaces. However, to dissolve a biofilm there must be a direct communication into the germ gang that fools its defense shield. Right now we don’t know how it works – we just know it works.

_http://www.wellnessresources.com/health/articles/nac_reduces_biofilm_formation/

A Fatty Acid Messenger Is Responsible for Inducing Dispersion in Microbial Biofilms


ABSTRACT

It is well established that in nature, bacteria are found primarily as residents of surface-associated communities called biofilms. These structures form in a sequential process initiated by attachment of cells to a surface, followed by the formation of matrix-enmeshed microcolonies, and culminating in dispersion of the bacteria from the mature biofilm. In the present study, we have demonstrated that, during growth, Pseudomonas aeruginosa produces an organic compound we have identified as cis-2-decenoic acid, which is capable of inducing the dispersion of established biofilms and of inhibiting biofilm development. When added exogenously to P. aeruginosa PAO1 biofilms at a native concentration of 2.5 nM, cis-2-decenoic acid was shown to induce the dispersion of biofilm microcolonies. This molecule was also shown to induce dispersion of biofilms, formed by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Streptococcus pyogenes, Bacillus subtilis, Staphylococcus aureus, and the yeast Candida albicans. Active at nanomolar concentrations, cis-2-decenoic acid appears to be functionally and structurally related to the class of short-chain fatty acid signaling molecules such as diffusible signal factor, which act as cell-to-cell communication molecules in bacteria and fungi.

_http://jb.asm.org/content/191/5/1393.short

 

[l apprenti de forgeron]

Video explaining how autism, cancer, .... Have been introduced in altering the auto immune system.

Link: _https://youtu.be/cALgIHETMDU

It is a long list to really know how parasites enable stress, curtailment of mental and physical energy toward chronic/deadly diseases. Perhaps even how they interact with electromagnetism and spiritual attachments.
All this seems like a major focus of an existential war, that few are aware. The destruction of the parasites in us has to be connected with be vigilant to not get infected again, which maybe will allow to be prepared for a future great invasion of cometary parasites.

 

[Altair]

Very interesting presentation.

The Clinical Implications of Gastrointestinal Biofilm with Stephen F. Olmsted, MD

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