Cowden Support Program & Related Topics
W. Lee Cowden, MD, MD(H)
USA Board-Certified Internal Med & Cardiology
Chairman Scientific Advisory Board of
Academy of Comprehensive Integrative Medicine
Panama City, Panama
MSMMI: (Multi-Symptom, Multi-Microbe Inflammation includes any or all of the following:)
Common co-infections (acquired at the same time)
Opportunistic infections/infestations (or co-conspirators)
Common co-infections (acquired at the same time)
Borrelia (36 species & at least 4 species known to cause disease)
Bartonella (cat scratch disease & 31 other species of bacteria)
Babesia (14 species of protozoa) and Theileria microti
Protomyxzoa (Stephen Fry Lab: at least 8 species of protozoa)
Leptospira (other spirochetal bacteria)
Ehrlichia, Coxiella & Anaplasma (and other rickettsia)
Mycoplasma (hundreds of L-forms)
Opportunistic infections/infestations (or co-conspirators)
Protozoa & worms (such as V.Klapowi lungworm)
Fungi (candida sp.,aspergillus sp.,penicillum sp.,cladysporium, etc.)
Treponema sp. & Ochrabactrum anthropi (oral bacteria)
Viruses (HSV-1 & 2, CMV, EBV, HHV-6, XMRV, coxsackie, etc.)
Lyme & Coinfections Can Cause MSMMI (Multi-Symptom, Multi-Microbe Inflammation)
•Most symptoms are caused by inflammation
•Inflammation usually caused by WBC response to microbes &/or toxins
•Toxins include heavy metals, man-made chemicals (including drugs) & biotoxins
•Toxins increase microbial growth
•“Microbes" include mycoplasma,chlamydia, fungi, viruses, borrelia, bartonella, protozoa, worms…
•To resolve inflammation, it’s best to remove toxins and microbes
Survival Strategy of Pleomorphologic Variation in Borrelia burgdorferi & Other Spirochetes
When exposed to antibiotics, Borrelia burgdorferi develops granules & cysts(round bodies)
which are resistant to antibiotics. Antimicrobial Agents & Chemotherapy, 1995;39(5):1127
Infection,1996, 24(3):218. Kersten A, Poitschek C, Rauch S, Aberer E. 1995
This is why cyclic therapy is needed
Emerging Infectious Determinants of Chronic Diseases CDC-Emerging Infectious Diseases Vol. 12, No. 7, July 2006 • www.cdc.gov/eid
•“Evidence now confirms that noncommunicable chronic diseases can stem from infectious agents. Furthermore, at least 13 of 39 recently described infectious agents induce chronic syndromes. Identifying the relationships can affect health across populations, creating opportunities to reduce the impact of chronic disease by preventing or treating infection.… infectious agents likely determine more cancers, immune-mediated syndromes, neurodevelopmental disorders, and other chronic conditions than currently appreciated.”
Copyright W.L.Cowden 2009-2015
Microbes in Various Chronic Diseases
•Multiple Sclerosis: 90+% Chlamydophila/ Mycoplasma/ Borrelia (38/41 CSF cultures + Borrelia- Lida Mattman)
•ALS: Ochrabactrum anthropi, spirochetes, viruses
•Autism: 16X more likely to have Borrelia, fungi, viruses, mycoplasma…
•Chronic Fatigue Syndrome: 18X more likely to have Mycoplasma, HHV-6, CMV, Borrelia (90% Borrelia +)
•Atherosclerosis/MI/stroke: increased when increased total microbial load (esp. dental, mycoplasma & Borrelia)
•Premature labor: linear relationship between total load of microbes in amniotic fluid (>18species)
•Alzheimers: 80% chlamydophila, 65% Treponema, 25% Borrelia (Miklossy), Herpes Simplex Virus…
Garth Nicolson, Judith Miklossy, Lida Mattman, Hal Huggins, Jim Roberts, & others
Alzheimer's disease - a neurospirochetosis Analysis of the evidence following Koch's & Hill's criteria Journal of Neuroinflammation 2011, 8:90 doi:10.1186/1742-2094-8-90 Judith Miklossy Copyright W.L.Cowden 2009-2015
MI-free/death-free survival curves according to pathogen burden (# of positive IgG to CMV, HepA, HSV1, HSV2).
Zhu J et al. Circulation 2001;103:45-51 Copyright © American Heart Association
Copyright W.L.Cowden 2009-2015
Copyright © 2012 American Medical Association. All rights reserved.
From: Periodontal Infections and Coronary Heart Disease: Role of Periodontal Bacteria and Importance of Total Pathogen Burden in the Coronary Event and Periodontal Disease (CORODONT) Study
Arch Intern Med. 2006;166(5):554-559. doi:10.1001/archinte.166.5.554
LYME BORRELIOSIS = 2nd GREAT IMITATOR Borrelia is one of biggest contributors to MSMMI
Lyme causes, mimics or contributes to more than 350 illnesses (www.nutramedix.ec)
Can mimic MS, myelopathy, polyneuropathy, brain tumor, encephalopathy (Neurosurgery.1992 May;30(5):769-73)
Can cause meningitis, encephalitis, neuritis, mania, OCD, depression, schizophrenia, anorexia, dementia (Am J Psychiatry. 1994 Nov;151(11):1571-83)
Lyme can cause cardiomyopathy, CHF, perimyocarditis, arrhythmias, AV block and conduction disturbances (Eur Heart J.1991 Aug;12 Suppl D:73-5)
90% of chronic fatigue patients are Lyme positive. (Informal study by American Lyme Disease Alliance)
Fetal borrelia can cause fetal death, SIDS, fetal anomalies… (Rheum Dis Clin North Am.1989 Nov;15(4):657-77)
Misconceptions about Lyme Disease (Borreliosis plus Co-infections)
•Lyme disease is only a concern in Northeastern US states
•All patients recall a tick bite or bulls eye rash (>30% don’t)
•ELISA is a sensitive screening test (misses Dx >30% of time)
•Only one infectious pathogen is usually transmitted by the tick bite (usually at least two microbe species & often more)
•A short course of antibiotics resolves all cases of Lyme disease (per “Treatment Guidelines” of IDSA)
Truth Lyme disease is worldwide, may present as chronic and complex ‘medically unexplained symptoms’, is difficult to diagnose, is multi-microbial and difficult to treat.
Copyright W.L.Cowden 2009-2015
Antibiotics Don’t Work For Chronic Lyme
•Survival of Borrelia burgdorferi in patients with Lyme borreliosis treated with antibiotics. Preac-Mursic V et al 1989
•Culture positive and PCR positive blood after antibiotics therapy. Oksi J et al 1999
•Treatment with tetracycline, erythromycin or doxycycline in mice failed to eradicate acute Borrelia infection. Moody KD et al 1994
•Chloramphenicol and azithromycin failed to eradicate the organism. Moody KD et al 1994
•Persistence of Borrelia burgdorferi following antibiotic treatment (ceftriaxone) in mice. Hodzic E, et al. Antimicrob Agents Chemother 2008; 52: 1728-36.
•In Vitro Study of the Susceptibility of Mobile and Cystic Forms of Borrelia burgdorferi to Metronidazole. Brorson O et al 1999
•Clinically treatment failures occur in 5 to 10% of EM patients when treated with oral doxycycline or amoxicillin for 14 to 30 days. Smith RP et al 2002
Other Lyme Testing & Treatment Issues Cameron D, 2007 J. Evaluation in Clinical Practice, 13(3):470-472
•Prior treatment with antibiotics can attenuate antibody response to Borrelia
(More likely to test negative, possibly forever)
•There is no “test for cure” of Lyme
•Treatment delay worsens outcome
–If >60days from onset to treatment, 6x more likely to remain ill chronically
–If EM rash+, then 5x more likely cured with treatment
•If symptoms persist after Lyme treatment, also consider Lyme Look-Alikes (www.acimconnect.com)
Co-morbid Conditions in Borreliosis (that can predispose to, perpetuate, or even mimic the symptoms of Borreliosis & Coinf’s)
1)Electromagnetic pollution
2)Gastrointestinal dysfunction
3)Fungi (candida,etc) and/or mycotoxin exposure
4)Parasites, “non-Lyme” bacteria & viruses
5)Focal infections (esp.in mouth)
6)Heavy metal & other toxins
7)Kryptopyroluria & genetic detox defects
8)Nutrient deficiencies
9)“Toxic” and/or allergenic foods
10)Emotional traumas
11)Adrenal and/or thyroid insufficiency
12)Structural misalignments
13)Hypoxia
14)Neuro/CCSVI
2 webinars recorded on www.acimconnect.com “Lyme Look-Alikes”
Health is like a Bathtub
“Dirty-water” faucets = Nutrient depleted foods, Electromagnetic fields, Radiation pollution, Toxic relationships, Toxic emotions, Heavy metals, Polluted air, Antibiotics, Pesticides, Biotoxins, Allergens, Microbes.
“Clean-water” faucets =
Healthy foods & nutrients,
Purpose & will to live,
Sunshine & exercise,
Good relationships,
Peace, joy & love,
Great attitude,
Restful sleep,
Pure water,
Fresh air
“Drains”= Bowel Liver Kidneys Lymphatics
Disease is a Bathtub full of Dirty Water = Hi Total Load
Dallas, Texas Pilot Study 2003 (unpublished)
The Question To Be Answered:
“Can Natural Medicine make a difference in patients with advanced Borreliosis & co-infections given no hope by conventional medical doctors?” Copyright W.L.Cowden 2009-2015
• Blood Type Diet
• Enzymes with meals
• Enzymes between meals
• Vitamins & Minerals
• Herbs to detoxify and support all organs
• Homeopathic drainage
• Samento (+/- Stevia)
• Laser Detox
• Chi machine/Light beam generator
• Skin Brushing/MLD
• Bath Detox
• Stretching
• Laughter
• Prayer
• Emotion Release
Multisystem Protocol for Borreliosis & Co-infections In The Integrative Group Copyright W.L.Cowden 2009-2015
•The die-off of toxin-producing micro- organisms releases toxins into the body and as one takes treatment to get better, they feel temporarily worse (described first by the German physician Karl Herxheimer)
•Herx reactions resolved rapidly in the study using drainage remedies
•Adverse reactions are rare with this natural treatment other than Herx
Herxheimer Reaction Or Healing-Crisis Reaction
U. tomentosa Mechanisms of Action
Uncaria tomentosa (Samento) has the following effects:
•Anti-microbial effects from POAs (pentacyclic oxindole alkaloids); since Samento is TOA-free, there is no blocking of POAs
•Anti-microbial effects from Quinovic acids
•Reduces inflammation by blocking NF-kappa B formation
•Reduces inflammation by blocking TNFa & other cytokines
•Reduces inflammation by inducing acute-phase liver proteins
•Prevents free radicals by blocking Nitric Oxide Synthase gene
•Protects cells by degrading peroxynitrite (free radical)
•Stimulates natural killer cells to kill cancer and microbes
•Increases phagocytosis by macrophages and neutrophils
•Causes apoptosis in human leukemic & lymphoma cells (Sheng)
•Reduces DNA damage & enhances DNA repair in chemo pts.
•Immune adaptogen
Evaluation Methods Used Each Visit in Dallas Pilot Study
•Physician Examination (all 27 pts)
•Medical Outcomes Short Form 8 (all 27 pts)
•Symptom Severity Questionaire (all 27 pts)
•Bioterrain (pH saliva & urine & urine minerals by electrical conductance in 13 integrative pts only)
•Kinesiologic Evaluation (in 13 integrative pts)
•Cell Blood Count, Chemistry Profile & Western Blot (1st & last visits only in all 27 pts)
•Dark Field Microscopy of Blood (in 13 integrative pts)
Blood Dark Field Microscopy Results In Samento Natural Treatment Group
•Before study- every patient had swarming microbes (spirochetes, fungi, babesia, etc.)
•2 weeks- fewer microbes than before the study
•4 weeks- very few microbes in serum
•6 weeks- no microbes in serum until red blood cells crushed, then many microbes seen
•8 weeks- no microbes until red cells crushed, then very few microbes seen
•10 weeks- no microbes seen before or after crushing red cells
• 28 Western-Blot-Positive Stage-3 Lyme patients started the study in Dec.2002 (Borrelia & 1+Co-inf.)
• 14 “control” patients continued using conventional therapy during study; one improved moderately, 6 improved slightly, 3 worsened & 4 remained the same.
• Of 14 patients in “integrative” treatment group, 13 completed study (1 dropped out due to tumor surgery) and all 13 improved subjectively and objectively (2 moderately and 11 markedly &/or significantly).
• By 18 weeks, further improvement in the “integrative” group but not in the “control” group.
Dallas Pilot Study at 10 Weeks
AFTER 18th WEEK
•Insomnia completely gone
•Joint pain 50% improved
•Energy- 90% improved
•Family & friends noticed dramatic difference
BEFORE TREATMENT
• Lost from 155 to 98lbs. during course of 3 years
• 100% disabled
• 50 specialists consulted (Including Mayo Clinic)
• 2 Lyme specialists said no treatment would help
35 year old caucasian man on disability with blood type A, bowel inflammation, carbohydrate intolerance, insomnia, joint pains, fatigue and muscle aches Case Study 1- J.M.
Copyright W.L.Cowden 2009-2015 AFTER 9th MONTH Built home with own hands Became naturopathic doctor
18 year old caucasian female with blood type O, extreme weakness and fatigue and anaphylactic food reactions.
• Taking care of herself
• Walking without walker
• Going on dates
• 50-75% improvement
• Completely dependent on family; home schooled
• Walked with walker
• Sick 15 years,since age 3
• Having anaphylaxis often
• No social life
• Dr. said she would not go to college or marry
Case Study 2- C.F. BEFORE TREATMENT
AFTER 18th WEEK Copyright W.L.Cowden 2009-2015 AFTER 9th MONTH
Went to college by herself
Was on honor role & worked
Got her masters & married
Now working on PhD & had a healthy baby
• Gluten/milk/sugar-free diet
• Enzymes with meals
• Enzymes between meals (Serrapeptase…)
• Magnesium Malate
• Trace Minerals,Lugol’s,C,D3
• Detox herbs= Pinella + Burbur/Parsley
• Stretching
• Cumanda or Banderol or Houttuynia + Samento
• Sulfa Detox= Sparga
• L-glutathione (liposomal)
• Light beam generator
• Lymph drainage/ Chi machine
• Bath Detox
• Laughter
• Emotional release
• Drink enough water
• Bind metals= Sealantro
• Mora or Enula +/- Quina
Empiric Cowden Support Program
For MSMMI (As It Evolved) Copyright W.L.Cowden 2009-2015
Horowitz Study
•Richard Horowitz MD, then vice-president of ILADS, in Dec.2006 started several hundred Lyme patients (who had failed to improve on antibiotic therapy) on the all-natural “Cowden Support Program”
•Cowden Support Program had developed from the Lyme Pilot Study in Dallas in 2003
•See program: www.nutramedix.ec
•70% of his patients improved fairly quickly (<6mo.)
•Dr. Horowitz presented this at ILADS Conf. 2007
•I evaluated some of the “failures” in his office
•Failures were toxic from mercury, biotoxins,& EMR, were dehydrated, had food allergies & were eating excess sugar
•Cowden Support Program was then modified
•> 80% of subsequent Lyme patients improved
Effect of Therapies on Borrelia Biofilm
Control Banderol Only
Samento Only
Banderol+Samento
Copyright W.L.Cowden 2009-2015
Doxycycline
More Borrelia Research- U. New Haven Eva Sapi, PhD presented at national Lyme conf. 2013 & 2015
•In vitro eval. of Banderol, Samento, Cumanda, Stevia, Jalapa, Enula, Mora, Takuna, Houttuynia & Doxycycline vs 3 forms of B.burgdorferi (spirochete, cyst & biofilm)
•Against Bb spirochete, Doxy & all of the tested herbs were effective
•Against Bb cyst, several of the herbs were effective (esp. Jalapa & Stevia) but Doxy was not effective
•Against Bb biofilm, all of the herbs were effective (esp. Jalapa & Stevia) but Doxy was not effective
Lack of Toxicity of Herbal Products in Condensed Cowden Lyme Protocol
•Pharmacology & toxicology studies were done at the University of Guayaquil in Ecuador
•Samento, Banderol, Cumanda, Houttuynia, Enula, Mora, Burbur, Parsley, Pinella, Sparga, Amantilla, Babuna, & Avea were all tested.
•Doses equivalent to hundreds to thousands of times the recommended doses for humans caused no acute or chronic organ damage nor any unexpected adverse-effects.
Anti-inflammatory Effects of Quantum-Enhanced Herbals
•Pharmacology & toxicology studies were done at the University of Guayaquil in Ecuador
•Drug Feldene reduced inflammation 99.8%
•Samento reduced inflammation 84%
•Cumanda reduced inflammation 97%
•Quina reduced inflammation 99.9%
•Noni Conc. reduced inflammation 99.4%
•Morinda Noni reduced inflammation 31.3%
Cowden Support Program (CSP)
•First 3 days take Burbur &Pinella 10drops 2x/day & 10 drops of Parsley-Detox 2X/day
•Day 4 add 2caps 2x/day Serrapeptase, 2+caps Mg.malate, 10drops 2X/day Sparga; also add Banderol & Samento-starting 1drop each & building to 30 drops of each 2X/day
•Day 4 add every 3rd night 15 drops Sealantro (+/-DMSA)
•On day 78, cycle Banderol to Cumanda+Mora then Enula+ Houttuynia 30drops2X/day for 12.5 days on, 36 hours off
•On day 78, cycle Samento 30 drops twice daily 12.5 days on, 36 hours off (with the Mora, Enula or Banderol)
•Stevia 30 drops can be given with every dose of Samento
•190-day program +2pg.Summary at www.nutramedix.ec
How to Take Antibiotics with CSP
•After day 78 of CSP, there is a 36 hour period OFF all Microbial Defense herbs every 2wks
•Pharmaceutical antibiotics must stop 12 hours before the Microbial Defense herbs and restart when the first Microbial Defense herbs restart
•Therefore, the pharmaceutical antibiotics are stopped for at least 48 hours each 2 weeks
•The time off all antimicrobials allows hiding forms of bugs to transform back into the invasive forms, which are the forms most responsive to bug killers
•Dr. Horowitz found those on CSP alone did as well as or better than pts. on pharmaceutical antibiotics plus CSP
• Gluten/milk/sugar-free diet
• Avoid all allergenic food
• Serrapeptase/Lumbrokinase
• +/- Enzymes with meals also
• Mag.malate & Lugol’s iodine
• Trace mins + vit.(C,D3,5MTHF)
• Cautious use of Zinc,Mn,Mb,B6
• Sealantro+/-DMSA/Lipo-EDTA
• Burbur/Parsley/Pinella/Mapalo
• Takuna/LDM/Lauricidin - viruses
• Cumanda/Lakato/Banderol/HH
• Enula/Mora for Babesia/parasites
• Flora + fiber + Stevia
• Laser Energetic Detox
• Chi-machine/MLD/LBG/ LymphStar-Pro/Skin-brush
• Clay scar treatment
• Stress-reduction +sauna
• Cranial suture release
• EMF avoidance, esp.nite
• Adrenal Support + vit.B5
• AmantillaRelax/Melatonin
• Avea/Lizyme- depression
• Ezov/Evox for emotions
• Samento+/-Artemisinin
Non-Empiric Program For MSMMI (Kinesiology or EDS-guided) Copyright W.L.Cowden 2009-2015
>95% improve
Nutramedix Products Used As-Needed
•Amantilla= imprinted extract of valerian root for anxiety & insomia
•Adrenal Support= Schizandra, Astragalus, Rhodiola, Rhododendron caucasicum & Panax Ginseng
•Avea= imprinted extract of tumeric for depression
•Chanca Piedra= for Babesia & dissolves stones
•Quina= broad-spectrum antimicrobial
•Stevia= used in place of sugar (to not feed microbes); very good anti-Borrelia/anti-fungal
•Takuna= antiviral (acute flu & chronic viruses)
•Tangarana= broad-spectrum antimicrobial
Detox Made Simple
Create A Toxin-Free Body & Home…Starting Today by William Lee Cowden, MD & Connie Strasheim
•Written for the lay public while highly beneficial for practitioners
•Toxicity & detoxification is key to all chronic diseases
•More info: www.acimconnect.com